Dendrimeric anticancer prodrugs for targeted delivery of ursolic acid to folate receptor-expressing cancer cells: Synthesis and biological evaluation

European Journal of Pharmaceutical Sciences

Volumn 70, Issue , 2015, Pages 55-63

  Gao, Yu ^a   Li, Zhihong ^a   Xie, Xiaodong ^a   Wang, Chaoqun ^a   You, Jiali ^a   Mo, Fan ^a   Jin, Biyu ^a   Chen, Jianzhong ^b   Shao, Jingwei ^a   Chen, Haijun ^a   Jia, Lee ^a  

^a FUZHOU UNIVERSITY   (China)

^b FUJIAN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Anti cancer; Polyamidoamine; Targeted drug delivery; Ursolic acid

Indexed keywords

DENDRIMER; FOLATE RECEPTOR; FOLIC ACID; PHOSPHATE BUFFERED SALINE; POLYAMIDOAMINE; PRODRUG; URSOLIC ACID; ANTINEOPLASTIC AGENT; PAMAM STARBURST; TRITERPENE;

ACIDITY; ARTICLE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL PH; COVALENT BOND; CYTOTOXICITY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG HYDROLYSIS; ENDOCYTOSIS; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; G2 PHASE CELL CYCLE CHECKPOINT; GENE OVEREXPRESSION; HELA CELL LINE; HEPG2 CELL LINE; HUMAN; HUMAN CELL; HYDROPHILICITY; IN VITRO STUDY; MOLECULAR WEIGHT; MOLECULARLY TARGETED THERAPY; MTT ASSAY; ONE POT SYNTHESIS; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SURFACE CHARGE; SUSTAINED DRUG RELEASE; ZETA POTENTIAL; CELL SURVIVAL; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; PHYSIOLOGY; PRECLINICAL STUDY; PROCEDURES; SYNTHESIS;

ANTINEOPLASTIC AGENTS; CELL SURVIVAL; DENDRIMERS; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; FOLATE RECEPTORS, GPI-ANCHORED; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HEP G2 CELLS; HUMANS; PRODRUGS; TRITERPENES;

EID: 84922586651     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2015.01.007     Document Type: Article

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