-
1
-
-
80052320481
-
- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway
-
Arroyo JP, Lagnaz D, Ronzaud C, Vázquez N, Ko BS, Moddes L, Ruffieux-Daidié D, Hausel P, Koesters R, Yang B, Stokes JB, Hoover RS, Gamba G, Staub O. Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway. J Am Soc Nephrol 22:1707-1719, 2011.
-
(2011)
J Am Soc Nephrol
, vol.22
, pp. 1707-1719
-
-
Arroyo, J.P.1
Lagnaz, D.2
Ronzaud, C.3
Vázquez, N.4
Ko, B.S.5
Moddes, L.6
Ruffieux-Daidié, D.7
Hausel, P.8
Koesters, R.9
Yang, B.10
Stokes, J.B.11
Hoover, R.S.12
Gamba, G.13
Staub, O.14
-
2
-
-
33745076253
-
WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells
-
Cai H, Cebotaru V, Wang YH, Zhang XM, Cebotaru L, Guggino SE, Guggino WB. WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells. Kidney Int 69: 2162-2170, 2006.
-
(2006)
Kidney Int
, vol.69
, pp. 2162-2170
-
-
Cai, H.1
Cebotaru, V.2
Wang, Y.H.3
Zhang, X.M.4
Cebotaru, L.5
Guggino, S.E.6
Guggino, W.B.7
-
3
-
-
56549094967
-
Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone
-
Chiga M, Rai T, Yang SS, Ohta A, Takizawa T, Sasaki S, Uchida S. Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone. Kidney Int 74: 1403-1409, 2008.
-
(2008)
Kidney Int
, vol.74
, pp. 1403-1409
-
-
Chiga, M.1
Rai, T.2
Yang, S.S.3
Ohta, A.4
Takizawa, T.5
Sasaki, S.6
Uchida, S.7
-
4
-
-
0347423198
-
Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
-
Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 42: 1206-1252, 2003.
-
(2003)
Hypertension
, vol.42
, pp. 1206-1252
-
-
Chobanian, A.V.1
Bakris, G.L.2
Black, H.R.3
Cushman, W.C.4
Green, L.A.5
Izzo Jr., J.L.6
Jones, D.W.7
Materson, B.J.8
Oparil, S.9
Wright Jr., J.T.10
Roccella, E.J.11
-
5
-
-
2442598041
-
Effects of chemical chaperones on partially retarded NaCl cotransporter mutants associated with Gitelman's syndrome in a mouse cortical collecting duct cell line
-
De Jong JC, Willems PH, Goossens M, Vandewalle A, Van Den Heuvel LP, Knoers NV, Bindels RJ. Effects of chemical chaperones on partially retarded NaCl cotransporter mutants associated with Gitelman's syndrome in a mouse cortical collecting duct cell line. Nephrol Dial Transplant 19: 1069-1076, 2004.
-
(2004)
Nephrol Dial Transplant
, vol.19
, pp. 1069-1076
-
-
de Jong, J.C.1
Willems, P.H.2
Goossens, M.3
Vandewalle, A.4
Van den, H.L.P.5
Knoers, N.V.6
Bindels, R.J.7
-
6
-
-
0042591321
-
The structural unit of the thiazide-sensitive NaCl cotransporter is a homodimer
-
de Jong JC, Willems PH, Mooren FJ, van den Heuvel LP, Knoers NV, Bindels RJ. The structural unit of the thiazide-sensitive NaCl cotransporter is a homodimer. J Biol Chem 278: 24302-24307, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 24302-24307
-
-
de Jong, J.C.1
Willems, P.H.2
Mooren, F.J.3
van den Heuvel, L.P.4
Knoers, N.V.5
Bindels, R.J.6
-
7
-
-
0141566892
-
Functional expression of the human thiazide-sensitive NaCl cotransporter in Madin-Darby canine kidney cells
-
De Jong JC, Willems PH, Van Den Heuvel LP, Knoers NV, Bindels RJ. Functional expression of the human thiazide-sensitive NaCl cotransporter in Madin-Darby canine kidney cells. J Am Soc Nephrol 14: 2428-2435, 2003.
-
(2003)
J Am Soc Nephrol
, vol.14
, pp. 2428-2435
-
-
de Jong, J.C.1
Willems, P.H.2
Van den Heuvel, L.P.3
Knoers, N.V.4
Bindels, R.J.5
-
8
-
-
79952346177
-
Adducin stimulates the thiazide-sensitive NaCl cotransporter
-
Dimke H, San-Cristobal P, de Graaf M, Lenders JW, Deinum J, Hoenderop JGJ, Bindels RJM. Adducin stimulates the thiazide-sensitive NaCl cotransporter. J Am Soc Nephrol 22: 508-517, 2011.
-
(2011)
J Am Soc Nephrol
, vol.22
, pp. 508-517
-
-
Dimke, H.1
San-Cristobal, P.2
de Graaf, M.3
Lenders, J.W.4
Deinum, J.5
Hoenderop, J.G.J.6
Bindels, R.J.M.7
-
11
-
-
70350719352
-
Surface expression of sodium channels and transporters in rat kidney: Effects of dietary sodium
-
Frindt G, Palmer LG. Surface expression of sodium channels and transporters in rat kidney: effects of dietary sodium. Am J Physiol Renal Physiol 297: F1249-F1255, 2009.
-
(2009)
Am J Physiol Renal Physiol
, vol.297
-
-
Frindt, G.1
Palmer, L.G.2
-
12
-
-
0028201013
-
Molecular cloning, primary structure, and characterization of two members of the mammalian electro neutral sodium-(potassium)-chloride cotransporter family expressed in kidney
-
Gamba G, Miyanoshita A, Lombardi M, Lytton J, Lee WS, Hediger MA, Hebert SC. Molecular cloning, primary structure, and characterization of two members of the mammalian electro neutral sodium-(potassium)-chloride cotransporter family expressed in kidney. J Biol Chem 269: 17713-17722, 1994.
-
(1994)
J Biol Chem
, vol.269
, pp. 17713-17722
-
-
Gamba, G.1
Miyanoshita, A.2
Lombardi, M.3
Lytton, J.4
Lee, W.S.5
Hediger, M.A.6
Hebert, S.C.7
-
14
-
-
0026782432
-
Mechanism of calcium transport stimulated by chlorothiazide in mouse distal convoluted tubule cells
-
Gesek FA, Friedman PA. Mechanism of calcium transport stimulated by chlorothiazide in mouse distal convoluted tubule cells. J Clin Invest 90: 429-438, 1992.
-
(1992)
J Clin Invest
, vol.90
, pp. 429-438
-
-
Gesek, F.A.1
Friedman, P.A.2
-
15
-
-
0026649401
-
On the mechanism of parathyroid hormone stimulation of calcium uptake by mouse distal convoluted tubule cells
-
Gesek FA, Friedman PA. On the mechanism of parathyroid hormone stimulation of calcium uptake by mouse distal convoluted tubule cells. J Clin Invest 90: 749-758, 1992.
-
(1992)
J Clin Invest
, vol.90
, pp. 749-758
-
-
Gesek, F.A.1
Friedman, P.A.2
-
17
-
-
0030771405
-
Molecular and functional identification of adrenergic receptors in distal convoluted tubule cells
-
Gesek FA, White KE. Molecular and functional identification of adrenergic receptors in distal convoluted tubule cells. Am J Physiol Renal Physiol 272: F712-F720, 1997.
-
(1997)
Am J Physiol Renal Physiol
, vol.272
-
-
Gesek, F.A.1
White, K.E.2
-
18
-
-
0013976561
-
A new familial disorder characterized by hypo kalemia and hypo magnesemia
-
Gitelman HJ, Graham JB, Welt LG. A new familial disorder characterized by hypo kalemia and hypo magnesemia. Trans Assoc Am Physicians 79: 221-235, 1966.
-
(1966)
Trans Assoc Am Physicians
, vol.79
, pp. 221-235
-
-
Gitelman, H.J.1
Graham, J.B.2
Welt, L.G.3
-
19
-
-
67449090606
-
Renal and brain isoforms of WNK3 have opposite effects on NCCT expression
-
Glover M, Zuber AM, O'Shaughnessy KM. Renal and brain isoforms of WNK3 have opposite effects on NCCT expression. J Am Soc Nephrol 20: 1314-1322, 2009.
-
(2009)
J Am Soc Nephrol
, vol.20
, pp. 1314-1322
-
-
Glover, M.1
Zuber, A.M.2
O'Shaughnessy, K.M.3
-
20
-
-
79953304695
-
The WNK kinase network regulating sodium, potassium, and blood pressure
-
Hoorn EJ, Nelson JH, McCormick JA, Ellison DH. The WNK kinase network regulating sodium, potassium, and blood pressure. J Am Soc Nephrol 22: 605-614, 2011.
-
(2011)
J Am Soc Nephrol
, vol.22
, pp. 605-614
-
-
Hoorn, E.J.1
Nelson, J.H.2
McCormick, J.A.3
Ellison, D.H.4
-
21
-
-
0037304650
-
- cotransporter
-
- cotransporter. J Am Soc Nephrol 14: 271-282, 2003.
-
(2003)
J Am Soc Nephrol
, vol.14
, pp. 271-282
-
-
Hoover, R.S.1
Poch, E.2
Monroy, A.3
Vazquez, N.4
Nishio, T.5
Gamba, G.6
Hebert, S.C.7
-
22
-
-
58149348583
-
Mechanism of regulation of renal ion transport by WNK kinases
-
Huang CL, Yang SS, Lin SH. Mechanism of regulation of renal ion transport by WNK kinases. Curr Opin Nephrol Hypertens 17: 519-525, 2008.
-
(2008)
Curr Opin Nephrol Hypertens
, vol.17
, pp. 519-525
-
-
Huang, C.L.1
Yang, S.S.2
Lin, S.H.3
-
23
-
-
38049159991
-
Phorbol ester stimulation of RasGRP1 regulates the sodium-chloride cotransporter by a PKC-independent pathway
-
Ko B, Joshi LM, Cooke LL, Vazquez N, Musch MW, Hebert SC, Gamba G, Hoover RS. Phorbol ester stimulation of RasGRP1 regulates the sodium-chloride cotransporter by a PKC-independent pathway. Proc Natl Acad Sci USA 104: 20120-20125, 2007.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 20120-20125
-
-
Ko, B.1
Joshi, L.M.2
Cooke, L.L.3
Vazquez, N.4
Musch, M.W.5
Hebert, S.C.6
Gamba, G.7
Hoover, R.S.8
-
24
-
-
77955395818
-
RasGRP1 stimulation enhances ubiquitination and endocytosis of the sodium-chloride cotransporter
-
Ko B, Kamsteeg EJ, Cooke LL, Moddes LN, Deen PMT, Hoover RS. RasGRP1 stimulation enhances ubiquitination and endocytosis of the sodium-chloride cotransporter. Am J Physiol Renal Physiol 299: F300-F309, 2010.
-
(2010)
Am J Physiol Renal Physiol
, vol.299
-
-
Ko, B.1
Kamsteeg, E.J.2
Cooke, L.L.3
Moddes, L.N.4
Deen, P.M.T.5
Hoover, R.S.6
-
25
-
-
0033868655
-
Characterization of the thiazide-sensitive NaCl cotransporter: A new model for ions and diuretics interaction
-
Monroy A, Plata C, Hebert SC, Gamba G. Characterization of the thiazide-sensitive NaCl cotransporter: a new model for ions and diuretics interaction. Am J Physiol Renal Physiol 279: F161-F169, 2000.
-
(2000)
Am J Physiol Renal Physiol
, vol.279
-
-
Monroy, A.1
Plata, C.2
Hebert, S.C.3
Gamba, G.4
-
26
-
-
83755181547
-
The thiazide-sensitive NaCl cotransporter is targeted for chaperone-dependent endoplasmic reticulum-associated degradation
-
Needham PG, Mikoluk K, Dhakarwal P, Khadem S, Snyder AC, Subramanya AR, Brodsky JL. The thiazide-sensitive NaCl cotransporter is targeted for chaperone-dependent endoplasmic reticulum-associated degradation. J Biol Chem 286: 43611-43621, 2011.
-
(2011)
J Biol Chem
, vol.286
, pp. 43611-43621
-
-
Needham, P.G.1
Mikoluk, K.2
Dhakarwal, P.3
Khadem, S.4
Snyder, A.C.5
Subramanya, A.R.6
Brodsky, J.L.7
-
28
-
-
70349581037
-
Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion, and lowers blood pressure
-
Ohta A, Rai T, Yui N, Chiga M, Yang SS, Lin SH, Sohara E, Sasaki S, Uchida S. Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion, and lowers blood pressure. Hum Mol Genet 18: 3978-3986, 2009.
-
(2009)
Hum Mol Genet
, vol.18
, pp. 3978-3986
-
-
Ohta, A.1
Rai, T.2
Yui, N.3
Chiga, M.4
Yang, S.S.5
Lin, S.H.6
Sohara, E.7
Sasaki, S.8
Uchida, S.9
-
29
-
-
0027327112
-
Regulation of Na channels of the rat cortical collecting tubule by aldosterone
-
Pacha J, Frindt G, Antonian L, Silver RB, Palmer LG. Regulation of Na channels of the rat cortical collecting tubule by aldosterone. J Gen Physiol 102: 25-42, 1993.
-
(1993)
J Gen Physiol
, vol.102
, pp. 25-42
-
-
Pacha, J.1
Frindt, G.2
Antonian, L.3
Silver, R.B.4
Palmer, L.G.5
-
30
-
-
33749386424
-
- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion
-
- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion. J Biol Chem 281: 28755-28763, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 28755-28763
-
-
Pacheco-Alvarez, D.1
Cristobal, P.S.2
Meade, P.3
Moreno, E.4
Vazquez, N.5
Munoz, E.6
Diaz, A.7
Juarez, M.E.8
Gimenez, I.9
Gamba, G.10
-
31
-
-
42149175531
-
- cotransporter by the WNK-regulated kinases SPAK and OSR1
-
- cotransporter by the WNK-regulated kinases SPAK and OSR1. J Cell Sci 121: 675-684, 2008.
-
(2008)
J Cell Sci
, vol.121
, pp. 675-684
-
-
Richardson, C.1
Rafiqi, F.H.2
Karlsson, H.K.3
Moleleki, N.4
Vandewalle, A.5
Campbell, D.G.6
Morrice, N.A.7
Alessi, D.R.8
-
32
-
-
63149133727
-
Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4- SPAK-dependent pathway
-
San-Cristobal P, Pacheco-Alvarez D, Richardson C, Ring AM, Vazquez N, Rafiqi FH, Chari D, Kahle KT, Leng Q, Bobadilla NA, Hebert SC, Alessi DR, Lifton RP, Gamba G. Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4- SPAK-dependent pathway. Proc Natl Acad Sci USA 106: 4384-4389, 2009.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 4384-4389
-
-
San-Cristobal, P.1
Pacheco-Alvarez, D.2
Richardson, C.3
Ring, A.M.4
Vazquez, N.5
Rafiqi, F.H.6
Chari, D.7
Kahle, K.T.8
Leng, Q.9
Bobadilla, N.A.10
Hebert, S.C.11
Alessi, D.R.12
Lifton, R.P.13
Gamba, G.14
-
33
-
-
9044235777
-
Gitelman's variant of Barter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazidesensitive Na-Cl cotransporter
-
Simon DB, Nelson-Williams C, Johnson Bia M, Ellison D, Karet FE, Morey Molina A, Vaara I, Iwata F, Cushner HM, Koolen M, Gainza FJ, Gitelman HJ, Lifton RP. Gitelman's variant of Barter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazidesensitive Na-Cl cotransporter. Nat Genet 12: 24-30, 1996.
-
(1996)
Nat Genet
, vol.12
, pp. 24-30
-
-
Simon, D.B.1
Nelson-Williams, C.2
Johnson, B.M.3
Ellison, D.4
Karet, F.E.5
Morey, M.A.6
Vaara, I.7
Iwata, F.8
Cushner, H.M.9
Koolen, M.10
Gainza, F.J.11
Gitelman, H.J.12
Lifton, R.P.13
-
34
-
-
67650533826
-
WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interaction
-
Subramanya AR, Liu J, Ellison DH, Wade JB, Welling PA. WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interaction. J Biol Chem 284: 18471-18480, 2009.
-
(2009)
J Biol Chem
, vol.284
, pp. 18471-18480
-
-
Subramanya, A.R.1
Liu, J.2
Ellison, D.H.3
Wade, J.B.4
Welling, P.A.5
-
36
-
-
17944373014
-
Human hypertension caused by mutations in WNK kinases
-
Wilson FH, Disse-Nicodeme S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, Lifton RP. Human hypertension caused by mutations in WNK kinases. Science 293: 1107-1112, 2001.
-
(2001)
Science
, vol.293
, pp. 1107-1112
-
-
Wilson, F.H.1
Disse-Nicodeme, S.2
Choate, K.A.3
Ishikawa, K.4
Nelson-Williams, C.5
Desitter, I.6
Gunel, M.7
Milford, D.V.8
Lipkin, G.W.9
Achard, J.M.10
Feely, M.P.11
Dussol, B.12
Berland, Y.13
Unwin, R.J.14
Mayan, H.15
Simon, D.B.16
Farfel, Z.17
Jeunemaitre, X.18
Lifton, R.P.19
-
37
-
-
0037457965
-
Molecular pathogenesis of inherited hypertension with hyperkalemia: The Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4
-
Wilson FH, Kahle KT, Sabath E, Lalioti MD, Rapson AK, Hoover RS, Hebert SC, Gamba G, Lifton RP. Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc Natl Acad Sci USA 100: 680-684, 2003.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 680-684
-
-
Wilson, F.H.1
Kahle, K.T.2
Sabath, E.3
Lalioti, M.D.4
Rapson, A.K.5
Hoover, R.S.6
Hebert, S.C.7
Gamba, G.8
Lifton, R.P.9
-
38
-
-
0037382807
-
WNK kinases regulate thiazide-sensitive Na-Cl cotransport
-
Yang CL, Angell J, Mitchell R, Ellison DH. WNK kinases regulate thiazide-sensitive Na-Cl cotransport. J Clin Invest 111: 1039-1045, 2003.
-
(2003)
J Clin Invest
, vol.111
, pp. 1039-1045
-
-
Yang, C.L.1
Angell, J.2
Mitchell, R.3
Ellison, D.H.4
-
39
-
-
18244373189
-
Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport
-
Yang CL, Zhu X, Wang Z, Subramanya AR, Ellison DH. Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport. J Clin Invest 115: 1379-1387, 2005.
-
(2005)
J Clin Invest
, vol.115
, pp. 1379-1387
-
-
Yang, C.L.1
Zhu, X.2
Wang, Z.3
Subramanya, A.R.4
Ellison, D.H.5
-
40
-
-
34247617951
-
Molecular pathogenesis of pseudohypoaldosteronism type II: Generation and analysis of a Wnk4(D561A/+) knockin mouse model
-
Yang SS, Morimoto T, Rai T, Chiga M, Sohara E, Ohno M, Uchida K, Lin SH, Moriguchi T, Shibuya H, Kondo Y, Sasaki S, Uchida S. Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. Cell Metab 5: 331-344, 2007.
-
(2007)
Cell Metab
, vol.5
, pp. 331-344
-
-
Yang, S.S.1
Morimoto, T.2
Rai, T.3
Chiga, M.4
Sohara, E.5
Ohno, M.6
Uchida, K.7
Lin, S.H.8
Moriguchi, T.9
Shibuya, H.10
Kondo, Y.11
Sasaki, S.12
Uchida, S.13
-
41
-
-
75149175239
-
WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway
-
Zhou B, Zhuang J, Gu D, Wang H, Cebotaru L, Guggino WB, Cai H. WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway. J Am Soc Nephrol 21: 82-92, 2010.
-
(2010)
J Am Soc Nephrol
, vol.21
, pp. 82-92
-
-
Zhou, B.1
Zhuang, J.2
Gu, D.3
Wang, H.4
Cebotaru, L.5
Guggino, W.B.6
Cai, H.7
|