Direct evidence for the formation of diastereoisomeric benzylpenicilloyl haptens from benzylpenicillin and benzylpenicillenic acid in patients

Journal of Pharmacology and Experimental Therapeutics

Volumn 338, Issue 3, 2011, Pages 841-849

  Meng, Xiaoli ^a   Jenkins, Rosalind E ^a   Berry, Neil G ^a   Maggs, James L ^a   Farrell, John ^a   Lane, Catherine S ^b   Stachulski, Andrew V ^c   French, Neil S ^a   Naisbitt, Dean J ^a   Pirmohamed, Munir ^a   Park, B Kevin ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b MDS SCIEX   (Canada)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLPENICILLENIC ACID; DRUG METABOLITE; EPITOPE; HAPTEN; HUMAN SERUM ALBUMIN; LYSINE; PENICILLIN G; UNCLASSIFIED DRUG;

ALBUMIN BLOOD LEVEL; ANTIGEN BINDING; ANTIGEN DETECTION; ANTIGEN FUNCTION; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ANTIGEN STRUCTURE; ARTICLE; CATALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIASTEREOISOMER; IN VITRO STUDY; INCUBATION TIME; MASS SPECTROMETRY; MOLECULAR INTERACTION; MOLECULAR MODEL; PATHOGENESIS; PENICILLIN ALLERGY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RESIDUE ANALYSIS; STEREOCHEMISTRY; STEREOISOMERISM;

ADULT; AGED; AGED, 80 AND OVER; AMINO ACID SEQUENCE; BLOTTING, WESTERN; CATALYSIS; COMPUTER SIMULATION; DRUG HYPERSENSITIVITY; EPITOPES; FEMALE; HAPTENS; HUMANS; INDICATORS AND REAGENTS; LYMPHOCYTE ACTIVATION; MALE; MASS SPECTROMETRY; MIDDLE AGED; PENICILLIN G; PENICILLINS; SERUM ALBUMIN; STEREOISOMERISM;

EID: 80052152347     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.183871     Document Type: Article

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