Methylation analysis of the neurofibromatosis type 1 (NF1) promoter in peripheral nerve sheath tumours

European Journal of Cancer

Volumn 40, Issue 18, 2004, Pages 2820-2828

  Harder, A ^a   Rosche, M ^a   Reuss D E ^a   Holtkamp, N ^a   Uhlmann, K ^a   Friedrich, R ^b   Mautner, V F ^c   Von Deimling, A ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c Klinik Ochsenzoll   (Germany)

Author keywords

Nerve sheath tumour; Neurofibromatosis; Neurofibromatosis type 1; Promoter methylation

Indexed keywords

BISULFITE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR SP1;

5' UNTRANSLATED REGION; ARTICLE; BINDING SITE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; DNA DETERMINATION; DNA METHYLATION; FEMALE; GENE; GENE SEQUENCE; HUMAN; HUMAN CELL; HUMAN GENOME; HUMAN TISSUE; INTERMETHOD COMPARISON; LEUKOCYTE; MALE; MOLECULAR INTERACTION; NERVE SHEATH TUMOR; NEUROFIBROMA; NEUROFIBROMATOSIS 1 GENE; NUCLEOTIDE SEQUENCE; PERIPHERAL NERVE TUMOR; PRIORITY JOURNAL; PROMOTER REGION; SERUM RESPONSIVE ELEMENT;

ANTIOXIDANTS; CLONE CELLS; DNA METHYLATION; DNA, NEOPLASM; FEMALE; HUMANS; LEUKOCYTES; LOSS OF HETEROZYGOSITY; MALE; MOLECULAR SEQUENCE DATA; NERVE SHEATH NEOPLASMS; NEUROFIBROMATOSIS 1; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); SULFITES; TRANSCRIPTION, GENETIC;

EID: 9644252849     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2004.07.021     Document Type: Article

References (37)

1. NIH Consensus Development Conference Statement. Neurofibromatosis. Arch Neurol 1988, 45, 575-78
2. M. Ruggieri The different forms of neurofibromatosis Childs Nerv Syst 15 1999 295 308
3. K. Leroy, V. Dumas, and N. Martin-Garcia Malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1: a clinicopathologic and molecular study of 17 patients Arch Dermatol 137 2001 908 913
4. J.M. Woodruff Pathology of tumors of the peripheral nerve sheath in type 1 neurofibromatosis Am J Med Genet 89 1999 23 30
5. E. Serra, S. Puig, and D. Otero Confirmation of a double-hit model for the NF1 gene in benign neurofibromas Am J Hum Genet 61 1997 512 519
6. E. Serra, T. Rosenbaum, and U. Winner Schwann cells harbor the somatic NF1 mutation in neurofibromas: evidence of two different Schwann cell subpopulations Hum Mol Genet 9 2000 3055 3064
7. A. Perry, K.A. Roth, R. Banerjee, C.E. Fuller, and D.H. Gutmann NF1 deletions in S-100 protein-positive and negative cells of sporadic and neurofibromatosis 1 (NF1)-associated plexiform neurofibromas and malignant peripheral nerve sheath tumors Am J Pathol 159 2001 57 61
8. G.P. Nielsen, A.O. Stemmer-Rachamimov, Y. Ino, M.B. Moller, A.E. Rosenberg, and D.N. Louis Malignant transformation of neurofibromas in neurofibromatosis 1 is associated with CDKN2A/p16 inactivation Am J Pathol 155 1999 1879 1884
9. A.M. John, M. Ruggieri, R. Ferner, and M. Upadhyaya A search for evidence of somatic mutations in the NF1 gene J Med Genet 37 2000 44 49
10. N. Peters, A. Waha, and R. Wellenreuther Quantitative analysis of NF1 gene transcripts in sporadic gliomas, sporadic meningiomas and Neurofibromatosis type 1 associated plexiform neurofibromas Acta Neuropathol Berl 58 1999 547 551
11. M.M. Feldkamp, L. Angelov, and A. Guha Neurofibromatosis type 1 peripheral nerve tumors: aberrant activation of the Ras pathway Surg Neurol 51 1999 211 218
12. T.R. Haines, D.I. Rodenhiser, and P.J. Ainsworth Allele-specific non-CpG methylation of the Nf1 gene during early mouse development Dev Biol 240 2001 585 598
13. J.R. Graff, J.G. Herman, S. Myohanen, S.B. Baylin, and P.M. Vertino Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation J Biol Chem 272 1997 22322 22329
14. N. Ohtani-Fujita, T. Fujita, A. Aoike, N.E. Osifchin, P.D. Robbins, and T. Sakai CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene Oncogene 8 1993 1063 1067
15. J.G. Herman, F. Latif, and Y. Weng Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma Proc Natl Acad Sci USA 91 1994 9700 9704
16. D.N. Mancini, D.I. Rodenhiser, and P.J. Ainsworth CpG methylation within the 5′ regulatory region of the BRCA1 gene is tumor specific and includes a putative CREB binding site Oncogene 16 1998 1161 1169
17. S.H. Song, H.S. Jong, and H.H. Choi Methylation of specific CpG sites in the promoter region could significantly down-regulate p16 (INK4a) expression in gastric adenocarcinoma Int J Cancer 87 2000 236 240
18. M. Wolter, J. Reifenberger, and B. Blaschke Oligodendroglial tumors frequently demonstrate hypermethylation of the CDKN2A (MTS1, p16INK4a), p14ARF, and CDKN2B (MTS2, p15INK4b) tumor suppressor genes J Neuropathol Exp Neurol 60 2001 1170 1180
19. A. Hajra, A. Martin-Gallardo, and S.A. Tarle DNA sequences in the promoter region of the NF1 gene are highly conserved between human and mouse Genomics 21 1994 649 652
20. D.N. Mancini, S.M. Singh, T.K. Archer, and D.I. Rodenhiser Site-specific DNA methylation in the neurofibromatosis (NF1) promoter interferes with binding of CREB and SP1 transcription factors Oncogene 18 1999 4108 4119
21. M.P. Horan, D.N. Cooper, and M. Upadhyaya Hypermethylation of the neurofibromatosis type 1 (NF1) gene promoter is not a common event in the inactivation of the NF1 gene in NF1-specific tumours Hum Genet 107 2000 33 39
22. M. Luijten, S. Redeker, M.M. van Noesel, D. Troost, A. Westerveld, and T.J. Hulsebos Microsatellite instability and promoter methylation as possible causes of NF1 gene inactivation in neurofibromas Eur J Hum Genet 8 2000 939 945
23. F.D. Araujo, J.D. Knox, M. Szyf, G.B. Price, and M. Zannis-Hadjopoulos Concurrent replication and methylation at mammalian origins of replication Mol Cell Biol 18 1998 3475 3482
24. B.H. Ramsahoye, D. Biniszkiewicz, F. Lyko, V. Clark, A.P. Bird, and R. Jaenisch Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a Proc Natl Acad Sci USA 97 2000 5237 5242
25. A. Olek, J. Oswald, and J. Walter A modified and improved method for bisulphite based cytosine methylation analysis Nucleic Acids Res 24 1996 5064 5066
26. T.N. Basu, D.H. Gutmann, J.A. Fletcher, T.W. Glover, F.S. Collins, and J. Downward Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients Nature 356 1992 713 715
27. P.A. Jones, and P.W. Laird Cancer epigenetics comes of age Nat Genet 21 1999 163 167
28. M. Ehrlich, G. Jiang, E. Fiala, J.S. Dome, M.C. Yu, and T.I. Long Hypomethylation and hypermethylation of DNA in Wilms tumors Oncogene 21 43 2002 6694 6702
29. M. Comb, and H.M. Goodman CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2 Nucleic Acids Res 18 1990 3975 3982
30. J.G. Jiang, M.C. DeFrances, J. Machen, C. Johnson, and R. Zarnegar The repressive function of AP2 transcription factor on the hepatocyte growth factor gene promoter Biochem Biophys Res Commun 272 2000 882 886
31. M. Upadhyaya, and D. Cooper Construction of expression plasmids from 5′ flanking sequence adjacent to the NF1 gene David Viskochil Neurofibromatosis type 1977 Bios Sci Publ London 49
32. H.J. Stewart, A. Brennan, M. Rahman, G. Zoidl, P.J. Mitchell, and K.R. Jessen Developmental regulation and overexpression of the transcription factor AP-2, a potential regulator of the timing of Schwann cell generation Eur J Neurosci 14 2001 363 372
33. D.H. Gutmann, G.I. Tennekoon, J.L. Cole, F.S. Collins, and J.L. Rutkowski Modulation of the neurofibromatosis type 1 gene product, neurofibromin, during Schwann cell differentiation J Neurosci Res 36 1993 216 223
34. S.J. Clark, J. Harrison, and M. Frommer CpNpG methylation in mammalian cells Nat Genet 10 1995 20 27
35. W. Chao, K.D. Huynh, R.J. Spencer, L.S. Davidow, and J.T. Lee CTCF, a candidate trans-acting factor for X-inactivation choice Science 295 2002 345 347
36. G.P. White, P.M. Watt, B.J. Holt, and P.G. Holt Differential patterns of methylation of the IFN-gamma promoter at CpG and non-CpG sites underlie differences in IFN-gamma gene expression between human neonatal and adult CD45RO-T cells J Immunol 168 2002 2820 2827
37. J.G. Herman, J.R. Graff, S. Myohanen, B.D. Nelkin, and S.B. Baylin Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands Proc Natl Acad Sci USA 93 1996 9821 9826