WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4

Hypertension

Volumn 64, Issue 5, 2014, Pages 1047-1053

  Chávez Canales, María ^a,b   Zhang, Chong ^a,c   Soukaseum, Christelle ^d,e   Moreno, Erika ^b   Pacheco Alvarez, Diana ^f   Vidal Petiot, Emmanuelle ^d,e,i   Castañeda Bueno, María ^a,b,j   Vázquez, Norma ^a,b   Rojas Vega, Lorena ^a,b   Meermeier, Nicholas P ^c   Rogers, Shaunessy ^c   Jeunemaitre, Xavier ^c,d,g   Yang, Chao Ling ^c   Ellison, David H ^c,h   Gamba, Gerardo ^a,b   Hadchouel, Juliette ^d,e  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d PARIS CARDIOVASCULAR RESEARCH CENTER   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

^f UNIVERSIDAD PANAMERICANA   (Mexico)

^g HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^h PORTLAND VA MEDICAL CENTER   (United States)

ⁱ BICHAT HOSPITAL   (France)

^j YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

Distal; Familial hypertensive hyperkalemia; Hypertension, renal; Kidney tubules; Knockout; Mice; Pseudohypoaldosteronism ; Type II; Water electrolyte balance; Xenopus laevis

Indexed keywords

PROTEIN KINASE; PROTEIN KINASE WNK1; PROTEIN KINASE WNK4; SODIUM CHLORIDE COTRANSPORTER; STE20 PROLINE ALANINE RICH KINASE; UNCLASSIFIED DRUG; PRKWNK1 PROTEIN, MOUSE; PRKWNK4 PROTEIN, MOUSE; PROTEIN SERINE THREONINE KINASE; STK39 PROTEIN, MOUSE;

ALTERNATIVE RNA SPLICING; ARTERIAL PRESSURE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EMBRYO; EXON; EXTRACELLULAR SPACE; GENE MUTATION; HEK293 CELL LINE; HEMATOCRIT; HUMAN; HUMAN CELL; HYPERKALEMIA; HYPERTENSION; INTRON; KIDNEY CELL; METABOLIC ACIDOSIS; METABOLIC ALKALOSIS; MOUSE; NONHUMAN; OOCYTE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; SYSTOLIC BLOOD PRESSURE; XENOPUS LAEVIS; ANIMAL; BLOOD PRESSURE; C57BL MOUSE; DEFICIENCY; DISEASE MODEL; FEMALE; GENETICS; IN VITRO STUDY; KIDNEY; KNOCKOUT MOUSE; MALE; MUTANT MOUSE STRAIN; PATHOPHYSIOLOGY; PHYSIOLOGY; PSEUDOHYPOALDOSTERONISM; SIGNAL TRANSDUCTION;

ANIMALS; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; IN VITRO TECHNIQUES; KIDNEY; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, MUTANT STRAINS; PHENOTYPE; PROTEIN-SERINE-THREONINE KINASES; PSEUDOHYPOALDOSTERONISM; SIGNAL TRANSDUCTION; SODIUM CHLORIDE SYMPORTERS;

EID: 84922392921     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.114.04036     Document Type: Article

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