Modulation of imidazoline I2 binding sites by CR4056 relieves postoperative hyperalgesia in male and female rats

British Journal of Pharmacology

Volumn 171, Issue 15, 2014, Pages 3693-3701

  Lanza, Marco ^a   Ferrari, Flora ^a   Menghetti, Ilaria ^a   Tremolada, Dario ^a   Caselli, Gianfranco ^a  

^a Department of Pharmacology and Toxicology Rottapharm Biotech Srl ^*  (Italy)

Author keywords

CR4056; drug synergism; imidazoline 2 receptors; postoperative pain; sex differences

Indexed keywords

CR 4056; EFAROXAN; IDAZOXAN; IMIDAZOLINE I2 RECEPTOR; MORPHINE; NALOXONE; UNCLASSIFIED DRUG; YOHIMBINE; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ANALGESIC AGENT; BENZOFURAN DERIVATIVE; CR4056; IMIDAZOLE DERIVATIVE; IMIDAZOLINE RECEPTOR; NARCOTIC ANALGESIC AGENT; NARCOTIC ANTAGONIST; QUINAZOLINE DERIVATIVE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; FEMALE; HYPERALGESIA; MALE; NONHUMAN; PAIN THRESHOLD; POSTOPERATIVE PAIN; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; TREATMENT RESPONSE; ANIMAL; ANTAGONISTS AND INHIBITORS; PAIN, POSTOPERATIVE; SPRAGUE DAWLEY RAT;

ADRENERGIC ALPHA-2 RECEPTOR ANTAGONISTS; ANALGESICS; ANALGESICS, OPIOID; ANIMALS; BENZOFURANS; BINDING SITES; DRUG SYNERGISM; FEMALE; HYPERALGESIA; IDAZOXAN; IMIDAZOLES; IMIDAZOLINE RECEPTORS; MALE; MORPHINE; NALOXONE; NARCOTIC ANTAGONISTS; PAIN, POSTOPERATIVE; QUINAZOLINES; RATS, SPRAGUE-DAWLEY; YOHIMBINE;

EID: 84904552447     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12728     Document Type: Article

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