Age dependent levels of plasma homocysteine and cognitive performance

Behavioural Brain Research

Volumn 283, Issue , 2015, Pages 139-144

  Agrawal, Aruna ^a   Ilango, K ^b   Singh, Praveen K ^c   Karmakar, Dipankar ^c   Singh, G P I ^d   Kumari, Rinki ^a,b,c,d   Dubey, G P ^a  

^a BANARAS HINDU UNIVERSITY   (India)

^b SRM INSTITUTE OF SCIENCE AND TECHNOLOGY   (India)

^c Arvind Remedies Ltd   (India)

^d Adesh 6 University   (India)

Author keywords

Cognition; Folate; Homocysteine; Interleukin 6; Vitamin B12

Indexed keywords

C REACTIVE PROTEIN; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; INTERLEUKIN 6; IL6 PROTEIN, HUMAN;

ADULT; AGE; AGED; AMINO ACID BLOOD LEVEL; ARTICLE; ATTENTION; BECK DEPRESSION INVENTORY; COGNITION; DEPRESSION; FEMALE; FOLIC ACID BLOOD LEVEL; HUMAN; HYPERHOMOCYSTEINEMIA; INDIA; MALE; MEMORY; MIDDLE AGED; PROTEIN BLOOD LEVEL; PSYCHOLOGIC TEST; SCORING SYSTEM; SENSITIVITY ANALYSIS; VITAMIN BLOOD LEVEL; ADOLESCENT; AGING; BLOOD; METABOLISM; NEUROPSYCHOLOGICAL TEST; PHYSIOLOGY; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; QUESTIONNAIRE; RECALL; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGING; ATTENTION; C-REACTIVE PROTEIN; COGNITION; DEPRESSION; FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; INDIA; INTERLEUKIN-6; MALE; MENTAL RECALL; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PSYCHIATRIC STATUS RATING SCALES; SURVEYS AND QUESTIONNAIRES; VITAMIN B 12; YOUNG ADULT;

EID: 84922330457     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2015.01.016     Document Type: Article

References (79)

1. Kessler H., Bleich S., Falkai P., Supprian T. Homocysteine and dementia. Fortschr Neurol Psychiatr 2003, 71:150-156.
2. Wald D.S., Law M., Morris J.K. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ 2002, 325:1202.
3. Morris M.S. Homocysteine and Alzheimer's disease. Lancet Neurol 2003, 2:425-428.
4. Zhuo J.M., Wang H., Praticò D. Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither?. Trends Pharmacol Sci 2011, 32:562-571.
5. Cacciapuoti F. Lowering homocysteine levels with folic acid and B-vitamins do not reduce early atherosclerosis, but could interfere with cognitive decline and Alzheimer's disease. J Thromb Thrombolysis 2013, 36:258-262.
6. Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999, 19:217-246.
7. Selhub J., Jacques P.F., Wilson P.W., Rush D., Rosenberg I.H. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 1993, 270:2693-2698.
8. Herrmann W., Schorr H., Purschwitz K., Rassoul F., Richter V. Total homocysteine, vitamin b12, and total antioxidant status in vegetarians. Clin Chem 2001, 47:1094-1101.
9. Obersby D., Chappell D.C., Dunnett A., Tsiami A.A. Plasma total homocysteine status of vegetarians compared with omnivores: a systematic review and meta-analysis. Br J Nutr 2013, 109:785-794.
10. Ganji V., Kafai M.R. Population reference values for plasma total homocysteine concentrations in US adults after the fortification of cereals with folic acid. Am J Clin Nutr 2006, 84:989-994.
11. Obeid R., Herrmann W. Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia. FEBS Lett 2006, 580:2994-3005.
12. Papatheodorou L., Weiss N. Vascular oxidant stress and inflammation in hyperhomocysteinemia. Antioxid Redox Signal 2007, 9:1941-1958.
13. Mattson M.P., Shea T.B. Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci 2003, 26:137-146.
14. Stott D.J., MacIntosh G., Lowe G.D.O., Rumley A., McMahon A.D., Langhorne P., et al. Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease. Am J Clin Nutr 2005, 82:1320-1326.
15. Lewerin C., Matousek M., Steen G., Johansson B., Steen B., Nilsson-Ehle H. Significant correlations of plasma homocysteine and serum methylmalonic acid with movement and cognitive performance in elderly subjects but no improvement from short-term vitamin therapy: a placebo-controlled randomized study. Am J Clin Nutr 2005, 81:1155-1162.
16. Eussen S.J., de Groot L.C., Joosten L.W., Bloo R.J., Clarke R., Ueland P.M., et al. Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial. Am J Clin Nutr 2006, 84:361-370.
17. McMahon J.A., Green T.J., Skeaff C.M., Knight R.G., Mann J.I., Williams S.M. A controlled trial of homocysteine lowering and cognitive performance. N Engl J Med 2006, 354:2764-2772.
18. Ford A.H., Flicker L., Alfonso H., Thomas J., Clarnette R., Martins R., et al. Vitamins B12, B6, and folic acid for cognition in older men. Neurology 2010, 75:1540-1547.
19. Bryan J., Calvaresi E., Hughes D. Short-term folate, vitamin B-12 or vitamin B-6 supplementation slightly affects memory performance but not mood in women of various ages. J Nutr 2002, 132:1345-1356.
20. Fioravanti M., Ferrario E., Massaia M., Cappa G., Rivolta G., Grossi E., et al. Low folate levels in the cognitive decline of elderly patients and the efficacy of folate as a treatment for improving memory deficits. Arch Gerontol Geriatr 1997, 26:1-13.
21. Kang J.H., Cook N., Manson J., Buring J.E., Albert C.M., Grodstein F. A trial of B vitamins and cognitive function among women at high risk of cardiovascular disease. Am J Clin Nutr 2008, 88:1602-1610.
22. Durga J., van Boxtel M.P.J., Schouten E.G., Kok F.J., Jolles J., Katan M.B., et al. Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 2007, 369:208-216.
23. Clarke R., Harrison G., Richards S. Effect of vitamins and aspirin on markers of platelet activation, oxidative stress and homocysteine in people at high risk of dementia. J Intern Med 2003, 254:67-75.
24. Kwok T., Lee J., Law C.B., Pan P.C., Yung C.Y., Choi K.C., et al. A randomized placebo controlled trial of homocysteine lowering to reduce cognitive decline in older demented people. Clin Nutr 2011, 30:297-302.
25. Aisen P.S., Schneider L.S., Sano M., Diaz-Arrastia R., van Dyck C.H., Weiner M.F., et al. High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial. JAMA 2008, 300:1774-1783.
26. Sun Y., Lu C.-J., Chien K.-L., Chen S.-T., Chen R.-C. Efficacy of multivitamin supplementation containing vitamins B6 and B12 and folic acid as adjunctive treatment with a cholinesterase inhibitor in Alzheimer's disease: a 26-week, randomized, double-blind, placebo-controlled study in Taiwanese patients. Clin Ther 2007, 29:2204-2214.
27. Jack C.R., Knopman D.S., Jagust W.J., Shaw L.M., Aisen P.S., Weiner M.W., et al. Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol 2010, 9:119-128.
28. Smith A.D., Smith S.M., de Jager C.A., Whitbread P., Johnston C., Agacinski G., et al. Homocysteine-lowering by b vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS ONE 2010, 5:1-10.
29. De Jager C.A., Oulhaj A., Jacoby R., Refsum H., Smith A.D. Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. Int J Geriatr Psychiatry 2012, 27:592-600.
30. Douaud G., Refsum H., de Jager C.A., Jacoby R., Nichols T.E., Smith S.M., et al. Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment. Proc Natl Acad Sci USA 2013, 110:9523-9528.
31. Nilsson K., Gustafson L., Hultberg B. Improvement of cognitive functions after cobalamin/folate supplementation in elderly patients with dementia and elevated plasma homocysteine. Int J Geriatr Psychiatry 2001, 16:609-614.
32. Morris M.S. The role of B vitamins in preventing and treating cognitive impairment and decline. Adv Nutr 2012, 3:801-812.
33. Zylberstein D.E., Lissner L., Björkelund C., Mehlig K., Thelle D.S., Gustafson D., et al. Midlife homocysteine and late-life dementia in women. A prospective population study. Neurobiol Aging 2011, 32:380-386.
34. Pfeffer R.I., Kurosaki T.T., Harrah C.H., Chance J.M., Filos S. Measurement of functional activities in older adults in the community. J Gerontol 1982, 37:323-329.
35. Beck A.T., Steer R.A., Ball R., Ranieri W. Comparison of beck depression inventories-IA and -II in psychiatric outpatients. J Pers Assess 1996, 67:588-597.
36. Seshadri S., Beiser A. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 2002, 346:476-483.
37. Clarke R., Smith A.D., Jobst K.A., Refsum H., Sutton L., Ueland P.M. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998, 55:1449-1455.
38. Teunissen C.E., Blom A.H.J., Van Boxtel M.P.J., Bosma H., de Bruijn C., Jolles J., et al. Homocysteine: a marker for cognitive performance? A longitudinal follow-up study. J Nutr Health Aging 2003, 7:153-159.
39. Smach M.A., Jacob N., Golmard J.L., Charfeddine B., Lammouchi T., Ben Othman L., et al. Folate and homocysteine in the cerebrospinal fluid of patients with Alzheimer's disease or dementia: a case control study. Eur Neurol 2011, 65:270-278.
40. Herrmann W., Obeid R. Homocysteine A biomarker in neurodegenerative diseases. Clin Chem Lab Med 2011, 49:435-441.
41. McCaddon A., Hudson P., Davies G., Hughes A., Williams J.H.H., Wilkinson C. Homocysteine and cognitive decline in healthy elderly. Dement Geriatr Cogn Disord 2001, 12:309-313.
42. Dufouil C., Alpérovitch A., Ducros V., Tzourio C. Homocysteine, white matter hyperintensities, and cognition in healthy elderly people. Ann Neurol 2003, 53:214-221.
43. Ravaglia G., Forti P., Maioli F., Muscari A., Sacchetti L., Arnone G., et al. Homocysteine and cognitive function in healthy elderly community dwellers in Italy. Am J Clin Nutr 2003, 77:668-673.
44. Elias M.F., Sullivan L.M., D'Agostino R.B., Elias P.K., Jacques P.F., Selhub J., et al. Homocysteine and cognitive performance in the Framingham Offspring Study: age is important. Am J Epidemiol 2005, 162:644-653.
45. Nurk E., Refsum H., Tell G.S., Engedal K., Vollset S.E., Ueland P.M., et al. Plasma total homocysteine and memory in the elderly: the Hordaland homocysteine study. Ann Neurol 2005, 58:847-857.
46. Feng L., Ng T.P., Chuah L., Niti M., Kua E.H. Homocysteine, folate, and vitamin B-12 and cognitive performance in older Chinese adults: findings from the Singapore Longitudinal Ageing Study. Am J Clin Nutr 2006, 84:1506-1512.
47. Hinterberger M., Fischer P. Folate and alzheimer: when time matters. J Neural Transm 2013, 120:211-224.
48. Andersson A., Brattström L., Israelsson B., Isaksson A., Hamfelt A., Hultberg B. Plasma homocysteine before and after methionine loading with regard to age, gender, and menopausal status. Eur J Clin Invest 1992, 22:79-87.
49. Brattström L., Lindgren A., Israelsson B., Andersson A., Hultberg B. Homocysteine and cysteine: determinants of plasma levels in middle-aged and elderly subjects. J Intern Med 1994, 236:633-641.
50. Norlund L., Grubb A., Fex G., Leksell H., Nilsson J.E., Schenck H., et al. The increase of plasma homocysteine concentrations with age is partly due to the deterioration of renal function as determined by plasma cystatin C. Clin Chem Lab Med 1998, 36:175-178.
51. Del Valle L.G. Oxidative stress in aging: theoretical outcomes and clinical evidences in humans. Biomed Aging Pathol 2011, 1:1-7.
52. Hoffman M. Hypothesis hyperhomocysteinemia is an indicator of oxidant stress. Med Hypotheses 2011, 77:1088-1093.
53. Vincent H.K., Innes K.E., Vincent K.R. Oxidative stress and potential interventions to reduce oxidative stress in overweight and obesity. Diabetes Obes Metab 2007, 9:813-839.
54. Wonisch W., Falk A., Sundl I., Winklhofer-Roob B.M., Lindschinger M. Oxidative stress increases continuously with BMI and age with unfavourable profiles in males. Aging Male 2012, 15:159-165.
55. Sastry B.K., Indira N., Anand B., Prabha B.S., Raju B.S. A case-control study of plasma homocysteine levels in South Indians with and without coronary artery disease. Indian Heart J 2001, 53:749-753.
56. Puri A., Gupta O.K., Dwivedi R.N., Bharadwaj R.P.S., Narain V.S., Singh S. Homocysteine and lipid levels in young patients with coronary artery disease. J Assoc Physicians India 2003, 51:681-685.
57. Abraham R, Joseph John M, Calton R, Dhanoa J. Raised serum homocysteine levels in patients of coronary artery disease and the effect of Vitamin B12 and folate on its concentration. Indian J Clin Biochem 2006;21:95-100.
58. Rama Devi R.A., Naushad S.M., Prasad K.C. Evaluation of total plasma homocysteine in Indian newborns using heel-prick samples. Indian J Pediatr 2006, 73:503-508.
59. Ghosh K., Khare A., Shetty S. Fasting plasma homocysteine levels are increased in young patients with acute myocardial infarction from Western India. Indian Heart J 2007, 59:242-245.
60. Kamat G.V., Metgud S.C., Pattanshetti V.M., Godhi A.S. A cross-sectional study to detect the prevalence of hyperhomocysteinemia in cases of deep vein thrombosis. Indian J Surg 2010, 72:323-326.
61. Gupta S.K., Kotwal J., Kotwal A., Dhall A., Garg S. Role of homocysteine & MTHFR C677T gene polymorphism as risk factors for coronary artery disease in young Indians. Indian J Med Res 2012, 135:506-512.
62. Pandey K., Dubay P., Bhagoliwal A., Gupta N., Tyagi G. Hyperhomocysteinemia as a risk factor for IUGR. J Obstet Gynaecol India 2012, 62:406-408.
63. Aishwarya S., Rajendiren S., Kattimani S., Dhiman P., Haritha S., Anantha Narayanan P.H. Homocysteine and serotonin: association with postpartum depression. Asian J Psychiatr 2013, 6:473-477.
64. Chakraborty P., Goswami S.K., Rajani S., Sharma S., Kabir S.N., Chakravarty B., et al. Recurrent pregnancy loss in polycystic ovary syndrome: role of hyperhomocysteinemia and insulin resistance. PLoS ONE 2013, 8:e64446.
65. Mahalle N.P., Garg M.K., Naik S.S., Kulkarni M.V. Study of pattern of dyslipidemia and its correlation with cardiovascular risk factors in patients with proven coronary artery disease. Indian J Endocrinol Metab 2014, 18:48-55.
66. Wadhwani N.S., Pisal H.R., Mehendale S.S., Joshi S.R. A prospective study of maternal fatty acids, micronutrients and homocysteine and their association with birth outcome. Matern Child Nutr 2013, 10.1111/mcn.12062.
67. Mascarenhas M., Habeebullah S., Sridhar M.G. Revisiting the role of first trimester homocysteine as an index of maternal and fetal outcome. J Pregnancy 2014, 2014:123024. 10.1155/2014/123024.
68. Shenoy V., Mehendale V., Prabhu K., Shetty R., Rao P. Correlation of serum homocysteine levels with the severity of coronary artery disease. Indian J Clin Biochem 2014, 29:339-344.
69. Strand T.A., Taneja S., Ueland P.M., Refsum H., Bahl R., Schneede J., et al. Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age. Am J Clin Nutr 2013, 97:310-317.
70. Ray L., Khemka V.K., Behera P., Bandyopadhyay K., Pal S., Pal K., et al. Serum homocysteine, dehydroepiandrosterone sulphate and lipoprotein (a) in Alzheimer's disease and vascular dementia. Aging Dis 2013, 4:57-64.
71. Kumudini N., Uma A., Naushad S.M., Mridula R., Borgohain R., Kutala V.K. Association of seven functional polymorphisms of one-carbon metabolic pathway with total plasma homocysteine levels and susceptibility to Parkinson's disease among South Indians. Neurosci Lett 2014, 568:1-5.
72. Narayan S.K., Verman A., Kattimani S., Ananthanarayanan P.H., Adithan C. Plasma homocysteine levels in depression and schizophrenia in South Indian Tamilian population. Indian J Psychiatry 2014, 56:46-53.
73. Lahiri K.D., Datta H., Das H.N. Reference interval determination of total plasma homocysteine in an Indian population. Indian J Clin Biochem 2014, 29:74-78.
74. Misra A., Vikram N.K., Pandey R.M., Dwivedi M., Ahmad F.U., Luthra K., et al. Hyperhomocysteinemia, and low intakes of folic acid and vitamin B12 in urban North India. Eur J Nutr 2002, 41:68-77.
75. 12. Int J Vitam Nutr Res 2011, 81:306-316.
76. 12 deficiency and levels of metabolites in an apparently normal urban south Indian elderly population. Indian J Med Res 2011, 134:432-439.
77. Yajnik C.S., Deshpande S.S., Lubree H.G., Naik S.S., Bhat D.S., Uradey B.S., et al. Vitamin B12 deficiency and hyperhomocysteinemia in rural and urban Indians. J Assoc Physicians India 2006, 54:775-782.
78. Gorelick P.B. Role of inflammation in cognitive impairment: results of observational epidemiological studies and clinical trials. Ann N Y Acad Sci 2010, 1207:155-162.
79. Bettcher B.M., Kramer J.H. Longitudinal inflammation, cognitive decline, and Alzheimer's disease: a mini-review. Clin Pharmacol Ther 2014, 96:464-469.