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Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 2, 2015, Pages 280-284

Novel heterocyclic scaffolds of GW4064 as farnesoid X receptor agonists

(8) Smalley, Terrence L a Boggs, Sharon a Caravella, Justin A a Chen, Lihong a Creech, Katrina L a Deaton, David N a Kaldor, Istvan a Parks, Derek J a

a GLAXOSMITHKLINE (United States)

Author keywords

FXR agonist; Heterocycles; Liver

Indexed keywords

3 [2 [2 CHLORO 4 [3 (2,6 DICHLOROPHENYL) 5 ISOPROPYL 4 ISOXAZOLYLMETHOXY]PHENYL]VINYL]BENZOIC ACID; FARNESOID X RECEPTOR; SILICA GEL; CELL RECEPTOR; FARNESOID X-ACTIVATED RECEPTOR; ISOXAZOLE DERIVATIVE; OXAZOLIDINONE DERIVATIVE;

ALKYLATION; ARTICLE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HORNER WADSWORTH EMMONS REACTION; HYDROGEN BOND; METABOLIC DISORDER; PUBLICATION; SAPONIFICATION; TRANSIENT TRANSFECTION; AGONISTS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG SCREENING; HUMAN; STRUCTURE ACTIVITY RELATION;

DRUG EVALUATION, PRECLINICAL; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; ISOXAZOLES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXAZOLIDINONES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84922333592 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.11.050 Document Type: Article

Times cited : (18)

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