Lipid abnormalities in alpha/beta2-syntrophin null mice are independent from ABCA1

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1851, Issue 5, 2015, Pages 527-536

  Hebel, Tobias ^a   Eisinger, Kristina ^a   Neumeier, Markus ^a   Rein Fischboeck, Lisa ^a   Pohl, Rebekka ^a   Meier, Elisabeth M ^a   Boettcher, Alfred ^a   Froehner, Stanley C ^b   Adams, Marvin E ^b   Liebisch, Gerhard ^a   Krautbauer, Sabrina ^a   Buechler, Christa ^a  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Glucose tolerance test; Insulin; Liver; Scavenger receptor B I; Sphingomyelin

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; ABC TRANSPORTER A1; BETA2 SYNTROPHIN; CHOLESTEROL; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE 1; SCAVENGER RECEPTOR BI; SPHINGOMYELIN; SYNTROPHIN; SYNTROPHIN ALPHA; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ABCA1 PROTEIN, MOUSE; DYSTROPHIN ASSOCIATED PROTEIN; GLUCOSE BLOOD LEVEL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LIPID; MAPK1 PROTEIN, MOUSE; PDZK1 PROTEIN, MOUSE; PHOSPHOPROTEIN; SCARB1 PROTEIN, MOUSE; SCAVENGER RECEPTOR B; SIGNAL PEPTIDE; SODIUM PROTON EXCHANGE PROTEIN; SODIUM-HYDROGEN EXCHANGER REGULATORY FACTOR; SREBF2 PROTEIN, MOUSE; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BROWN ADIPOSE TISSUE; CHOLESTEROL LIVER LEVEL; CHOLESTEROL METABOLISM; CONTROLLED STUDY; GLUCOSE TOLERANCE; HUMAN; HUMAN CELL; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; KNOCKOUT MOUSE; LIPID ANALYSIS; LIPOPROTEIN BLOOD LEVEL; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; WEIGHT GAIN; ANIMAL; BLOOD; C57BL MOUSE; DEFICIENCY; DISEASE MODEL; ENZYME ACTIVATION; GENETICS; GENOTYPE; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; LIPID DIET; LIVER; METABOLISM; PATHOPHYSIOLOGY; PHENOTYPE; PHOSPHORYLATION; TUMOR CELL LINE;

MUS;

ADIPOSE TISSUE, BROWN; ADIPOSITY; ANIMALS; ATP BINDING CASSETTE TRANSPORTER 1; BLOOD GLUCOSE; CELL LINE, TUMOR; CHOLESTEROL; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; DYSTROPHIN-ASSOCIATED PROTEINS; ENZYME ACTIVATION; GENOTYPE; GLUCOSE INTOLERANCE; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPIDS; LIVER; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 1; OBESITY; PHENOTYPE; PHOSPHOPROTEINS; PHOSPHORYLATION; SCAVENGER RECEPTORS, CLASS B; SODIUM-HYDROGEN ANTIPORTER; SPHINGOMYELINS; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRIGLYCERIDES; WEIGHT GAIN;

EID: 84922470862     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2015.01.012     Document Type: Article

References (52)

1. C. Buechler, J. Wanninger, and M. Neumeier Adiponectin, a key adipokine in obesity related liver diseases World J. Gastroenterol. 17 2011 2801 2811
2. S.M. Haffner Relationship of metabolic risk factors and development of cardiovascular disease and diabetes Obesity (Silver Spring) 14 Suppl. 3 2006 121S 127S
3. I. Hjermann The metabolic cardiovascular syndrome: syndrome X, Reaven's syndrome, insulin resistance syndrome, atherothrombogenic syndrome J. Cardiovasc. Pharmacol. 20 Suppl. 8 1992 S5 S10
4. C. Buechler, and S. Bauer ATP binding cassette transporter A1 (ABCA1) associated proteins: potential drug targets in the metabolic syndrome and atherosclerotic disease? Curr. Pharm. Biotechnol. 13 2012 319 330
5. S. Chung, J.M. Timmins, M. Duong, C. Degirolamo, S. Rong, J.K. Sawyer, R.R. Singaraja, M.R. Hayden, N. Maeda, L.L. Rudel, G.S. Shelness, and J.S. Parks Targeted deletion of hepatocyte ABCA1 leads to very low density lipoprotein triglyceride overproduction and low density lipoprotein hypercatabolism J. Biol. Chem. 285 2010 12197 12209
6. V.I. Zannis, A. Chroni, and M. Krieger Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL J. Mol. Med. (Berl.) 84 2006 276 294
7. A. Yesilaltay, O. Kocher, R. Pal, A. Leiva, V. Quinones, A. Rigotti, and M. Krieger PDZK1 is required for maintaining hepatic scavenger receptor, class B, type I (SR-BI) steady state levels but not its surface localization or function J. Biol. Chem. 281 2006 28975 28980
8. O. Kocher, A. Yesilaltay, C. Cirovic, R. Pal, A. Rigotti, and M. Krieger Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism J. Biol. Chem. 278 2003 52820 52825
9. H.F. Bhat, M.E. Adams, and F.A. Khanday Syntrophin proteins as Santa Claus: role(s) in cell signal transduction Cell. Mol. Life Sci. 70 14 2013 2533 2554 (Jul.)
10. M.E. Adams, N. Kramarcy, T. Fukuda, A.G. Engel, R. Sealock, and S.C. Froehner Structural abnormalities at neuromuscular synapses lacking multiple syntrophin isoforms J. Neurosci. 24 2004 10302 10309
11. T. Ort, S. Voronov, J. Guo, K. Zawalich, S.C. Froehner, W. Zawalich, and M. Solimena Dephosphorylation of beta2-syntrophin and Ca2 +/mu-calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion EMBO J. 20 2001 4013 4023
12. M.F. Peters, M.E. Adams, and S.C. Froehner Differential association of syntrophin pairs with the dystrophin complex J. Cell Biol. 138 1997 81 93
13. J. Wanninger, M. Neumeier, J. Weigert, S. Bauer, T.S. Weiss, A. Schaffler, C. Krempl, C. Bleyl, C. Aslanidis, J. Scholmerich, and C. Buechler Adiponectin-stimulated CXCL8 release in primary human hepatocytes is regulated by ERK1/ERK2, p38 MAPK, NF-kappaB, and STAT3 signaling pathways Am. J. Physiol. Gastrointest. Liver Physiol. 297 2009 G611 G618
14. Krautbauer, K. Eisinger, Y.H., M. Neumeier, and C. Buechler Mol. Cell. Biochem. 393 2014 69 76
15. S. Bauer, J. Wanninger, S. Schmidhofer, J. Weigert, M. Neumeier, C. Dorn, C. Hellerbrand, N. Zimara, A. Schaffler, C. Aslanidis, and C. Buechler Sterol regulatory element-binding protein 2 (SREBP2) activation after excess triglyceride storage induces chemerin in hypertrophic adipocytes Endocrinology 152 2011 26 35
16. C.A. Schneider, W.S. Rasband, and K.W. Eliceiri NIH Image to ImageJ: 25 years of image analysis Nat. Methods 9 2012 671 675
17. M.A. Kawashiri, C. Maugeais, and D.J. Rader High-density lipoprotein metabolism: molecular targets for new therapies for atherosclerosis Curr. Atheroscler. Rep. 2 2000 363 372
18. P. Handa, B.D. Maliken, J.E. Nelson, V. Morgan-Stevenson, D.J. Messner, B.K. Dhillon, H.M. Klintworth, M. Beauchamp, M.M. Yeh, C.T. Elfers, C.L. Roth, and K.V. Kowdley Reduced adiponectin signaling due to weight gain results in nonalcoholic steatohepatitis through impaired mitochondrial biogenesis Hepatology 60 2014 133 145
19. S. Krautbauer, K. Eisinger, M. Lupke, J. Wanninger, P. Ruemmele, Y. Hader, T.S. Weiss, and C. Buechler Manganese superoxide dismutase is reduced in the liver of male but not female humans and rodents with non-alcoholic fatty liver disease Exp. Mol. Pathol. 95 2013 330 335
20. M.E. Miquilena-Colina, E. Lima-Cabello, S. Sanchez-Campos, M.V. Garcia-Mediavilla, M. Fernandez-Bermejo, T. Lozano-Rodriguez, J. Vargas-Castrillon, X. Buque, B. Ochoa, P. Aspichueta, J. Gonzalez-Gallego, and C. Garcia-Monzon Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C Gut 60 2011 1394 1402
21. C. Fernandez-Hernando, and K.J. Moore MicroRNA modulation of cholesterol homeostasis Arterioscler. Thromb. Vasc. Biol. 31 2011 2378 2382
22. P.G. Frank, S. Pavlides, M.W. Cheung, K. Daumer, and M.P. Lisanti Role of caveolin-1 in the regulation of lipoprotein metabolism Am. J. Physiol. Cell Physiol. 295 2008 C242 C248
23. H. Motoshima, B.J. Goldstein, M. Igata, and E. Araki AMPK and cell proliferation - AMPK as a therapeutic target for atherosclerosis and cancer J. Physiol. 574 2006 63 71
24. S. Docke, J.F. Lock, A.L. Birkenfeld, S. Hoppe, S. Lieske, A. Rieger, N. Raschzok, I.M. Sauer, S. Florian, M.A. Osterhoff, R. Heller, K. Herrmann, S. Lindenmuller, P. Horn, M. Bauer, M.O. Weickert, P. Neuhaus, M. Stockmann, M. Mohlig, A.F. Pfeiffer, and C. von Loeffelholz Elevated hepatic chemerin mRNA expression in human non-alcoholic fatty liver disease Eur. J. Endocrinol./Eur. Fed. Endocr. Soc. 169 2013 547 557
25. S. Krautbauer, J. Wanninger, K. Eisinger, Y. Hader, M. Beck, A. Kopp, A. Schmid, T.S. Weiss, C. Dorn, and C. Buechler Chemerin is highly expressed in hepatocytes and is induced in non-alcoholic steatohepatitis liver Exp. Mol. Pathol. 95 2013 199 205
26. N. Wang, T. Arai, Y. Ji, F. Rinninger, and A.R. Tall Liver-specific overexpression of scavenger receptor BI decreases levels of very low density lipoprotein ApoB, low density lipoprotein ApoB, and high density lipoprotein in transgenic mice J. Biol. Chem. 273 1998 32920 32926
27. Z. Hu, J. Hu, Z. Zhang, W.J. Shen, C.C. Yun, C.H. Berlot, F.B. Kraemer, and S. Azhar Regulation of expression and function of scavenger receptor class B, type I (SR-BI) by Na +/H + exchanger regulatory factors (NHERFs) J. Biol. Chem. 288 2013 11416 11435
28. J.Y. Chiang Bile acids: regulation of synthesis J. Lipid Res. 50 2009 1955 1966
29. P. Wood, V. Mulay, M. Darabi, K.C. Chan, J. Heeren, A. Pol, G. Lambert, K.A. Rye, C. Enrich, and T. Grewal Ras/mitogen-activated protein kinase (MAPK) signaling modulates protein stability and cell surface expression of scavenger receptor SR-BI J. Biol. Chem. 286 2011 23077 23092
30. S. Heimerl, G. Liebisch, S. Le Lay, A. Bottcher, P. Wiesner, S. Lindtner, T.V. Kurzchalia, K. Simons, and G. Schmitz Caveolin-1 deficiency alters plasma lipid and lipoprotein profiles in mice Biochem. Biophys. Res. Commun. 367 2008 826 833
31. P.V. Subbaiah, X.C. Jiang, N.A. Belikova, B. Aizezi, Z.H. Huang, and C.A. Reardon Regulation of plasma cholesterol esterification by sphingomyelin: effect of physiological variations of plasma sphingomyelin on lecithin-cholesterol acyltransferase activity Biochim. Biophys. Acta 1821 2012 908 913
32. P.V. Subbaiah, L.R. Gesquiere, and K. Wang Regulation of the selective uptake of cholesteryl esters from high density lipoproteins by sphingomyelin J. Lipid Res. 46 2005 2699 2705
33. P.V. Subbaiah, P. Horvath, and S.B. Achar Regulation of the activity and fatty acid specificity of lecithin-cholesterol acyltransferase by sphingomyelin and its metabolites, ceramide and ceramide phosphate Biochemistry 45 2006 5029 5038
34. Y. Li, J. Dong, T. Ding, M.S. Kuo, G. Cao, X.C. Jiang, and Z. Li Sphingomyelin synthase 2 activity and liver steatosis: an effect of ceramide-mediated peroxisome proliferator-activated receptor gamma2 suppression Arterioscler. Thromb. Vasc. Biol. 33 2013 1513 1520
35. M. Benharouga, M. Sharma, J. So, M. Haardt, L. Drzymala, M. Popov, B. Schwapach, S. Grinstein, K. Du, and G.L. Lukacs The role of the C terminus and Na +/H + exchanger regulatory factor in the functional expression of cystic fibrosis transmembrane conductance regulator in nonpolarized cells and epithelia J. Biol. Chem. 278 2003 22079 22089
36. J. Saras, and C.H. Heldin PDZ domains bind carboxy-terminal sequences of target proteins Trends Biochem. Sci. 21 1996 455 458
37. E.B. Neufeld, A.T. Remaley, S.J. Demosky, J.A. Stonik, A.M. Cooney, M. Comly, N.K. Dwyer, M. Zhang, J. Blanchette-Mackie, S. Santamarina-Fojo, and H.B. Brewer Jr. Cellular localization and trafficking of the human ABCA1 transporter J. Biol. Chem. 276 2001 27584 27590
38. M.L. Fitzgerald, K. Okuhira, G.F. Short III, J.J. Manning, S.A. Bell, and M.W. Freeman ATP-binding cassette transporter A1 contains a novel C-terminal VFVNFA motif that is required for its cholesterol efflux and ApoA-I binding activities J. Biol. Chem. 279 2004 48477 48485
39. J.J. Zachwieja Exercise as treatment for obesity Endocrinol. Metab. Clin. N. Am. 25 1996 965 988
40. A. Rigotti, B.L. Trigatti, M. Penman, H. Rayburn, J. Herz, and M. Krieger A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism Proc. Natl. Acad. Sci. U. S. A. 94 1997 12610 12615
41. G. Li, A.M. Thomas, J.A. Williams, B. Kong, J. Liu, Y. Inaba, W. Xie, and G.L. Guo Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding PLoS One 7 2012 e35895
42. Y. Zou, H. Du, M. Yin, L. Zhang, L. Mao, N. Xiao, G. Ren, C. Zhang, and J. Pan Effects of high dietary fat and cholesterol on expression of PPAR alpha, LXR alpha, and their responsive genes in the liver of apoE and LDLR double deficient mice Mol. Cell. Biochem. 323 2009 195 205
43. A. Leiva, H. Verdejo, M.L. Benitez, A. Martinez, D. Busso, and A. Rigotti Mechanisms regulating hepatic SR-BI expression and their impact on HDL metabolism Atherosclerosis 217 2011 299 307
44. R. Martinez-Beamonte, J.M. Lou-Bonafonte, M.V. Martinez-Gracia, and J. Osada Sphingomyelin in high-density lipoproteins: structural role and biological function Int. J. Mol. Sci. 14 2013 7716 7741
45. K. Oorni, J.K. Hakala, A. Annila, M. Ala-Korpela, and P.T. Kovanen Sphingomyelinase induces aggregation and fusion, but phospholipase A2 only aggregation, of low density lipoprotein (LDL) particles. Two distinct mechanisms leading to increased binding strength of LDL to human aortic proteoglycans J. Biol. Chem. 273 1998 29127 29134
46. A. Schlitt, M.R. Hojjati, H. von Gizycki, K.J. Lackner, S. Blankenberg, B. Schwaab, J. Meyer, H.J. Rupprecht, and X.C. Jiang Serum sphingomyelin levels are related to the clearance of postprandial remnant-like particles J. Lipid Res. 46 2005 196 200
47. N.D. Ridgway Inhibition of acyl-CoA:cholesterol acyltransferase in Chinese hamster ovary (CHO) cells by short-chain ceramide and dihydroceramide Biochim. Biophys. Acta 1256 1995 39 46
48. J. Dong, J. Liu, B. Lou, Z. Li, X. Ye, M. Wu, and X.C. Jiang Adenovirus-mediated overexpression of sphingomyelin synthases 1 and 2 increases the atherogenic potential in mice J. Lipid Res. 47 2006 1307 1314
49. J.P. Guegan, C. Fremin, and G. Baffet The MAPK MEK1/2-ERK1/2 pathway and its implication in hepatocyte cell cycle control Int. J. Hepatol. 2012 2012 328372
50. K.A. Burns, and J.P. Vanden Heuvel Modulation of PPAR activity via phosphorylation Biochim. Biophys. Acta 1771 2007 952 960
51. D. Lan, and D.L. Silver Fenofibrate induces a novel degradation pathway for scavenger receptor B-I independent of PDZK1 J. Biol. Chem. 280 2005 23390 23396
52. K. Tsukamoto, L. Buck, W. Inman, L. Griffith, O. Kocher, and M. Krieger Challenges in using cultured primary rodent hepatocytes or cell lines to study hepatic HDL receptor SR-BI regulation by its cytoplasmic adaptor PDZK1 PLoS One 8 2013 e69725