Dot1 binding induces chromatin rearrangements by histone methylation-dependent and -independent mechanisms

Epigenetics and Chromatin

Volumn 4, Issue 1, 2011, Pages

  Stulemeijer, Iris J E ^a   Pike, Brietta L ^b   Faber, Alex W ^a   Verzijlbergen, Kitty F ^a   Van Welsem, Tibor ^a   Frederiks, Floor ^a   Lenstra, Tineke L ^c   Holstege, Frank C P ^c   Gasser, Susan M ^b   Van Leeuwen, Fred ^a,c  

^a NETHERLANDS PROTEOMICS CENTRE   (Netherlands)

^b FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE ACETYLTRANSFERASE GCN5; HISTONE H3; HYBRID PROTEIN; PROTEIN DOT1; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL NUCLEUS; CHROMATIN ASSEMBLY AND DISASSEMBLY; GENE EXPRESSION; GENE REPRESSION; GENE SILENCING; HISTONE METHYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; TELOMERE;

EID: 79551545956     PISSN: None     EISSN: 17568935     Source Type: Journal    
DOI: 10.1186/1756-8935-4-2     Document Type: Article

References (98)

1. Covalent modifications of histones during development and disease pathogenesis. SR Bhaumik E Smith A Shilatifard, Nat (Pubitemid 350060343)
2. Dot1p modulates silencing in yeast by methylation of the nucleosome core. F van Leeuwen PR Gafken DE Gottschling, Cell 2002 109 745 756 10.1016/S0092-8674(02)00759-6 12086673 (Pubitemid 34727348)
3. Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation. JM Schulze J Jackson S Nakanishi JM Gardner T Hentrich J Haug M Johnston SL Jaspersen MS Kobor A Shilatifard, Mol Cell 2009 35 626 641 10.1016/j.molcel. 2009.07.017 19682934
4. The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. D Schubeler DM MacAlpine D Scalzo C Wirbelauer C Kooperberg F van Leeuwen DE Gottschling LP O'Neill BM Turner J Delrow,, et al. Genes Dev 2004 18 1263 1271 10.1101/gad.1198204 15175259 (Pubitemid 38720594)
5. DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. D Steger M Lefterova L Ying A Stonestrom M Schupp D Zhuo A Vakoc J Kim J Chen M Lazar,, et al. Mol Cell Biol 2008 28 2825 2839 10.1128/MCB.02076-07 18285465 (Pubitemid 351542379)
6. Histone H2B ubiquitylation controls processive methylation but not monomethylation by Dot1 and Set1. MD Shahbazian K Zhang M Grunstein, Mol Cell 2005 19 271 277 10.1016/j.molcel.2005.06.010 16039595 (Pubitemid 41019673)
7. Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: A potential mechanism for position-effect variegation. HH Ng D Ciccone K Morshead M Oettinger K Struhl, Proc Natl Acad Sci USA 2003 100 1820 1825 10.1073/pnas.0437846100 12574507 (Pubitemid 36254532)
8. The leukemia-associated Mllt10/Af10-Dot1l Are Tcf4/beta-catenin coactivators essential for intestinal homeostasis. T Mahmoudi SF Boj P Hatzis VS Li N Taouatas RG Vries H Teunissen H Begthel J Korving S Mohammed,, et al. PLoS Biol 2010 8 1000539 10.1371/journal.pbio.1000539 21103407
9. Impaired recruitment of the histone methyltransferase DOT1L contributes to the incomplete reactivation of tumor suppressor genes upon DNA demethylation. FV Jacinto E Ballestar M Esteller, Oncogene 2009 28 4212 4224 10.1038/onc.2009.267 19734945
10. MLL translocations, histone modifications and leukaemia stem-cell development. AV Krivtsov SA Armstrong, Nat Rev Cancer 2007 7 823 833 10.1038/nrc2253 17957188 (Pubitemid 350006257)
11. H3K79 methylation profiles define murine and human MLL-AF4 leukemias. AV Krivtsov Z Feng ME Lemieux J Faber S Vempati AU Sinha X Xia J Jesneck AP Bracken LB Silverman,, et al. Cancer Cell 2008 14 355 368 10.1016/j.ccr.2008.10.001 18977325
12. Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia. M Guenther L Lawton T Rozovskaia G Frampton S Levine T Volkert C Croce T Nakamura E Canaani R Young, Genes Dev 2008 22 3403 3408 10.1101/gad.1741408 19141473
13. Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L. Y Okada Q Jiang M Lemieux L Jeannotte L Su Y Zhang, Nat Cell Biol 2006 8 1017 1024 10.1038/ncb1464 16921363 (Pubitemid 44314734)
14. Sirtuin 1 functionally and physically interacts with disruptor of telomeric silencing-1 to regulate -ENaC transcription in collecting duct. D Zhang S Li P Cruz B Kone, J Biol Chem 2009 284 20917 20926 10.1074/jbc.M109. 020073 19491102
15. Characterization of the grappa gene, the Drosophila histone H3 lysine 79 methyltransferase. G Shanower M Muller J Blanton V Honti H Gyurkovics P Schedl, Genetics 2005 169 173 184 10.1534/genetics.104.033191 15371351 (Pubitemid 40239162)
16. An elaborate pathway required for Ras-mediated epigenetic silencing. C Gazin N Wajapeyee S Gobeil CM Virbasius MR Green, Nature 2007 449 1073 1077 10.1038/nature06251 17960246 (Pubitemid 350014604)
17. Allele-specific H3K79 Di- versus trimethylation distinguishes opposite parental alleles at imprinted regions. P Singh L Han GE Rivas DH Lee TB Nicholson GP Larson T Chen PE Szabo, Mol Cell Biol 2010 30 2693 2707 10.1128/MCB.01537-09 20351169
18. A histone methyltransferase modulates antigenic variation in African trypanosomes. L Figueiredo C Janzen G Cross, PLoS Biol 2008 6 161 10.1371/journal.pbio.0060161 18597556
19. The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure. B Jones H Su A Bhat H Lei J Bajko S Hevi GA Baltus S Kadam H Zhai R Valdez,, et al. PLoS Genet 2008 4 1000190 10.1371/journal.pgen.1000190 18787701
20. The establishment, inheritance, and function of silenced chromatin in Saccharomyces cerevisiae. LN Rusche AL Kirchmaier J Rine, Annu Rev Biochem 2003 72 481 516 10.1146/annurev.biochem.72.121801.161547 12676793 (Pubitemid 36930453)
21. Nonprocessive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation states. F Frederiks M Tzouros G Oudgenoeg T van Welsem M Fornerod J Krijgsveld F van Leeuwen, Nat Struct Mol Biol 2008 15 550 557 10.1038/nsmb.1432 18511943 (Pubitemid 351799139)
22. Silent information regulator 3: the Goldilocks of the silencing complex. A Norris JD Boeke, Genes Dev 2010 24 115 122 10.1101/gad.1865510 20080949
23. Role for the silencing protein Dot1 in meiotic checkpoint control. PA San Segundo GS Roeder, Mol Biol Cell 2000 11 3601 3615 11029058
24. Multiple histone modifications in euchromatin promote heterochromatin formation by redundant mechanisms in Saccharomyces cerevisiae. KF Verzijlbergen AW Faber IJE Stulemeijer F van Leeuwen, BMC Molecular Biology 2009 10 10.1186/1471-2199-10-76 19638198
25. Synthetic lethal screens in yeast identify gene silencing pathways and implicate the acetylated amino terminus of Sir3 in recognition of the nucleosome core. T van Welsem F Frederiks KF Verzijlbergen AW Faber Z Nelson DA Egan DE Gottschling F van Leeuwen, Mol Cell Biol 2008 28 3861 3872 10.1128/MCB.02050-07 18391024 (Pubitemid 351732918)
26. A charge-based interaction between histone H4 and Dot1 is required for H3K79 methylation and telomere silencing: identification of a new trans-histone pathway. I Fingerman H Li S Briggs, Genes Dev 2007 21 2018 2029 10.1101/gad.1560607 17675446 (Pubitemid 47267288)
27. Interplay of chromatin modifiers on a short basic patch of histone H4 tail defines the boundary of telomeric heterochromatin. M Altaf RT Utley N Lacoste S Tan SD Briggs J Cote, Mol Cell 2007 28 1002 1014 10.1016/j.molcel. 2007.12.002 18158898 (Pubitemid 350297030)
28. Histone chaperone Chz1p regulates H2B ubiquitination and subtelomeric anti-silencing. Y Wan JH Chiang CH Lin CE Arens RA Saleem JJ Smith JD Aitchison, Nucleic Acids Res 2010 38 1431 1440 10.1093/nar/gkp1099 20008511
29. Repressive and non-repressive chromatin at native telomeres in Saccharomyces cerevisiae. ER Loney PW Inglis S Sharp FE Pryde NA Kent J Mellor EJ Louis, Epigenetics Chromatin 2009 2 18 10.1186/1756-8935-2-18 19954519
30. Ubp10/Dot4p regulates the persistence of ubiquitinated histone H2B: distinct roles in telomeric silencing and general chromatin. R Gardner Z Nelson D Gottschling, Mol Cell Biol 2005 25 6123 6139 10.1128/MCB.25.14.6123-6139.2005 15988024 (Pubitemid 40946563)
31. Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing. NC Emre K Ingvarsdottir A Wyce A Wood NJ Krogan KW Henry K Li R Marmorstein JF Greenblatt A Shilatifard,, et al. Mol Cell 2005 17 585 594 10.1016/j.molcel.2005.01.007 15721261 (Pubitemid 40269122)
32. Reconstitution of yeast silent chromatin: Multiple contact sites and O-AADPR binding load SIR complexes onto nucleosomes in vitro. F Martino S Kueng P Robinson M Tsai-Pflugfelder F van Leeuwen M Ziegler F Cubizolles M Cockell D Rhodes S Gasser, Mol Cell 2009 33 323 334 10.1016/j.molcel.2009.01.009 19217406
33. Role of the conserved Sir3-BAH domain in nucleosome binding and silent chromatin assembly. M Onishi GG Liou JR Buchberger T Walz D Moazed, Mol Cell 2007 28 1015 1028 10.1016/j.molcel.2007.12.004 18158899 (Pubitemid 350297032)
34. The establishment of gene silencing at single-cell resolution. EA Osborne S Dudoit J Rine, Nat Genet 2009 41 800 806 10.1038/ng.402 19543267
35. Reconstitution of heterochromatin-dependent transcriptional gene silencing. A Johnson G Li TW Sikorski S Buratowski CL Woodcock D Moazed, Mol Cell 2009 35 769 781 10.1016/j.molcel.2009.07.030 19782027
36. Heterochromatin formation involves changes in histone modifications over multiple cell generations. Y Katan-Khaykovich K Struhl, EMBO J 2005 24 2138 2149 10.1038/sj.emboj.7600692 15920479 (Pubitemid 40961798)
37. Functional discovery via a compendium of expression profiles. TR Hughes MJ Marton AR Jones CJ Roberts R Stoughton CD Armour HA Bennett E Coffey H Dai YD He,, et al. Cell 2000 102 109 126 10.1016/S0092-8674(00)00015-5 10929718
38. Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles. CJ Roberts B Nelson MJ Marton R Stoughton MR Meyer HA Bennett YD He H Dai WL Walker TR Hughes,, et al. Science 2000 287 873 880 10.1126/science.287.5454.873 10657304 (Pubitemid 30084333)
39. Chromatin assembly factor 1 interacts with histone H3 methylated at lysine 79 in the processes of epigenetic silencing and DNA repair. H Zhou BJ Madden DC Muddiman Z Zhang, Biochemistry 2006 45 2852 2861 10.1021/bi0521083 16503640 (Pubitemid 43334534)
40. Design of a minimal silencer for the silent mating-type locus HML of Saccharomyces cerevisiae. J Weber A Ehrenhofer-Murray, Nucleic Acids Res 2010 kq689
41. Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10 positive leukemias. Y Lin P Kakadia Y Chen Y Li A Deshpande C Buske K Zhang Y Zhang G Xu S Bohlander, Blood 2009 114 651 658 10.1182/blood-2009-03-209395 19443658
42. Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression. BD Strahl PA Grant SD Briggs ZW Sun JR Bone JA Caldwell S Mollah RG Cook J Shabanowitz DF Hunt,, et al. Mol Cell Biol 2002 22 1298 1306 10.1128/MCB.22.5.1298-1306.2002 11839797 (Pubitemid 34150767)
43. Chromosome ends: different sequences may provide conserved functions. EJ Louis AV Vershinin, Bioessays 2005 27 685 697 10.1002/bies.20259 15954099 (Pubitemid 41153353)
44. Assays for gene silencing in yeast. F van Leeuwen DE Gottschling, Methods Enzymol 2002 350 165 186 full-text 12073311 (Pubitemid 34619490)
45. Barrier proteins remodel and modify chromatin to restrict silenced domains. M Oki L Valenzuela T Chiba T Ito R Kamakaka, Mol Cell Biol 2004 24 1956 1967 10.1128/MCB.24.5.1956-1967.2004 14966276 (Pubitemid 38248936)
46. Multiple bromodomain genes are involved in restricting the spread of heterochromatic silencing at the Saccharomyces cerevisiae HMR-tRNA boundary. N Jambunathan AW Martinez EC Robert NB Agochukwu ME Ibos SL Dugas D Donze, Genetics 2005 171 913 922 10.1534/genetics.105.046938 16079223 (Pubitemid 43234832)
47. Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation. J Zhou B Zhou B Lenzmeier J Zhou, Nucleic Acids Res 2009 37 3699 3713 10.1093/nar/gkp233 19372273
48. Rpd3-dependent boundary formation at telomeres by removal of Sir2 substrate. S Ehrentraut JM Weber JN Dybowski D Hoffmann AE Ehrenhofer-Murray, Proc Natl Acad Sci USA 2010 107 5522 5527 10.1073/pnas.0909169107 20133733
49. Structural and dynamic functions establish chromatin domains. K Ishii U Laemmli, Mol Cell 2003 11 237 248 10.1016/S1097-2765(03)00010-8 12535536 (Pubitemid 36126604)
50. Telomere looping permits gene activation by a downstream UAS in yeast. D de Bruin Z Zaman R Liberatore M Ptashne, Nature 2001 409 109 113 10.1038/35051119 11343124 (Pubitemid 32098635)
51. A targeted histone acetyltransferase can create a sizable region of hyperacetylated chromatin and counteract the propagation of transcriptionally silent chromatin. YH Chiu Q Yu JJ Sandmeier X Bi, Genetics 2003 165 115 125 14504221 (Pubitemid 37204059)
52. Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferase. K Sawada Z Yang JR Horton RE Collins X Zhang X Cheng, J Biol Chem 2004 279 43296 43306 10.1074/jbc.M405902200 15292170 (Pubitemid 39372225)
53. Subtelomeric elements influence but do not determine silencing levels at Saccharomyces cerevisiae telomeres. MA Mondoux VA Zakian, Genetics 2007 177 2541 2546 10.1534/genetics.107.079806 18073447 (Pubitemid 350277027)
54. Cohabitation of insulators and silencing elements in yeast subtelomeric regions. G Fourel E Revardel CE Koering E Gilson, EMBO J 1999 18 2522 2537 10.1093/emboj/18.9.2522 10228166 (Pubitemid 29213284)
55. A core nucleosome surface crucial for transcriptional silencing. JH Park MS Cosgrove E Youngman C Wolberger JD Boeke, Nat Genet 2002 32 273 279 10.1038/ng982 12244315
56. Mechanism of the long range anti-silencing function of targeted histone acetyltransferases in yeast. Q Yu J Sandmeier H Xu Y Zou X Bi, J Biol Chem 2006 281 3980 3988 10.1074/jbc.M510140200 16368686 (Pubitemid 43847822)
57. Molecular requirements for gene expression mediated by targeted histone acetyltransferases. S Jacobson L Pillus, Mol Cell Biol 2004 24 6029 6039 10.1128/MCB.24.13.6029-6039.2004 15199156 (Pubitemid 38787985)
58. RNA polymerase III and RNA polymerase II promoter complexes are heterochromatin barriers in Saccharomyces cerevisiae. D Donze RT Kamakaka, EMBO J 2001 20 520 531 10.1093/emboj/20.3.520 11157758 (Pubitemid 32126987)
59. Autoregulation of the Rsc4 tandem bromodomain by Gcn5 acetylation. A VanDemark M Kasten E Ferris A Heroux C Hill B Cairns, Mol Cell 2007 27 817 828 10.1016/j.molcel.2007.08.018 17803945 (Pubitemid 47333230)
60. Transcription and the nuclear periphery: edge of darkness? E Deniaud WA Bickmore, Curr Opin Genet Dev 2009 19 187 191 10.1016/j.gde.2009.01.005 19231154
61. The nuclear envelope - a scaffold for silencing? BD Towbin P Meister SM Gasser, Curr Opin Genet Dev 2009 19 180 186 10.1016/j.gde.2009.01.006 19303765
62. Connecting the transcription site to the nuclear pore: a multi-tether process that regulates gene expression. G Dieppois F Stutz, J Cell Sci 2010 123 1989 1999 10.1242/jcs.053694 20519581
63. The nuclear envelope in genome organization, expression and stability. K Mekhail D Moazed, Nat Rev Mol Cell Biol 2010 11 317 328 10.1038/nrm2894 20414256
64. The functional importance of telomere clustering: global changes in gene expression result from SIR factor dispersion. A Taddei G Van Houwe S Nagai I Erb E van Nimwegen SM Gasser, Genome Res 2009 19 611 625 10.1101/gr.083881.108 19179643
65. Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation. RK McGinty J Kim C Chatterjee RG Roeder TW Muir, Nature 2008 453 812 816 10.1038/nature06906 18449190 (Pubitemid 351793779)
66. Crosstalk among histone modifications. T Suganuma J Workman, Cell 2008 135 604 607 10.1016/j.cell.2008.10.036 19013272
67. Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79. HH Ng RM Xu Y Zhang K Struhl, J Biol Chem 2002 277 34655 34657 10.1074/jbc.C200433200 12167634
68. The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation. NJ Krogan J Dover A Wood J Schneider J Heidt MA Boateng K Dean OW Ryan A Golshani M Johnston,, et al. Mol Cell 2003 11 721 729 10.1016/S1097-2765(03)00091-1 12667454 (Pubitemid 36385125)
69. The Rtf1 component of the Paf1 transcriptional elongation complex is required for ubiquitination of histone H2B. HH Ng S Dole K Struhl, J Biol Chem 2003 278 33625 33628 10.1074/jbc.C300270200 12876293 (Pubitemid 37553194)
70. Gene silencing: trans-histone regulatory pathway in chromatin. SD Briggs T Xiao ZW Sun JA Caldwell J Shabanowitz DF Hunt CD Allis BD Strahl, Nature 2002 418 498 10.1038/nature00970 12152067 (Pubitemid 34851387)
71. A role for gcn5-mediated global histone acetylation in transcriptional regulation. RM Imoberdorf I Topalidou M Strubin, Mol Cell Biol 2006 26 1610 1616 10.1128/MCB.26.5.1610-1616.2006 16478983
72. Untargeted tail acetylation of histones in chromatin: lessons from yeast. RM Friis MC Schultz, Biochem Cell Biol 2009 87 107 116 10.1139/O08-097 19234527
73. Analysis of transcriptional activation at a distance in Saccharomyces cerevisiae. KC Dobi F Winston, Mol Cell Biol 2007 27 5575 5586 10.1128/MCB.00459-07 17526727 (Pubitemid 47124409)
74. We gather together: insulators and genome organization. JA Wallace G Felsenfeld, Curr Opin Genet Dev 2007 17 400 407 10.1016/j.gde.2007.08.005 17913488 (Pubitemid 350016897)
75. Perinuclear localization of chromatin facilitates transcriptional silencing. ED Andrulis AM Neiman DC Zappulla R Sternglanz, Nature 1998 394 592 595 10.1038/29100 9707122 (Pubitemid 28366836)
76. Evidence for silencing compartments within the yeast nucleus: a role for telomere proximity and Sir protein concentration in silencer-mediated repression. L Maillet C Boscheron M Gotta S Marcand E Gilson SM Gasser, Genes Dev 1996 10 1796 1811 10.1101/gad.10.14.1796 8698239 (Pubitemid 26272385)
77. Gene regulation through nuclear organization. T Sexton H Schober P Fraser SM Gasser, Nat Struct Mol Biol 2007 14 1049 1055 10.1038/nsmb1324 17984967 (Pubitemid 350060340)
78. The nuclear envelope and transcriptional control. A Akhtar SM Gasser, Nat Rev Genet 2007 8 507 517 10.1038/nrg2122 17549064 (Pubitemid 46955211)
79. Yeast silent mating type loci form heterochromatic clusters through silencer protein-dependent long-range interactions. A Miele K Bystricky J Dekker, PLoS Genet 2009 5 1000478 10.1371/journal.pgen.1000478 19424429
80. Separation of silencing from perinuclear anchoring functions in yeast Ku80, Sir4 and Esc1 proteins. A Taddei F Hediger FR Neumann C Bauer SM Gasser, EMBO J 2004 23 1301 1312 10.1038/sj.emboj.7600144 15014445 (Pubitemid 38525002)
81. Protosilencers in Saccharomyces cerevisiae subtelomeric regions. E Lebrun E Revardel C Boscheron R Li E Gilson G Fourel, Genetics 2001 158 167 176 11333227 (Pubitemid 32428639)
82. Limitations of silencing at native yeast telomeres. FE Pryde EJ Louis, EMBO J 1999 18 2538 2550 10.1093/emboj/18.9.2538 10228167 (Pubitemid 29213285)
83. Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae. MS Singer A Kahana AJ Wolf LL Meisinger SE Peterson C Goggin M Mahowald DE Gottschling, Genetics 1998 150 613 632 9755194 (Pubitemid 28463040)
84. Tethered Sir3p nucleates silencing at telomeres and internal loci in Saccharomyces cerevisiae. AJ Lustig C Liu C Zhang JP Hanish, Mol Cell Biol 1996 16 2483 2495 8628316 (Pubitemid 26124451)
85. Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription. DE Gottschling OM Aparicio BL Billington VA Zakian, Cell 1990 63 751 762 10.1016/0092-8674(90)90141-Z 2225075 (Pubitemid 120035048)
86. Formation of boundaries of transcriptionally silent chromatin by nucleosome-excluding structures. X Bi Q Yu JJ Sandmeier Y Zou, Mol Cell Biol 2004 24 2118 2131 10.1128/MCB.24.5.2118-2131.2004 14966290 (Pubitemid 38248950)
87. An improved genetic system for detection and analysis of protein nuclear import signals. K Marshall Z Zhang J Curran S Derbyshire J Mymryk, BMC Molecular Biology 2007 8 6 10.1186/1471-2199-8-6 17254328
88. A genetic system for detection of protein nuclear import and export. Y Rhee F Gurel Y Gafni C Dingwall V Citovsky, Nat Biotech 2000 18 433 437 10.1038/74500 (Pubitemid 30217533)
89. Three new dominant drug resistance cassettes for gene disruption in Saccharomyces cerevisiae. AL Goldstein JH McCusker, Yeast 1999 15 1541 1553 10.1002/(SICI)1097-0061(199910)15:14<1541::AID-YEA476>3.0.CO;2-K 10514571 (Pubitemid 29472165)
90. Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. CB Brachmann A Davies GJ Cost E Caputo J Li P Hieter JD Boeke, Yeast 1998 14 115 132 10.1002/(SICI)1097-0061(19980130)14:2<115::AID- YEA204>3.0.CO;2-2 9483801 (Pubitemid 28062863)
91. Sequence determinants for regulated degradation of yeast 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. R Gardner S Cronin B Leader J Rine R Hampton, Mol Biol Cell 1998 9 2611 2626 9725915 (Pubitemid 28425897)
92. A consensus of core protein complex compositions for Saccharomyces cerevisiae. JJ Benschop N Brabers D van Leenen LV Bakker HW van Deutekom NL van Berkum E Apweiler P Lijnzaad FC Holstege P Kemmeren, Mol Cell 2010 38 916 928 10.1016/j.molcel.2010.06.002 20620961
93. Nuclear pore association confers optimal expression levels for an inducible yeast gene. A Taddei G Van Houwe F Hediger V Kalck F Cubizolles H Schober S Gasser, Nature 2006 441 774 778 10.1038/nature04845 16760983 (Pubitemid 43865226)
94. Snf1p-dependent Spt-Ada-Gcn5-acetyltransferase (SAGA) recruitment and chromatin remodeling activities on the HXT2 and HXT4 promoters. CJ van Oevelen HA van Teeffelen FJ van Werven HT Timmers, J Biol Chem 2006 281 4523 4531 10.1074/jbc.M509330200 16368692 (Pubitemid 43847884)
95. Histone acetylation regulates the time of replication origin firing. M Vogelauer L Rubbi I Lucas BJ Brewer M Grunstein, Mol Cell 2002 10 1223 1233 10.1016/S1097-2765(02)00702-5 12453428 (Pubitemid 35453838)
96. Gcn4 activator targets Gcn5 histone acetyltransferase to specific promoters independently of transcription. MH Kuo E vom Baur K Struhl CD Allis, Mol Cell 2000 6 1309 1320 10.1016/S1097-2765(00)00129-5 11163205 (Pubitemid 32045924)
97. A multiplicity of coactivators is required by Gcn4p at individual promoters in vivo. MJ Swanson H Qiu L Sumibcay A Krueger SJ Kim K Natarajan S Yoon AG Hinnebusch, Mol Cell Biol 2003 23 2800 2820 10.1128/MCB.23.8.2800-2820. 2003 12665580 (Pubitemid 36403079)
98. Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase. J Min Q Feng Z Li Y Zhang RM Xu, Cell 2003 112 711 723 10.1016/S0092-8674(03)00114-4 12628190 (Pubitemid 36331782)