The αa66-80 peptide interacts with soluble α-crystallin and induces its aggregation and precipitation: A contribution to age-related cataract formation

Biochemistry

Volumn 52, Issue 21, 2013, Pages 3638-3650

  Kannan, Rama ^a   Santhoshkumar, Puttur ^a   Mooney, Brian P ^b   Sharma, K Krishna ^a  

^a University of Missouri   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C-TERMINAL EXTENSIONS; CHEMICAL CROSS-LINKING; GUANIDINIUM HYDROCHLORIDE; LOW-MOLECULAR WEIGHT; PROGRESSIVE ACCUMULATION; SPECIFIC INTERACTION; SUBUNIT INTERACTIONS; TRANSIENT INTERMEDIATE;

AGGREGATES; CROSSLINKING; IONIC STRENGTH; ISOTOPES; MASS SPECTROMETRY; PLANTS (BOTANY); UREA;

PEPTIDES;

ALPHA A66 80 PEPTIDE; ALPHA CRYSTALLIN; AMYLOID; CHAPERONE; GUANIDINE; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG; UREA;

AGING; ARTICLE; BIOACCUMULATION; CARBOXY TERMINAL SEQUENCE; CATARACT; CIRCULAR DICHROISM; CONTROLLED STUDY; GEL PERMEATION CHROMATOGRAPHY; HYDROPHOBICITY; IONIC STRENGTH; LENS; MOLECULAR WEIGHT; PATHOGENESIS; PRECIPITATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; WESTERN BLOTTING;

AGING; ALPHA-CRYSTALLINS; AMINO ACID SEQUENCE; CATARACT; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN BINDING;

EID: 84878315115     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi301662w     Document Type: Article

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