메뉴 건너뛰기




Volumn 56, Issue 2, 2015, Pages 816-826

Knockout of αA-crystallin inhibits ocular neovascularization

Author keywords

Choroidal neovascularization; Human umbilical vein endothelial cell; Neovascularization; Oxygeninduced retinopathy; Vascular endothelial growth factor; A crystallin

Indexed keywords

ALPHA CRYSTALLIN; CASPASE 3; CASPASE 9; FOCAL ADHESION KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOLIPASE C GAMMA1; PROTEIN KINASE B; SMALL INTERFERING RNA; STEROID RECEPTOR COACTIVATOR 1; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2; RNA;

EID: 84922344176     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.14-14734     Document Type: Article
Times cited : (25)

References (60)
  • 1
    • 84886246337 scopus 로고    scopus 로고
    • Retinopathy of prematurity
    • Hellström A, Smith LEH, Dammann O. Retinopathy of prematurity. Lancet. 2013;382:1445-1457.
    • (2013) Lancet , vol.382 , pp. 1445-1457
    • Hellström, A.1    Smith, L.2    Dammann, O.3
  • 2
    • 84903713976 scopus 로고    scopus 로고
    • The alternative complement pathway regulates pathological angiogenesis in the retina
    • Sweigard JH, Yanai R, Gaissert P, et al. The alternative complement pathway regulates pathological angiogenesis in the retina. FASEB J. 2014;28:251014-251041.
    • (2014) FASEB J , vol.28 , pp. 251014-251041
    • Sweigard, J.H.1    Yanai, R.2    Gaissert, P.3
  • 3
    • 48549088705 scopus 로고    scopus 로고
    • Vascular endothelial growth factor in eye disease
    • Penn JS, Madan A, Caldwell RB, et al. Vascular endothelial growth factor in eye disease. Prog Retin Eye Res. 2008;27: 331-371.
    • (2008) Prog Retin Eye Res , vol.27 , pp. 331-371
    • Penn, J.S.1    Madan, A.2    Caldwell, R.B.3
  • 4
    • 0037277741 scopus 로고    scopus 로고
    • Vascular endothelial growth factors and angiogenesis in eye disease
    • Witmer AN, Vrensen G, Van Noorden CJF, et al. Vascular endothelial growth factors and angiogenesis in eye disease. Prog Retin Eye Res. 2003;22:1-29.
    • (2003) Prog Retin Eye Res , vol.22 , pp. 1-29
    • Witmer, A.N.1    Vrensen, G.2    Van Noorden, C.3
  • 5
    • 84873371459 scopus 로고    scopus 로고
    • Hyperoxia causes regression of vitreous neovascularization by downregulating VEGF/VEGFR2 pathway
    • Liu H, Zhang W, Xu Z, et al. Hyperoxia causes regression of vitreous neovascularization by downregulating VEGF/VEGFR2 pathway. Invest Ophthalmol Vis Sci. 2013;54:918-931.
    • (2013) Invest Ophthalmol Vis Sci , vol.54 , pp. 918-931
    • Liu, H.1    Zhang, W.2    Xu, Z.3
  • 6
    • 84874514724 scopus 로고    scopus 로고
    • Pathogenic role of the Wnt signaling pathway activation in laser-induced choroidal neovascularization
    • Hu Y, Chen Y, Lin M, et al. Pathogenic role of the Wnt signaling pathway activation in laser-induced choroidal neovascularization. Invest Ophthalmol Vis Sci. 2013;54:141-154.
    • (2013) Invest Ophthalmol Vis Sci , vol.54 , pp. 141-154
    • Hu, Y.1    Chen, Y.2    Lin, M.3
  • 7
    • 77956056292 scopus 로고    scopus 로고
    • Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular agerelated macular degeneration: PIER study year 2
    • Abraham P, Yue H, Wilson L. Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular agerelated macular degeneration: PIER study year 2. Am J Ophthalmol. 2010;150:315-324.
    • (2010) Am J Ophthalmol , vol.150 , pp. 315-324
    • Abraham, P.1    Yue, H.2    Wilson, L.3
  • 8
    • 67149101784 scopus 로고    scopus 로고
    • A variable-dosing regimen with intravitreal ranibizumab for neovascular agerelated macular degeneration: Year 2 of the PrONTO Study
    • Lalwani GA, Rosenfeld PJ, Fung AE, et al. A variable-dosing regimen with intravitreal ranibizumab for neovascular agerelated macular degeneration: year 2 of the PrONTO Study. Am J Ophthalmol. 2009;148:43-58.
    • (2009) Am J Ophthalmol , vol.148 , pp. 43-58
    • Lalwani, G.A.1    Rosenfeld, P.J.2    Fung, A.E.3
  • 9
    • 84906938535 scopus 로고    scopus 로고
    • Safety and efficacy of conbercept in neovascular age-related macular degeneration: Results from a 12-month randomized phase 2 study: AURORA study
    • Li X, Xu G, Wang Y, et al. Safety and efficacy of conbercept in neovascular age-related macular degeneration: results from a 12-month randomized phase 2 study: AURORA study. Ophthalmology. 2014;121:1740-1747.
    • (2014) Ophthalmology , vol.121 , pp. 1740-1747
    • Li, X.1    Xu, G.2    Wang, Y.3
  • 10
    • 84865129521 scopus 로고    scopus 로고
    • Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab
    • Papadopoulos N, Martin J, Ruan Q, et al. Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab. Angiogenesis. 2012;15:171-185.
    • (2012) Angiogenesis , vol.15 , pp. 171-185
    • Papadopoulos, N.1    Martin, J.2    Ruan, Q.3
  • 11
    • 84870723704 scopus 로고    scopus 로고
    • Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration
    • Heier JS, Brown DM, Chong V, et al. Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration. Ophthalmology. 2012;119:2537-2548.
    • (2012) Ophthalmology , vol.119 , pp. 2537-2548
    • Heier, J.S.1    Brown, D.M.2    Chong, V.3
  • 12
    • 33846783133 scopus 로고    scopus 로고
    • Intravitreal bevacizumab (Avastin) as treatment for subfoveal choroidal neovascularisation secondary to pathological myopia
    • Yamamoto I, Rogers AH, Reichel E, et al. Intravitreal bevacizumab (Avastin) as treatment for subfoveal choroidal neovascularisation secondary to pathological myopia. Br J Ophthalmol. 2007;91:157-160.
    • (2007) Br J Ophthalmol , vol.91 , pp. 157-160
    • Yamamoto, I.1    Rogers, A.H.2    Reichel, E.3
  • 13
    • 84896712264 scopus 로고    scopus 로고
    • Tumor resistance to anti-VEGF therapy through up-regulation of VEGF-C expression
    • Li D, Xie K, Ding G, et al. Tumor resistance to anti-VEGF therapy through up-regulation of VEGF-C expression. Cancer Lett. 2014;346:45-52.
    • (2014) Cancer Lett , vol.346 , pp. 45-52
    • Li, D.1    Xie, K.2    Ding, G.3
  • 14
    • 84885458908 scopus 로고    scopus 로고
    • The association of alternate VEGF ligands with resistance to anti-VEGF therapy in metastatic colorectal cancer
    • Lieu CH, Tran H, Jiang ZQ, et al. The association of alternate VEGF ligands with resistance to anti-VEGF therapy in metastatic colorectal cancer. PLoS One. 2013;8:e77117.
    • (2013) Plos One , vol.8
    • Lieu, C.H.1    Tran, H.2    Jiang, Z.Q.3
  • 15
    • 84055216939 scopus 로고    scopus 로고
    • AlphαB-crystallin, an effector of unfolded protein response, confers anti-VEGF resistance to breast cancer via maintenance of intracrine VEGF in endothelial cells
    • Ruan Q, Han S, Jiang WG, et al. alphαB-crystallin, an effector of unfolded protein response, confers anti-VEGF resistance to breast cancer via maintenance of intracrine VEGF in endothelial cells. Mol Cancer Res. 2011;9:1632-1643.
    • (2011) Mol Cancer Res , vol.9 , pp. 1632-1643
    • Ruan, Q.1    Han, S.2    Jiang, W.G.3
  • 16
    • 34250365240 scopus 로고    scopus 로고
    • Mechanisms of adverse effects of anti-VEGF therapy for cancer
    • Kamba T, McDonald DM. Mechanisms of adverse effects of anti-VEGF therapy for cancer. Br J Cancer. 2007;96:1788-1795.
    • (2007) Br J Cancer , vol.96 , pp. 1788-1795
    • Kamba, T.1    McDonald, D.M.2
  • 17
    • 79960837857 scopus 로고    scopus 로고
    • Ocular complications after anti-vascular endothelial growth factor therapy in medicare patients with age-related macular degeneration
    • Day S, Acquah K, Mruthyunjaya P, et al. Ocular complications after anti-vascular endothelial growth factor therapy in medicare patients with age-related macular degeneration. Am J Ophthalmol. 2011;152:266-272.
    • (2011) Am J Ophthalmol , vol.152 , pp. 266-272
    • Day, S.1    Acquah, K.2    Mruthyunjaya, P.3
  • 18
    • 79951525187 scopus 로고    scopus 로고
    • Systemic and ocular safety of intravitreal anti-VEGF therapies for ocular neovascular disease
    • Tolentino M. Systemic and ocular safety of intravitreal anti-VEGF therapies for ocular neovascular disease. Surv Ophthalmol. 2011;56:95-113.
    • (2011) Surv Ophthalmol , vol.56 , pp. 95-113
    • Tolentino, M.1
  • 19
    • 77956123282 scopus 로고    scopus 로고
    • Cardiovascular safety of VEGF-targeting therapies: Current evidence and handling strategies
    • Girardi F, Franceschi E, Brandes AA. Cardiovascular safety of VEGF-targeting therapies: current evidence and handling strategies. Oncologist. 2010;15:683-694.
    • (2010) Oncologist , vol.15 , pp. 683-694
    • Girardi, F.1    Franceschi, E.2    Brandes, A.A.3
  • 20
    • 80052512394 scopus 로고    scopus 로고
    • A systematic review of the adverse events of intravitreal antivascular endothelial growth factor injections
    • Van der Reis MI, La Heij EC, De Jong-Hesse Y, et al. A systematic review of the adverse events of intravitreal antivascular endothelial growth factor injections. Retina. 2011;31: 1449-1469.
    • (2011) Retina , vol.31 , pp. 1449-1469
    • Van Der Reis, M.I.1    La Heij, E.C.2    De Jong-Hesse, Y.3
  • 21
    • 84893353624 scopus 로고    scopus 로고
    • Quantification of vascular tortuosity as an early outcome measure in oxygen induced retinopathy (OIR)
    • Scott A, Powner MB, Fruttiger M. Quantification of vascular tortuosity as an early outcome measure in oxygen induced retinopathy (OIR). Exp Eye Res. 2014;120:55-60.
    • (2014) Exp Eye Res , vol.120 , pp. 55-60
    • Scott, A.1    Powner, M.B.2    Fruttiger, M.3
  • 22
    • 84883645944 scopus 로고    scopus 로고
    • The role of macrophage class a scavenger receptors in a laser-induced murine choroidal neovascularization model
    • Jawad S, Liu B, Li Z, et al. The role of macrophage class a scavenger receptors in a laser-induced murine choroidal neovascularization model. Invest Ophthalmol Vis Sci. 2013; 54:5959-5970.
    • (2013) Invest Ophthalmol Vis Sci , vol.54 , pp. 5959-5970
    • Jawad, S.1    Liu, B.2    Li, Z.3
  • 23
    • 33845425645 scopus 로고    scopus 로고
    • Crystallins in the eye: Function and pathology
    • Andley UP. Crystallins in the eye: function and pathology. Prog Retina Eye Res. 2007;26:78-98.
    • (2007) Prog Retina Eye Res , vol.26 , pp. 78-98
    • Andley, U.P.1
  • 24
    • 0026483279 scopus 로고
    • Alpha-crystallin can function as a molecular chaperone
    • Horwitz J. Alpha-crystallin can function as a molecular chaperone. Proc Natl Acad Sci U S A. 1992;10449-10453.
    • (1992) Proc Natl Acad Sci U S A , pp. 10449-10453
    • Horwitz, J.1
  • 25
    • 84867401896 scopus 로고    scopus 로고
    • Novel roles for α-crystallins in retinal function and disease
    • Kannan R, Sreekumar PG, Hinton DR. Novel roles for α-crystallins in retinal function and disease. Prog Retin Eye Res. 2012;31:576-604.
    • (2012) Prog Retin Eye Res , vol.31 , pp. 576-604
    • Kannan, R.1    Sreekumar, P.G.2    Hinton, D.R.3
  • 26
    • 41949083991 scopus 로고    scopus 로고
    • Elevated retina-specific expression of the small heat shock protein, αA-crystallin, is associated with photoreceptor protection in experimental uveitis
    • Rao NA, Saraswathy S, Wu GS, et al. Elevated retina-specific expression of the small heat shock protein, αA-crystallin, is associated with photoreceptor protection in experimental uveitis. Invest Ophthalmol Vis Sci. 2008;49:1161-1171.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 1161-1171
    • Rao, N.A.1    Saraswathy, S.2    Wu, G.S.3
  • 27
    • 0142056039 scopus 로고    scopus 로고
    • A comprehensive analysis of the expression of crystallins in mouse retina
    • Xi J, Farjo R, Yoshida S, et al. A comprehensive analysis of the expression of crystallins in mouse retina. Mol Vis. 2003;28: 410-419.
    • (2003) Mol Vis , vol.28 , pp. 410-419
    • Xi, J.1    Farjo, R.2    Yoshida, S.3
  • 28
    • 39149145829 scopus 로고    scopus 로고
    • Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia
    • Yaung J, Kannan R, Wawrousek EF, et al. Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia. Exp Eye Res. 2008; 86:355-365.
    • (2008) Exp Eye Res , vol.86 , pp. 355-365
    • Yaung, J.1    Kannan, R.2    Wawrousek, E.F.3
  • 29
    • 66149122699 scopus 로고    scopus 로고
    • The retinal proteome in experimental diabetic retinopathy: Up-regulation of crystallins and reversal by systemic and periocular insulin
    • Fort PE, Freeman WM, Losiewicz MK, et al. The retinal proteome in experimental diabetic retinopathy: up-regulation of crystallins and reversal by systemic and periocular insulin. Mol Cell Proteomics. 2009;8:767-779.
    • (2009) Mol Cell Proteomics , vol.8 , pp. 767-779
    • Fort, P.E.1    Freeman, W.M.2    Losiewicz, M.K.3
  • 30
    • 84859114916 scopus 로고    scopus 로고
    • Small heat shock protein αA-crystallin prevents photoreceptor degeneration in experimental autoimmune uveitis
    • Rao NA, Saraswathy S, Pararajasegaram G, et al. Small heat shock protein αA-crystallin prevents photoreceptor degeneration in experimental autoimmune uveitis. PloS One. 2012;7: e33582.
    • (2012) Plos One , vol.7
    • Rao, N.A.1    Saraswathy, S.2    Pararajasegaram, G.3
  • 31
    • 84867795105 scopus 로고    scopus 로고
    • Alpha-crystallins and tumorigenesis
    • Chen P, Ji W, Liu FY, et al. Alpha-crystallins and tumorigenesis. Curr Mol Med. 2012;12:1164-1173.
    • (2012) Curr Mol Med , vol.12 , pp. 1164-1173
    • Chen, P.1    Ji, W.2    Liu, F.Y.3
  • 32
    • 37449027288 scopus 로고    scopus 로고
    • BA3/A1-Crystallin in astroglial cells regulates retinal vascular remodeling during development
    • Sinha D, Klise A, Sergeev Y, et al. bA3/A1-Crystallin in astroglial cells regulates retinal vascular remodeling during development. Mol Cell Neurosci. 2008;37:85-95.
    • (2008) Mol Cell Neurosci , vol.37 , pp. 85-95
    • Sinha, D.1    Klise, A.2    Sergeev, Y.3
  • 33
    • 23944461004 scopus 로고    scopus 로고
    • A potential role for band c-crystallins in the vascular remodeling of the eye
    • Zhang C, Gehlbach P, Gongora C, et al. A potential role for band c-crystallins in the vascular remodeling of the eye. Dev Dyn. 2005;234:36-47.
    • (2005) Dev Dyn , vol.234 , pp. 36-47
    • Zhang, C.1    Gehlbach, P.2    Gongora, C.3
  • 34
    • 77951448229 scopus 로고    scopus 로고
    • αB-crystallin regulation of angiogenesis by modulation of VEGF
    • Kase S, He S, Sonoda S, et al. αB-crystallin regulation of angiogenesis by modulation of VEGF. Blood. 2010;115:3398-3406.
    • (2010) Blood , vol.115 , pp. 3398-3406
    • Kase, S.1    He, S.2    Sonoda, S.3
  • 35
    • 41349121374 scopus 로고    scopus 로고
    • αB-crystallin promotes tumor angiogenesis by increasing vascular survival during tube morphogenesis
    • Dimberg A, Rylova S, Dieterich LC, et al. αB-crystallin promotes tumor angiogenesis by increasing vascular survival during tube morphogenesis. Blood. 2008;111:2015-2023.
    • (2008) Blood , vol.111 , pp. 2015-2023
    • Dimberg, A.1    Rylova, S.2    Dieterich, L.C.3
  • 36
    • 84860230383 scopus 로고    scopus 로고
    • αA-crystallin in the pathogenesis and intervention of experimental murine corneal neovascularization
    • Zhu W, Qi X, Ren S, et al. αA-crystallin in the pathogenesis and intervention of experimental murine corneal neovascularization. Exp Eye Res. 2012;98:44-51.
    • (2012) Exp Eye Res , vol.98 , pp. 44-51
    • Zhu, W.1    Qi, X.2    Ren, S.3
  • 37
    • 80052998847 scopus 로고    scopus 로고
    • Comparison of genome-wide gene expression in suture-and alkali burn-induced murine corneal neovascularization
    • Jia C, Zhu W, Ren S, et al. Comparison of genome-wide gene expression in suture-and alkali burn-induced murine corneal neovascularization. Mol Vis. 2011;17:2386.
    • (2011) Mol Vis , vol.2011 , pp. 17
    • Jia, C.1    Zhu, W.2    Ren, S.3
  • 38
    • 0042572526 scopus 로고    scopus 로고
    • Gene transfer of kringle 5 of plasminogen by electroporation inhibits corneal neovascularization
    • Yu WZ, Li XX, She HC, et al. Gene transfer of kringle 5 of plasminogen by electroporation inhibits corneal neovascularization. Ophthalmic Res. 2003;35:239-246.
    • (2003) Ophthalmic Res , vol.35 , pp. 239-246
    • Yu, W.Z.1    Li, X.X.2    She, H.C.3
  • 39
    • 84862492038 scopus 로고    scopus 로고
    • Polyethylene glycol-modified pigment epithelial-derived factor: New prospects for treatment of retinal neovascularization
    • Bai YJ, Huang LZ, Xu XL, et al. Polyethylene glycol-modified pigment epithelial-derived factor: new prospects for treatment of retinal neovascularization. J Pharmacol Exp Ther. 2012; 342:131-139.
    • (2012) J Pharmacol Exp Ther , vol.342 , pp. 131-139
    • Bai, Y.J.1    Huang, L.Z.2    Xu, X.L.3
  • 40
    • 84863574268 scopus 로고    scopus 로고
    • Ephrin-a4 is involved in retinal neovascularization by regulating the VEGF signaling pathway
    • Du W, Yu W, Huang L, et al. Ephrin-a4 is involved in retinal neovascularization by regulating the VEGF signaling pathway. Invest Ophthalmol Vis Sci. 2012;53:1990-1998.
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 1990-1998
    • Du, W.1    Yu, W.2    Huang, L.3
  • 42
    • 84860424365 scopus 로고    scopus 로고
    • Is asthma related to choroidal neovascularization?
    • Sun Y, Yu W, Huang L, et al. Is asthma related to choroidal neovascularization? PLoS One. 2012;7:e35415.
    • (2012) Plos One , vol.7
    • Sun, Y.1    Yu, W.2    Huang, L.3
  • 43
    • 45549105260 scopus 로고    scopus 로고
    • Evaluation of the new photosensitizer Stakel WST-11 for photodynamic choroidal vessel occlusion in rabbit and rat eyes
    • Berdugo M, Bejjani RA, Valamanesh F, et al. Evaluation of the new photosensitizer Stakel (WST-11) for photodynamic choroidal vessel occlusion in rabbit and rat eyes. Invest Ophthalmol Vis Sci. 2008;49:1633-1644.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 1633-1644
    • Berdugo, M.1    Bejjani, R.A.2    Valamanesh, F.3
  • 44
    • 77957315428 scopus 로고    scopus 로고
    • The anti-angiogenic effect of chlorogenic acid on choroidal neovascularization
    • Kim C, Yu HG, Sohn J. The anti-angiogenic effect of chlorogenic acid on choroidal neovascularization. Korean J Ophthalmol. 2010;24:163-168.
    • (2010) Korean J Ophthalmol , vol.24 , pp. 163-168
    • Kim, C.1    Yu, H.G.2    Sohn, J.3
  • 46
    • 84878315115 scopus 로고    scopus 로고
    • The αA66-80 peptide interacts with soluble a-crystallin and induces its aggregation and precipitation: A contribution to age-related cataract formation
    • Kannan R, Santhoshkumar P, Mooney BP, et al. The αA66-80 peptide interacts with soluble a-crystallin and induces its aggregation and precipitation: a contribution to age-related cataract formation. Biochemistry. 2013;28:3638-3650.
    • (2013) Biochemistry , vol.28 , pp. 3638-3650
    • Kannan, R.1    Santhoshkumar, P.2    Mooney, B.P.3
  • 47
    • 84873987331 scopus 로고    scopus 로고
    • Identification of a novel oligomerization disrupting mutation in CRYAA associated with congenital cataract in a South Australian family
    • Laurie KJ, Dave A, Straga T, et al. Identification of a novel oligomerization disrupting mutation in CRYAA associated with congenital cataract in a South Australian family. Hum Mutat. 2013;28:435-438.
    • (2013) Hum Mutat , vol.28 , pp. 435-438
    • Laurie, K.J.1    Dave, A.2    Straga, T.3
  • 48
    • 0346963154 scopus 로고    scopus 로고
    • Modified αA crystallin in the retina: Altered expression and truncation with aging
    • Kapphahn RJ, Ethen CM, Peters EA, et al. Modified αA crystallin in the retina: altered expression and truncation with aging. Biochemistry. 2003;42:15310-15325.
    • (2003) Biochemistry , vol.42 , pp. 15310-15325
    • Kapphahn, R.J.1    Ethen, C.M.2    Peters, E.A.3
  • 49
    • 20444390503 scopus 로고    scopus 로고
    • Crystallin distribution in Bruch’s membrane-choroid complex from AMD and agematched donor eyes
    • Nakata K, Crabb JW, Hollyfield JG. Crystallin distribution in Bruch’s membrane-choroid complex from AMD and agematched donor eyes. Exp Eye Res. 2005;80:821-826.
    • (2005) Exp Eye Res , vol.80 , pp. 821-826
    • Nakata, K.1    Crabb, J.W.2    Hollyfield, J.G.3
  • 50
    • 73349101064 scopus 로고    scopus 로고
    • Mitochondrial proteomics in experimental autoimmune uveitis oxidative stress
    • Saraswathy S, Rao NA. Mitochondrial proteomics in experimental autoimmune uveitis oxidative stress. Invest Ophthalmol Vis Sci. 2009;50:5559-5566.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 5559-5566
    • Saraswathy, S.1    Rao, N.A.2
  • 51
    • 68349103136 scopus 로고    scopus 로고
    • The role of αA-and αB-crystallins in the survival of retinal ganglion cells after optic nerve axotomy
    • Munemasa Y, Kwong JMK, Caprioli J, et al. The role of αA-and αB-crystallins in the survival of retinal ganglion cells after optic nerve axotomy. Invest Ophthalmol Vis Sci. 2009;50:3869-3875.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 3869-3875
    • Munemasa, Y.1    Kwong, J.2    Caprioli, J.3
  • 52
    • 28444468107 scopus 로고    scopus 로고
    • Elevated expression of αA-and αB-crystallins in streptozotocin-induced diabetic rat
    • Kumar PA, Haseeb A, Suryanarayana P, et al. Elevated expression of αA-and αB-crystallins in streptozotocin-induced diabetic rat. Arch Biochem Biophys. 2005;444:77-83.
    • (2005) Arch Biochem Biophys , vol.444 , pp. 77-83
    • Kumar, P.A.1    Haseeb, A.2    Suryanarayana, P.3
  • 53
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau W. Mechanisms of angiogenesis. Nature. 1997;386:671-674.
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 54
    • 4644301879 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor receptor 2-mediated phosphorylation of focal adhesion kinase by heat shock protein 90 and Src kinase activities
    • Le Boeuf F, Houle F, Huot J, et al. Regulation of vascular endothelial growth factor receptor 2-mediated phosphorylation of focal adhesion kinase by heat shock protein 90 and Src kinase activities. J Biol Chem. 2004;279:39175-39185.
    • (2004) J Biol Chem , vol.279 , pp. 39175-39185
    • Le Boeuf, F.1    Houle, F.2    Huot, J.3
  • 55
    • 51649099579 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC?Ca2þ signaling pathways
    • Yoon CM, Hong BS, Moon HG, et al. Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC?Ca2þ signaling pathways. Blood. 2008;112:1129-1138.
    • (2008) Blood , vol.112 , pp. 1129-1138
    • Yoon, C.M.1    Hong, B.S.2    Moon, H.G.3
  • 56
    • 0037235049 scopus 로고    scopus 로고
    • VEGF increases endothelial permeability by separate signaling pathways involving ERK-1/2 and nitric oxide
    • Breslin JW, Pappas PJ, Cerveira JJ, et al. VEGF increases endothelial permeability by separate signaling pathways involving ERK-1/2 and nitric oxide. Am J Physiol Heart Circ Physiol. 2003;284:H92-H100.
    • (2003) Am J Physiol Heart Circ Physiol , vol.284 , pp. H92-H100
    • Breslin, J.W.1    Pappas, P.J.2    Cerveira, J.J.3
  • 57
    • 79959506144 scopus 로고    scopus 로고
    • The anti-apoptotic function of human αA-crystallin is directly related to its chaperone activity
    • Pasupuleti N, Matsuyama S, Voss O, et al. The anti-apoptotic function of human αA-crystallin is directly related to its chaperone activity. Cell Death Dis. 2010;1:e31.
    • (2010) Cell Death Dis , vol.1
    • Pasupuleti, N.1    Matsuyama, S.2    Voss, O.3
  • 58
    • 78649947487 scopus 로고    scopus 로고
    • BAX and tumor suppressor TRP53 are important in regulating mutagenesis in spermatogenic cells in mice
    • Xu G, Vogel KS, McMahan CA, et al. BAX and tumor suppressor TRP53 are important in regulating mutagenesis in spermatogenic cells in mice. Biol Reprod. 2010;83:979-987.
    • (2010) Biol Reprod , vol.83 , pp. 979-987
    • Xu, G.1    Vogel, K.S.2    McMahan, C.A.3
  • 59
    • 39449127365 scopus 로고    scopus 로고
    • Big wheel keeps on turning: Apoptosome regulation and its role in chemoresistance
    • Fadeel B, Ottosson A, Pervaiz S. Big wheel keeps on turning: apoptosome regulation and its role in chemoresistance. Cell Death Differ. 2008;15:443-452.
    • (2008) Cell Death Differ , vol.15 , pp. 443-452
    • Fadeel, B.1    Ottosson, A.2    Pervaiz, S.3
  • 60
    • 84867656154 scopus 로고    scopus 로고
    • TGFb1 induces apoptosis in invasive prostate cancer and bladder cancer cells via Aktindependent, p38 MAPK and JNK/SAPK-mediated activation of caspases
    • Al-Azayzih A, Gao F, Goc A, et al. TGFb1 induces apoptosis in invasive prostate cancer and bladder cancer cells via Aktindependent, p38 MAPK and JNK/SAPK-mediated activation of caspases. Biochem Biophys Res Commun. 2012;427:165-170.
    • (2012) Biochem Biophys Res Commun , vol.427 , pp. 165-170
    • Al-Azayzih, A.1    Gao, F.2    Goc, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.