Auto-Oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin

Chemical Research in Toxicology

Volumn 28, Issue 1, 2015, Pages 51-58

  Meng, Xiaoli ^a   Maggs, James L ^a   Usui, Toru ^a   Whitaker, Paul ^b   French, Neil S ^a   Naisbitt, Dean J ^a   Park, B Kevin ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; HUMAN SERUM ALBUMIN; ISONIAZID; ISONICOTINIC ACID; ISONICOTINIC N ACETYLLYSINE; LYSINE; LYSINE DERIVATIVE; N ACETYLLYSINE; OXIDOREDUCTASE; UNCLASSIFIED DRUG; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PROTEIN BINDING; SERUM ALBUMIN;

ADULT; AGED; ARTICLE; AUTOOXIDATION; BLOOD SAMPLING; CASE REPORT; CONTROLLED STUDY; COVALENT BOND; DRUG BLOOD LEVEL; DRUG OXIDATION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY; LIVER MICROSOME; LUNG TUBERCULOSIS; MALE; MAXIMUM PLASMA CONCENTRATION; MIDDLE AGED; PLASMA; PROTEIN MODIFICATION; TANDEM MASS SPECTROMETRY; VERY ELDERLY; BLOOD; METABOLISM; OXIDATION REDUCTION REACTION;

ADULT; AGED, 80 AND OVER; FEMALE; HUMANS; ISONIAZID; LYSINE; MALE; MICROSOMES, LIVER; MIDDLE AGED; NADP; OXIDATION-REDUCTION; PROTEIN BINDING; SERUM ALBUMIN;

EID: 84922422561     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx500285k     Document Type: Article

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