Modulation of type II TGF-β receptor degradation by integrin-linked kinase

Journal of Investigative Dermatology

Volumn 135, Issue 3, 2015, Pages 885-894

  Vi, Linda ^a   Boo, Stellar ^a   Sayedyahossein, Samar ^a   Singh, Randeep K ^a   Mclean, Sarah ^a   Di Guglielmo, Gianni M ^a   Dagnino, Lina ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN LINKED KINASE; PROTEASOME; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; INTEGRIN-LINKED KINASE; PROTEIN SERINE THREONINE KINASE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; FIBROBLAST; GENE INACTIVATION; MOUSE; MYOFIBROBLAST; NONHUMAN; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; UBIQUITINATION; ANIMAL; ANIMAL MODEL; CELL CULTURE; METABOLISM; MUTANT MOUSE STRAIN; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SKIN;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; FIBROBLASTS; MICE; MICE, MUTANT STRAINS; MODELS, ANIMAL; MYOFIBROBLASTS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SKIN;

EID: 84922609052     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2014.427     Document Type: Article

References (53)

1. Alcolea S, Anton R, Camacho M et al. (2012) Interaction between head and neck squamous cell carcinoma cells and fibroblasts in the biosynthesis of PGE2. J Lipid Res 53:630-42
2. Apostolova MD, Ivanova IA, Dagnino C et al. (2002) Active nuclear import and export pathways regulate E2F-5 subcellular localization. J Biol Chem 277:34471-9
3. Atfi A, Dumont E, Colland F et al. (2007) The disintegrin and metalloproteinase ADAM12 contributes to TGF-beta signaling through interaction with the type II receptor. J Cell Biol 178:201-8
4. Blumbach K, Zweers MC, Brunner G et al. (2010) Defective granulation tissue formation in mice with specific ablation of integrin-linked kinase in fibroblasts-role of TGFbeta1 levels and RhoA activity. J Cell Sci 123:3872-83
5. Boo S, Dagnino L (2013) Integrins as modulators of TGF-b signaling in skin regeneration after injury. Adv Wound Care 2:225-37
6. Chen Y-G (2009) Endocytic regulation of TGF-b signaling. Cell Res 19: 58-70
7. Cirri P, Chiarugi P (2011) Cancer associated fibroblasts: the dark side of the coin. Am J Cancer Res 1:482-97
8. Dagnino L (2011) Integrin-linked kinase: a scaffold protein unique among its ilk. J Cell Commun Signal 5:81-3
9. Di Guglielmo GM, Le Roy C, Goodfellow AF et al. (2003) Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover. Nat Cell Biol 5:410-21
10. Dore JJ Jr., Yao D, Edens M et al. (2001) Mechanisms of transforming growth factor-beta receptor endocytosis and intracellular sorting differ between fibroblasts and epithelial cells. Mol Biol Cell 12:675-84
11. Driskell RR, Lichtemberger BM, Hoste E et al. (2013) Distinct fibroblast lineages determine dermal architecture in skin development and repair. Nature 504:277-82
12. Fullar A, Kovalsky I, Bitsche M et al. (2012) Tumor cell and carcinomaassociated fibroblast interaction regulates matrix metalloproteinases and their inhibitors in oral squamous cell carcinoma. Exp Cell Res 318:1517-27
13. Hinz B, Phan SH, Thannickal VJ et al. (2007) The myofibroblast: one function, multiple origins. Am J Pathol 170:1807-16
14. Hinz B, Phan SH, Thannickal VJ et al. (2012) Recent developments in myofibroblast biology: paradigms for connective tissue remodeling. Am J Pathol 180:1340-55
15. Ho E, Dagnino L (2012a) Emerging role of ILK and ELMO2 in the integration of adhesion and migration pathways. Cell Adh Migr 6:168-72
16. Ho E, Dagnino L (2012b) Epidermal growth factor induction of front-rear polarity and migration in keratinocytes is mediated by integrin-linked kinase and ELMO2. Mol Biol Cell 23:492-502
17. Ho E, Irvine T, Vilk GJ et al. (2009) Integrin-linked kinase interactions with ELMO2 modulate cell polarity. Mol Biol Cell 20:3033-43
18. Hong DS, Banerji U, Tavana B et al. (2013) Targeting the molecular chaperone heat shock protein 90 (HSP90): lessons learned and future directions. Cancer Treat Rev 39:375-87
19. Hsu HY, Lin TY, Hwang PA et al. (2013) Fucoidan induces changes in the epithelial to mesenchymal transition and decreases metastasis by enhancing ubiquitin-dependent TGF beta receptor degradation in breast cancer. Carcinogenesis 34:874-84
20. Inman GJ, Nicolas FJ, Callahan JF et al. (2002) SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol 62:65-74
21. Judah D, Rudkouskaya A, Wilson R et al. (2012) Multiple roles of integrinlinked kinase in epidermal development, maturation and pigmentation revealed by molecular profiling. PLoS One 7:e36704
22. Kojima Y, Acar A, Eaton EN et al. (2010) Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumorpromoting mammary stromal myofibroblasts. Proc Natl Acad Sci USA 107:20009-14
23. Leyme A, Bourd-Boittin K, Bonnier D et al. (2012) Identification of ILK as a new partner of the ADAM12 disintegrin and metalloprotease in cell adhesion and survival. Mol Biol Cell 23:3461-72
24. Lonn P, Moren A, Raja E et al. (2009) Regulating the stability of TGFbeta receptors and Smads. Cell Res 19:21-35
25. Lorenz K, Grashoff C, Torka R et al. (2007) Integrin-linked kinase is required for epidermal and hair follicle morphogenesis. J Cell Biol 177:501-13
26. Luga V, McLean S, Le Roy C et al. (2009) The extracellular domain of the TGFbeta type II receptor regulates membrane raft partitioning. Biochem J 421:119-31
27. Luo K, Lodish HF (1997) Positive and negative regulation of type II TGF-beta receptor signal transduction by autophosphorylation on multiple serine residues. EMBO J 16:1970-81
28. Malan D, Elischer A, Hesse M et al. (2013) Deletion of integrin linked kinase in endothelial cells results in defective RTK signaling caused by caveolin 1 mislocalization. Development 140:987-95
29. Massague J (2012) TGFbeta signalling in context. Nat Rev Mol Cell Biol 13:616-30
30. McAnulty RJ (2007) Fibroblasts and myofibroblasts: their source, function and role in disease. Int J Biochem Cell Biol 39:666-71
31. Mitchell H, Choudhury A, Pagano RE et al. (2004) Ligand-dependent and-independent transforming growth factor-beta receptor recycling regulated by clathrin-mediated endocytosis and Rab11. Mol Biol Cell 15:4166-78
32. Nakrieko KA, Rudkouskaya A, Irvine TS et al. (2011) Targeted inactivation of integrin-linked kinase in hair follicle stem cells reveals an important modulatory role in skin repair after injury. Mol Biol Cell 22:2532-40
33. Nakrieko KA, Vespa A, Mason D et al. (2008a) Modulation of integrin-linked kinase nucleo-cytoplasmic shuttling by ILKAP and CRM1. Cell Cycle 7:2157-66
34. Nakrieko KA, Welch I, Dupuis H et al. (2008b) Impaired hair follicle morphogenesis and polarized keratinocyte movement upon conditional inactivation of integrin-linked kinase in the epidermis. Mol Biol Cell 19:1462-73
35. Nakrieko KA, Welch I, Dupuis H et al. (2008c) Impaired hair follicle morphogenesis and polarized keratinocyte movement upon conditional inactivation opf integrin-linked kinase in the epidermis. Mol Biol Cell 19:1462-73
36. Nikolopoulos SN, Turner CE (2001) Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions. J Biol Chem 276:23499-505
37. Nikolopoulos SN, Turner CE (2002) Molecular dissection of actopaxin-integrinlinked kinase-paxillin interactions and their role in subcellular localization. J Biol Chem 277:1568-75
38. Noh H, Kim HJ, Yu MR et al. (2012) Heat shock protein 90 inhibitor attenuates renal fibrosis through degradation of transforming growth factor-beta type II receptor. Lab Invest 92:1583-96
39. Orimo A, Weinberg RA (2006) Stromal fibroblasts in cancer: a novel tumorpromoting cell type. Cell Cycle 5:1597-601
40. Polanska UM, Orimo A (2013) Carcinoma-Associated fibroblasts: non-neoplastic tumour-promoting mesenchymal cells. J Cell Physiol 228:1651-7
41. Radovanac K, Morgner J, Schulz JN et al. (2013) Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response. EMBO J 32:1409-24
42. Rechtman MM, Nakaryakov A, Shapira KE et al. (2009) Different domains regulate homomeric and heteromeric complex formation among type I and type II transforming growth factor-beta receptors. J Biol Chem 284:7843-52
43. Rudkouskaya A, Welch I, Dagnino L (2013) ILK modulates epithelial polarity and matrix formation in hair follicles. Mol Biol Cell 25:620-32
44. Sandulache VC, Parekh A, Dohar JE et al. (2007) Fetal dermal fibroblasts retain a hyperactive migratory and contractile phenotype under 2-And 3-dimensional constraints compared to normal adult fibroblasts. Tissue Eng 13:2791-801
45. Sayedyahossein S, Nini L, Irvine TS et al. (2012) Essential role of integrinlinked kinase in regulation of phagocytosis in keratinocytes. FASEB J 26: 4218-29
46. Stautz D, Leyme A, Grandal MV et al. (2012) Cell-surface metalloprotease ADAM12 is internalized by a clathrin-And Grb2-dependent mechanism. Traffic 13:1532-46
47. Terpstra L, Prud'homme J, Arabian A et al. (2003) Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes. J Cell Biol 162:139-48
48. Vespa A, D'Souza SJ, Dagnino L (2005) A novel role for integrinlinked kinase in epithelial sheet morphogenesis. Mol Biol Cell 16: 4084-95
49. Vi L, de Lasa C, DiGuglielmo GM et al. (2011) Integrin-linked kinase is required for TGF-beta1 induction of dermal myofibroblast differentiation. J Invest Dermatol 131:586-93
50. Wrana JL, Attisano L, Carcamo J et al. (1992) TGF beta signals through a heteromeric protein kinase receptor complex. Cell 71:1003-14
51. Wrighton KH, Lin X, Feng XH (2008) Critical regulation of TGFbeta signaling by Hsp90. Proc Natl Acad Sci USA 105:9244-9
52. Yamaji S, Suzuki A, Sugiyama Y et al. (2001) A novel integrin-linked kinasebinding protein, affixin, is involved in the early stage of cell-substrate interaction. J Cell Biol 153:1251-64
53. Zuo W, Huang F, Chiang YJ et al. (2013) c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-beta type II receptor. Mol Cell 49:499-510