Integrin-linked kinase is required for TGF-Β1 induction of dermal myofibroblast differentiation

Journal of Investigative Dermatology

Volumn 131, Issue 3, 2011, Pages 586-593

  Vi, Linda ^a   De Lasa, Cristina ^a   Diguglielmo, Gianni M ^a   Dagnino, Lina ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ALPHA SMOOTH MUSCLE ACTIN; F ACTIN; GROWTH FACTOR; INTEGRIN LINKED KINASE; MITOGEN ACTIVATED PROTEIN KINASE; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELL MIGRATION; CYTOSKELETON; EXTRACELLULAR MATRIX; FOCAL ADHESION; MOUSE; MUSCLE CONTRACTILITY; MYOFIBROBLAST; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SKIN CELL; STRESS FIBER; WOUND HEALING;

EID: 79951514190     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2010.362     Document Type: Article

References (23)

1. Asano Y, Ihn H, Yamane K et al. (2006) Increased expression of integrin alphavbeta5 induces the myofibroblastic differentiation of dermal fibroblasts. Am J Pathol 168:499-510 (Pubitemid 43271148)
2. Dahlmann-Noor AH, Martin-Martin B, Eastwood M et al. (2007) Dynamic protrusive cell behaviour generates force and drives early matrix contraction by fibroblasts. Exp Cell Res 313:4158-69 (Pubitemid 350087046)
3. Eitzman DT, McCoy RD, Zheng X et al. (1996) Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene. J Clin Invest 97:232-7 (Pubitemid 26021713)
4. Gu L, Zhu YJ, Yang X et al. (2007) Effect of TGF-beta/Smad signaling pathway on lung myofibroblast differentiation. Acta Pharmacol Sin 28:382-91
5. Guo X, Wang XF (2009) Signaling cross-talk between TGF-beta/BMP and other pathways. Cell Res 19:71-88
6. Hinz B (2007) Formation and function of the myofibroblast during tissue repair. J Invest Dermatol 127:526-37
7. Hinz B (2010) The myofibroblast: paradigm for a mechanically active cell. J Biomech 43:146-55
8. Hinz B, Phan SH, Thannickal VJ et al. (2007) The myofibroblast: one function, multiple origins. Am J Pathol 170:1807-16 (Pubitemid 47339255)
9. Ho E, Irvine T, Vilk GJ et al. (2009) Integrin-linked kinase interactions with ELMO2 modulate cell polarity. Mol Biol Cell 20:3033-43
10. Ivanova IA, Nakrieko KA, Dagnino L (2009) Phosphorylation by p38 MAP kinase is required for E2F1 degradation and keratinocyte differentiation. Oncogene 28:52-63
11. Katsumi A, Orr AW, Tzima E et al. (2004) Integrins in mechanotransduction. J Biol Chem 279:12001-4 (Pubitemid 38445760)
12. Kim A, Lakshman N, Petroll WM (2006) Quantitative assessment of local collagen matrix remodeling in 3-D culture: the role of Rho kinase. Exp Cell Res 312:3683-92 (Pubitemid 44470785)
13. Li Y, Yang J, Dai C et al. (2003) Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis. J Clin Invest 112:503-16 (Pubitemid 38056335)
14. Lorenz K, Grashoff C, Torka R et al. (2007) Integrin-linked kinase is required for epidermal and hair follicle morphogenesis. J Cell Biol 177:501-13 (Pubitemid 46718278)
15. Margadant C, Sonnenberg A (2010) Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing. EMBO Rep 11:97-105
16. Martinac B (2004) Mechanosensitive ion channels: molecules of mechan-otransduction. J Cell Sci 117:2449-60 (Pubitemid 38877841)
17. Nakrieko KA, Welch I, Dupuis H et al. (2008) Impaired hair follicle morphogenesis and polarized keratinocyte movement upon conditional inactivation opf integrin-linked kinase in the epidermis. Mol Biol Cell 19:1462-73 (Pubitemid 351805100)
18. Qian Y, Zhong X, Flynn DC et al. (2005) ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling. Oncogene 24:3154-65 (Pubitemid 40695084)
19. Scaffidi AK, Petrovic N, Moodley YP et al. (2004) Alpha(v)beta(3) Integrin interacts with the transforming growth factor beta (TGFbeta) type II receptor to potentiate the proliferative effects of TGFbeta1 in living human lung fibroblasts. J Biol Chem 279:37726-33 (Pubitemid 39195486)
20. Terpstra L, Prud'homme J, Arabian A et al. (2003) Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes. J Cell Biol 162:139-48 (Pubitemid 36859541)
21. Voytik-Harbin SL, Rajwa B, Robinson JP (2001) Three-dimensional imaging of extracellular matrix and extracellular matrix-cell interactions. Methods Cell Biol 63:583-97
22. Wang S, Basson MD (2009) Integrin-linked kinase: a multi-functional regulator modulating extracellular pressure-stimulated cancer cell adhesion through focal adhesion kinase and AKT. Cell Oncol 31:273-89
23. Wickstrom SA, Lange A, Montanez E et al. (2010) The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!. EMBO J 29:281-91