Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 21, 2012, Pages 8218-8223

  Castaño Betancourt, Martha C ^a,b   Cailotto, Frederic ^c   Kerkhof, Hanneke J ^a,b   Cornelis, Frederique M F ^c   Doherty, Sally A ^d   Hart, Deborah J ^e   Hofman, Albert ^a   Luyten, Frank P ^c,f   Maciewicz, Rose A ^g   Mangino, Massimo ^e   Metrustry, Sarah ^e   Muir, Kenneth ^h   Peters, Marjolein J ^a,b   Rivadeneira, Fernando ^a,b   Wheeler, Maggie ^d   Zhang, Weiya ^d   Arden, Nigel ⁱ   Spector, Tim D ^e   Uitterlinden, Andre G ^a,b   Doherty, Michael ^d   Lories, Rik J U ^c,f   Valdes, Ana M ^e   Van Meurs, Joyce B J ^a,b   more..

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Netherlands Genomics Initiative   (Netherlands)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^e ST THOMAS HOSPITAL   (United Kingdom)

^f UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^g ASTRAZENECA   (United Kingdom)

^h UNIVERSITY OF WARWICK   (United Kingdom)

ⁱ UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Common variant; Complex disease; Joint development; Pleiotropism; Synovial joint

Indexed keywords

HISTONE METHYLTRANSFERASE; PROTEOGLYCAN; WNT PROTEIN;

ALLELE; ANIMAL TISSUE; ARTICLE; BONE MINERALIZATION; CARTILAGE; CELL CULTURE; CHONDROGENESIS; CHROMOSOME 19P; DOT1L GENE; GENE; GENE ACTIVATION; GENE EXPRESSION; GENE IDENTIFICATION; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HIP OSTEOARTHRITIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; JOINT CAVITY; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED KINGDOM;

AGE FACTORS; ANIMALS; CARTILAGE, ARTICULAR; CELL LINE; CHONDROCYTES; CHONDROGENESIS; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HUMANS; METHYLTRANSFERASES; MICE; OSTEOARTHRITIS, HIP; RISK FACTORS; WNT SIGNALING PATHWAY;

EID: 84861422537     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1119899109     Document Type: Article

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