메뉴 건너뛰기




Volumn 17, Issue 1, 2015, Pages 63-69

Methylated RASSF1A in malignant peripheral nerve sheath tumors identifies neurofibromatosis type 1 patients with inferior prognosis

Author keywords

Methylation; MPNST; NF1; RASSF1A; Survival

Indexed keywords

RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; RASSF1 PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

EID: 84922572928     PISSN: 15228517     EISSN: 15235866     Source Type: Journal    
DOI: 10.1093/neuonc/nou140     Document Type: Article
Times cited : (15)

References (50)
  • 1
    • 84857921368 scopus 로고    scopus 로고
    • Molecular mechanisms promoting the pathogenesis of Schwann cell neoplasms
    • Carroll SL. Molecular mechanisms promoting the pathogenesis of Schwann cell neoplasms. Acta Neuropathol. 2012;123(3): 321-348.
    • (2012) Acta Neuropathol , vol.123 , Issue.3 , pp. 321-348
    • Carroll, S.L.1
  • 2
    • 84893640262 scopus 로고    scopus 로고
    • Malignant peripheral nerve sheath tumours in inherited disease
    • Evans DG, Huson SM, Birch JM. Malignant peripheral nerve sheath tumours in inherited disease. Clin Sarcoma Res. 2012;2(1):17-12.
    • (2012) Clin Sarcoma Res , vol.2 , Issue.1 , pp. 17-12
    • Evans, D.G.1    Huson, S.M.2    Birch, J.M.3
  • 3
    • 33747872815 scopus 로고    scopus 로고
    • Malignant peripheral nerve sheath tumors: Prognostic factors and survival in a series of patients treated at a single institution
    • Anghileri M, Miceli R, Fiore M, et al. Malignant peripheral nerve sheath tumors: prognostic factors and survival in a series of patients treated at a single institution. Cancer. 2006;107(5): 1065-1074.
    • (2006) Cancer , vol.107 , Issue.5 , pp. 1065-1074
    • Anghileri, M.1    Miceli, R.2    Fiore, M.3
  • 4
    • 84875702670 scopus 로고    scopus 로고
    • Survival meta-analyses for. 1800 malignant peripheral nerve sheath tumor patients with and without neurofibromatosis type 1
    • Kolberg M, Holand M, Agesen TH, et al. Survival meta-analyses for .1800 malignant peripheral nerve sheath tumor patients with and without neurofibromatosis type 1. Neuro Oncol. 2013;15(2): 135-147.
    • (2013) Neuro Oncol , vol.15 , Issue.2 , pp. 135-147
    • Kolberg, M.1    Holand, M.2    Agesen, T.H.3
  • 5
    • 67649209942 scopus 로고    scopus 로고
    • Clinical, pathological, and molecular variables predictive of malignant peripheral nerve sheath tumor outcome
    • Zou C, Smith KD, Liu J, et al. Clinical, pathological, and molecular variables predictive of malignant peripheral nerve sheath tumor outcome. Ann Surg. 2009;249(6):1014-1022.
    • (2009) Ann Surg , vol.249 , Issue.6 , pp. 1014-1022
    • Zou, C.1    Smith, K.D.2    Liu, J.3
  • 6
    • 1542438624 scopus 로고    scopus 로고
    • Topoisomerase-II alpha is upregulated in malignant peripheral nerve sheath tumors and associated with clinical outcome
    • Skotheim RI, Kallioniemi A, Bjerkhagen B, et al. Topoisomerase-II alpha is upregulated in malignant peripheral nerve sheath tumors and associated with clinical outcome. J Clin Oncol. 2003;21(24): 4586-4591.
    • (2003) J Clin Oncol , vol.21 , Issue.24 , pp. 4586-4591
    • Skotheim, R.I.1    Kallioniemi, A.2    Bjerkhagen, B.3
  • 7
    • 70349628640 scopus 로고    scopus 로고
    • Identification of p53 as a strong predictor of survival for patients with malignant peripheral nerve sheath tumors
    • Brekke HR, Kolberg M, Skotheim RI, et al. Identification of p53 as a strong predictor of survival for patients with malignant peripheral nerve sheath tumors. Neuro-oncol. 2009;11:514-528.
    • (2009) Neuro-oncol , vol.11 , pp. 514-528
    • Brekke, H.R.1    Kolberg, M.2    Skotheim, R.I.3
  • 8
    • 77951904713 scopus 로고    scopus 로고
    • Genomic changes in chromosomes 10, 16, and X in malignant peripheral nerve sheath tumors identify a high-risk patient group
    • Brekke HR, Ribeiro FR, Kolberg M, et al. Genomic changes in chromosomes 10, 16, and X in malignant peripheral nerve sheath tumors identify a high-risk patient group. J Clin Oncol. 2010;28(9):1573-1582.
    • (2010) J Clin Oncol , vol.28 , Issue.9 , pp. 1573-1582
    • Brekke, H.R.1    Ribeiro, F.R.2    Kolberg, M.3
  • 9
    • 79959226237 scopus 로고    scopus 로고
    • Activated MET is a molecular prognosticator and potential therapeutic target for malignant peripheral nerve sheath tumors
    • Torres KE, Zhu QS, Bill K, et al. Activated MET is a molecular prognosticator and potential therapeutic target for malignant peripheral nerve sheath tumors. Clin Cancer Res. 2011;17(12): 3943-3955.
    • (2011) Clin Cancer Res , vol.17 , Issue.12 , pp. 3943-3955
    • Torres, K.E.1    Zhu, Q.S.2    Bill, K.3
  • 10
    • 84858277359 scopus 로고    scopus 로고
    • Microarray-based copy number analysis of neurofibromatosis type-1 (NF1)-associated malignant peripheral nerve sheath tumors reveals a role for Rho-GTPase pathway genes in NF1 tumorigenesis
    • Upadhyaya M, Spurlock G, Thomas L, et al. Microarray-based copy number analysis of neurofibromatosis type-1 (NF1)-associated malignant peripheral nerve sheath tumors reveals a role for Rho-GTPase pathway genes in NF1 tumorigenesis. Hum Mutat. 2012;33(4):763-776.
    • (2012) Hum Mutat , vol.33 , Issue.4 , pp. 763-776
    • Upadhyaya, M.1    Spurlock, G.2    Thomas, L.3
  • 11
    • 84879690769 scopus 로고    scopus 로고
    • Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis
    • Rahrmann EP, Watson AL, Keng VW, et al. Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis. Nat Genet. 2013; 45(7):756-766.
    • (2013) Nat Genet , vol.45 , Issue.7 , pp. 756-766
    • Rahrmann, E.P.1    Watson, A.L.2    Keng, V.W.3
  • 12
    • 19944431853 scopus 로고    scopus 로고
    • Expression patterns of cell cycle components in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors
    • Aagesen TH, Florenes VA, Molenaar WM, et al. Expression patterns of cell cycle components in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors. J Neuropathol Exp Neurol. 2005;64(1):74-81.
    • (2005) J Neuropathol Exp Neurol , vol.64 , Issue.1 , pp. 74-81
    • Aagesen, T.H.1    Florenes, V.A.2    Molenaar, W.M.3
  • 13
    • 0032879327 scopus 로고    scopus 로고
    • Chromosome band 9p21 is frequently altered in malignant peripheral nerve sheath tumors: Studies of CDKN2A and other genes of the pRB pathway
    • Berner JM, Sorlie T, Mertens F, et al. Chromosome band 9p21 is frequently altered in malignant peripheral nerve sheath tumors: studies of CDKN2A and other genes of the pRB pathway. Genes Chromosomes Cancer. 1999;26(2):151-160.
    • (1999) Genes Chromosomes Cancer , vol.26 , Issue.2 , pp. 151-160
    • Berner, J.M.1    Sorlie, T.2    Mertens, F.3
  • 14
    • 0032762177 scopus 로고    scopus 로고
    • Expression of p27(kip) and other cell cycle regulators in malignant peripheral nerve sheath tumors and neurofibromas: The emerging role of p27(kip) in malignant transformation of neurofibromas
    • Kourea HP, Cordon-Cardo C, Dudas M, et al. Expression of p27(kip) and other cell cycle regulators in malignant peripheral nerve sheath tumors and neurofibromas: the emerging role of p27(kip) in malignant transformation of neurofibromas. Am J Pathol. 1999;155(6):1885-1891.
    • (1999) Am J Pathol , vol.155 , Issue.6 , pp. 1885-1891
    • Kourea, H.P.1    Cordon-Cardo, C.2    Dudas, M.3
  • 15
    • 0032762784 scopus 로고    scopus 로고
    • Malignant transformation of neurofibromas in neurofibromatosis 1 is associated with CDKN2A/p16 inactivation
    • Nielsen GP, Stemmer-Rachamimov AO, Ino Y, et al. Malignant transformation of neurofibromas in neurofibromatosis 1 is associated with CDKN2A/p16 inactivation. Am J Pathol. 1999; 155(6):1879-1884.
    • (1999) Am J Pathol , vol.155 , Issue.6 , pp. 1879-1884
    • Nielsen, G.P.1    Stemmer-Rachamimov, A.O.2    Ino, Y.3
  • 16
    • 70349533148 scopus 로고    scopus 로고
    • PDGFRA, PDGFRB, EGFR, and downstream signaling activation in malignant peripheral nerve sheath tumor
    • Perrone F, Da RL, Orsenigo M, et al. PDGFRA, PDGFRB, EGFR, and downstream signaling activation in malignant peripheral nerve sheath tumor. Neuro Oncol. 2009;11(6):725-736.
    • (2009) Neuro Oncol , vol.11 , Issue.6 , pp. 725-736
    • Perrone, F.1    Da, R.L.2    Orsenigo, M.3
  • 17
    • 60549108776 scopus 로고    scopus 로고
    • EGFR and erbB2 in malignant peripheral nerve sheath tumors and implications for targeted therapy
    • Holtkamp N, Malzer E, Zietsch J, et al. EGFR and erbB2 in malignant peripheral nerve sheath tumors and implications for targeted therapy. Neuro Oncol. 2008;10(6):946-957.
    • (2008) Neuro Oncol , vol.10 , Issue.6 , pp. 946-957
    • Holtkamp, N.1    Malzer, E.2    Zietsch, J.3
  • 18
    • 33644862170 scopus 로고    scopus 로고
    • Mutation and expression of PDGFRA and KIT in malignant peripheral nerve sheath tumors, and its implications for imatinib sensitivity
    • Holtkamp N, Okuducu AF, Mucha J, et al. Mutation and expression of PDGFRA and KIT in malignant peripheral nerve sheath tumors, and its implications for imatinib sensitivity. Carcinogenesis. 2006; 27(3):664-671.
    • (2006) Carcinogenesis , vol.27 , Issue.3 , pp. 664-671
    • Holtkamp, N.1    Okuducu, A.F.2    Mucha, J.3
  • 19
    • 38149064478 scopus 로고    scopus 로고
    • Germline and somatic NF1 gene mutation spectrum in NF1-associated malignant peripheral nerve sheath tumors (MPNSTs)
    • Upadhyaya M, Kluwe L, Spurlock G, et al. Germline and somatic NF1 gene mutation spectrum in NF1-associated malignant peripheral nerve sheath tumors (MPNSTs). Hum Mutat. 2008; 29(1):74-82.
    • (2008) Hum Mutat , vol.29 , Issue.1 , pp. 74-82
    • Upadhyaya, M.1    Kluwe, L.2    Spurlock, G.3
  • 20
    • 64549151639 scopus 로고    scopus 로고
    • Germline and somatic NF1 mutations in sporadic and NF1-associated malignant peripheral nerve sheath tumours
    • Bottillo I, Ahlquist T, Brekke H, et al. Germline and somatic NF1 mutations in sporadic and NF1-associated malignant peripheral nerve sheath tumours. J Pathol. 2008;217(5):693-701.
    • (2008) J Pathol , vol.217 , Issue.5 , pp. 693-701
    • Bottillo, I.1    Ahlquist, T.2    Brekke, H.3
  • 21
    • 84856994155 scopus 로고    scopus 로고
    • Oncogene mutation survey in MPNST cell lines enhances the dominant role of hyperactive Ras in NF1 associated pro-survival and malignancy
    • Sun D, Tainsky MA, Haddad R. Oncogene mutation survey in MPNST cell lines enhances the dominant role of hyperactive Ras in NF1 associated pro-survival and malignancy. Transl Oncogenomics. 2012;5:1-7; doi:10.4137/TOG.S8830.
    • (2012) Transl Oncogenomics , vol.5 , pp. 1-7
    • Sun, D.1    Tainsky, M.A.2    Haddad, R.3
  • 22
    • 84885744050 scopus 로고    scopus 로고
    • RASSF1A and the rs2073498 cancer associated SNP
    • Donninger H, Barnoud T, Nelson N, et al. RASSF1A and the rs2073498 cancer associated SNP. Front Oncol. 2011;1(54): 11-17.
    • (2011) Front Oncol , vol.1 , Issue.54 , pp. 11-17
    • Donninger, H.1    Barnoud, T.2    Nelson, N.3
  • 23
    • 18144411303 scopus 로고    scopus 로고
    • Role of the Ras-association domain family 1 tumor suppressor gene in human cancers
    • Agathanggelou A, Cooper WN, Latif F. Role of the Ras-association domain family 1 tumor suppressor gene in human cancers. Cancer Res. 2005;65(9):3497-3508.
    • (2005) Cancer Res , vol.65 , Issue.9 , pp. 3497-3508
    • Agathanggelou, A.1    Cooper, W.N.2    Latif, F.3
  • 24
    • 35548987430 scopus 로고    scopus 로고
    • The RASSF1A tumor suppressor
    • Donninger H, Vos MD, Clark GJ. The RASSF1A tumor suppressor. J Cell Sci. 2007;120(18):3163-3172.
    • (2007) J Cell Sci , vol.120 , Issue.18 , pp. 3163-3172
    • Donninger, H.1    Vos, M.D.2    Clark, G.J.3
  • 25
    • 32844460417 scopus 로고    scopus 로고
    • DNA hypermethylation status of multiple genes in soft tissue sarcomas
    • Kawaguchi KI, Oda Y, Saito T, et al. DNA hypermethylation status of multiple genes in soft tissue sarcomas. Mod Pathol. 2006;19(1): 106-114.
    • (2006) Mod Pathol , vol.19 , Issue.1 , pp. 106-114
    • Kawaguchi, K.I.1    Oda, Y.2    Saito, T.3
  • 26
    • 79953296221 scopus 로고    scopus 로고
    • Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors
    • Feber A, Wilson GA, Zhang L, et al. Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors. Genome Res. 2011;21(4):515-524.
    • (2011) Genome Res , vol.21 , Issue.4 , pp. 515-524
    • Feber, A.1    Wilson, G.A.2    Zhang, L.3
  • 27
    • 70349174971 scopus 로고    scopus 로고
    • The RASSF proteins in cancer; From epigenetic silencing to functional characterization
    • Richter AM, Pfeifer GP, Dammann RH. The RASSF proteins in cancer; from epigenetic silencing to functional characterization. Biochim Biophys Acta. 2009;1796(2):114-128.
    • (2009) Biochim Biophys Acta , vol.1796 , Issue.2 , pp. 114-128
    • Richter, A.M.1    Pfeifer, G.P.2    Dammann, R.H.3
  • 28
    • 33845679095 scopus 로고    scopus 로고
    • ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis
    • Lind GE, Kleivi K, Meling GI, et al. ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis. Cell Oncol. 2006;28(5-6):259-272.
    • (2006) Cell Oncol , vol.28 , Issue.5-6 , pp. 259-272
    • Lind, G.E.1    Kleivi, K.2    Meling, G.I.3
  • 29
    • 0035407651 scopus 로고    scopus 로고
    • Bisulfite genomic sequencing: Systematic investigation of critical experimental parameters
    • Grunau C, Clark SJ, Rosenthal A. Bisulfite genomic sequencing: systematic investigation of critical experimental parameters. Nucleic Acids Res. 2001;29(13):e65.
    • (2001) Nucleic Acids Res , vol.29 , Issue.13 , pp. e65
    • Grunau, C.1    Clark, S.J.2    Rosenthal, A.3
  • 30
    • 0036753290 scopus 로고    scopus 로고
    • DNA methylation: A profile of methods and applications
    • Fraga MF, Esteller M. DNA methylation: a profile of methods and applications. Biotechniques. 2002;33(3):632-649.
    • (2002) Biotechniques , vol.33 , Issue.3 , pp. 632-649
    • Fraga, M.F.1    Esteller, M.2
  • 31
    • 0029843950 scopus 로고    scopus 로고
    • Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
    • Herman JG, Graff JR, Myohanen S, et al. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. PNAS. 1996;93(18):9821-9826.
    • (1996) PNAS , vol.93 , Issue.18 , pp. 9821-9826
    • Herman, J.G.1    Graff, J.R.2    Myohanen, S.3
  • 32
    • 85027949861 scopus 로고    scopus 로고
    • SPG20, a novel biomarker for early detection of colorectal cancer, encodes a regulator of cytokinesis
    • Lind GE, Raiborg C, Danielsen SA, et al. SPG20, a novel biomarker for early detection of colorectal cancer, encodes a regulator of cytokinesis. Oncogene. 2011;30(37):3967-3978.
    • (2011) Oncogene , vol.30 , Issue.37 , pp. 3967-3978
    • Lind, G.E.1    Raiborg, C.2    Danielsen, S.A.3
  • 33
    • 29244490041 scopus 로고    scopus 로고
    • Analysis of repetitive element DNA methylation by MethyLight
    • Weisenberger DJ, Campan M, Long TI, et al. Analysis of repetitive element DNA methylation by MethyLight. Nucleic Acids Res. 2005; 33(21):6823-6836.
    • (2005) Nucleic Acids Res , vol.33 , Issue.21 , pp. 6823-6836
    • Weisenberger, D.J.1    Campan, M.2    Long, T.I.3
  • 34
    • 21544483241 scopus 로고    scopus 로고
    • Methylation of the tumor suppressor gene RASSF1A in human tumors
    • Pfeifer GP, Dammann R. Methylation of the tumor suppressor gene RASSF1A in human tumors. Biochemistry (Mosc). 2005;70(5): 576-583.
    • (2005) Biochemistry (Mosc) , vol.70 , Issue.5 , pp. 576-583
    • Pfeifer, G.P.1    Dammann, R.2
  • 35
    • 3042655534 scopus 로고    scopus 로고
    • A role for the RASSF1A tumor suppressor in the regulation of tubulin polymerization and genomic stability
    • Vos MD, Martinez A, Elam C, et al. A role for the RASSF1A tumor suppressor in the regulation of tubulin polymerization and genomic stability. Cancer Res. 2004;64(12):4244-4250.
    • (2004) Cancer Res , vol.64 , Issue.12 , pp. 4244-4250
    • Vos, M.D.1    Martinez, A.2    Elam, C.3
  • 36
    • 34548220076 scopus 로고    scopus 로고
    • The Ras-association domain family (RASSF) members and their role in human tumourigenesis
    • van der Weyden L, Adams DJ. The Ras-association domain family (RASSF) members and their role in human tumourigenesis. Biochim Biophys Acta. 2007;1776(1):58-85.
    • (2007) Biochim Biophys Acta , vol.1776 , Issue.1 , pp. 58-85
    • Van Der Weyden, L.1    Adams, D.J.2
  • 37
    • 47249090517 scopus 로고    scopus 로고
    • The methylation status of RASSF1A promoter predicts responsiveness to chemotherapy and eventual cure in hepatoblastoma patients
    • Honda S, Haruta M, Sugawara W, et al. The methylation status of RASSF1A promoter predicts responsiveness to chemotherapy and eventual cure in hepatoblastoma patients. Int J Cancer. 2008; 123(5):1117-1125.
    • (2008) Int J Cancer , vol.123 , Issue.5 , pp. 1117-1125
    • Honda, S.1    Haruta, M.2    Sugawara, W.3
  • 39
    • 79960847694 scopus 로고    scopus 로고
    • High RASSF1A promoter methylation levels are predictive of poor prognosis in fine-needle aspirate washings of breast cancer lesions
    • Martins AT, Monteiro P, Ramalho-Carvalho J, et al. High RASSF1A promoter methylation levels are predictive of poor prognosis in fine-needle aspirate washings of breast cancer lesions. Breast Cancer Res Treat. 2011;129(1):1-9.
    • (2011) Breast Cancer Res Treat , vol.129 , Issue.1 , pp. 1-9
    • Martins, A.T.1    Monteiro, P.2    Ramalho-Carvalho, J.3
  • 40
    • 79952306961 scopus 로고    scopus 로고
    • The prognostic value of RASSF1A promoter hypermethylation in non-small cell lung carcinoma: A systematic review and meta-analysis
    • Wang J, Wang B, Chen X, et al. The prognostic value of RASSF1A promoter hypermethylation in non-small cell lung carcinoma: a systematic review and meta-analysis. Carcinogenesis. 2011; 32(3):411-416.
    • (2011) Carcinogenesis , vol.32 , Issue.3 , pp. 411-416
    • Wang, J.1    Wang, B.2    Chen, X.3
  • 41
    • 14044279223 scopus 로고    scopus 로고
    • Alterations of cancerrelated genes in soft tissue sarcomas: Hypermethylation of RASSF1A is frequently detected in leiomyosarcoma and associated with poor prognosis in sarcoma
    • Seidel C, Bartel F, Rastetter M, et al. Alterations of cancerrelated genes in soft tissue sarcomas: hypermethylation of RASSF1A is frequently detected in leiomyosarcoma and associated with poor prognosis in sarcoma. Int J Cancer. 2005; 114(3):442-447.
    • (2005) Int J Cancer , vol.114 , Issue.3 , pp. 442-447
    • Seidel, C.1    Bartel, F.2    Rastetter, M.3
  • 42
    • 0035992419 scopus 로고    scopus 로고
    • Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21. 3 in stage i lung adenocarcinoma
    • Tomizawa Y, Kohno T, Kondo H, et al. Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma. Clin Cancer Res. 2002;8(7): 2362-2368.
    • (2002) Clin Cancer Res , vol.8 , Issue.7 , pp. 2362-2368
    • Tomizawa, Y.1    Kohno, T.2    Kondo, H.3
  • 43
    • 77954615960 scopus 로고    scopus 로고
    • Methylation level of the RASSF1A promoter is an independent prognostic factor for clear-cell renal cell carcinoma
    • Kawai Y, Sakano S, Suehiro Y, et al. Methylation level of the RASSF1A promoter is an independent prognostic factor for clear-cell renal cell carcinoma. Ann Oncol. 2010;21(8): 1612-1617.
    • (2010) Ann Oncol , vol.21 , Issue.8 , pp. 1612-1617
    • Kawai, Y.1    Sakano, S.2    Suehiro, Y.3
  • 44
    • 0344494159 scopus 로고    scopus 로고
    • Aberrant CpG island methylation in neurofibromas and neurofibrosarcomas
    • Gonzalez-Gomez P, Bella MJ, Arjona D, et al. Aberrant CpG island methylation in neurofibromas and neurofibrosarcomas. Oncol Rep. 2003;10(5):1519-1523.
    • (2003) Oncol Rep , vol.10 , Issue.5 , pp. 1519-1523
    • Gonzalez-Gomez, P.1    Bella, M.J.2    Arjona, D.3
  • 45
    • 9644252849 scopus 로고    scopus 로고
    • Methylation analysis of the neurofibromatosis type 1 (NF1) promoter in peripheral nerve sheath tumours
    • Harder A, Rosche M, Reuss DE, et al. Methylation analysis of the neurofibromatosis type 1 (NF1) promoter in peripheral nerve sheath tumours. Eur J Cancer. 2004;40(18): 2820-2828.
    • (2004) Eur J Cancer , vol.40 , Issue.18 , pp. 2820-2828
    • Harder, A.1    Rosche, M.2    Reuss, D.E.3
  • 46
    • 0034515334 scopus 로고    scopus 로고
    • Microsatellite instability and promoter methylation as possible causes of NF1 gene inactivation in neurofibromas
    • Luijten M, Redeker S, van Noesel MM, et al. Microsatellite instability and promoter methylation as possible causes of NF1 gene inactivation in neurofibromas. Eur J Hum Genet. 2000;8(12): 939-945.
    • (2000) Eur J Hum Genet , vol.8 , Issue.12 , pp. 939-945
    • Luijten, M.1    Redeker, S.2    Van Noesel, M.M.3
  • 47
    • 13844296571 scopus 로고    scopus 로고
    • Analysis of somatic NF1 promoter methylation in plexiform neurofibromas and Schwann cells
    • Fishbein L, Eady B, Sanek N, et al. Analysis of somatic NF1 promoter methylation in plexiform neurofibromas and Schwann cells. Cancer Genet Cytogenet. 2005;157(2): 181-186.
    • (2005) Cancer Genet Cytogenet , vol.157 , Issue.2 , pp. 181-186
    • Fishbein, L.1    Eady, B.2    Sanek, N.3
  • 48
    • 84876442920 scopus 로고    scopus 로고
    • Impaired PTEN expression in human malignant peripheral nerve sheath tumours
    • Bradtmo ller M, Hartmann C, Zietsch J, et al. Impaired PTEN expression in human malignant peripheral nerve sheath tumours. PLoS ONE. 2012;7(11):e47595.
    • (2012) PLoS ONE , vol.7 , Issue.11 , pp. e47595
    • Bradtmo Ller, M.1    Hartmann, C.2    Zietsch, J.3
  • 49
    • 3843053704 scopus 로고    scopus 로고
    • P15INK4b, p14ARF, and p16INK4a inactivation in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors
    • Perrone F, Tabano S, Colombo F, et al. p15INK4b, p14ARF, and p16INK4a inactivation in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors. Clin Cancer Res. 2003;9(11):4132-4138.
    • (2003) Clin Cancer Res , vol.9 , Issue.11 , pp. 4132-4138
    • Perrone, F.1    Tabano, S.2    Colombo, F.3
  • 50
    • 79957901656 scopus 로고    scopus 로고
    • Prognostic significance of p14ARF, p15INK4b, and p16INK4a inactivation in malignant peripheral nerve sheath tumors
    • Endo M, Kobayashi C, Setsu N, et al. Prognostic significance of p14ARF, p15INK4b, and p16INK4a inactivation in malignant peripheral nerve sheath tumors. Clin Cancer Res. 2011;17(11): 3771-3782.
    • (2011) Clin Cancer Res , vol.17 , Issue.11 , pp. 3771-3782
    • Endo, M.1    Kobayashi, C.2    Setsu, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.