Direct oxidation and covalent binding of isoniazid to rodent liver and human hepatic microsomes: Humans are more like mice than rats

Chemical Research in Toxicology

Volumn 25, Issue 11, 2012, Pages 2567-2576

  Metushi, Imir G ^a   Nakagawa, Tetsuya ^b   Uetrecht, Jack ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; GLUTAMIC ACID; IDITOL DEHYDROGENASE; ISONIAZID; LYSINE DERIVATIVE; PYRAZINE DIAZOHYDROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; COVALENT BOND; FATTY LIVER; FEMALE; HUMAN; HUMAN CELL; LIVER INJURY; LIVER MICROSOME; LIVER TOXICITY; MALE; METABOLITE; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATION; RAT;

ANIMALS; BINDING SITES; HUMANS; ISONIAZID; LIVER; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICROSOMES, LIVER; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; RATS; RATS, INBRED BN; RATS, WISTAR;

ANIMALIA; MUS; ORYCTOLAGUS CUNICULUS; RATTUS; RODENTIA;

EID: 84869479030     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx300341r     Document Type: Article

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