-
1
-
-
34249337761
-
Perceptions of epigenetics
-
COI: 1:CAS:528:DC%2BD2sXlsFOgsrk%3D
-
Bird A. Perceptions of epigenetics. Nature 2007; 447: 396–398. DOI: 10.1038/nature05913
-
(2007)
Nature
, vol.447
, pp. 396-398
-
-
Bird, A.1
-
3
-
-
84859893371
-
Histone methylation: a dynamic mark in health, disease and inheritance
-
COI: 1:CAS:528:DC%2BC38XkvVGgsbo%3D
-
Greer EL, Shi Y. Histone methylation: a dynamic mark in health, disease and inheritance. Nat Rev Genet 2012; 13: 343–357. DOI: 10.1038/nrg3173
-
(2012)
Nat Rev Genet
, vol.13
, pp. 343-357
-
-
Greer, E.L.1
Shi, Y.2
-
4
-
-
0037172665
-
Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain
-
COI: 1:CAS:528:DC%2BD38XlsVyjtLY%3D
-
Feng Q, Wang H, Ng HH, Erdjument-Bromage H, Tempst P, Struhl K et al. Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain. Curr Biol 2002; 12: 1052–1058. DOI: 10.1016/S0960-9822(02)00901-6
-
(2002)
Curr Biol
, vol.12
, pp. 1052-1058
-
-
Feng, Q.1
Wang, H.2
Ng, H.H.3
Erdjument-Bromage, H.4
Tempst, P.5
Struhl, K.6
-
5
-
-
0031658303
-
Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae
-
COI: 1:CAS:528:DyaK1cXmvVSmtbw%3D, PID: 1460361
-
Singer MS, Kahana A, Wolf AJ, Meisinger LL, Peterson SE, Goggin C et al. Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae. Genetics 1998; 150: 613–632.
-
(1998)
Genetics
, vol.150
, pp. 613-632
-
-
Singer, M.S.1
Kahana, A.2
Wolf, A.J.3
Meisinger, L.L.4
Peterson, S.E.5
Goggin, C.6
-
6
-
-
0037163016
-
Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase
-
COI: 1:CAS:528:DC%2BD38XmsFyqsLc%3D
-
Lacoste N, Utley RT, Hunter JM, Poirier GG, Côte J. Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase. J Biol Chem 2002; 277: 30421–30424. DOI: 10.1074/jbc.C200366200
-
(2002)
J Biol Chem
, vol.277
, pp. 30421-30424
-
-
Lacoste, N.1
Utley, R.T.2
Hunter, J.M.3
Poirier, G.G.4
Côte, J.5
-
7
-
-
0037077178
-
Dot1p modulates silencing in yeast by methylation of the nucleosome core
-
COI: 1:CAS:528:DC%2BD38XkvV2ju78%3D
-
Van Leeuwen F, Gafken PPR, Gottschling DE DE. Dot1p modulates silencing in yeast by methylation of the nucleosome core. Cell 2002; 109: 745–756. DOI: 10.1016/S0092-8674(02)00759-6
-
(2002)
Cell
, vol.109
, pp. 745-756
-
-
Van Leeuwen, F.1
Gafken, P.P.R.2
Gottschling, D.E.D.E.3
-
8
-
-
79959960773
-
The diverse functions of Dot1 and H3K79 methylation
-
Nguyen A, Zhang Y. The diverse functions of Dot1 and H3K79 methylation. Genes Dev 2011; 3: 1345–1358. DOI: 10.1101/gad.2057811
-
(2011)
Genes Dev
, vol.3
, pp. 1345-1358
-
-
Nguyen, A.1
Zhang, Y.2
-
9
-
-
84897995587
-
The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle
-
COI: 1:CAS:528:DC%2BC2cXhtFOht7fO
-
Kim W, Choi M, Kim J-E. The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle. Cell Cycle 2014; 13: 726–738. DOI: 10.4161/cc.28104
-
(2014)
Cell Cycle
, vol.13
, pp. 726-738
-
-
Kim, W.1
Choi, M.2
Kim, J.-E.3
-
10
-
-
42149146774
-
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells
-
COI: 1:CAS:528:DC%2BD1cXksFWqt7Y%3D
-
Steger DJ, Lefterova MI, Ying L, Stonestrom AJ, Schupp M, Zhuo D et al. DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. Mol Cell Biol 2008; 28: 2825–2839. DOI: 10.1128/MCB.02076-07
-
(2008)
Mol Cell Biol
, vol.28
, pp. 2825-2839
-
-
Steger, D.J.1
Lefterova, M.I.2
Ying, L.3
Stonestrom, A.J.4
Schupp, M.5
Zhuo, D.6
-
11
-
-
79955964337
-
Evidence that the histone methyltransferase Dot1 mediates global genomic repair by methylating histone H3 on lysine 79
-
COI: 1:CAS:528:DC%2BC3MXmtVGjtr0%3D
-
Tatum D, Li S. Evidence that the histone methyltransferase Dot1 mediates global genomic repair by methylating histone H3 on lysine 79. J Biol Chem 2011; 286: 17530–17535. DOI: 10.1074/jbc.M111.241570
-
(2011)
J Biol Chem
, vol.286
, pp. 17530-17535
-
-
Tatum, D.1
Li, S.2
-
12
-
-
69749117490
-
Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation
-
COI: 1:CAS:528:DC%2BD1MXhsVChsr3E
-
Schulze JM, Jackson J, Nakanishi S, Gardner JM, Hentrich T, Haug J et al. Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation. Mol Cell 2009; 35: 626–641. DOI: 10.1016/j.molcel.2009.07.017
-
(2009)
Mol Cell
, vol.35
, pp. 626-641
-
-
Schulze, J.M.1
Jackson, J.2
Nakanishi, S.3
Gardner, J.M.4
Hentrich, T.5
Haug, J.6
-
13
-
-
17444375685
-
hDOT1L links histone methylation to leukemogenesis
-
COI: 1:CAS:528:DC%2BD2MXjvV2jtLk%3D
-
Okada Y, Feng Q, Lin Y, Jiang Q, Li Y, Coffield VM et al. hDOT1L links histone methylation to leukemogenesis. Cell 2005; 121: 167–178. DOI: 10.1016/j.cell.2005.02.020
-
(2005)
Cell
, vol.121
, pp. 167-178
-
-
Okada, Y.1
Feng, Q.2
Lin, Y.3
Jiang, Q.4
Li, Y.5
Coffield, V.M.6
-
14
-
-
33748207226
-
Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L
-
COI: 1:CAS:528:DC%2BD28XovFyktLY%3D
-
Okada Y, Jiang Q, Lemieux M, Jeannotte L, Su L, Zhang Y. Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L. Nat Cell Biol 2006; 8: 1017–1024. DOI: 10.1038/ncb1464
-
(2006)
Nat Cell Biol
, vol.8
, pp. 1017-1024
-
-
Okada, Y.1
Jiang, Q.2
Lemieux, M.3
Jeannotte, L.4
Su, L.5
Zhang, Y.6
-
15
-
-
79960058024
-
Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor
-
COI: 1:CAS:528:DC%2BC3MXoslCms7c%3D
-
Daigle SR, Olhava EJ, Therkelsen Ca, Majer CR, Sneeringer CJ, Song J et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell 2011; 20: 53–65. DOI: 10.1016/j.ccr.2011.06.009
-
(2011)
Cancer Cell
, vol.20
, pp. 53-65
-
-
Daigle, S.R.1
Olhava, E.J.2
Therkelsen, C.3
Majer, C.R.4
Sneeringer, C.J.5
Song, J.6
-
16
-
-
84876143288
-
Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l
-
COI: 1:CAS:528:DC%2BC3sXmsVamt7s%3D
-
Chen L, Deshpande AJ, Banka D, Bernt KM, Dias S, Buske C et al. Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l. Leukemia 2013; 27: 813–822. DOI: 10.1038/leu.2012.327
-
(2013)
Leukemia
, vol.27
, pp. 813-822
-
-
Chen, L.1
Deshpande, A.J.2
Banka, D.3
Bernt, K.M.4
Dias, S.5
Buske, C.6
-
17
-
-
84886864184
-
Potent inhibition of DOT1L as treatment for MLL-fusion leukemia
-
COI: 1:CAS:528:DC%2BC3sXhtlWltLfE
-
Daigle SR, Olhava EJ, Therkelsen CA, Basavapathruni A, Jin L, Boriack-Sjodin PA et al. Potent inhibition of DOT1L as treatment for MLL-fusion leukemia. Blood 2013; 122: 1017–1025. DOI: 10.1182/blood-2013-04-497644
-
(2013)
Blood
, vol.122
, pp. 1017-1025
-
-
Daigle, S.R.1
Olhava, E.J.2
Therkelsen, C.A.3
Basavapathruni, A.4
Jin, L.5
Boriack-Sjodin, P.A.6
-
18
-
-
0019826665
-
Establishment in culture of pluripotential cells from mouse embryos
-
COI: 1:STN:280:DyaL3M3itV2qsg%3D%3D
-
Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981; 292: 154–156. DOI: 10.1038/292154a0
-
(1981)
Nature
, vol.292
, pp. 154-156
-
-
Evans, M.J.1
Kaufman, M.H.2
-
19
-
-
0001007610
-
Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells
-
COI: 1:STN:280:DyaL387ltV2htg%3D%3D
-
Martin GR. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA 1981; 78: 7634–7638. DOI: 10.1073/pnas.78.12.7634
-
(1981)
Proc Natl Acad Sci USA
, vol.78
, pp. 7634-7638
-
-
Martin, G.R.1
-
20
-
-
52949107241
-
The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure
-
Jones B, Su H, Bhat A, Lei H, Bajko J, Hevi S et al. The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure. PLoS Genet 2008; 4: e1000190. DOI: 10.1371/journal.pgen.1000190
-
(2008)
PLoS Genet
, vol.4
-
-
Jones, B.1
Su, H.2
Bhat, A.3
Lei, H.4
Bajko, J.5
Hevi, S.6
-
21
-
-
68049125868
-
ES cell cycle progression and differentiation require the action of the histone methyltransferase Dot1L
-
COI: 1:CAS:528:DC%2BD1MXhtVGjsb%2FL
-
Barry ER, Krueger W, Jakuba CM, Veilleux E, Ambrosi DJ, Nelson CE et al. ES cell cycle progression and differentiation require the action of the histone methyltransferase Dot1L. Stem Cells 2009; 27: 1538–1547. DOI: 10.1002/stem.86
-
(2009)
Stem Cells
, vol.27
, pp. 1538-1547
-
-
Barry, E.R.1
Krueger, W.2
Jakuba, C.M.3
Veilleux, E.4
Ambrosi, D.J.5
Nelson, C.E.6
-
22
-
-
0030034110
-
Withdrawal of differentiation inhibitory activity/leukemia inhibitory factor up-regulates D-type cyclins and cyclin-dependent kinase inhibitors in mouse embryonic stem cells
-
COI: 1:CAS:528:DyaK28XotV2qug%3D%3D, PID: 8570208
-
Savatier P, Lapillonne H, Van Grunsven LA, Rudkin BB, Samarut J. Withdrawal of differentiation inhibitory activity/leukemia inhibitory factor up-regulates D-type cyclins and cyclin-dependent kinase inhibitors in mouse embryonic stem cells. Oncogene 1996; 12: 309–322.
-
(1996)
Oncogene
, vol.12
, pp. 309-322
-
-
Savatier, P.1
Lapillonne, H.2
Van Grunsven, L.A.3
Rudkin, B.B.4
Samarut, J.5
-
23
-
-
84871456408
-
Induced pluripotency and oncogenic transformation are related processes
-
Riggs JW, Barrilleaux BL, Varlakhanova N, Bush KM, Chan V, Knoepfler PS. Induced pluripotency and oncogenic transformation are related processes. Stem Cells Dev 2012; 22: 37–50. DOI: 10.1089/scd.2012.0375
-
(2012)
Stem Cells Dev
, vol.22
, pp. 37-50
-
-
Riggs, J.W.1
Barrilleaux, B.L.2
Varlakhanova, N.3
Bush, K.M.4
Chan, V.5
Knoepfler, P.S.6
-
24
-
-
84863115862
-
Deficiency of H3K79 histone methyltransferase Dot1-like protein (DOT1L) inhibits cell proliferation
-
COI: 1:CAS:528:DC%2BC38XisVyltLo%3D
-
Kim W, Kim R, Park G, Park J-W, Kim J-E. Deficiency of H3K79 histone methyltransferase Dot1-like protein (DOT1L) inhibits cell proliferation. J Biol Chem 2012; 287: 5588–5599. DOI: 10.1074/jbc.M111.328138
-
(2012)
J Biol Chem
, vol.287
, pp. 5588-5599
-
-
Kim, W.1
Kim, R.2
Park, G.3
Park, J.-W.4
Kim, J.-E.5
-
25
-
-
78650358037
-
Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes
-
COI: 1:CAS:528:DC%2BC3cXhsFGrt7bN
-
Chang M-J, Wu H, Achille NJ, Reisenauer MR, Chou C-W, Zeleznik-Le NJ et al. Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes. Cancer Res 2010; 70: 10234–10242. DOI: 10.1158/0008-5472.CAN-10-3294
-
(2010)
Cancer Res
, vol.70
, pp. 10234-10242
-
-
Chang, M.-J.1
Wu, H.2
Achille, N.J.3
Reisenauer, M.R.4
Chou, C.-W.5
Zeleznik-Le, N.J.6
-
26
-
-
79960044951
-
MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L
-
COI: 1:CAS:528:DC%2BC3MXoslCmsL4%3D
-
Bernt KM, Zhu N, Sinha AU, Vempati S, Faber J, Krivtsov AV et al. MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. Cancer Cell 2011; 20: 66–78. DOI: 10.1016/j.ccr.2011.06.010
-
(2011)
Cancer Cell
, vol.20
, pp. 66-78
-
-
Bernt, K.M.1
Zhu, N.2
Sinha, A.U.3
Vempati, S.4
Faber, J.5
Krivtsov, A.V.6
-
27
-
-
79955948524
-
Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation
-
COI: 1:CAS:528:DC%2BC3MXmsVWmsro%3D
-
Jo SY, Granowicz EM, Maillard I, Thomas D, Hess JL. Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation. Blood 2011; 117: 4759–4768. DOI: 10.1182/blood-2010-12-327668
-
(2011)
Blood
, vol.117
, pp. 4759-4768
-
-
Jo, S.Y.1
Granowicz, E.M.2
Maillard, I.3
Thomas, D.4
Hess, J.L.5
-
28
-
-
79551607266
-
DOT1L regulates dystrophin expression and is critical for cardiac function
-
COI: 1:CAS:528:DC%2BC3MXisVehtr8%3D
-
Nguyen AT, Xiao B, Neppl RL, Kallin EM, Li J, Chen T et al. DOT1L regulates dystrophin expression and is critical for cardiac function. Genes Dev 2011; 25: 263–274. DOI: 10.1101/gad.2018511
-
(2011)
Genes Dev
, vol.25
, pp. 263-274
-
-
Nguyen, A.T.1
Xiao, B.2
Neppl, R.L.3
Kallin, E.M.4
Li, J.5
Chen, T.6
-
29
-
-
84876454836
-
DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions
-
COI: 1:CAS:528:DC%2BC3sXmsVGkt7o%3D
-
Ho L-L, Sinha A, Verzi M, Bernt KM, Armstrong S, Shivdasani Ra. DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions. Mol Cell Biol 2013; 33: 1735–1745. DOI: 10.1128/MCB.01463-12
-
(2013)
Mol Cell Biol
, vol.33
, pp. 1735-1745
-
-
Ho, L.-L.1
Sinha, A.2
Verzi, M.3
Bernt, K.M.4
Armstrong, S.5
Shivdasani, R.6
-
30
-
-
82255191954
-
Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine
-
COI: 1:CAS:528:DC%2BC3MXhs1KhsbbK
-
Kim J, Orkin SH. Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine. Genome Med 2011; 3: 75. DOI: 10.1186/gm291
-
(2011)
Genome Med
, vol.3
, pp. 75
-
-
Kim, J.1
Orkin, S.H.2
-
31
-
-
84859218238
-
Chromatin-modifying enzymes as modulators of reprogramming
-
COI: 1:CAS:528:DC%2BC38XjtFOgsro%3D
-
Onder TTT, Kara N, Cherry A, Sinha AUA, Zhu N, Bernt KM et al. Chromatin-modifying enzymes as modulators of reprogramming. Nature 2012; 483: 598–602. DOI: 10.1038/nature10953
-
(2012)
Nature
, vol.483
, pp. 598-602
-
-
Onder, T.T.T.1
Kara, N.2
Cherry, A.3
Sinha, A.U.A.4
Zhu, N.5
Bernt, K.M.6
-
32
-
-
36248966518
-
Induction of pluripotent stem cells from adult human fibroblasts by defined factors
-
COI: 1:CAS:528:DC%2BD2sXhsVCntbbK
-
Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131: 861–872. DOI: 10.1016/j.cell.2007.11.019
-
(2007)
Cell
, vol.131
, pp. 861-872
-
-
Takahashi, K.1
Tanabe, K.2
Ohnuki, M.3
Narita, M.4
Ichisaka, T.5
Tomoda, K.6
-
33
-
-
40949103054
-
Changes in H3K79 methylation during preimplantation development in mice
-
COI: 1:CAS:528:DC%2BD1cXisFSltbo%3D
-
Ooga M, Inoue A, Kageyama S, Akiyama T, Nagata M, Aoki F. Changes in H3K79 methylation during preimplantation development in mice. Biol Reprod 2008; 78: 413–424. DOI: 10.1095/biolreprod.107.063453
-
(2008)
Biol Reprod
, vol.78
, pp. 413-424
-
-
Ooga, M.1
Inoue, A.2
Kageyama, S.3
Akiyama, T.4
Nagata, M.5
Aoki, F.6
-
34
-
-
84897560870
-
Dynamics of DOT1L localization and H3K79 methylation during meiotic prophase I in mouse spermatocytes
-
Ontoso D, Kauppi L, Keeney S, San-Segundo PA. Dynamics of DOT1L localization and H3K79 methylation during meiotic prophase I in mouse spermatocytes. Chromosoma 2013; 123: 147–164. DOI: 10.1007/s00412-013-0438-5
-
(2013)
Chromosoma
, vol.123
, pp. 147-164
-
-
Ontoso, D.1
Kauppi, L.2
Keeney, S.3
San-Segundo, P.A.4
-
35
-
-
13744259076
-
Characterization of the grappa gene, the Drosophila histone H3 lysine 79 methyltransferase
-
COI: 1:CAS:528:DC%2BD2MXit1yhsrs%3D
-
Shanower Ga, Muller M, Blanton JL, Honti V, Gyurkovics H, Schedl P. Characterization of the grappa gene, the Drosophila histone H3 lysine 79 methyltransferase. Genetics 2005; 169: 173–184. DOI: 10.1534/genetics.104.033191
-
(2005)
Genetics
, vol.169
, pp. 173-184
-
-
Shanower, G.1
Muller, M.2
Blanton, J.L.3
Honti, V.4
Gyurkovics, H.5
Schedl, P.6
-
36
-
-
85127418292
-
Structure and regulation of the mDot1 gene, a mouse histone H3 methyltransferase
-
Zhang W, Hayashizaki Y, Kone BBC. Structure and regulation of the mDot1 gene, a mouse histone H3 methyltransferase. Biochem J 2004; 377: 1–36. DOI: 10.1042/bj20031000
-
(2004)
Biochem J
, vol.377
, pp. 1-36
-
-
Zhang, W.1
Hayashizaki, Y.2
Kone, B.B.C.3
-
37
-
-
78649458797
-
Early mammalian erythropoiesis requires the Dot1L methyltransferase
-
COI: 1:CAS:528:DC%2BC3cXhsFGgtbrE
-
Feng Y, Yang Y. Early mammalian erythropoiesis requires the Dot1L methyltransferase. Blood 2010; 116: 4483–4491. DOI: 10.1182/blood-2010-03-276501
-
(2010)
Blood
, vol.116
, pp. 4483-4491
-
-
Feng, Y.1
Yang, Y.2
-
38
-
-
0346634892
-
Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis
-
COI: 1:CAS:528:DC%2BD3sXhs1KhsQ%3D%3D
-
Hove JR, Köster RW, Forouhar AS, Acevedo-Bolton G, Fraser SE, Gharib M. Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis. Nature 2003; 421: 172–177. DOI: 10.1038/nature01282
-
(2003)
Nature
, vol.421
, pp. 172-177
-
-
Hove, J.R.1
Köster, R.W.2
Forouhar, A.S.3
Acevedo-Bolton, G.4
Fraser, S.E.5
Gharib, M.6
-
39
-
-
16244392084
-
Epigenetic histone modification and cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress
-
COI: 1:CAS:528:DC%2BD2MXitFCgsbs%3D
-
Illi B, Scopece A, Nanni S, Farsetti A, Morgante L, Biglioli P et al. Epigenetic histone modification and cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress. Circ Res 2005; 96: 501–508. DOI: 10.1161/01.RES.0000159181.06379.63
-
(2005)
Circ Res
, vol.96
, pp. 501-508
-
-
Illi, B.1
Scopece, A.2
Nanni, S.3
Farsetti, A.4
Morgante, L.5
Biglioli, P.6
-
40
-
-
84879001958
-
De novo mutations in histone-modifying genes in congenital heart disease
-
COI: 1:CAS:528:DC%2BC3sXotFSns7s%3D
-
Zaidi S, Choi M, Wakimoto H, Ma L, Jiang J, Overton JD et al. De novo mutations in histone-modifying genes in congenital heart disease. Nature 2013; 498: 220–223. DOI: 10.1038/nature12141
-
(2013)
Nature
, vol.498
, pp. 220-223
-
-
Zaidi, S.1
Choi, M.2
Wakimoto, H.3
Ma, L.4
Jiang, J.5
Overton, J.D.6
-
41
-
-
27944454433
-
Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation
-
COI: 1:CAS:528:DC%2BD2MXht12msrzJ
-
Zhu B, Zheng Y, Pham A-D, Mandal SS, Erdjument-Bromage H, Tempst P et al. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Mol Cell 2005; 20: 601–611. DOI: 10.1016/j.molcel.2005.09.025
-
(2005)
Mol Cell
, vol.20
, pp. 601-611
-
-
Zhu, B.1
Zheng, Y.2
Pham, A.-D.3
Mandal, S.S.4
Erdjument-Bromage, H.5
Tempst, P.6
-
42
-
-
84861422537
-
Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis
-
Castaño MC, Cailotto F, Kerkhof HJ, Cornelis FMF. Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis. Proc Natl Acad Sci 2012; 109: 8218–8223. DOI: 10.1073/pnas.1119899109
-
(2012)
Proc Natl Acad Sci
, vol.109
, pp. 8218-8223
-
-
Castaño, M.C.1
Cailotto, F.2
Kerkhof, H.J.3
Cornelis, F.M.F.4
-
43
-
-
3142518219
-
Leukemic transformation
-
COI: 1:CAS:528:DC%2BD2cXjsVGiur0%3D
-
Lin Y-W, Aplan PD. Leukemic transformation. Cancer Biol Ther 2004; 3: 13–20. DOI: 10.4161/cbt.3.1.537
-
(2004)
Cancer Biol Ther
, vol.3
, pp. 13-20
-
-
Lin, Y.-W.1
Aplan, P.D.2
-
44
-
-
77949563562
-
Targeting DOT1L action and interactions in leukemia: the role of DOT1L in transformation and development
-
COI: 1:CAS:528:DC%2BC3cXjt1Kqt78%3D
-
Barry ER, Corry GN, Rasmussen TP. Targeting DOT1L action and interactions in leukemia: the role of DOT1L in transformation and development. Expert Opin Ther Targets 2010; 14: 405–418. DOI: 10.1517/14728221003623241
-
(2010)
Expert Opin Ther Targets
, vol.14
, pp. 405-418
-
-
Barry, E.R.1
Corry, G.N.2
Rasmussen, T.P.3
-
45
-
-
18744416572
-
Cooperative and antagonistic interplay between PU. 1 and GATA-2 in the specification of myeloid cell fates
-
COI: 1:CAS:528:DC%2BD38XovF2ls78%3D
-
Walsh J, DeKoter R, Lee H, Smith E. Cooperative and antagonistic interplay between PU. 1 and GATA-2 in the specification of myeloid cell fates. Immunity 2002; 17: 665–676. DOI: 10.1016/S1074-7613(02)00452-1
-
(2002)
Immunity
, vol.17
, pp. 665-676
-
-
Walsh, J.1
DeKoter, R.2
Lee, H.3
Smith, E.4
-
46
-
-
80052480322
-
Essential role of DOT1L in maintaining normal adult hematopoiesis
-
COI: 1:CAS:528:DC%2BC3MXhtFWksbrI
-
Nguyen AT, He J, Taranova O, Zhang Y. Essential role of DOT1L in maintaining normal adult hematopoiesis. Cell Res 2011; 21: 1370–1373. DOI: 10.1038/cr.2011.115
-
(2011)
Cell Res
, vol.21
, pp. 1370-1373
-
-
Nguyen, A.T.1
He, J.2
Taranova, O.3
Zhang, Y.4
-
47
-
-
0024433697
-
vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells
-
COI: 1:CAS:528:DyaK3cXhsFakurg%3D
-
Katzav S, Martin-Zanca D, Barbacid M. vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. EMBO J 1989; 8: 2283–2290. DOI: 10.1002/j.1460-2075.1989.tb08354.x
-
(1989)
EMBO J
, vol.8
, pp. 2283-2290
-
-
Katzav, S.1
Martin-Zanca, D.2
Barbacid, M.3
-
48
-
-
84871737742
-
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
-
Yu W, Chory EJ, Wernimont AK, Tempel W, Scopton A, Federation A et al. Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat Commun 2012; 3: 1288. DOI: 10.1038/ncomms2304
-
(2012)
Nat Commun
, vol.3
, pp. 1288
-
-
Yu, W.1
Chory, E.J.2
Wernimont, A.K.3
Tempel, W.4
Scopton, A.5
Federation, A.6
-
49
-
-
77954217479
-
Exploiting the balance between life and death: targeted cancer therapy and ‘oncogenic shock’
-
COI: 1:CAS:528:DC%2BC3cXosV2is7c%3D
-
Sharma SV, Settleman J. Exploiting the balance between life and death: targeted cancer therapy and ‘oncogenic shock’. Biochem Pharmacol 2010; 80: 666–673. DOI: 10.1016/j.bcp.2010.03.001
-
(2010)
Biochem Pharmacol
, vol.80
, pp. 666-673
-
-
Sharma, S.V.1
Settleman, J.2
-
50
-
-
79551545956
-
Dot1 binding induces chromatin rearrangements by histone methylation- dependent and -independent mechanisms
-
COI: 1:CAS:528:DC%2BC3MXjtFymtb4%3D
-
Stulemeijer IJE, Pike BL, Faber AW, Verzijlbergen KF, Welsem T, Van, Frederiks F et al. Dot1 binding induces chromatin rearrangements by histone methylation- dependent and -independent mechanisms. Epigenetics Chromatin 2011; 4: 2. DOI: 10.1186/1756-8935-4-2
-
(2011)
Epigenetics Chromatin
, vol.4
, pp. 2
-
-
Stulemeijer, I.J.E.1
Pike, B.L.2
Faber, A.W.3
Verzijlbergen, K.F.4
Welsem, T.5
Van, Frederiks, F.6
-
51
-
-
84897984812
-
Involvement of DOT1L in the remodeling of heterochromatin configuration during early preimplantation development in mice
-
Ooga M, Suzuki MG, Aoki F. Involvement of DOT1L in the remodeling of heterochromatin configuration during early preimplantation development in mice. Biol Reprod 2013; 89: 1–10. DOI: 10.1095/biolreprod.113.113258
-
(2013)
Biol Reprod
, vol.89
, pp. 1-10
-
-
Ooga, M.1
Suzuki, M.G.2
Aoki, F.3
-
52
-
-
84869221559
-
Human histone H3K79 methyltransferase DOT1L protein binds actively transcribing RNA polymerase II to regulate gene expression
-
COI: 1:CAS:528:DC%2BC38Xhs12lu7fE
-
Kim S-K, Jung I, Lee H, Kang K, Kim M, Jeong K et al. Human histone H3K79 methyltransferase DOT1L protein binds actively transcribing RNA polymerase II to regulate gene expression. J Biol Chem 2012; 287: 39698–39709. DOI: 10.1074/jbc.M112.384057
-
(2012)
J Biol Chem
, vol.287
, pp. 39698-39709
-
-
Kim, S.-K.1
Jung, I.2
Lee, H.3
Kang, K.4
Kim, M.5
Jeong, K.6
-
53
-
-
2642570305
-
The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote
-
Schübeler D, MacAlpine DM, Scalzo D, Wirbelauer C, Kooperberg C, van Leeuwen F et al. The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. Genes Dev 2004; 18: 1263–1271. DOI: 10.1101/gad.1198204
-
(2004)
Genes Dev
, vol.18
, pp. 1263-1271
-
-
Schübeler, D.1
MacAlpine, D.M.2
Scalzo, D.3
Wirbelauer, C.4
Kooperberg, C.5
van Leeuwen, F.6
-
54
-
-
33645459867
-
Aldosterone-sensitive repression of ENaCα transcription by a histone H3 lysine-79 methyltransferase
-
Zhang W, Xia X, Jalal D. Aldosterone-sensitive repression of ENaCα transcription by a histone H3 lysine-79 methyltransferase. Am J Physiol Cell Physiol 2006; 77030: 936–946. DOI: 10.1152/ajpcell.00431.2005
-
(2006)
Am J Physiol Cell Physiol
, vol.77030
, pp. 936-946
-
-
Zhang, W.1
Xia, X.2
Jalal, D.3
-
55
-
-
84880817785
-
The ZFP-1(AF10)/DOT-1 complex opposes H2B ubiquitination to reduce Pol II transcription
-
COI: 1:CAS:528:DC%2BC3sXhtVWlsr7N
-
Cecere G, Hoersch S, Jensen MB, Dixit S, Grishok A. The ZFP-1(AF10)/DOT-1 complex opposes H2B ubiquitination to reduce Pol II transcription. Mol Cell 2013; 50: 894–907. DOI: 10.1016/j.molcel.2013.06.002
-
(2013)
Mol Cell
, vol.50
, pp. 894-907
-
-
Cecere, G.1
Hoersch, S.2
Jensen, M.B.3
Dixit, S.4
Grishok, A.5
-
56
-
-
53549124960
-
The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure
-
COI: 1:CAS:528:DC%2BD1cXht1Sisb7K
-
Lu X, Simon MD, Chodaparambil JV, Hansen JC, Shokat KM, Luger K. The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure. Nat Struct Mol Biol 2008; 15: 1122–1124. DOI: 10.1038/nsmb.1489
-
(2008)
Nat Struct Mol Biol
, vol.15
, pp. 1122-1124
-
-
Lu, X.1
Simon, M.D.2
Chodaparambil, J.V.3
Hansen, J.C.4
Shokat, K.M.5
Luger, K.6
-
57
-
-
84883385816
-
The tudor protein survival motor neuron (SMN) is a chromatin-binding protein that interacts with methylated histone H3 lysine 79
-
COI: 1:CAS:528:DC%2BC3sXhsFeksrzO
-
Sabra M, Texier P, El Maalouf J, Lomonte P. The tudor protein survival motor neuron (SMN) is a chromatin-binding protein that interacts with methylated histone H3 lysine 79. J Cell Sci 2013; 126: 3664–3677. DOI: 10.1242/jcs.126003
-
(2013)
J Cell Sci
, vol.126
, pp. 3664-3677
-
-
Sabra, M.1
Texier, P.2
El Maalouf, J.3
Lomonte, P.4
-
58
-
-
29144463310
-
Spinal muscular atrophy: a deficiency in a ubiquitous protein; a motor neuron-specific disease
-
COI: 1:CAS:528:DC%2BD28XivFSltQ%3D%3D
-
Monani UR. Spinal muscular atrophy: a deficiency in a ubiquitous protein; a motor neuron-specific disease. Neuron 2005; 48: 885–896. DOI: 10.1016/j.neuron.2005.12.001
-
(2005)
Neuron
, vol.48
, pp. 885-896
-
-
Monani, U.R.1
-
59
-
-
84883132550
-
lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs
-
COI: 1:CAS:528:DC%2BC3sXhtlWisrbN
-
Yang L, Lin C, Jin C, Yang JC, Tanasa B, Li W et al. lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs. Nature 2013; 500: 598–602. DOI: 10.1038/nature12451
-
(2013)
Nature
, vol.500
, pp. 598-602
-
-
Yang, L.1
Lin, C.2
Jin, C.3
Yang, J.C.4
Tanasa, B.5
Li, W.6
-
60
-
-
77949409084
-
Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)
-
COI: 1:CAS:528:DC%2BC3cXktFOks74%3D
-
Mohan M, Herz H-M, Takahashi Y-H, Lin C, Lai KC, Zhang Y et al. Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom). Genes Dev 2010; 24: 574–589. DOI: 10.1101/gad.1898410
-
(2010)
Genes Dev
, vol.24
, pp. 574-589
-
-
Mohan, M.1
Herz, H.-M.2
Takahashi, Y.-H.3
Lin, C.4
Lai, K.C.5
Zhang, Y.6
-
61
-
-
78649920369
-
The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis
-
Mahmoudi T, Boj SF, Hatzis P, Li VSW, Taouatas N, Vries RGJ et al. The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis. PLoS Biol 2010; 8: e1000539. DOI: 10.1371/journal.pbio.1000539
-
(2010)
PLoS Biol
, vol.8
-
-
Mahmoudi, T.1
Boj, S.F.2
Hatzis, P.3
Li, V.S.W.4
Taouatas, N.5
Vries, R.G.J.6
-
62
-
-
84864924323
-
Histone H3K79 methyltransferase Dot1L is directly activated by thyroid hormone receptor during Xenopus metamorphosis
-
COI: 1:CAS:528:DC%2BC38XhslKjtLbF
-
Matsuura K, Fujimoto K, Das B, Fu L, Lu CD, Shi Y. Histone H3K79 methyltransferase Dot1L is directly activated by thyroid hormone receptor during Xenopus metamorphosis. Cell Biosci 2012; 2: 25. DOI: 10.1186/2045-3701-2-25
-
(2012)
Cell Biosci
, vol.2
, pp. 25
-
-
Matsuura, K.1
Fujimoto, K.2
Das, B.3
Fu, L.4
Lu, C.D.5
Shi, Y.6
-
63
-
-
0029933616
-
Amphibian metamorphosis: An exquisite model for hormonal regulation of postembryonic development in vertebrates
-
COI: 1:CAS:528:DyaK28XkvVOmu70%3D
-
Tata JR. Amphibian metamorphosis: An exquisite model for hormonal regulation of postembryonic development in vertebrates. Dev Growth Differ 1996; 38: 223–231. DOI: 10.1046/j.1440-169X.1996.t01-2-00001.x
-
(1996)
Dev Growth Differ
, vol.38
, pp. 223-231
-
-
Tata, J.R.1
-
64
-
-
64049113786
-
Overexpression of grappa encoding a histone methyltransferase enhances stress resistance in Drosophila
-
List O, Togawa T, Tsuda M, Matsuo T, Elard L, Aigaki T. Overexpression of grappa encoding a histone methyltransferase enhances stress resistance in Drosophila. Hereditas 2009; 146: 19–28. DOI: 10.1111/j.1601-5223.2008.02080.x
-
(2009)
Hereditas
, vol.146
, pp. 19-28
-
-
List, O.1
Togawa, T.2
Tsuda, M.3
Matsuo, T.4
Elard, L.5
Aigaki, T.6
|