Behavioural changes and psychological symptoms in dementia disorders

Lancet Neurology

Volumn 4, Issue 11, 2005, Pages 735-742

  McKeith, Ian ^a   Cummings, Jeffrey ^b  

^a NEWCASTLE GENERAL HOSPITAL   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; CHOLINESTERASE INHIBITOR; HYPNOTIC SEDATIVE AGENT; MEMANTINE; MOOD STABILIZER; NEUROLEPTIC AGENT; RIVASTIGMINE; SEROTONIN UPTAKE INHIBITOR;

AGITATION; ALZHEIMER DISEASE; ANXIETY; ANXIETY DISORDER; APATHY; BEHAVIOR DISORDER; CLINICAL TRIAL; COGNITIVE DEFECT; CORTICOBASAL DEGENERATION; DELUSION; DEMENTIA; DEPRESSION; DIAGNOSTIC ACCURACY; DISEASE SEVERITY; EVIDENCE BASED MEDICINE; FRONTOTEMPORAL DEMENTIA; HALLUCINATION; HUMAN; MENTAL DISEASE; MULTIINFARCT DEMENTIA; NEUROANATOMY; NEUROPATHOLOGY; PATHOPHYSIOLOGY; PHYSICAL DISABILITY; PRIORITY JOURNAL; PROGRESSIVE SUPRANUCLEAR PALSY; PSYCHOSIS; REM SLEEP; REVIEW; RISK ASSESSMENT; SYMPTOMATOLOGY;

ACTIVITIES OF DAILY LIVING; BEHAVIOR; COGNITION DISORDERS; DEMENTIA; HUMANS; PSYCHOMETRICS; TERMINOLOGY;

EID: 26844580209     PISSN: 14744422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1474-4422(05)70219-2     Document Type: Review

References (102)

1. American Psychiatric Association Diagnostic and statistical manual of mental disorders 4th edn. 1994 American Psychiatric Association Washington DC
2. C Sauvaget, M Yamada, S Fujiwara, H Sasaki, Y Mimori Dementia as a predictor of functional disability: a four-year follow-up study Gerontology 48 2002 226 233
3. J Hoe, C Katona, B Roch, G Livingston Use of the QOL-AD for measuring quality of life in people with severe dementia: the LASER-AD study Age Ageing 34 2005 130 205
4. SI Finkel, A Burns, G Cohen Behavioral and psychological symptoms of dementia (BPSD): a clinical and research update, overview Int Psychogeriatr 12 2000 13 18
5. IG McKeith, D Galasko, K Kosaka Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop Neurology 47 1996 1113 1124
6. B Boeve, M Silber, T Ferman, J Lucas, J Parisi Association of REM sleep behavior disorder and neurodegenerative disease may reflect an underlying synucleinopathy Mov Disord 16 2001 622 630
7. D Neary, J Snowden Fronto-temporal dementia: nosology, neuropsychology, and neuropathology Brain Cogn 31 1996 176 187
8. JL Cummings, M Mega, K Gray, S Rosenberg-Thompson, DA Carusi, J Gornbein The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia Neurology 44 1994 2308 2314
9. WHO. The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and diagnostic guidelines. Geneva: WHO.
10. MS Mega, JL Cummings, T Fiorello, J Gornbein The spectrum of behavioral changes in Alzheimer's disease Neurology 46 1996 130 135
11. ML Levy, JL Cummings, LA Fairbanks Apathy is not depression J Neuropsychiatry Clin Neurosci 10 1998 314 319
12. J Cummings The Neuropsychiatry of Alzheimer's Disease and Related Dementias 2003 Martin Dunitz London, England
13. DV Jeste, SI Finkel Psychosis of Alzheimer's disease and related dementias Am J Geriatr Psychiatry 8 2000 29 34
14. JT Olin, LS Schneider, IR Katz Provisional diagnostic criteria for depression of Alzheimer disease Am J Geriatr Psychiatry 10 2002 125 128
15. JE Overall, DR Gorham The Brief Pyschiatric Rating Scale Psychol Rep 10 1962 799 812
16. M Hamilton Hamilton Depression Rating Scale J Neurol Neurosurg Psychiatry 23 1960 56 62
17. SR Kay, A Fiszbein, LA Opler The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia Schizophr Bull 13 1987 261 276
18. JL Cummings, M Mega, K Gray, S Rosenberg-Thompson, DA Carusi, J Gornbein The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia 1994
19. B Reisberg, J Borenstein, SP Salob, SH Ferris, E Franssen, A Georgotas Behavioral symptoms in Alzheimer's disease: phenomenology and treatment J Clin Psychiatry 48 1987 9 15
20. GS Alexopoulos, RC Abrams, RC Young, CA Shamoian Cornell scale for depression in dementia Biol Psychiatry 23 1988 271 284
21. J Cohen-Mansfield, N Billig Agitated behaviors in the elderly, I; a conceptual review J Am Geriatr Soc 34 1986 711 721
22. PN Tariot, JL Mack, MB Patterson The behavior rating scale for dementia of the consortium to establish a registry for Alzheimer's disease Am J Psychiatry 152 1995 1349 1357
23. A Burns, B Lawlor, S Craig Assessment scales in old age psychiatry 2004 Martin Dunitz London
24. MP Walker, GA Ayre, JL Cummings The clinician assessment of fluctuation and the one day fluctuation assessment scale: two methods to assess fluctuating confusion in dementia Br J Psychiatry 177 2000 252 256
25. MP Walker, GA Ayre, JL Cummings Quantifying fluctuation in dementia with Lewy bodies, Alzheimer's disease and vascular dementia Neurology 54 2000 1616 1624
26. TJ Ferman, GE Smith, BF Boeve DLB fluctuations: specific features that reliably differentiate from AD and normal aging Neurology 62 2004 181 187
27. J Bradshaw, M Saling, M Hopwood, V Anderson, A Brodtmann Fluctuating cognition in dementia with Lewy bodies and Alzheimer's disease is qualitatively distinct J Neurol Neurosurg Psychiatry 75 2004 382 387
28. A Kertesz, W Davidson, H Fox Frontal Behavioral Inventory: diagnostic criteria for frontal lobe dementia Canad J Neurol Sci 24 1997 26 36
29. F Lebert, F Pasquier, L Souliez, H Petit Frontotemporal behavioral scale Alzheimer Dis Assoc Disord 12 1998 335 339
30. MS Mega, JL Cummings, T Fiorello, J Gornbein The spectrum of behavioral changes in Alzheimer's disease Neurology 46 1996 130 135
31. CG Lyketsos, J-ME Sheppard, M Steinberg Neuropsychiatric disturbance in Alzheimer's disease clusters into three groups: the Cache County Study Int J Geriatr Psychiatry 16 2001 1043 1053
32. MS Mega, JL Cummings Frontal subcortical circuits: anatomy and function SP Salloway PF Malloy JD Duffy The frontal lobes and neuropsychiatric illness 2001 American Psychiatric Washington, DC 15 32
33. N Hirono, K Ishii, M Sasaki Features of regional cerebral glucose metabolism abnormality in corticobasal degeneration Dement Geriatr Cogn Disord 11 2000 139 146
34. S Tekin, MS Mega, DL Masterman Orbitofrontal and anterior cingulate cortex: neurofibrillary tangle burden is associated with agitation in Alzheimer's disease Ann Neurol 49 2001 355 361
35. R Barber, JS Snowden, D Craufurd Frontotemporal dementia and Alzheimer's disease: retrospective differentiation using information from informants J Neurol Neurosurg Psychiatry 59 1995 61 70
36. F Assal, M Alarcon, EC Solomon, D Masterman, DH Geschwind, JL Cummings Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease Arch Neurol 61 2004 1249 1253
37. CJ Holmes, MJ Arranz, JF Powell, DA Collier, S Lovestone 5-HT2A and 5-HT2C receptor polymorphisms and psychopathology in late onset Alzheimer's disease Hum Mol Genet 7 1998 1507 1509
38. B Nacmias, A Tedde, P Forleo Association between 5-HT2A receptor polymorphism and psychotic symptoms in Alzheimer's disease Biol Psychiatry 50 2001 472 475
39. DL Sukonick, BG Pollock, RA Sweet The 5-HTTPR*S/*L polymorphism and aggressive behavior in Alzheimer disease Arch Neurol 58 2001 1425 1428
40. IG McKeith, RH Perry, AF Fairbairn, S Jabeen, EK Perry Operational criteria for senile dementia of Lewy body type (SDLT) Psychol Med 22 1992 911 922
41. DP Birkett, A Desouky, L Han, M Kaufman Lewy bodies in psychiatric patients Int J Geriatr Psychiatry 7 1992 235 240
42. D Collerton, D Burn, I McKeith, J O'Brien Systematic review and meta-analysis show that dementia with Lewy bodies is a visual-perceptual and attentional-executive dementia Dement Geriatr Cogn Disord 16 2003 229 237
43. S Minoshima, NL Foster, AAF Sima, KA Frey, RL Albin, DE Kuhl Alzheimer's disease versus dementia with Lewy bodies: Cerebral metabolic distinction with autopsy confirmation Ann Neurol 50 2001 358 365
44. AJ Harding, E Stimson, JM Henderson, GM Halliday Clinical correlates of selective pathology in the amygdala of patients with Parkinson's disease Brain 125 2002 2431 2445
45. EK Perry, MA Piggott, M Johnson Neurotransmitter correlates of neuropsychiatric symptoms in dementia with Lewy bodies M-A Bedard Y Agid S Chouinard S Fahn AD Korczyn P Lesperance Mental and Behavioral Dysfunction in Movement Disorders 2003 Humana Press Inc Totowa, NJ 285 294
46. T Del-Ser, I McKeith, R Anand, A Cicin-Sain, R Ferrara, R Spiegel Dementia with Lewy bodies: Findings from an international multicentre study Int J Geriatr Psychiatry 15 2000 1034 1045
47. C Ballard, R Jacoby, T del Ser Neuropathologic substrates of clinical phenotype in dementia with Lewy bodies Neurology 58 suppl 3 2002 A318
48. C Ballard, C Holmes, I McKeith Psychiatric morbidity in dementia with Lewy bodies: A prospective clinical and neuropathological comparative study with Alzheimer's disease Am J Psychiatry 156 1999 1039 1045
49. BF Boeve, MH Silber, TJ Ferman REM sleep behavior disorder in Parkinson's disease and dementia with Lewy bodies J Geriatr Psychiatry Neurol 17 2004 146 157
50. JT O'Brien, T Erkinjuntti, B Reisberg Vascular cognitive impairment Lancet Neurol 2 2003 89 98
51. R Vataja, A Leppavuori, T Pohjasvaara Poststroke depression and lesion location revisited J Neuropsychiatry Clin Neurosci 16 2004 156 162
52. ML Levy, BL Miller, JL Cummings, LA Fairbanks, A Craig Alzheimer disease and frontotemporal dementias: behavioral distinctions Arch Neurol 53 1996 687 690
53. J Snowden, D Bathgate, A Varma, A Blackshaw, ZC Gibbons, D Neary Distinct behavioural profiles in fronototemporal dementia and semantic dementia J Neurol Neurosurg Psychiatry 70 2001 323 332
54. D Ames, JL Cummings, WC Wirshing, B Quinn, M Mahler Repetitive and compulsive behavior in frontal lobe degenerations J Neuropsychiatry Clin Neurosci 6 1994 100 113
55. BL Miller, WW Seeley, P Mychack, HJ Rosen, I Mena, K Boone Neuroanatomy of the self: evidence from patients with frontotemporal dementia Neurology 57 2001 817 821
56. P Mychack, JH Kramer, K Boone, BL Miller The influence of right frontotemporal dysfunction on social behavior in frontotemporal dementia Neurology 56 2001 S11 S15
57. W Liu, BL Miller, JH Kramer Behavioral disorders in the frontal and temporal variants of frontotemporal dementia Neurology 62 2004 742 748
58. L Wang, SC Joshi, MI Miller, JG Csernansky Statistical analysis of hippocampal asymmetry in schizophrenia Neuroimage 14 2001 531 545
59. OL Lopez, WJ Jagust, ST DeKosky Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1 Arch Neurol 60 2003 1385 1389
60. CG Lyketsos, O Lopez, B Jones, AL Fitzpatrick, JC Breitner, S DeKosky Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study JAMA 288 2002 1475 1483
61. S Tekin, LA Fairbanks, S O'Connor, S Rosenberg, JL Cummings Activities of daily living in Alzheimer's disease: neuropsychiatric, cognitive, and medical illness influences Am J Geriatr Psychiatry 9 2001 81 86
62. J Cohen-Mansfield, JE Mintzer Time for change: the role of non-pharmacological interventions in treating behavior problems in nursing home residents with dementia Alzheimer Dis Assoc Disord 19 2005 37 40
63. RS Doody, JC Stevens, C Beck Practice parameter: management of dementia (an evidence-based review): report of the quality standards subcommittee of the American Academy of Neurology Neurology 56 2001 1154 1166
64. C Magai, CI Cohen, D Gomberg Impact of training dementia caregivers in sensitivity to nonverbal emotion signals Int Psychogeriatr 14 2002 25 38
65. J Cohen-Mansfield Nonpharmacologic interventions for inappropriate behaviors in dementia: a review, summary, and critique Am J Geriatr Psychiatry 9 2001 361 381
66. H Brodaty, A Green, A Koschera Meta-analysis of psychosocial interventionas for caregivers of people with dementia J Am Geriatr Soc 51 2003 657 664
67. M Mittelman, S Ferris, E Shulman, G Steinberg, B Levin A family intervention to delay nursing home placement of patients with Alzheimer disease JAMA 276 1996 1725 1731
68. R Bullock The needs of the caregiver in the long-term treatment of Alzheimer disease Alzheimer Dis Assoc Disord 18 2004 S17 S23
69. MS Mittelman, DL Roth, DW Coon, WE Haley Sustained benefit of supportive intervention for depressive symptoms in caregivers of patients with Alzheimer's disease Am J Psychiatry 161 2004 850 856
70. KM Sink, KF Holden, K Yaffe Pharmacological treatment of neuropsychiatric symptoms of dementia: a review of the evidence JAMA 293 2005 596 608
71. DP Devanand, K Marder, KS Michaels A randomized, placebo-controlled dose-comparison trial of haloperidol for psychosis and disruptive behaviors in Alzheimer's disease Am J Psychiatry 155 1998 1512 1520
72. D Sultzer, K Gray, I Gunay, M Berisford, M Mahler A double-blind comparison of trazodone and haloperidol for treatment of agitation in patients with dementia Am J Geriatr Psychiatry 5 1997 60 69
73. P DeDeyn, P Scheltens, B Kittner A double-blind, placebo-controlled trial assessing the effects of propentofylline in patients with Alzheimer's disease and vascular dementia: safety, efficacy and impact on disease progression Alzheimers Rep 2 1999 S45
74. H Brodaty, D Ames, J Snowdon A randomized placebo-controlled trial of risperidone for the treatment of aggression, agitation, and psychosis of dementia J Clin Psychiatry 64 2003 134 143
75. IR Katz, DV Jeste, JE Mintzer, C Clyde, J Napolitano, M Brecher Comparison of risperidone and placebo for psychosis and behavioral disturbances associated with dementia: a randomized, double-blind trial J Clin Psychiatry 60 1999 107 115
76. J Street, W Clark, B Juliar, P Feldman, D Kadam, A Breier Longterm efficacy of olanzapine in the control of psychotic and behavioral symptoms in patients with Alzheimer's dementia J Am Geriatr Soc 48 2000 S80 80
77. K Zhong, PN Tariot, MC Minkwitz Quetiapine for the treatment of agitation in patients with Alzheimer's disease Internat Psychogeriatrics 17 2005 325 326
78. Medicines. CoSo. Neuroleptic sensitivity in patients with dementia Curr Probl Pharmacovigilance 20 1994 6
79. SS Gill, PA Rochon, N Herrmann Atypical antipsychotic drugs and risk of ischaemic stroke: population based retrospective cohort study BMJ 330 2005 445 published online January 24, DOI:10.1136/bmj.38330.47048.8F
80. FDA Research CfDEa Deaths with Antipsychotics in Elderly Patients with Behavioral Disturbances http://www.fda.gov/cder/drug/advisory/antipsychotics.htm (accessed Oct 4, 2005)
81. D Ames, C Ballard, J Cream, A Shah, G Suh, I McKeith Should novel antipsychotics ever be used to treat the behavioral and psychological symptoms of dementia (BPSD)? Int Psychogeriatr 17 2005 3 30
82. I McKeith, A Fairbairn, R Perry, P Thompson, E Perry Neuroleptic sensitivity in patients with senile dementia of Lewy body type BMJ 305 1992 673 678
83. GS Alexopoulos, JM Silver, DA Kahn, A Frances, D Carpenter Treatment of agitation in older persons with dementia: special report Postgrad Med 1998 1 85
84. PN Tariot, R Erb, C Podgorski Efficacy and tolerability of cabamazepine for agitation and agression in dementia Am J Psychiatry 155 1998 54 61
85. A Porteinsson, PN Tariot, R Erb Placebo-controlled study of divalproex sodium for agitation in dementia Am J Geriatr Psychiatry 9 2001 58 66
86. N Herrmann, K Lanctot, M Myszak Effectiveness of gabapentin for the treatment of behavioral disorders in dementia J Clin Psychopharmacol 20 2000 90 93
87. CG Lyketsos, L DelCampo, M Steinberg Treating depression in Alzheimer's disease: efficacy and safety of sertraline therapy, and the benefits of depression reduction, the DIADS Arch Gen Psychiatry 60 2003 737 746
88. CG Lyketsos, HB Lee Diagnosis and treatment of depression in Alzheimer's disease Dement Geriatr Cogn Disord 17 2004 55 64
89. JL Cummings Cholinesterase inhibitors: a new class of psychotropic agents Am J Psychiatry 157 2000 4 15
90. NH Trinh, J Hoblyn, S Mohanty, K Yaffe Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer's disease: a meta-analysis JAMA 289 2003 210 216
91. PN Tariot, PR Solomon, JC Morris, P Kershaw, S Lilienfeld, C Ding A 5-month, randomized, placebo-controlled trial of galantamine in AD Neurology 54 2000 2269 2276
92. M Rosler, W Retz, P Retz-Junginger, HJ Dennler Effects of two-year treatment with the cholinesterase inhibitor rivastigmine on behavioural symptoms in Alzheimer's disease Behav Neurol 11 1998 211 216
93. S Gauthier, H Feldman, J Hecker Efficacy of donepezil on behavioral symptoms in patients with moderate to severe Alzheimer's disease Int Psychogeriatr 14 2002 389 404
94. C Holmes, D Wilkinson, C Dean The efficacy of donepezil in the treatment of neuropsychiatric symptoms in Alzheimer's disease Neurology 63 2004 214 219
95. JL Cummings, L Schneider, PN Tariot, PR Kershaw, WY Yuan Reduction of behavioral disturbances and caregiver distress by galantamine in patients with Alzheimer's disease Am J Psychiatry 161 2004 532 538
96. C Ballard, M Margallo-Lana, E Juszczak Quetiapine and rivastigmine and cognitive decline in Alzheimer's disease: randonised double blind placebo controlled trial BMJ 330 2005 874 877
97. I McKeith, T Del-Ser, PF Spano Efficacy of rivastigmine in dementia with Lewy bodies: a randomised, double-blind, placebo-controlled international study Lancet 356 2000 2031 2036
98. T Erkinjuntti, A Kurz, S Gauthier Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial Lancet 359 2002 1283 1290
99. M Emre, D Aarsland, A Albanese Rivastigmine for dementia associated with Parkinson's disease N Engl J Med 351 2004 2509 2518
100. PN Tariot, MR Farlow, GT Grossberg, SM Graham, S McDonald, I Gergel Memantine treatment in patients with moderate to severe Alzheimer's disease already receiving donepezil: a randomized controlled trial JAMA 291 2004 317 324
101. JL Cummings Towards a molecular neuropsychiatry of neurodegenerative diseases Ann Neurol 54 2003 147 154
102. JQ Trojanowski Protein mis-folding emerges as a "drugable" target for discovery of novel therapies for neuropsychiatric diseases of aging Am J Geriatr Psychiatry 12 2004 134 135