Discriminative stimulus effects of the imidazoline I2 receptor ligands BU224 and phenyzoline in rats

European Journal of Pharmacology

Volumn 749, Issue , 2015, Pages 133-141

  Qiu, Yanyan ^a   Zhang, Yanan ^b   Li, Jun Xu ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b RTI INTERNATIONAL   (United States)

Author keywords

BU224; Drug discrimination; Imidazoline I2 receptors; Phenyzoline; Rats

Indexed keywords

2 (2 IMIDAZOLIN 2 YL)QUINOLINE; IMIDAZOLE DERIVATIVE; IMIDAZOLINE I2 RECEPTOR; PHENYZOLINE; UNCLASSIFIED DRUG; IMIDAZOLINE RECEPTOR; LIGAND;

ADULT; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; BRAIN FUNCTION; CONTROLLED STUDY; DISCRIMINATIVE STIMULUS; DRUG DISCRIMINATION TEST; DRUG EFFICACY; DRUG MECHANISM; DRUG RESPONSE; FUNCTIONAL ASSESSMENT; MALE; NONHUMAN; PROTEIN DETERMINATION; PROTEIN FUNCTION; RAT; STIMULUS RESPONSE; AGONISTS; ANIMAL; METABOLISM; PERCEPTIVE DISCRIMINATION; SPRAGUE DAWLEY RAT;

ANIMALS; DISCRIMINATION (PSYCHOLOGY); IMIDAZOLES; IMIDAZOLINE RECEPTORS; LIGANDS; MALE; RATS, SPRAGUE-DAWLEY;

EID: 84922573071     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.01.013     Document Type: Article

References (41)

1. An, X.F., Zhang, Y., Winter, J.C., Li, J.X., 2012. Effects of imidazoline I(2) receptor agonists and morphine on schedule-controlled responding in rats. Pharmacol. Biochem. Behav. 101, 354-359.
2. Brown, C.M., MacKinnon, A.C., Redfern, W.S., Williams, A., Linton, C., Stewart, M., Clague, R.U., Clark, R., Spedding, M., 1995. RS-45041-190: A selective, high-affinity ligand for I2 imidazoline receptors. Br. J. Pharmacol. 116, 1737-1744.
3. Chang, C.H., Wu, H.T., Cheng, K.C., Lin, H.J., Cheng, J.T., 2010. Increase of beta-endorphin secretion by agmatine is induced by activation of imidazoline I(2A) receptors in adrenal gland of rats. Neurosci. Lett. 468, 297-299.
4. Chen, M.F., Tsai, J.T., Chen, L.J., Wu, T.P., Yang, J.J., Yin, L.T., Yang, Y.L., Chiang, T.A., Lu, H.L., Wu, M.C., 2014. Characterization of imidazoline receptors in blood vessels for the development of antihypertensive agents. BioMed. Res. Int. 2014, 182846.
5. Colpaert, F.C., 1988. Intrinsic activity and discriminative effects of drugs. Psychopharmacol. Ser. 4, 154-160.
6. Colpaert, F.C., 1999. Drug discrimination in neurobiology. Pharmacol. Biochem. Behav. 64, 337-345.
7. Colpaert, F.C., Niemegeers, C.J., Janssen, P.A., 1980. Factors regulating drug cue sensitivity: the effect of training dose in fentanyl-saline discrimination. Neuropharmacology 19, 705-713.
8. Comer, S.D., France, C.P., Woods, J.H., 1991. Training dose: Influences in opioid drug discrimination. NIDA Res. Monogr., 145-161.
9. Donahue, T.J., Hillhouse, T.M., Webster, K.A., Young, R., De Oliveira, E.O., Porter, J.H., 2014. (S)-amisulpride as a discriminative stimulus in C57BL/6 mice and its comparison to the stimulus effects of typical and atypical antipsychotics. Eur. J. Pharmacol. 734, 15-22.
10. Eglen, R.M., Hudson, A.L., Kendall, D.A., Nutt, D.J., Morgan, N.G., Wilson, V.G., Dillon, M.P., 1998. 'Seeing through a glass darkly': casting light on imidazoline 'I' sites. Trends Pharmacol. Sci. 19, 381-390.
11. Ernsberger, P., Meeley, M.P., Mann, J.J., Reis, D.J., 1987. Clonidine binds to imidazole binding sites as well as alpha 2-adrenoceptors in the ventrolateral medulla. Eur. J. Pharmacol. 134, 1-13.
12. Ferrari, F., Fiorentino, S., Mennuni, L., Garofalo, P., Letari, O., Mandelli, S., Giordani, A., Lanza, M., Caselli, G., 2011. Analgesic efficacy of CR4056, a novel imidazoline-2 receptor ligand, in rat models of inflammatory and neuropathic pain. J. Pain Res. 4, 111-125.
13. Gentili, F., Cardinaletti, C., Carrieri, A., Ghelfi, F., Mattioli, L., Perfumi, M., Vesprini, C., Pigini, M., 2006. Involvement of I2-imidazoline binding sites in positive and negative morphine analgesia modulatory effects. Eur. J. Pharmacol. 553, 73-81.
14. Hudson, A.L., Gough, R., Tyacke, R., Lione, L., Lalies, M., Lewis, J., Husbands, S., Knight, P., Murray, F., Hutson, P., Nutt, D.J., 1999. Novel selective compounds for the investigation of imidazoline receptors. Ann. NY Acad. Sci. 881, 81-91.
15. Jordan, S., Jackson, H.C., Nutt, D.J., Handley, S.L., 1996. Discriminative stimulus produced by the imidazoline I2 site ligand, 2 -BFI. J. Psychopharmacol. 10, 273-278.
16. Kimura, A., Tyacke, R.J., Robinson, J.J., Husbands, S.M., Minchin, M.C., Nutt, D.J., Hudson, A.L., 2009. Identification of an imidazoline binding protein: Creatine kinase and an imidazoline-2 binding site. Brain Res. 1279, 21-28.
17. Lanza, M., Ferrari, F., Menghetti, I., Tremolada, D., Caselli, G., 2014. Modulation of imidazoline I2 binding sites by CR4056 relieves postoperative hyperalgesia in male and female rats. Br. J. Pharmacol. 171, 3693-3701.
18. Lelas, S., Spealman, R.D., Rowlett, J.K., 2000. Using behavior to elucidate receptor mechanisms: A review of the discriminative stimulus effects of benzodiazepines. Exp. Clin. Psychopharmacol. 8, 294-311.
19. Li, G., Regunathan, S., Barrow, C.J., Eshraghi, J., Cooper, R., Reis, D.J., 1994. Agmatine: an endogenous clonidine-displacing substance in the brain. Science 263, 966-969.
20. Li, J.X., Unzeitig, A., Javors, M.A., Rice, K.C., Koek, W., France, C.P., 2009. Discriminative stimulus effects of DOM, ketanserin and MDL100907 in rats. J. Pharmacol. Exp. Ther. 331, 671-679.
21. Li, J.X., Thorn, D.A., Jin, C., 2013. The GPR88 receptor agonist 2-PCCA does not alter the behavioral effects of methamphetamine in rats. Eur. J. Pharmacol. 698, 272-277.
22. Li, J.X., Thorn, D.A., Qiu, Y., Peng, B.W., Zhang, Y., 2014. Antihyperalgesic effects of imidazoline I(2) receptor ligands in rat models of in.ammatory and neuropathic pain. Br. J. Pharmacol. 171, 1580-1590.
23. Li, J.X., Zhang, Y., 2011. Imidazoline I2 receptors: target for new analgesics? Eur. J. Pharmacol. 658, 49-56.
24. Li, J.X., Zhang, Y., Winter, J.C., 2011. Morphine-induced antinociception in the rat: Supra-additive interactions with imidazoline I(2) receptor ligands. Eur. J. Pharmacol. 669, 59-65.
25. Macinnes, N., Duty, S., 2004. Locomotor effects of imidazoline I2-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxydopamine lesion of the nigrostriatal pathway. Br. J. Pharmacol. 143, 952-959.
26. MacInnes, N., Handley, S.L., 2002. Characterization of the discriminable stimulus produced by 2-BFI: Effects of imidazoline I(2)-site ligands, MAOIs, beta-carbolines, agmatine and ibogaine. Br. J. Pharmacol. 135, 1227-1234.
27. MacInnes, N., Handley, S.L., 2003. Potential serotonergic and noradrenergic involvement in the discriminative stimulus effects of the selective imidazoline I2-site ligand 2-BFI. Pharmacol. Biochem. Behav. 75, 427-433.
28. Meregalli, C., Ceresa, C., Canta, A., Carozzi, V.A., Chiorazzi, A., Sala, B., Oggioni, N., Lanza, M., Letari, O., Ferrari, F., Avezza, F., Marmiroli, P., Caselli, G., Cavaletti, G., 2012. CR4056, a new analgesic I2 ligand, is highly effective against bortezomib-induced painful neuropathy in rats. J. Pain Res. 5, 151-167.
29. Min, J.W., Peng, B.W., He, X., Zhang, Y., Li, J.X., 2013. Gender difference in epileptogenic effects of 2-BFI and BU224 in mice. Eur. J. Pharmacol. 718, 81-86.
30. Olmos, G., Alemany, R., Boronat, M.A., Garcia-Sevilla, J.A., 1999. Pharmacologic and molecular discrimination of I2-imidazoline receptor subtypes. Ann. NY Acad. Sci. 881, 144-160.
31. Parini, A., Moudanos, C.G., Pizzinat, N., Lanier, S.M., 1996. The elusive family of imidazoline binding sites. Trends Pharmacol. Sci. 17, 13-16.
32. Pigini, M., Bousquet, P., Carotti, A., Dontenwill, M., Giannella, M., Moriconi, R., Piergentili, A., Quaglia, W., Tayebati, S.K., Brasili, L., 1997. Imidazoline receptors: Qualitative structure-activity relationships and discovery of tracizoline and benazoline. Two ligands with high affinity and unprecedented selectivity. Bioorg. Med. Chem. 5, 833-841.
33. Porter, J.H., Prus, A.J., 2009. Discriminative stimulus properties of atypical and typical antipsychotic drugs: A review of preclinical studies. Psychopharmacology 203, 279-294.
34. Qiu, Y., He, X.H., Zhang, Y., Li, J.X., 2014a. Discriminative stimulus effects of the novel imidazoline I2 receptor ligand CR4056 in rats. Sci. Rep. 4, 6605.
35. Qiu, Y., Thorn, D.A., Zhang, Y., He, X., Li, J.X., 2014b. Behavioral effects of the imidazoline I(2) receptor ligand BU99006 in rats. Behav. Pharmacol. 25, 130-136.
36. Ruiz-Durantez, E., Torrecilla, M., Pineda, J., Ugedo, L., 2003. Attenuation of acute and chronic effects of morphine by the imidazoline receptor ligand 2-(2-benzofuranyl)-2-imidazoline in rat locus coeruleus neurons. Br. J. Pharmacol. 138, 494-500.
37. Sanchez-Blazquez, P., Boronat, M.A., Olmos, G., Garcia-Sevilla, J.A., Garzon, J., 2000. Activation of I(2)-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br. J. Pharmacol. 130, 146-152.
38. Thorn, D.A., An, X.F., Zhang, Y., Pigini, M., Li, J.X., 2012. Characterization of the hypothermic effects of imidazoline I(2) receptor agonists in rats. Br. J. Pharmacol. 166, 1936-1945.
39. Thorn, D.A., Zhang, Y., Peng, B.W., Winter, J.C., Li, J.X., 2011. Effects of imidazoline I (2) receptor ligands on morphine- and tramadol-induced antinociception in rats. Eur. J. Pharmacol. 670, 435-440.
40. Tonello, R., Villarinho, J.G., da Silva Sant'Anna, G., Tamiozzo, L., Machado, P., Trevisan, G., Pinto Martins, M.A., Ferreira, J., Rubin, M.A., 2012. The potential antidepressant-like effect of imidazoline I2 ligand 2-BFI in mice. Prog. Neuropsychopharmacol. Biol. Psychiatry 37, 15-21.
41. Yang, T.T., Ku, P.M., Hsu, C.T., Chung, H.H., Lee, W.J., Cheng, J.T., 2013. Mediation of AMP kinase in the increase of glucose uptake in L6 cells induced by activation of imidazoline I-2 receptors. Horm. Metab. Res. 45, 359-363.