-
1
-
-
15544384004
-
Molecular physiology and pathophysiology of the electroneutral cation-chloride cotransporters
-
Gamba G: Molecular physiology and pathophysiology of the electroneutral cation-chloride cotransporters. Physiol Rev 2005;85:423-493.
-
(2005)
Physiol Rev
, vol.85
, pp. 423-493
-
-
Gamba, G.1
-
2
-
-
8644288484
-
Regulation of K-Cl cotransport: From function to genes
-
Adragna NC, Fulvio MD, Lauf PK: Regulation of K-Cl cotransport: From function to genes. J Membr Biol 2004;201:109-137.
-
(2004)
J Membr Biol
, vol.201
, pp. 109-137
-
-
Adragna, N.C.1
Fulvio, M.D.2
Lauf, P.K.3
-
3
-
-
33846941876
-
Cotransporters, WNKs and hypertension: Important leads from the study of monogenetic disorders of blood pressure regulation
-
Flatman PW: Cotransporters, WNKs and hypertension: Important leads from the study of monogenetic disorders of blood pressure regulation. ClinSci 2007;112:203-216.
-
(2007)
ClinSci
, vol.112
, pp. 203-216
-
-
Flatman, P.W.1
-
4
-
-
0035860734
-
Modulation of ion transport by direct targeting of protein phosphatase type 1 to the Na-K-Cl cotransporter
-
Darman RB, Flemmer A, Forbush B: Modulation of ion transport by direct targeting of protein phosphatase type 1 to the Na-K-Cl cotransporter. J BiolChem 2001;276:34359-34362.
-
(2001)
J BiolChem
, vol.276
, pp. 34359-34362
-
-
Darman, R.B.1
Flemmer, A.2
Forbush, B.3
-
5
-
-
0037020145
-
A regulatory locus of phosphorylation in the N terminus of the Na-K-Cl cotransporter, NKCC1
-
Darman RB, Forbush B: A regulatory locus of phosphorylation in the N terminus of the Na-K-Cl cotransporter, NKCC1. J BiolChem 2002;277:37542-37550.
-
(2002)
J BiolChem
, vol.277
, pp. 37542-37550
-
-
Darman, R.B.1
Forbush, B.2
-
6
-
-
0037020095
-
Activation of the Na-K-Cl cotransporter NKCC1 detected with a phospho-specific antibody
-
Flemmer AW, Gimenez I, Dowd BF, Darman RB, Forbush B: Activation of the Na-K-Cl cotransporter NKCC1 detected with a phospho-specific antibody. J Biol Chem 2002;277:37551-37558.
-
(2002)
J Biol Chem
, vol.277
, pp. 37551-37558
-
-
Flemmer, A.W.1
Gimenez, I.2
Dowd, B.F.3
Darman, R.B.4
Forbush, B.5
-
7
-
-
0026465685
-
The Na-KClcotransport protein of shark rectal gland. II Regulation by direct phosphorylation
-
Lytle C, Forbush III B: The Na-KClcotransport protein of shark rectal gland. II Regulation by direct phosphorylation. J Biol Chem 1992;267:25438- 25443.
-
(1992)
J Biol Chem
, vol.267
, pp. 25438-25443
-
-
Lytle, C.1
Forbush III, B.2
-
8
-
-
0036838195
-
Coordinate modulation of Na-K-2Cl cotransport and K-Cl cotransport by cell volume and chloride
-
Lytle C, McManus T: Coordinate modulation of Na-K-2Cl cotransport and K-Cl cotransport by cell volume and chloride. Am J Physiol Cell Physiol 2002;283:C1422-C1431.
-
(2002)
Am J Physiol Cell Physiol
, vol.283
-
-
Lytle, C.1
McManus, T.2
-
9
-
-
0029881331
-
III: Regulatory phosphorylation of the secretory Na-KCl cotransporter: modulation by cytoplasmic Cl
-
Lytle C, Forbush B, III: Regulatory phosphorylation of the secretory Na-KCl cotransporter: modulation by cytoplasmic Cl. Am J Physiol 1996;270:C437-C448.
-
(1996)
Am J Physiol
, vol.270
-
-
Lytle, C.1
Forbush, B.2
-
10
-
-
0042847432
-
PASK (prolinealanine- rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1)
-
Dowd BF, Forbush B: PASK (prolinealanine- rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1). J Biol Chem 2003;278:27347-27353.
-
(2003)
J Biol Chem
, vol.278
, pp. 27347-27353
-
-
Dowd, B.F.1
Forbush, B.2
-
11
-
-
32444437942
-
WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway
-
De Los Heros P, Kahle KT, Rinehart J, Bobadilla NA, Vazquez N, San Cristobal P, Mount DB, Lifton RP, Hebert SC, Gamba G: WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway. Proc Natl Acad Sci USA 2006;103:1976-1981.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 1976-1981
-
-
De Los Heros, P.1
Kahle, K.T.2
Rinehart, J.3
Bobadilla, N.A.4
Vazquez, N.5
San Cristobal, P.6
Mount, D.B.7
Lifton, R.P.8
Hebert, S.C.9
Gamba, G.10
-
12
-
-
28044473649
-
WNK3 modulates transport of Cl- in and out of cells: Implications for control of cell volume and neuronal excitability
-
Kahle KT, Rinehart J, De Los Heros P, Louvi A, Meade P, Vazquez N, Hebert SC, Gamba G, Gimenez I, Lifton RP: WNK3 modulates transport of Cl- in and out of cells: Implications for control of cell volume and neuronal excitability. Proc Natl Acad Sci USA 2005;102:16783-16788.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 16783-16788
-
-
Kahle, K.T.1
Rinehart, J.2
De Los Heros, P.3
Louvi, A.4
Meade, P.5
Vazquez, N.6
Hebert, S.C.7
Gamba, G.8
Gimenez, I.9
Lifton, R.P.10
-
13
-
-
28044458544
-
WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Clcotransporters required for normal blood pressure homeostasis
-
Rinehart J, Kahle KT, De Los Heros P, Vazquez N, Meade P, Wilson FH, Hebert SC, Gimenez I, Gamba G, Lifton RP: WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Clcotransporters required for normal blood pressure homeostasis. ProcNatlAcadSci USA 2005;102:16777-16782.
-
(2005)
ProcNatlAcadSci USA
, vol.102
, pp. 16777-16782
-
-
Rinehart, J.1
Kahle, K.T.2
De Los Heros, P.3
Vazquez, N.4
Meade, P.5
Wilson, F.H.6
Hebert, S.C.7
Gimenez, I.8
Gamba, G.9
Lifton, R.P.10
-
14
-
-
33749440293
-
WNK protein kinases modulate cellular Cl- flux by altering the phosphorylation state of the Na-K-Cl and K-Cl cotransporters
-
Kahle KT, Rinehart J, Ring A, Gimenez I, Gamba G, Hebert SC, Lifton RP: WNK protein kinases modulate cellular Cl- flux by altering the phosphorylation state of the Na-K-Cl and K-Cl cotransporters. Physiology 2006;21:326-335.
-
(2006)
Physiology
, vol.21
, pp. 326-335
-
-
Kahle, K.T.1
Rinehart, J.2
Ring, A.3
Gimenez, I.4
Gamba, G.5
Hebert, S.C.6
Lifton, R.P.7
-
15
-
-
30644472724
-
Characterization of SPAK and OSR1, regulatory kinases of the NA-K-2CL cotransporter
-
Gagnon KB, England R, Delpire E: Characterization of SPAK and OSR1, Regulatory Kinases of the Na-K-2Cl Cotransporter. Mol Cell Biol 2006;26:689-698.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 689-698
-
-
Gagnon, K.B.1
England, R.2
Delpire, E.3
-
16
-
-
0037184942
-
Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-Alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1)
-
Piechotta K, Lu J, Delpire E: Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-Alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1). J Biol Chem 2002;277:50812-50819.
-
(2002)
J Biol Chem
, vol.277
, pp. 50812-50819
-
-
Piechotta, K.1
Lu, J.2
Delpire, E.3
-
17
-
-
0346101747
-
Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase
-
Piechotta K, Garbarini N, England R, Delpire E: Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase. J Biol Chem 2003;278:52848-52856.
-
(2003)
J Biol Chem
, vol.278
, pp. 52848-52856
-
-
Piechotta, K.1
Garbarini, N.2
England, R.3
Delpire, E.4
-
18
-
-
33744820299
-
SPAK and OSR1, key kinases involved in the regulation of chloride transport
-
Delpire E, Gagnon KB: SPAK and OSR1, key kinases involved in the regulation of chloride transport. Acta Physiol 2006;187:103-113.
-
(2006)
Acta Physiol
, vol.187
, pp. 103-113
-
-
Delpire, E.1
Gagnon, K.B.2
-
19
-
-
79952798017
-
Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways
-
Richardson C, Sakamoto K, De Los Heros P, Deak M, Campbell DG, Prescott AR, Alessi DR: Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways. J Cell Sci 2011;124:789-800.
-
(2011)
J Cell Sci
, vol.124
, pp. 789-800
-
-
Richardson, C.1
Sakamoto, K.2
De Los Heros, P.3
Deak, M.4
Campbell, D.G.5
Prescott, A.R.6
Alessi, D.R.7
-
20
-
-
42149175531
-
Activation of the thiazide-sensitive Na+-Clcotransporter by the WNK-regulated kinases SPAK and OSR1
-
Richardson C, Rafiqi FH, Karlsson HK, Moleleki N, Vandewalle A, Campbell DG, Morrice NA, Alessi DR: Activation of the thiazide-sensitive Na+-Clcotransporter by the WNK-regulated kinases SPAK and OSR1. J Cell Sci 2008;121:675-684.
-
(2008)
J Cell Sci
, vol.121
, pp. 675-684
-
-
Richardson, C.1
Rafiqi, F.H.2
Karlsson, H.K.3
Moleleki, N.4
Vandewalle, A.5
Campbell, D.G.6
Morrice, N.A.7
Alessi, D.R.8
-
21
-
-
26844532768
-
The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome, phosphorylate and active SPAK and OSR1 protein kinases
-
Vitari AC, Deak M, Morrice NA, Alessi DR: The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome, phosphorylate and active SPAK and OSR1 protein kinases. Biochem J 2005;391:17-24.
-
(2005)
Biochem J
, vol.391
, pp. 17-24
-
-
Vitari, A.C.1
Deak, M.2
Morrice, N.A.3
Alessi, D.R.4
-
22
-
-
30044442784
-
WNK1 Regulates Phosphorylation of Cation- Chloride-coupled Cotransporters via the STE20-related Kinases, SPAK and OSR1
-
Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H: WNK1 Regulates Phosphorylation of Cation- Chloride-coupled Cotransporters via the STE20-related Kinases, SPAK and OSR1. J Biol Chem 2005;280:42685-42693.
-
(2005)
J Biol Chem
, vol.280
, pp. 42685-42693
-
-
Moriguchi, T.1
Urushiyama, S.2
Hisamoto, N.3
Iemura, S.4
Uchida, S.5
Natsume, T.6
Matsumoto, K.7
Shibuya, H.8
-
23
-
-
33745530924
-
Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1
-
Vitari AC, Thastrup J, Rafiqi FH, Deak M, Morrice NA, Karlsson HK, Alessi DR: Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1. Biochem J 2006;397:223-231.
-
(2006)
Biochem J
, vol.397
, pp. 223-231
-
-
Vitari, A.C.1
Thastrup, J.2
Rafiqi, F.H.3
Deak, M.4
Morrice, N.A.5
Karlsson, H.K.6
Alessi, D.R.7
-
24
-
-
46149116565
-
Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases
-
Ponce-Coria J, San Cristobal P, Kahle KT, Vazquez N, Pacheco-Alvarez D, De Los HP, Juarez P, Munoz E, Michel G, Bobadilla NA, Gimenez I, Lifton RP, Hebert SC, Gamba G: Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases. Proc Natl Acad Sci U S A 2008;105:8458-8463.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 8458-8463
-
-
Ponce-Coria, J.1
San Cristobal, P.2
Kahle, K.T.3
Vazquez, N.4
Pacheco-Alvarez, D.5
De Los, H.P.6
Juarez, P.7
Munoz, E.8
Michel, G.9
Bobadilla, N.A.10
Gimenez, I.11
Lifton, R.P.12
Hebert, S.C.13
Gamba, G.14
-
25
-
-
34147142555
-
WNK4 Kinase is a Negative Regulator of K+-Cl- Cotransporters
-
Garzon-Muvdi T, Pacheco-Alvarez D, Gagnon KB, Vazquez N, Ponce-Coria J, Moreno E, Delpire E, Gamba G: WNK4 Kinase is a Negative Regulator of K+-Cl- Cotransporters. Am J Physiol Renal Physiol 2007;292:F1197-F1207.
-
(2007)
Am J Physiol Renal Physiol
, vol.292
-
-
Garzon-Muvdi, T.1
Pacheco-Alvarez, D.2
Gagnon, K.B.3
Vazquez, N.4
Ponce-Coria, J.5
Moreno, E.6
Delpire, E.7
Gamba, G.8
-
26
-
-
0028201013
-
Molecular cloning, primary structure and characterization of two members of the mammalian electroneutral sodium- (potassium)-chloride cotransporter family expressed in kidney
-
Gamba G, Miyanoshita A, Lombardi M, Lytton J, Lee WS, Hediger MA, Hebert SC: Molecular cloning, primary structure and characterization of two members of the mammalian electroneutral sodium- (potassium)-chloride cotransporter family expressed in kidney. J Biol Chem 1994;269:17713-17722.
-
(1994)
J Biol Chem
, vol.269
, pp. 17713-17722
-
-
Gamba, G.1
Miyanoshita, A.2
Lombardi, M.3
Lytton, J.4
Lee, W.S.5
Hediger, M.A.6
Hebert, S.C.7
-
27
-
-
0034730622
-
Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4
-
Mercado A, Song L, Vazquez N, Mount DB, Gamba G: Functional Comparison of the K+-Cl- Cotransporters KCC1 and KCC4. J Biol Chem 2000;275:30326-30334.
-
(2000)
J Biol Chem
, vol.275
, pp. 30326-30334
-
-
Mercado, A.1
Song, L.2
Vazquez, N.3
Mount, D.B.4
Gamba, G.5
-
28
-
-
33749386424
-
The Na-Cl cotransporter is activated and phosphorylated at the amino terminal domain upon intracellular chloride depletion
-
Pacheco-Alvarez D, San Cristobal P, Meade P, Moreno E, Vazquez N, Munoz E, Diaz A, Juarez ME, Gimenez I, Gamba G: The Na-Cl cotransporter is activated and phosphorylated at the amino terminal domain upon intracellular chloride depletion. J Biol Chem 2006;281:28755-28763.
-
(2006)
J Biol Chem
, vol.281
, pp. 28755-28763
-
-
Pacheco-Alvarez, D.1
San Cristobal, P.2
Meade, P.3
Moreno, E.4
Vazquez, N.5
Munoz, E.6
Diaz, A.7
Juarez, M.E.8
Gimenez, I.9
Gamba, G.10
-
29
-
-
78349297507
-
A Single Residue in Transmembrane Domain 11 defines the different affinity for thiazides between Mammalian and Flounder NaCl transporter
-
Castaneda-Bueno M, Vazquez N, Bustos- Jaimes I, Hernandez D, Rodriguez-Lobato E, Pacheco-Alvarez D, Carino-Cortes R, Moreno E, Bobadilla NA, Gamba G: A Single Residue in Transmembrane Domain 11 defines the different affinity for thiazides between Mammalian and Flounder NaCl transporter. Am J Physiol Renal Physiol 2010;299:F1111-F1119.
-
(2010)
Am J Physiol Renal Physiol
, vol.299
-
-
Castaneda-Bueno, M.1
Vazquez, N.2
Bustos- Jaimes, I.3
Hernandez, D.4
Rodriguez-Lobato, E.5
Pacheco-Alvarez, D.6
Carino-Cortes, R.7
Moreno, E.8
Bobadilla, N.A.9
Gamba, G.10
-
30
-
-
35648999986
-
A novel Nterminal isoform of the neuron-specific K-Cl cotransporter KCC2
-
Uvarov P, Ludwig A, Markkanen M, Pruunsild P, Kaila K, Delpire E, Timmusk T, Rivera C, Airaksinen MS: A novel Nterminal isoform of the neuron-specific K-Cl cotransporter KCC2. J Biol Chem 2007;282:30570-30576.
-
(2007)
J Biol Chem
, vol.282
, pp. 30570-30576
-
-
Uvarov, P.1
Ludwig, A.2
Markkanen, M.3
Pruunsild, P.4
Kaila, K.5
Delpire, E.6
Timmusk, T.7
Rivera, C.8
Airaksinen, M.S.9
-
31
-
-
56349151939
-
The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway
-
Richardson C, Alessi DR: The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway. J Cell Sci 2008;121:3293-3304.
-
(2008)
J Cell Sci
, vol.121
, pp. 3293-3304
-
-
Richardson, C.1
Alessi, D.R.2
-
32
-
-
77953459148
-
Role of the WNK-Activated SPAK kinase in regulating blood pressure
-
Rafiqi FH, Zuber AM, Glover M, Richardson C, Fleming S, Jovanovic S, Jovanovic A, O'Shaughnessy KM, Alessi DR: Role of the WNK-Activated SPAK kinase in regulating blood pressure. EMBO Mol Med 2010;2:63-75.
-
(2010)
EMBO Mol Med
, vol.2
, pp. 63-75
-
-
Rafiqi, F.H.1
Zuber, A.M.2
Glover, M.3
Richardson, C.4
Fleming, S.5
Jovanovic, S.6
Jovanovic, A.7
O'Shaughnessy, K.M.8
Alessi, D.R.9
-
33
-
-
38749087627
-
SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells
-
Delpire E, Gagnon KB: SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells. Biochem J 2008;409:321-331.
-
(2008)
Biochem J
, vol.409
, pp. 321-331
-
-
Delpire, E.1
Gagnon, K.B.2
-
34
-
-
0037457965
-
Molecular pathogenesis of inherited hypertension with hyperkalemia: The Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4
-
Wilson FH, Kahle KT, Sabath E, Lalioti MD, Rapson AK, Hoover RS, Hebert SC, Gamba G, Lifton RP: Molecular pathogenesis of inherited hypertension with hyperkalemia: The Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc Natl Acad Sci USA 2003;100:680-684.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 680-684
-
-
Wilson, F.H.1
Kahle, K.T.2
Sabath, E.3
Lalioti, M.D.4
Rapson, A.K.5
Hoover, R.S.6
Hebert, S.C.7
Gamba, G.8
Lifton, R.P.9
-
35
-
-
34250785553
-
A single binding motif is required for SPAK activation of the Na-K-2Cl cotransporter
-
Gagnon KB, England R, Delpire E: A single binding motif is required for SPAK activation of the Na-K-2Cl cotransporter. Cell Physiol Biochem 2007;20:131-142.
-
(2007)
Cell Physiol Biochem
, vol.20
, pp. 131-142
-
-
Gagnon, K.B.1
England, R.2
Delpire, E.3
-
36
-
-
1242319290
-
WNK4 regulates apical and basolateralCl- flux in extrarenal epithelia
-
Kahle KT, Gimenez I, Hassan H, Wilson FH, Wong RD, Forbush B, Aronson PS, Lifton RP: WNK4 regulates apical and basolateralCl- flux in extrarenal epithelia. Proc Natl Acad Sci USA 2004;101:2064-2069.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 2064-2069
-
-
Kahle, K.T.1
Gimenez, I.2
Hassan, H.3
Wilson, F.H.4
Wong, R.D.5
Forbush, B.6
Aronson, P.S.7
Lifton, R.P.8
-
37
-
-
30644458584
-
Volume sensitivity of cation-Clcotransporters is modulated by the interaction of two kinases: Ste20-related proline-Alanine-rich kinase and WNK4
-
Gagnon KB, England R, Delpire E: Volume sensitivity of cation-Clcotransporters is modulated by the interaction of two kinases: Ste20-related proline-Alanine-rich kinase and WNK4. Am J Physiol Cell Physiol 2006;290:C134-C142.
-
(2006)
Am J Physiol Cell Physiol
, vol.290
-
-
Gagnon, K.B.1
England, R.2
Delpire, E.3
-
38
-
-
33749118898
-
Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule
-
3H8 Lalioti MD, Zhang J, Volkman HM, Kahle KT, Hoffmann KE, Toka HR, Nelson- Williams C, Ellison DH, Flavell R, Booth CJ, Lu Y, Geller DS, Lifton RP: Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule. Nat Genet 2006;38:1124-1132.
-
(2006)
Nat Genet
, vol.38
, pp. 1124-1132
-
-
Lalioti, M.D.1
Zhang, J.2
Volkman, H.M.3
Kahle, K.T.4
Hoffmann, K.E.5
Toka, H.R.6
Nelson- Williams, C.7
Ellison, D.H.8
Flavell, R.9
Booth, C.J.10
Lu, Y.11
Geller, D.S.12
Lifton, R.P.13
|