Discriminative stimulus produced by the imidazoline I2 site ligand, 2-BFI

Journal of Psychopharmacology

Volumn 10, Issue 4, 1996, Pages 273-278

  Jordan, S ^a   Jackson, H C ^b   Nutt, D J ^c   Handley, S L ^d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ABBOTT LABORATORIES   (United States)

^c SCHOOL OF MEDICAL SCIENCES   (United Kingdom)

^d ASTON UNIVERSITY   (United Kingdom)

Author keywords

2 adrenoceptor antagonists; 2 BFI; Drug discrimination; Imidazoline I2 binding sites; Monoamine oxidase inhibitors

Indexed keywords

2 (2 BENZOFURANYL) 2 IMIDAZOLINE; 2 (2 ETHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; CLONIDINE; DIAZEPAM; FLUPAROXAN; GUANABENZ; IDAZOXAN; IMIDAZOLINE DERIVATIVE; IMIDAZOLINE I2 RECEPTOR; MOCLOBEMIDE; MONOAMINE OXIDASE INHIBITOR; PARGYLINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISCRIMINATIVE STIMULUS; DRUG DISCRIMINATION; DRUG RECEPTOR BINDING; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TRAINING;

EID: 0030461721     PISSN: 02698811     EISSN: None     Source Type: Journal    
DOI: 10.1177/026988119601000403     Document Type: Article

References (38)

1. Abercrombie E D, Keller R W, Zigmond M J (1988) Characterisation of hippocampal norepinephrine release as measured by microdialysis perfusion: pharmacological and behavioural studies. Neuroscience 27: 897-904
2. 2 imidazoline-preferring receptors. Br J Pharmacol 114: 837-845
3. Ator N A, Griffiths R R (1989) Asymmetrical cross-generalisation in drug discrimination with lorazepam and pentobarbital training conditions. Drug Dev Res 16: 355-364
4. Brown J, Handley S L (1980) Effects on the pinna reflex of drugs acting as a-adrenoceptors. J Pharm Pharmacol 32: 436-437
5. Burkard W P, Bonetti E P, Da Prada M, Martin J R, Pole P, Schaffner R, Scherschlidt R, Hefti F, Muller R K M, Wyss P-C, Haefely W (1989) Pharmacological profile of moclobemide, a short-acting and reversible inhibitor of monoamine oxidase type A. J Pharmacol Exp Ther 248: 391-399
6. Butcher S P, Fairbrother I S, Kelly J S, Arbuthnott G W (1990) Effects of selective monoamine oxidase inhibitors on the in vivo release and metabolism of dopamine in the rat striatum. J Neurochem 55: 981-988
7. 2-imidazoline sites (NAIBS). J Pharmacol Exp Ther 272: 681-688
8. Colzi A, d-Agostini F, Kettler R, Borroni E, Da Prada M (1990) Effect of selective and reversible MAO inhibitors on dopamine outflow in rat striatum: a microdialysis study. J Neural Transm Suppl 32: 79-84
9. 2-adrenoceptors play a major role in the effects of idazoxan on cortical noradrenaline release (as measured by in vivo dialysis) in the rat. J Pharmacol Exp Ther 241: 642-649
10. Emmett-Oglesby M W, Spencer D G, Arnoult D E (1982) A TRS-80 based system for the control of behavioural experiments. Pharmacol Biochem Behav 17: 584-587
11. 2 subtypes. Fund Clin Pharmacol 6: 55S
12. 2-adrenoceptors in the ventrolateral medulla. Eur J Pharmacol 134: 1-13
13. 2-receptors in the rostral ventrolateral medulla. J Hypertension 6: S554-S557
14. 2-adrenoceptor antagonist. Br J Pharmacol 102: 887-895
15. Jackson H C, Nutt D J (1995) Imidazoline receptors and ingestion. In Cooper S J, Clifton P G (eds), Drug receptor subtypes and ingestive behaviour. Academic Press, London, pp. 278-283
16. 2-adrenoceptor antagonists on food and water intake in the rat. Br J Pharmacol 104: 258-262
17. 2-adrenoceptor binding sites. PhD Thesis, Aston University, UK
18. 2-adrenoceptors are responsible for a clonidine-induced cue in a rat drug discrimination paradigm. Psychopharmacology 110: 209-212
19. Jordan S, Jackson H C, Nutt D J, Handley S L (1995) Discriminative stimulus properties of ethoxyidazoxan. J Psychopharmacol 9: 228-233
20. Lanier B, Raddatz R, Bakthavachalam V, Coupry I, Neumeyer J L, Lanier S M (1995) Structural and ligand recognition properties of imidazoline binding proteins in tissues of rat and rabbit. Mol Pharmacol 48: 703-710
21. Li G, Regunathan S, Barrow C J, Eshraghi J, Cooper R, Reis D J (1994) Agmatine, an endogenous clonidine-displacing substance. Science 263: 966-969
22. Mallard N J, Hudson A L (1992) Characterisation and autoradiographical localisation of non-adrenoceptor idazoxan binding sites in the rat brain. Br J Pharmacol 106: 1019-1027
23. Mallard N J, Tyacke R, Hudson A L (1991) Comparative binding studies of [3H] idazoxan and [3H] RX821002 in the rat brain. Br J Pharmacol 102: 221P
24. Michel M C, Insel P A (1989) Are there multiple binding sites? Trends Pharmacol Sci 10: 342-344
25. Michel M C, Ersnberger P (1992) Keeping an eye on the I site: imidazoline-preferring receptors. Trends Pharmacol Sci 13: 369-370
26. Mongeau R, de Montigny C, Blier P (1994) Effects of long-term alpha-2 adrenergic antagonists and electroconvulsive treatments on the alpha-2 adrenoceptors modulating serotonin neurotransmission. J Pharmacol Exp Ther 269: 1162-1159
27. Musgrave I F, Seifert R (1995) Alpha 2A-adrenoceptors mediate activation of non-selective cation channels via Gi-proteins in human erythroleukaemia (HEL) cells. No evidence for a functional role of imidazoline receptors in modulating calcium. Biochem Pharmacol 49: 187-196
28. Nutt D J, French N, Handley S L, Hudson A, Husbands S, Jackson H, Jordan S, Lalies M D, Lewis J, Lione N, Mallard N, Pratt J (1995) Functional studies of specific imidazoline-2 receptor ligands. In Reis D J, Bousquet P, Parini A (eds), The imidazoline receptor: pharmacology, functions, ligands and relevance to biology and medicine. New York Academy of Science, New York, pp. 125-139
29. 2-adrenoceptors regulating norepinephrine and serotonin release. J Pharmacol Exp Ther 224: 679-384
30. Reis D J, Regunathan S, Wang H, Feinstein D L, Meeley M P (1992) Imidazoline receptors in the nervous system. Fund Clin Pharmacol 6: 23S-29S
31. 3H]RX821002-labelled rat R alpha-2A adrenergic receptors in cerebral cortex to human alpha-2A adrenergic receptor and other populations of alpha-2 adrenergic subtypes. J Pharmacol Exp Ther 270: 946-957
32. 2 with MAO-B sites. J Neurochem 61: 881-889
33. Tesson F, Prip-Buus C, Lemoine A, Pegorier J-P, Parini A (1991) Subcellular distribution of imidazoline-guanidinium-receptive sites in human and rabbit liver. J Biol Chem 266: 155-160
34. Thomas D N, Holman R B (1991) A microdialysis study of the regulation of endogenous noradrenaline release in the rat hippocampus. J Neurochem 56: 1741-1746
35. Trendelenberg A U, Starke K, Limburger N (1994) Presynaptic alpha 2A-adrenoceptors inhibit release of endogenous dopamine in rabbit caudate nucleus slices. Naunyn Schmiedeberg's Arch Pharmacol 350: 473-481
36. U'Prichard D C (1981) 3H-clonidine and 3H-p-aminoclonidine interactions in vitro with central and peripheral alpha 2-adrenergic receptors. Prog Clin Biol Res 71: 53-74
37. Winter J C, Rabin R A (1992) Yohimbine as a serotonergic agent: evidence from receptor binding and drug discrimination. J Pharmacol Exp Ther 263: 682-689
38. Yang X-M, Luo Z-P, Zhou J-H (1988) Behavioural evidence for the role of noradrenaline in putative anxiolytic and sedative effects of benzodiazepines. Psychopharmacology 95: 280-286