Sterol regulatory element-binding protein 2 (SREBP2) activation after excess triglyceride storage induces chemerin in hypertrophic adipocytes

Endocrinology

Volumn 152, Issue 1, 2011, Pages 26-35

  Bauer, Sabrina ^a   Wanninger, Josef ^a   Schmidhofer, Sandra ^a   Weigert, Johanna ^a   Neumeier, Markus ^a   Dorn, Christoph ^a   Hellerbrand, Claus ^a   Zimara, Nicole ^a   Schäffler, Andreas ^a   Aslanidis, Charalampos ^a   Buechler, Christa ^a  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; CHEMERIN; FATTY ACID; LIPOPOLYSACCHARIDE; MEVALONIC ACID; MEVINOLIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL MATURATION; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE ACTIVATION; GENE INDUCTION; LIPID DIET; MACROPHAGE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; UPREGULATION;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; CHEMOTACTIC FACTORS; FEMALE; GENE EXPRESSION REGULATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN-6; MICE; MICE, INBRED C57BL; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 78650851267     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-1157     Document Type: Article

References (45)

1. Cusi K 2010 The role of adipose tissue and lipotoxicity in the patho-genesis of type 2 diabetes. Curr Diab Rep 10:306-315
2. de Ferranti S, Mozaffarian D 2008 The perfect storm: obesity, adi-pocyte dysfunction, and metabolic consequences. Clin Chem 54: 945-955
3. Ferrannini E, Balkau B, Coppack SW, Dekker JM, Mari A, Nolan J, Walker M, Natali A, Beck-Nielsen H 2007 Insulin resistance, insulin response, and obesity as indicators of metabolic risk. J Clin Endocrinol Metab 92:2885-2892
4. Schäffler A, Schölmerich J, Büchler C 2005 Mechanisms of disease: adipocytokines and visceral adipose tissue-emerging role in intestinal and mesenteric diseases. Nat Clin Pract Gastroenterol Hepatol 2:103-111 (Pubitemid 40790157)
5. Hajer GR, van Haeften TW, Visseren FL 2008 Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J 29:2959-2971
6. Yu BL, Zhao SP, Hu JR 2010 Cholesterol imbalance in adipocytes: a possible mechanism of adipocytes dysfunction in obesity. Obes Rev 11:560-567
7. Boizard M, Le Liepvre X, Lemarchand P, Foufelle F, Ferré P, Dugail I 1998 Obesity-related overexpression of fatty-acid synthase gene in adipose tissue involves sterol regulatory element-binding protein transcription factors. J Biol Chem 273:29164-29171
8. Ceperuelo-Mallafré V, Miranda M, Chacón MR, Vilarrasa N, Megia A, Gutiérrez C, Fernández-Real JM, Gó mez JM, Caubet E, Frü hbeck G, Vendrell J 2007 Adipose tissue expression of the glyc-erol channel aquaporin-7 gene is altered in severe obesity but not in type 2 diabetes. J Clin Endocrinol Metab 92:3640-3645
9. Le Lay S, Ferré P, Dugail I 2004 Adipocyte cholesterol balance in obesity. Biochem Soc Trans 32:103-106
10. Rabe K, Lehrke M, Parhofer KG, Broedl UC 2008 Adipokines and insulin resistance. Mol Med 14:741-751
11. Bozaoglu K, Bolton K, McMillan J, Zimmet P, Jowett J, Collier G, Walder K, Segal D 2007 Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Endocrinology 148:4687-4694
12. Lehrke M, Becker A, Greif M, Stark R, Laubender RP, von Ziegler F, Lebherz C, Tittus J, Reiser M, Becker C, Göke B, Leber AW, Parhofer KG, Broedl U C 2009 Chemerin is associated with markers of inflammation and components of the metabolic syndrome but does not predict coronary atherosclerosis. Eur J Endocrinol 161: 339-344
13. Stejskal D, Karpisek M, Hanulova Z, Svestak M 2008 Chemerin is an independent marker of the metabolic syndrome in a Caucasian population: a pilot study. Biomed Pap Med Fac Univ Palacky Olo-mouc Czech Repub 152:217-221
14. Weigert J, Neumeier M, Wanninger J, Filarsky M, Bauer S, Wiest R, Farkas S, Scherer MN, Schaffler A, Aslanidis C, Scholmerich J, Buechler C 2009 Systemic chemerin is related to inflammation rather than obesity in type 2 diabetes. Clin Endocrinol (Oxf) 72: 342-348
15. Sell H, Laurencikiene J, Taube A, Eckardt K, Cramer A, Horrighs A, Arner P, Eckel J 2009 Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cells. Diabetes 58:2731-2740
16. Cawthorn WP, Sethi JK 2008 TNF-a and adipocyte biology. FEBS Lett 582:117-131
17. Kralisch S, Weise S, Sommer G, Lipfert J, Lossner U, Bluher M, Stumvoll M, Fasshauer M 2009 Interleukin-1beta induces the novel adipokine chemerin in adipocytes in vitro. Regul Pept 154:102-106
18. Parlee SD, Ernst MC, Muruganandan S, Sinal CJ, Goralski KB 2010 Serum chemerin levels vary with time of day and are modified by obesity and tumor necrosis factor-a. Endocrinology 151: 2590-2602
19. Goralski KB, McCarthy TC, Hanniman EA, Zabel BA, Butcher EC, Parlee SD, Muruganandan S, Sinal CJ 2007 Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. J Biol Chem 282:28175-28188
20. Roh SG, Song SH, Choi KC, Katoh K, Wittamer V, Parmentier M, Sasaki S 2007 Chemerin: a new adipokine that modulates adipogenesis via its own receptor. Biochem Biophys Res Commun 362: 1013-1018
21. Ernst MC, Issa M, Goralski KB, Sinal CJ 2010 Chemerin exacerbates glucose intolerance in mouse models of obesity and diabetes. Endocrinology 151:1998-2007
22. Tan BK, Chen J, Farhatullah S, Adya R, Kaur J, Heutling D, Lewandowski KC, O'Hare JP, Lehnert H, Randeva HS 2009 Insulin and metformin regulate circulating and adipose tissue chemerin. Diabetes 58:1971-1977
23. Zabel BA, Ohyama T, Zuniga L, Kim JY, Johnston B, Allen SJ, Guido DG, Handel TM, Butcher EC 2006 Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-/3 and TLR ligands. Exp Hematol 34:1106-1114
24. Bradley RL, Fisher FF, Maratos-Flier E 2008 Dietary fatty acids differentially regulate production of TNF-a and IL-10 by murine 3T3-L1 adipocytes. Obesity (Silver Spring) 16:938-944
25. Fontana L, Eagon J C, Trujillo M E, Scherer P E, Klein S 2007 Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 56:1010-1013
26. Neumeier M, Sigruener A, Eggenhofer E, Weigert J, Weiss TS, Schaeffler A, Schlitt HJ, Aslanidis C, Piso P, Langmann T, Schmitz G, Scholmerich J, Buechler C 2007 High molecular weight adi-ponectin reduces apolipoprotein B and E release in human hepato-cytes. Biochem Biophys Res Commun 352:543-548
27. Neumeier M, Weigert J, Schaffler A, Weiss TS, Schmidl C, Buttner R, Bollheimer C, Aslanidis C, Scholmerich J, Buechler C 2006 Aldehyde oxidase 1 is highly abundant in hepatic steatosis and is down-regulated by adiponectin and fenofibric acid in hepatocytes in vitro. Biochem Biophys Res Commun 350:731-735
28. Paigen B, Morrow A, Brandon C, Mitchell D, Holmes P 1985 Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis 57:65-73
29. Nishina PM, Verstuyft J, Paigen B 1990 Synthetic low and high fat diets for the study of atherosclerosis in the mouse. J Lipid Res 31: 859-869
30. Poulain-Godefroy O, Froguel P 2007 Preadipocyte response and impairment of differentiation in an inflammatory environment. Biochem Biophys Res Commun 356:662-667
31. Weigert J, Neumeier M, Bauer S, Mages W, Schnitzbauer AA, Obed A, Groschl B, Hartmann A, Schaffler A, Aslanidis C, Scholmerich J, Buechler C 2008 Small-interference RNA-mediated knock-down of aldehyde oxidase 1 in 3T3-L1 cells impairs adipogenesis and adiponectin release. FEBS Lett 582:2965-2972
32. Hoggard N, Cruickshank M, Moar KM, Barrett P, Bashir S, Miller JD 2009 Inhibin/3B (INHBB) expression in murine adipose tissue and its regulation by leptin, insulin and dexamethasone. J Mol Endocrinol 43:171-177
33. Grimaldi PA, Knobel SM, Whitesell RR, Abumrad N A 1992 Induction of aP2 gene expression by nonmetabolized long-chain fatty acids. Proc Natl Acad Sci USA 89:10930-10934
34. Le Lay S, Krief S, Farnier C, Lefrere I, Le Liepvre X, Bazin R, Ferre P, Dugail I 2001 Cholesterol, a cell size-dependent signal that regulates glucose metabolism and gene expression in adipocytes. J Biol Chem 276:16904-16910
35. Sato R 2009 SREBPs: protein interaction and SREBPs. FEBS J 276: 622-627
36. Heilbronn LK, Campbell L V 2008 Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity. Curr Pharm Des 14:1225-1230
37. Gustafson B, Gogg S, Hedjazifar S, Jenndahl L, Hammarstedt A, Smith U 2009 Inflammation and impaired adipogenesis in hypertrophic obesity in man. Am J Physiol Endocrinol Metab 297:E999-E 1003
38. Kopp A, Buechler C, Bala M, Neumeier M, Scholmerich J, Schaffler A 2010 Toll-like receptor ligands cause proinflammatory and pro-diabetic activation of adipocytes via phosphorylation of extracellular signal-regulated kinase and c-Jun N-terminal kinase but not interferon regulatory factor-3. Endocrinology 151:1097-1108
39. Ajuwon KM, Spurlock M E 2005 Palmitate activates the NF-KB transcription factor and induces IL-6 and TNFa expression in 3T3-L1 adipocytes. J Nutr 135:1841-1846
40. Schaeffler A, Gross P, Buettner R, Bollheimer C, Buechler C, Neumeier M, Kopp A, Schoelmerich J, Falk W 2009 Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-B pathway in adipocytes links nutritional signalling with innate immunity. Immunology 126:233-245
41. Mirhashemi F, Scherneck S, Kluth O, Kaiser D, Vogel H, Kluge R, Schurmann A, Neschen S, Joost HG 8 September 2010 Diet Dependence of Diabetes in the New Zealand Obese (NZO) Mouse: Total Fat, But not Fat Quality or Sucrose Accelerates and Aggravates Diabetes. Exp Clin Endocrinol Diabetes 10.1055/s-0030-1263127
42. Vergnes L, Phan J, Strauss M, Tafuri S, Reue K 2003 Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression. J Biol Chem 278:42774-42784
43. Sell H, Divoux A, Poitou C, Basdevant A, Bouillot JL, Bedossa P, Tordjman J, Eckel J, Clement K 2010 Chemerin correlates with markers for fatty liver in morbidly obese patients and strongly decreases after weight loss induced by bariatric surgery. J Clin Endocrinol Metab 95:2892-2896
44. Yoshimura T, Oppenheim JJ 2008 Chemerin reveals its chimeric nature. J Exp Med 205:2187-2190
45. Takahashi M, Takahashi Y, Takahashi K, Zolotaryov FN, Hong KS, Kitazawa R, Iida K, Okimura Y, Kaji H, Kitazawa S, Kasuga M, Chihara K 2008 Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes. FEBS Lett 582:573-578