메뉴 건너뛰기




Volumn 21, Issue 5, 2015, Pages 1457-1467

Loss of CDX2 expression is associated with poor prognosis in colorectal cancer patients

Author keywords

CDX2; Colorectal cancer; CpG island methylator phenotype; Microsatellite instability; Survival

Indexed keywords

B RAF KINASE; CYTOKERATIN 20; CYTOKERATIN 7; FLUOROURACIL; K RAS PROTEIN; TRANSCRIPTION FACTOR CDX2; CDX2 PROTEIN, HUMAN; HOMEODOMAIN PROTEIN; TUMOR MARKER;

EID: 84922569390     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v21.i5.1457     Document Type: Article
Times cited : (97)

References (51)
  • 1
    • 27744507676 scopus 로고    scopus 로고
    • Increasing incidence of colorectal cancer in Asia: Implications for screening
    • PMID: 16257795
    • Sung JJ, Lau JY, Goh KL, Leung WK. Increasing incidence of colorectal cancer in Asia: implications for screening. Lancet Oncol 2005; 6: 871-876 [PMID: 16257795 DOI: 10.1016/S1470-2045(05)70422-8]
    • (2005) Lancet Oncol , vol.6 , pp. 871-876
    • Sung, J.J.1    Lau, J.Y.2    Goh, K.L.3    Leung, W.K.4
  • 2
    • 84900433711 scopus 로고    scopus 로고
    • Cancer statistics in Korea: Incidence, mortality, survival, and prevalence in 2011
    • PMID: 24851102
    • Jung KW, Won YJ, Kong HJ, Oh CM, Lee DH, Lee JS. Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2011. Cancer Res Treat 2014; 46: 109-123 [PMID: 24851102 DOI: 10.4143/crt.2014.46.2.109]
    • (2014) Cancer Res Treat , vol.46 , pp. 109-123
    • Jung, K.W.1    Won, Y.J.2    Kong, H.J.3    Oh, C.M.4    Lee, D.H.5    Lee, J.S.6
  • 4
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • PMID: 22810696
    • Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature 2012; 487: 330-337 [PMID: 22810696 DOI: 10.1038/nature11252]
    • (2012) Nature , vol.487 , pp. 330-337
    • Cancer Genome Atlas Network1
  • 5
    • 0033769822 scopus 로고    scopus 로고
    • Cdx1 and cdx2 expression during intestinal development
    • PMID: 11040183
    • Silberg DG, Swain GP, Suh ER, Traber PG. Cdx1 and cdx2 expression during intestinal development. Gastroenterology 2000; 119: 961-971 [PMID: 11040183]
    • (2000) Gastroenterology , vol.119 , pp. 961-971
    • Silberg, D.G.1    Swain, G.P.2    Suh, E.R.3    Traber, P.G.4
  • 6
    • 16244388032 scopus 로고    scopus 로고
    • The role of Cdx proteins in intestinal development and cancer
    • PMID: 15136761
    • Guo RJ, Suh ER, Lynch JP. The role of Cdx proteins in intestinal development and cancer. Cancer Biol Ther 2004; 3: 593-601 [PMID: 15136761]
    • (2004) Cancer Biol Ther , vol.3 , pp. 593-601
    • Guo, R.J.1    Suh, E.R.2    Lynch, J.P.3
  • 7
    • 64549114508 scopus 로고    scopus 로고
    • Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2
    • PMID: 19386267
    • Gao N, White P, Kaestner KH. Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2. Dev Cell 2009; 16: 588-599 [PMID: 19386267 DOI: 10.1016/j.devcel.2009.02.010]
    • (2009) Dev Cell , vol.16 , pp. 588-599
    • Gao, N.1    White, P.2    Kaestner, K.H.3
  • 8
    • 0023032871 scopus 로고
    • A molecular gradient in early Drosophila embryos and its role in specifying the body pattern
    • PMID: 2878369
    • Macdonald PM, Struhl G. A molecular gradient in early Drosophila embryos and its role in specifying the body pattern. Nature 1986; 324: 537-545 [PMID: 2878369 DOI: 10.1038/324537a0]
    • (1986) Nature , vol.324 , pp. 537-545
    • Macdonald, P.M.1    Struhl, G.2
  • 9
    • 0028243649 scopus 로고
    • Structure of the murine homeobox gene cdx-2. Expression in embryonic and adult intestinal epithelium
    • PMID: 7910823
    • James R, Erler T, Kazenwadel J. Structure of the murine homeobox gene cdx-2. Expression in embryonic and adult intestinal epithelium. J Biol Chem 1994; 269: 15229-15237 [PMID: 7910823]
    • (1994) J Biol Chem , vol.269 , pp. 15229-15237
    • James, R.1    Erler, T.2    Kazenwadel, J.3
  • 10
    • 0037200071 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor-1 alpha, GATA-4, and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription. Implication for the developmental regulation of the sucrase-isomaltase gene
    • PMID: 12060663
    • Boudreau F, Rings EH, van Wering HM, Kim RK, Swain GP, Krasinski SD, Moffett J, Grand RJ, Suh ER, Traber PG. Hepatocyte nuclear factor-1 alpha, GATA-4, and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription. Implication for the developmental regulation of the sucrase-isomaltase gene. J Biol Chem 2002; 277: 31909-31917 [PMID: 12060663 DOI: 10.1074/jbc.M204622200]
    • (2002) J Biol Chem , vol.277 , pp. 31909-31917
    • Boudreau, F.1    Rings, E.H.2    Van Wering, H.M.3    Kim, R.K.4    Swain, G.P.5    Krasinski, S.D.6    Moffett, J.7    Grand, R.J.8    Suh, E.R.9    Traber, P.G.10
  • 11
    • 65349114168 scopus 로고    scopus 로고
    • Ets transcription factors control epithelial maturation and transit and crypt-villus morphogenesis in the mammalian intestine
    • PMID: 19264912
    • Jedlicka P, Sui X, Sussel L, Gutierrez-Hartmann A. Ets transcription factors control epithelial maturation and transit and crypt-villus morphogenesis in the mammalian intestine. Am J Pathol 2009; 174: 1280-1290 [PMID: 19264912 DOI: 10.2353/ajpath.2009.080409]
    • (2009) Am J Pathol , vol.174 , pp. 1280-1290
    • Jedlicka, P.1    Sui, X.2    Sussel, L.3    Gutierrez-Hartmann, A.4
  • 12
    • 70449411394 scopus 로고    scopus 로고
    • Mapping of HNF4alpha target genes in intestinal epithelial cells
    • PMID: 19761587
    • Boyd M, Bressendorff S, Moller J, Olsen J, Troelsen JT. Mapping of HNF4alpha target genes in intestinal epithelial cells. BMC Gastroenterol 2009; 9: 68 [PMID: 19761587 DOI: 10.1186/1471-230X-9-68]
    • (2009) BMC Gastroenterol , vol.9 , pp. 68
    • Boyd, M.1    Bressendorff, S.2    Moller, J.3    Olsen, J.4    Troelsen, J.T.5
  • 13
    • 33947174458 scopus 로고    scopus 로고
    • Metabolome, transcriptome, and bioinformatic cis-element analyses point to HNF-4 as a central regulator of gene expression during enterocyte differentiation
    • PMID: 16868071
    • Stegmann A, Hansen M, Wang Y, Larsen JB, Lund LR, Ritié L, Nicholson JK, Quistorff B, Simon-Assmann P, Troelsen JT, Olsen J. Metabolome, transcriptome, and bioinformatic cis-element analyses point to HNF-4 as a central regulator of gene expression during enterocyte differentiation. Physiol Genomics 2006; 27: 141-155 [PMID: 16868071 DOI: 10.1152/physiolgenomics.00314.2005]
    • (2006) Physiol Genomics , vol.27 , pp. 141-155
    • Stegmann, A.1    Hansen, M.2    Wang, Y.3    Larsen, J.B.4    Lund, L.R.5    Ritié, L.6    Nicholson, J.K.7    Quistorff, B.8    Simon-Assmann, P.9    Troelsen, J.T.10    Olsen, J.11
  • 14
    • 34547940716 scopus 로고    scopus 로고
    • The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells
    • PMID: 17553805
    • Jonckheere N, Vincent A, Perrais M, Ducourouble MP, Male AK, Aubert JP, Pigny P, Carraway KL, Freund JN, Renes IB, Van Seuningen I. The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells. J Biol Chem 2007; 282: 22638-22650 [PMID: 17553805 DOI: 10.1074/jbc.M700905200]
    • (2007) J Biol Chem , vol.282 , pp. 22638-22650
    • Jonckheere, N.1    Vincent, A.2    Perrais, M.3    Ducourouble, M.P.4    Male, A.K.5    Aubert, J.P.6    Pigny, P.7    Carraway, K.L.8    Freund, J.N.9    Renes, I.B.10    Van Seuningen, I.11
  • 16
    • 0344826531 scopus 로고    scopus 로고
    • Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice
    • PMID: 14625550
    • Aoki K, Tamai Y, Horiike S, Oshima M, Taketo MM. Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. Nat Genet 2003; 35: 323-330 [PMID: 14625550 DOI: 10.1038/ng1265]
    • (2003) Nat Genet , vol.35 , pp. 323-330
    • Aoki, K.1    Tamai, Y.2    Horiike, S.3    Oshima, M.4    Taketo, M.M.5
  • 17
    • 0141869045 scopus 로고    scopus 로고
    • The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development
    • PMID: 12970140
    • Bonhomme C, Duluc I, Martin E, Chawengsaksophak K, Chenard MP, Kedinger M, Beck F, Freund JN, Domon-Dell C. The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development. Gut 2003; 52: 1465-1471 [PMID: 12970140]
    • (2003) Gut , vol.52 , pp. 1465-1471
    • Bonhomme, C.1    Duluc, I.2    Martin, E.3    Chawengsaksophak, K.4    Chenard, M.P.5    Kedinger, M.6    Beck, F.7    Freund, J.N.8    Domon-Dell, C.9
  • 18
    • 78751520560 scopus 로고    scopus 로고
    • Suppression of colonic polyposis by homeoprotein CDX2 through its nontranscriptional function that stabilizes p27Kip1
    • PMID: 21224344
    • Aoki K, Kakizaki F, Sakashita H, Manabe T, Aoki M, Taketo MM. Suppression of colonic polyposis by homeoprotein CDX2 through its nontranscriptional function that stabilizes p27Kip1. Cancer Res 2011; 71: 593-602 [PMID: 21224344 DOI: 10.1158/0008-5472.can-10-2842]
    • (2011) Cancer Res , vol.71 , pp. 593-602
    • Aoki, K.1    Kakizaki, F.2    Sakashita, H.3    Manabe, T.4    Aoki, M.5    Taketo, M.M.6
  • 19
    • 77649224168 scopus 로고    scopus 로고
    • The intestine-specific transcription factor Cdx2 inhibits beta-catenin/TCF transcriptional activity by disrupting the beta-catenin-TCF protein complex
    • PMID: 19734199
    • Guo RJ, Funakoshi S, Lee HH, Kong J, Lynch JP. The intestine-specific transcription factor Cdx2 inhibits beta-catenin/TCF transcriptional activity by disrupting the beta-catenin-TCF protein complex. Carcinogenesis 2010; 31: 159-166 [PMID: 19734199 DOI: 10.1093/carcin/bgp213]
    • (2010) Carcinogenesis , vol.31 , pp. 159-166
    • Guo, R.J.1    Funakoshi, S.2    Lee, H.H.3    Kong, J.4    Lynch, J.P.5
  • 20
    • 0141742109 scopus 로고    scopus 로고
    • Cdx2 protein expression in normal and malignant human tissues: An immunohistochemical survey using tissue microarrays
    • PMID: 13679455
    • Moskaluk CA, Zhang H, Powell SM, Cerilli LA, Hampton GM, Frierson HF. Cdx2 protein expression in normal and malignant human tissues: an immunohistochemical survey using tissue microarrays. Mod Pathol 2003; 16: 913-919 [PMID: 13679455 DOI: 10.1097/01.mp.0000086073.92773.55]
    • (2003) Mod Pathol , vol.16 , pp. 913-919
    • Moskaluk, C.A.1    Zhang, H.2    Powell, S.M.3    Cerilli, L.A.4    Hampton, G.M.5    Frierson, H.F.6
  • 22
    • 77956863080 scopus 로고    scopus 로고
    • Immunohistochemical analysis of colorectal cancer with gastric phenotype: Claudin-18 is associated with poor prognosis
    • PMID: 20846265
    • Matsuda M, Sentani K, Noguchi T, Hinoi T, Okajima M, Matsusaki K, Sakamoto N, Anami K, Naito Y, Oue N, Yasui W. Immunohistochemical analysis of colorectal cancer with gastric phenotype: claudin-18 is associated with poor prognosis. Pathol Int 2010; 60: 673-680 [PMID: 20846265 DOI: 10.1111/j.1440-1827.2010.02587.x]
    • (2010) Pathol Int , vol.60 , pp. 673-680
    • Matsuda, M.1    Sentani, K.2    Noguchi, T.3    Hinoi, T.4    Okajima, M.5    Matsusaki, K.6    Sakamoto, N.7    Anami, K.8    Naito, Y.9    Oue, N.10    Yasui, W.11
  • 23
    • 0035190672 scopus 로고    scopus 로고
    • Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon
    • PMID: 11733373
    • Hinoi T, Tani M, Lucas PC, Caca K, Dunn RL, Macri E, Loda M, Appelman HD, Cho KR, Fearon ER. Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon. Am J Pathol 2001; 159: 2239-2248 [PMID: 11733373 DOI: 10.1016/s0002- 9440(10)63074-x]
    • (2001) Am J Pathol , vol.159 , pp. 2239-2248
    • Hinoi, T.1    Tani, M.2    Lucas, P.C.3    Caca, K.4    Dunn, R.L.5    Macri, E.6    Loda, M.7    Appelman, H.D.8    Cho, K.R.9    Fearon, E.R.10
  • 25
    • 80052926952 scopus 로고    scopus 로고
    • Comprehensive analysis of CpG island methylator phenotype (CIMP)-high, -low, and -negative colorectal cancers based on protein marker expression and molecular features
    • PMID: 21660972
    • Zlobec I, Bihl M, Foerster A, Rufle A, Lugli A. Comprehensive analysis of CpG island methylator phenotype (CIMP)-high, -low, and -negative colorectal cancers based on protein marker expression and molecular features. J Pathol 2011; 225: 336-343 [PMID: 21660972 DOI: 10.1002/path.2879]
    • (2011) J Pathol , vol.225 , pp. 336-343
    • Zlobec, I.1    Bihl, M.2    Foerster, A.3    Rufle, A.4    Lugli, A.5
  • 26
    • 85027952096 scopus 로고    scopus 로고
    • The clinical perspectives of CDX2 expression in colorectal cancer: A qualitative systematic review
    • PMID: 25126956
    • Olsen J, Espersen ML, Jess P, Kirkeby LT, Troelsen JT. The clinical perspectives of CDX2 expression in colorectal cancer: a qualitative systematic review. Surg Oncol 2014; 23: 167-176 [PMID: 25126956 DOI: 10.1016/j.suronc.2014.07.003]
    • (2014) Surg Oncol , vol.23 , pp. 167-176
    • Olsen, J.1    Espersen, M.L.2    Jess, P.3    Kirkeby, L.T.4    Troelsen, J.T.5
  • 27
    • 84876127439 scopus 로고    scopus 로고
    • Reduced CDX2 expression predicts poor overall survival in patients with colorectal cancer
    • PMID: 23574843
    • Hong KD, Lee D, Lee Y, Lee SI, Moon HY. Reduced CDX2 expression predicts poor overall survival in patients with colorectal cancer. Am Surg 2013; 79: 353-360 [PMID: 23574843]
    • (2013) Am Surg , vol.79 , pp. 353-360
    • Hong, K.D.1    Lee, D.2    Lee, Y.3    Lee, S.I.4    Moon, H.Y.5
  • 28
    • 84883142215 scopus 로고    scopus 로고
    • Prognostic implication of the CpG island methylator phenotype in colorectal cancers depends on tumour location
    • PMID: 23900220
    • Bae JM, Kim JH, Cho NY, Kim TY, Kang GH. Prognostic implication of the CpG island methylator phenotype in colorectal cancers depends on tumour location. Br J Cancer 2013; 109: 1004-1012 [PMID: 23900220 DOI: 10.1038/bjc.2013.430]
    • (2013) Br J Cancer , vol.109 , pp. 1004-1012
    • Bae, J.M.1    Kim, J.H.2    Cho, N.Y.3    Kim, T.Y.4    Kang, G.H.5
  • 29
    • 57749112183 scopus 로고    scopus 로고
    • Differential diagnostic and functional role of the multi-marker phenotype CDX2/CK20/CK7 in colorectal cancer stratified by mismatch repair status
    • PMID: 18587323
    • Lugli A, Tzankov A, Zlobec I, Terracciano LM. Differential diagnostic and functional role of the multi-marker phenotype CDX2/CK20/CK7 in colorectal cancer stratified by mismatch repair status. Mod Pathol 2008; 21: 1403-1412 [PMID: 18587323 DOI: 10.1038/modpathol.2008.117]
    • (2008) Mod Pathol , vol.21 , pp. 1403-1412
    • Lugli, A.1    Tzankov, A.2    Zlobec, I.3    Terracciano, L.M.4
  • 30
    • 73449118889 scopus 로고    scopus 로고
    • Prognostic implications of CpG island hypermethylator phenotype in colorectal cancers
    • PMID: 19911194
    • Kim JH, Shin SH, Kwon HJ, Cho NY, Kang GH. Prognostic implications of CpG island hypermethylator phenotype in colorectal cancers. Virchows Arch 2009; 455: 485-494 [PMID: 19911194 DOI: 10.1007/s00428-009-0857-0]
    • (2009) Virchows Arch , vol.455 , pp. 485-494
    • Kim, J.H.1    Shin, S.H.2    Kwon, H.J.3    Cho, N.Y.4    Kang, G.H.5
  • 31
    • 0037371192 scopus 로고    scopus 로고
    • CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: An immunohistochemical survey of 476 primary and metastatic carcinomas
    • PMID: 12604886
    • Werling RW, Yaziji H, Bacchi CE, Gown AM. CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: an immunohistochemical survey of 476 primary and metastatic carcinomas. Am J Surg Pathol 2003; 27: 303-310 [PMID: 12604886]
    • (2003) Am J Surg Pathol , vol.27 , pp. 303-310
    • Werling, R.W.1    Yaziji, H.2    Bacchi, C.E.3    Gown, A.M.4
  • 32
    • 84895928210 scopus 로고    scopus 로고
    • Possible role of Cdx2 in the serrated pathway of colorectal cancer characterized by BRAF mutation, high-level CpG island methylator phenotype and mismatch repair-deficiency
    • PMID: 24166180
    • Dawson H, Galván JA, Helbling M, Muller DE, Karamitopoulou E, Koelzer VH, Economou M, Hammer C, Lugli A, Zlobec I. Possible role of Cdx2 in the serrated pathway of colorectal cancer characterized by BRAF mutation, high-level CpG Island methylator phenotype and mismatch repair-deficiency. Int J Cancer 2014; 134: 2342-2351 [PMID: 24166180 DOI: 10.1002/ijc.28564]
    • (2014) Int J Cancer , vol.134 , pp. 2342-2351
    • Dawson, H.1    Galván, J.A.2    Helbling, M.3    Muller, D.E.4    Karamitopoulou, E.5    Koelzer, V.H.6    Economou, M.7    Hammer, C.8    Lugli, A.9    Zlobec, I.10
  • 33
    • 84871982705 scopus 로고    scopus 로고
    • Demonstration of CDX2 is highly antibody dependant
    • PMID: 22595949
    • Borrisholt M, Nielsen S, Vyberg M. Demonstration of CDX2 is highly antibody dependant. Appl Immunohistochem Mol Morphol 2013; 21: 64-72 [PMID: 22595949 DOI: 10.1097/PAI.0b013e318257f8aa]
    • (2013) Appl Immunohistochem Mol Morphol , vol.21 , pp. 64-72
    • Borrisholt, M.1    Nielsen, S.2    Vyberg, M.3
  • 35
    • 0032950713 scopus 로고    scopus 로고
    • Genomic structure and alterations of homeobox gene CDX2 in colorectal carcinomas
    • PMID: 10027310
    • Yagi OK, Akiyama Y, Yuasa Y. Genomic structure and alterations of homeobox gene CDX2 in colorectal carcinomas. Br J Cancer 1999; 79: 440-444 [PMID: 10027310 DOI: 10.1038/sj.bjc.6690068]
    • (1999) Br J Cancer , vol.79 , pp. 440-444
    • Yagi, O.K.1    Akiyama, Y.2    Yuasa, Y.3
  • 38
    • 0242497802 scopus 로고    scopus 로고
    • Silencing of CDX2 expression in colon cancer via a dominant repression pathway
    • PMID: 12947088
    • Hinoi T, Loda M, Fearon ER. Silencing of CDX2 expression in colon cancer via a dominant repression pathway. J Biol Chem 2003; 278: 44608-44616 [PMID: 12947088 DOI: 10.1074/jbc. M307435200]
    • (2003) J Biol Chem , vol.278 , pp. 44608-44616
    • Hinoi, T.1    Loda, M.2    Fearon, E.R.3
  • 39
  • 42
    • 84984879041 scopus 로고    scopus 로고
    • Prognostic value of CpG island methylator phenotype among colorectal cancer patients: A systematic review and meta-analysis
    • PMID: 24718889
    • Juo YY, Johnston FM, Zhang DY, Juo HH, Wang H, Pappou EP, Yu T, Easwaran H, Baylin S, van Engeland M, Ahuja N. Prognostic value of CpG island methylator phenotype among colorectal cancer patients: a systematic review and meta-analysis. Ann Oncol 2014; 25: 2314-2327 [PMID: 24718889 DOI: 10.1093/annonc/mdu149]
    • (2014) Ann Oncol , vol.25 , pp. 2314-2327
    • Juo, Y.Y.1    Johnston, F.M.2    Zhang, D.Y.3    Juo, H.H.4    Wang, H.5    Pappou, E.P.6    Yu, T.7    Easwaran, H.8    Baylin, S.9    Van Engeland, M.10    Ahuja, N.11
  • 44
    • 84922017795 scopus 로고    scopus 로고
    • Aberrant expression of annexin A10 is closely related to gastric phenotype in serrated pathway to colorectal carcinoma
    • Epub ahead of print, PMID: 25081749
    • Tsai JH, Lin YL, Cheng YC, Chen CC, Lin LI, Tseng LH, Cheng ML6, Liau JY1, Jeng YM. Aberrant expression of annexin A10 is closely related to gastric phenotype in serrated pathway to colorectal carcinoma. Mod Pathol 2014; Epub ahead of print [PMID: 25081749 DOI: 10.1038/modpathol.2014.96]
    • (2014) Mod Pathol
    • Tsai, J.H.1    Lin, Y.L.2    Cheng, Y.C.3    Chen, C.C.4    Lin, L.I.5    Tseng, L.H.6    Cheng, M.L.7    Liau, J.Y.8    Jeng, Y.M.9
  • 45
    • 84891072642 scopus 로고    scopus 로고
    • Loss of Cdx2 expression in primary tumors and lymph node metastases is specific for mismatch repair-deficiency in colorectal cancer
    • PMID: 24130965
    • Dawson H, Koelzer VH, Lukesch AC, Mallaev M, Inderbitzin D, Lugli A, Zlobec I. Loss of Cdx2 Expression in Primary Tumors and Lymph Node Metastases is Specific for Mismatch Repair-Deficiency in Colorectal Cancer. Front Oncol 2013; 3: 265 [PMID: 24130965 DOI: 10.3389/fonc.2013.00265]
    • (2013) Front Oncol , vol.3 , pp. 265
    • Dawson, H.1    Koelzer, V.H.2    Lukesch, A.C.3    Mallaev, M.4    Inderbitzin, D.5    Lugli, A.6    Zlobec, I.7
  • 46
    • 77949759545 scopus 로고    scopus 로고
    • The role of the CpG island methylator phenotype in colorectal cancer prognosis depends on microsatellite instability screening status
    • PMID: 20197478
    • Dahlin AM, Palmqvist R, Henriksson ML, Jacobsson M, Eklöf V, Rutegård J, Oberg A, Van Guelpen BR. The role of the CpG island methylator phenotype in colorectal cancer prognosis depends on microsatellite instability screening status. Clin Cancer Res 2010; 16: 1845-1855 [PMID: 20197478 DOI: 10.1158/1078-0432.ccr-09-2594]
    • (2010) Clin Cancer Res , vol.16 , pp. 1845-1855
    • Dahlin, A.M.1    Palmqvist, R.2    Henriksson, M.L.3    Jacobsson, M.4    Eklöf, V.5    Rutegård, J.6    Oberg, A.7    Van Guelpen, B.R.8
  • 47
    • 58249089525 scopus 로고    scopus 로고
    • CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer
    • PMID: 18832519
    • Ogino S, Nosho K, Kirkner GJ, Kawasaki T, Meyerhardt JA, Loda M, Giovannucci EL, Fuchs CS. CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer. Gut 2009; 58: 90-96 [PMID: 18832519 DOI: 10.1136/gut.2008.155473]
    • (2009) Gut , vol.58 , pp. 90-96
    • Ogino, S.1    Nosho, K.2    Kirkner, G.J.3    Kawasaki, T.4    Meyerhardt, J.A.5    Loda, M.6    Giovannucci, E.L.7    Fuchs, C.S.8
  • 50
    • 84888128154 scopus 로고    scopus 로고
    • Overfitting in prediction models - Is it a problem only in high dimensions?
    • PMID: 23811117
    • Subramanian J, Simon R. Overfitting in prediction models - is it a problem only in high dimensions? Contemp Clin Trials 2013; 36: 636-641 [PMID: 23811117 DOI: 10.1016/j.cct.2013.06.011]
    • (2013) Contemp Clin Trials , vol.36 , pp. 636-641
    • Subramanian, J.1    Simon, R.2
  • 51
    • 84904022083 scopus 로고    scopus 로고
    • Why have so few proteomic biomarkers "survived" validation? (Sample size and independent validation considerations)
    • PMID: 24737731
    • Hernández B, Parnell A, Pennington SR. Why have so few proteomic biomarkers "survived" validation? (Sample size and independent validation considerations). Proteomics 2014; 14: 1587-1592 [PMID: 24737731 DOI: 10.1002/pmic.201300377]
    • (2014) Proteomics , vol.14 , pp. 1587-1592
    • Hernández, B.1    Parnell, A.2    Pennington, S.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.