Antihyperalgesic effects of imidazoline I2 receptor ligands in rat models of inflammatory and neuropathic pain

British Journal of Pharmacology

Volumn 171, Issue 6, 2014, Pages 1580-1590

  Li, Jun Xu ^a   Thorn, David A ^a   Qiu, Yanyan ^a   Peng, Bi Wen ^b   Zhang, Yanan ^c  

^a UNIVERSITY AT BUFFALO   (United States)

^b WUHAN UNIVERSITY   (China)

^c RTI INTERNATIONAL   (United States)

Author keywords

affective pain; chronic constriction injury; complete Freund's adjuvant; hyperalgesia; plantar test; von Frey test

Indexed keywords

2 (2 IMIDAZOLIN 2 YL)QUINOLINE; 2 BFI; ANALGESIC AGENT; CR 4056; MORPHINE SULFATE; TRACIZOLINE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; AVOIDANCE BEHAVIOR; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG TOLERANCE; ESCAPE BEHAVIOR; HYPERALGESIA; INFLAMMATORY PAIN; MALE; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; RAT;

AFFECTIVE PAIN; CHRONIC CONSTRICTION INJURY; COMPLETE FREUND'S ADJUVANT; HYPERALGESIA; IMIDAZOLINE I2 RECEPTOR; PLANTAR TEST; VON FREY TEST;

ANIMALS; DISEASE MODELS, ANIMAL; IMIDAZOLINE RECEPTORS; INFLAMMATION; LIGANDS; MALE; PAIN; PERIPHERAL NERVOUS SYSTEM DISEASES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84895730242     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12555     Document Type: Article

References (40)

1. Alba-Delgado C, Mico JA, Sanchez-Blazquez P, Berrocoso E, (2012). Analgesic antidepressants promote the responsiveness of locus coeruleus neurons to noxious stimulation: implications for neuropathic pain. Pain 153: 1438-1449.
2. Almarestani L, Fitzcharles MA, Bennett GJ, Ribeiro-da-Silva A, (2011). Imaging studies in Freund's complete adjuvant model of regional polyarthritis, a model suitable for the study of pain mechanisms, in the rat. Arthritis Rheum 63: 1573-1581.
3. An XF, Zhang Y, Winter JC, Li JX, (2012). Effects of imidazoline I(2) receptor agonists and morphine on schedule-controlled responding in rats. Pharmacol Biochem Behav 101: 354-359.
4. Bennett GJ, Xie YK, (1988). A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33: 87-107.
5. Colpaert FC, De Witte P, Maroli AN, Awouters F, Niemegeers CJ, Janssen PA, (1980). Self-administration of the analgesic suprofen in arthritic rats: evidence of Mycobacterium butyricum-induced arthritis as an experimental model of chronic pain. Life Sci 27: 921-928. (Pubitemid 11254918)
6. Fernandez E, Turk DC, (1992). Sensory and affective components of pain: separation and synthesis. Psychol Bull 112: 205-217.
7. Ferrari F, Fiorentino S, Mennuni L, Garofalo P, Letari O, Mandelli S, et al. (2011). Analgesic efficacy of CR4056, a novel imidazoline-2 receptor ligand, in rat models of inflammatory and neuropathic pain. J Pain Res 4: 111-125.
8. Fuchs PN, McNabb CT, (2012). The place escape/avoidance paradigm: a novel method to assess nociceptive processing. J Integr Neurosci 11: 61-72.
9. Gebhart GF, Bielefeldt K, (2011). Visceral pain. In:, Basbaum AI, Bushnell C, (eds). Science of Pain, 1st edn. Elsevier: Oxford, pp. 543-569.
10. Hargreaves K, Dubner R, Brown F, Flores C, Joris J, (1988). A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32: 77-88.
11. Houghton AK, Westlund KN, (1996). An I2 imidazoline ligand, RS 45041, potentiates hyperalgesia in acute arthritis. Neuroreport 7: 1497-1501. (Pubitemid 26281130)
12. Ishihara M, Togo H, (2007). Direct oxidative conversion of aldehydes and alcohols to 2-imidazolines and 2-oxazolines using molecular iodine. Tetrahedron 63: 1474-1480. (Pubitemid 44969407)
13. Itoh H, Kitamura F, Yokoyama K, (2013). Estimates of annual medical costs of work-related low back pain in Japan. Ind Health 51: 524-529.
14. Jarry C, Forfar I, Bosc J, Renard P, Scalbert E, Guardiola B, (1997). 5-(Arloxymethyl)oxazoline. US Patent 5,686,477, Adir e Compagnie.
15. Jett MF, Hedley LR, Dillon MP, Eglen RM, Hunter JC, (1999). Behavioral effects of RS-45041-190, a selective I2 imidazoline ligand, in rats. Ann N Y Acad Sci 881: 369-371. (Pubitemid 29349530)
16. Kilkenny C, Browne W, Cuthill IC, Emerson M, Altman DG, (2010). Animal research: reporting in vivo experiments: the ARRIVE guidelines. Br J Pharmacol 160: 1577 -1579.
17. Kissin I, (2010). The development of new analgesics over the past 50 years: a lack of real breakthrough drugs. Anesth Analg 110: 780-789.
18. LaBuda CJ, Fuchs PN, (2000a). A behavioral test paradigm to measure the aversive quality of inflammatory and neuropathic pain in rats. Exp Neurol 163: 490-494. (Pubitemid 30399099)
19. LaBuda CJ, Fuchs PN, (2000b). Morphine and gabapentin decrease mechanical hyperalgesia and escape/avoidance behavior in a rat model of neuropathic pain. Neurosci Lett 290: 137-140. (Pubitemid 30628360)
20. Le Bars D, Gozariu M, Cadden SW, (2001). Animal models of nociception. Pharmacol Rev 53: 597-652. (Pubitemid 33136239)
21. Li JX, (2013). The application of conditioning paradigms in the measurement of pain. Eur J Pharmacol 716: 158-168.
22. Li JX, Zhang Y, (2011). Imidazoline I2 receptors: target for new analgesics? Eur J Pharmacol 658: 49-56.
23. Li JX, Zhang Y, (2012). Emerging drug targets for pain treatment. Eur J Pharmacol 681: 1-5.
24. Li JX, McMahon LR, France CP, (2008). Comparison of naltrexone, 6alpha-naltrexol, and 6beta-naltrexol in morphine-dependent and in nondependent rhesus monkeys. Psychopharmacology (Berl) 195: 479-486. (Pubitemid 350160485)
25. Li JX, Crocker C, Koek W, Rice KC, France CP, (2011a). Effects of serotonin (5-HT)1A and 5-HT2A receptor agonists on schedule-controlled responding in rats: drug combination studies. Psychopharmacology (Berl) 213: 489-497.
26. Li JX, Zhang Y, Winter JC, (2011b). Morphine-induced antinociception in the rat: supra-additive interactions with imidazoline I(2) receptor ligands. Eur J Pharmacol 669: 59-65.
27. McGrath J, Drummond G, McLachlan E, Kilkenny C, Wainwright C, (2010). Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol 160: 1573 -1576.
28. Melzack R, (1999). From the gate to the neuromatrix. Pain (Suppl 6): S121-S126.
29. Meregalli C, Ceresa C, Canta A, Carozzi VA, Chiorazzi A, Sala B, et al. (2012). CR4056, a new analgesic I2 ligand, is highly effective against bortezomib-induced painful neuropathy in rats. J Pain Res 5: 151-167.
30. Mogil JS, (2009). Animal models of pain: progress and challenges. Nat Rev Neurosci 10: 283-294.
31. Nagakura Y, Okada M, Kohara A, Kiso T, Toya T, Iwai A, et al. (2003). Allodynia and hyperalgesia in adjuvant-induced arthritic rats: time course of progression and efficacy of analgesics. J Pharmacol Exp Ther 306: 490-497. (Pubitemid 36886145)
32. Neogi T, (2013). The epidemiology and impact of pain in osteoarthritis. Osteoarthritis Cartilage 21: 1145-1153.
33. Sampson C, Zhang Y, Del Bello F, Li JX, (2012). Effects of imidazoline I2 receptor ligands on acute nociception in rats. Neuroreport 23: 73-77.
34. Sanchez-Blazquez P, Boronat MA, Olmos G, Garcia-Sevilla JA, Garzon J, (2000). Activation of I(2)-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol 130: 146-152. (Pubitemid 30248438)
35. Soignier RD, Taylor BK, Baiamonte BA, Lee FA, Paul D, Gould HJ 3rd, (2011). Measurement of CFA-induced hyperalgesia and morphine-induced analgesia in rats: dorsal vs plantar mechanical stimulation of the hindpaw. Pain Med 12: 451-458.
36. Thorn DA, Zhang Y, Peng BW, Winter JC, Li JX, (2011). Effects of imidazoline I(2) receptor ligands on morphine- and tramadol-induced antinociception in rats. Eur J Pharmacol 670: 435-440.
37. Thorn DA, An XF, Zhang Y, Pigini M, Li JX, (2012). Characterization of the hypothermic effects of imidazoline I(2) receptor agonists in rats. Br J Pharmacol 166: 1936-1945.
38. Uhelski ML, Davis MA, Fuchs PN, (2012). Pain affect in the absence of pain sensation: evidence of asomaesthesia after somatosensory cortex lesions in the rat. Pain 153: 885-892.
39. Wenger GR, (1980). Cumulative dose-response curves in behavioral pharmacology. Pharmacol Biochem Behav 13: 647-651. (Pubitemid 11253886)
40. Zimmermann M, (1983). Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16: 109-110. (Pubitemid 13058546)