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Volumn 86, Issue 2, 2013, Pages 130-142

Targeting tumor neovasculature in non-small-cell lung cancer

Author keywords

Angiogenesis; Bevacizumab; NSCLC; VEGF; VEGFR

Indexed keywords

AFLIBERCEPT; AXITINIB; BEVACIZUMAB; BIOLOGICAL MARKER; CARBOPLATIN; CEDIRANIB; CISPLATIN; DOCETAXEL; ERLOTINIB; GEMCITABINE; MOTESANIB; N [2 [(4 HYDROXYPHENYL)AMINO] 3 PYRIDINYL] 4 METHOXYBENZENESULFONAMIDE; NINTEDANIB; PACLITAXEL; PAZOPANIB; PEMETREXED; PLACEBO; PROTEIN TYROSINE KINASE INHIBITOR; SORAFENIB; SUNITINIB; VADIMEZAN; VANDETANIB; VASCULAR TARGETING AGENT; VASCULOTROPIN;

EID: 84875119425     PISSN: 10408428     EISSN: 18790461     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2012.10.003     Document Type: Review
Times cited : (26)

References (96)
  • 2
    • 53749097825 scopus 로고    scopus 로고
    • Chemotherapy in addition to supportive care improves survival in advanced non-small-cell lung cancer: a systematic review and meta-analysis of individual patient data from 16 randomized controlled trials
    • Chemotherapy in addition to supportive care improves survival in advanced non-small-cell lung cancer: a systematic review and meta-analysis of individual patient data from 16 randomized controlled trials. Journal of Clinical Oncology 2008, 26:4617-4625.
    • (2008) Journal of Clinical Oncology , vol.26 , pp. 4617-4625
  • 3
    • 0037050355 scopus 로고    scopus 로고
    • Lung cancer - time to move on from chemotherapy
    • Carney D.N. Lung cancer - time to move on from chemotherapy. The New England Journal of Medicine 2002, 346:126-128.
    • (2002) The New England Journal of Medicine , vol.346 , pp. 126-128
    • Carney, D.N.1
  • 4
    • 0034076189 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis and arteriogenesis
    • Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nature Medicine 2000, 6:389-395.
    • (2000) Nature Medicine , vol.6 , pp. 389-395
    • Carmeliet, P.1
  • 5
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: an organizing principle for drug discovery?
    • Folkman J. Angiogenesis: an organizing principle for drug discovery?. Nature Reviews Drug Discovery 2007, 6:273-286.
    • (2007) Nature Reviews Drug Discovery , vol.6 , pp. 273-286
    • Folkman, J.1
  • 6
    • 0036984640 scopus 로고    scopus 로고
    • Role of angiogenesis in tumor growth and metastasis
    • Folkman J. Role of angiogenesis in tumor growth and metastasis. Seminars in Oncology 2002, 29:15-18.
    • (2002) Seminars in Oncology , vol.29 , pp. 15-18
    • Folkman, J.1
  • 8
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung D.W., Cachianes G., Kuang W.J., Goeddel D.V., Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989, 246:1306-1309.
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3    Goeddel, D.V.4    Ferrara, N.5
  • 9
    • 0031039243 scopus 로고    scopus 로고
    • The biology of vascular endothelial growth factor
    • Ferrara N., Davis-Smyth T. The biology of vascular endothelial growth factor. Endocrine Reviews 1997, 18:4-25.
    • (1997) Endocrine Reviews , vol.18 , pp. 4-25
    • Ferrara, N.1    Davis-Smyth, T.2
  • 11
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: basic science and clinical progress
    • Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocrine Reviews 2004, 25:581-611.
    • (2004) Endocrine Reviews , vol.25 , pp. 581-611
    • Ferrara, N.1
  • 12
    • 0030969559 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is associated with neovascularization and influences progression of non-small cell lung carcinoma
    • Fontanini G., Vignati S., Boldrini L., et al. Vascular endothelial growth factor is associated with neovascularization and influences progression of non-small cell lung carcinoma. Clinical Cancer Research 1997, 3:861-865.
    • (1997) Clinical Cancer Research , vol.3 , pp. 861-865
    • Fontanini, G.1    Vignati, S.2    Boldrini, L.3
  • 13
    • 0035863288 scopus 로고    scopus 로고
    • Vascular endothelial growth factor 189 mRNA isoform expression specifically correlates with tumor angiogenesis, patient survival, and postoperative relapse in non-small-cell lung cancer
    • Yuan A., Yu C.J., Kuo S.H., et al. Vascular endothelial growth factor 189 mRNA isoform expression specifically correlates with tumor angiogenesis, patient survival, and postoperative relapse in non-small-cell lung cancer. Journal of Clinical Oncology 2001, 19:432-441.
    • (2001) Journal of Clinical Oncology , vol.19 , pp. 432-441
    • Yuan, A.1    Yu, C.J.2    Kuo, S.H.3
  • 14
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
    • Jain R.K. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005, 307:58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 15
    • 69249160309 scopus 로고    scopus 로고
    • Targeted therapies in the treatment of advanced/metastatic NSCLC
    • Pallis A.G., Serfass L., Dziadziusko R., et al. Targeted therapies in the treatment of advanced/metastatic NSCLC. European Journal of Cancer 2009, 45:2473-2487.
    • (2009) European Journal of Cancer , vol.45 , pp. 2473-2487
    • Pallis, A.G.1    Serfass, L.2    Dziadziusko, R.3
  • 16
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A., Gray R., Perry M.C., et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. The New England Journal of Medicine 2006, 355:2542-2550.
    • (2006) The New England Journal of Medicine , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 17
    • 62449124416 scopus 로고    scopus 로고
    • Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil
    • Reck M., von Pawel J., Zatloukal P., et al. Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil. Journal of Clinical Oncology 2009, 27:1227-1234.
    • (2009) Journal of Clinical Oncology , vol.27 , pp. 1227-1234
    • Reck, M.1    von Pawel, J.2    Zatloukal, P.3
  • 18
    • 77951473661 scopus 로고    scopus 로고
    • Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL)
    • Reck M., von Pawel J., Zatloukal P., et al. Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL). Annals of Oncology 2010, 21:1804-1809.
    • (2010) Annals of Oncology , vol.21 , pp. 1804-1809
    • Reck, M.1    von Pawel, J.2    Zatloukal, P.3
  • 19
    • 37849052774 scopus 로고    scopus 로고
    • Outcomes for elderly, advanced-stage non small-cell lung cancer patients treated with bevacizumab in combination with carboplatin and paclitaxel: analysis of Eastern Cooperative Oncology Group Trial 4599
    • Ramalingam S.S., Dahlberg S.E., Langer C.J., et al. Outcomes for elderly, advanced-stage non small-cell lung cancer patients treated with bevacizumab in combination with carboplatin and paclitaxel: analysis of Eastern Cooperative Oncology Group Trial 4599. Journal of Clinical Oncology 2008, 26:60-65.
    • (2008) Journal of Clinical Oncology , vol.26 , pp. 60-65
    • Ramalingam, S.S.1    Dahlberg, S.E.2    Langer, C.J.3
  • 20
    • 78650515286 scopus 로고    scopus 로고
    • Efficacy and safety of bevacizumab-based therapy in elderly patients with advanced or recurrent nonsquamous non-small cell lung cancer in the phase III BO17704 study (AVAiL)
    • Leighl N.B., Zatloukal P., Mezger J., et al. Efficacy and safety of bevacizumab-based therapy in elderly patients with advanced or recurrent nonsquamous non-small cell lung cancer in the phase III BO17704 study (AVAiL). Journal of Thoracic Oncology 2010, 5:1970-1976.
    • (2010) Journal of Thoracic Oncology , vol.5 , pp. 1970-1976
    • Leighl, N.B.1    Zatloukal, P.2    Mezger, J.3
  • 21
    • 77955268612 scopus 로고    scopus 로고
    • Safety and efficacy of first-line bevacizumab-based therapy in advanced non-squamous non-small-cell lung cancer (SAiL, MO19390): a phase 4 study
    • Crino L., Dansin E., Garrido P., et al. Safety and efficacy of first-line bevacizumab-based therapy in advanced non-squamous non-small-cell lung cancer (SAiL, MO19390): a phase 4 study. Lancet Oncology 2010, 11:733-740.
    • (2010) Lancet Oncology , vol.11 , pp. 733-740
    • Crino, L.1    Dansin, E.2    Garrido, P.3
  • 22
    • 71949093186 scopus 로고    scopus 로고
    • Safety of first-line bevacizumab (bv) plus chemotherapy in elderly patients (pts) with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): MO19390 (SAIL) study group
    • abstr 240P
    • Jager E., Wu Y., Mezger J., et al. Safety of first-line bevacizumab (bv) plus chemotherapy in elderly patients (pts) with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): MO19390 (SAIL) study group. Annals of Oncology 2008, 19. abstr 240P.
    • (2008) Annals of Oncology , vol.19
    • Jager, E.1    Wu, Y.2    Mezger, J.3
  • 23
    • 78651107053 scopus 로고    scopus 로고
    • Sex differences in outcome with bevacizumab therapy: analysis of patients with advanced-stage non-small cell lung cancer treated with or without bevacizumab in combination with paclitaxel and carboplatin in the Eastern Cooperative Oncology Group Trial 4599
    • Brahmer J.R., Dahlberg S.E., Gray R.J., et al. Sex differences in outcome with bevacizumab therapy: analysis of patients with advanced-stage non-small cell lung cancer treated with or without bevacizumab in combination with paclitaxel and carboplatin in the Eastern Cooperative Oncology Group Trial 4599. Journal of Thoracic Oncology 2011, 6:103-108.
    • (2011) Journal of Thoracic Oncology , vol.6 , pp. 103-108
    • Brahmer, J.R.1    Dahlberg, S.E.2    Gray, R.J.3
  • 24
    • 79960183862 scopus 로고    scopus 로고
    • Clinical outcomes (CO) for special populations of patients (pts) with advanced non-small cell lung cancer (NSCLC): results from ARIES, a bevacizumab (BV) observational cohort study (OCS)
    • abstr 7618
    • Wozniak A., Garst J., Jahanzeb M., et al. Clinical outcomes (CO) for special populations of patients (pts) with advanced non-small cell lung cancer (NSCLC): results from ARIES, a bevacizumab (BV) observational cohort study (OCS). Journal of Clinical Oncology 2010, 28. abstr 7618.
    • (2010) Journal of Clinical Oncology , vol.28
    • Wozniak, A.1    Garst, J.2    Jahanzeb, M.3
  • 25
    • 70449725036 scopus 로고    scopus 로고
    • Safety of bevacizumab in patients with non-small-cell lung cancer and brain metastases
    • Socinski M.A., Langer C.J., Huang J.E., et al. Safety of bevacizumab in patients with non-small-cell lung cancer and brain metastases. Journal of Clinical Oncology 2009, 27:5255-5261.
    • (2009) Journal of Clinical Oncology , vol.27 , pp. 5255-5261
    • Socinski, M.A.1    Langer, C.J.2    Huang, J.E.3
  • 26
    • 78651060614 scopus 로고    scopus 로고
    • BRIDGE: an open-label phase II trial evaluating the safety of bevacizumab+carboplatin/paclitaxel as first-line treatment for patients with advanced, previously untreated, squamous non-small cell lung cancer
    • Hainsworth J.D., Fang L., Huang J.E., et al. BRIDGE: an open-label phase II trial evaluating the safety of bevacizumab+carboplatin/paclitaxel as first-line treatment for patients with advanced, previously untreated, squamous non-small cell lung cancer. Journal of Thoracic Oncology 2011, 6:109-114.
    • (2011) Journal of Thoracic Oncology , vol.6 , pp. 109-114
    • Hainsworth, J.D.1    Fang, L.2    Huang, J.E.3
  • 27
    • 77954428008 scopus 로고    scopus 로고
    • A multicenter, phase 2 study of vascular endothelial growth factor trap (Aflibercept) in platinum- and erlotinib-resistant adenocarcinoma of the lung
    • Leighl N.B., Raez L.E., Besse B., et al. A multicenter, phase 2 study of vascular endothelial growth factor trap (Aflibercept) in platinum- and erlotinib-resistant adenocarcinoma of the lung. Journal of Thoracic Oncology 2010, 5:1054-1059.
    • (2010) Journal of Thoracic Oncology , vol.5 , pp. 1054-1059
    • Leighl, N.B.1    Raez, L.E.2    Besse, B.3
  • 28
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm S.M., Carter C., Tang L., et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Research 2004, 64:7099-7109.
    • (2004) Cancer Research , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 29
    • 78650084078 scopus 로고    scopus 로고
    • A front-line window of opportunity phase 2 study of sorafenib in patients with advanced nonsmall cell lung cancer: North Central Cancer Treatment Group Study N0326
    • Dy G.K., Hillman S.L., Rowland K.M., et al. A front-line window of opportunity phase 2 study of sorafenib in patients with advanced nonsmall cell lung cancer: North Central Cancer Treatment Group Study N0326. Cancer 2010, 116:5686-5693.
    • (2010) Cancer , vol.116 , pp. 5686-5693
    • Dy, G.K.1    Hillman, S.L.2    Rowland, K.M.3
  • 30
    • 70349304196 scopus 로고    scopus 로고
    • Phase II, multicenter, uncontrolled trial of single-agent sorafenib in patients with relapsed or refractory, advanced non-small-cell lung cancer
    • Blumenschein G.R., Gatzemeier U., Fossella F., et al. Phase II, multicenter, uncontrolled trial of single-agent sorafenib in patients with relapsed or refractory, advanced non-small-cell lung cancer. Journal of Clinical Oncology 2009, 27:4274-4280.
    • (2009) Journal of Clinical Oncology , vol.27 , pp. 4274-4280
    • Blumenschein, G.R.1    Gatzemeier, U.2    Fossella, F.3
  • 31
    • 65349161533 scopus 로고    scopus 로고
    • A randomized discontinuation phase II study of sorafenib versus placebo in patients with non-small cell lung cancer who have failed at least two prior chemotherapy regimens: E2501
    • Schiller H.J., Lee J.W., Hanna N.H., Traynor A.M., Carbone D.P. A randomized discontinuation phase II study of sorafenib versus placebo in patients with non-small cell lung cancer who have failed at least two prior chemotherapy regimens: E2501. Journal of Clinical Oncology 2008, 26.
    • (2008) Journal of Clinical Oncology , pp. 26
    • Schiller, H.J.1    Lee, J.W.2    Hanna, N.H.3    Traynor, A.M.4    Carbone, D.P.5
  • 32
    • 78549289509 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of sorafenib in combination with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer
    • Okamoto I., Miyazaki M., Morinaga R., et al. Phase I clinical and pharmacokinetic study of sorafenib in combination with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer. Investigational New Drugs 2010, 28:844-853.
    • (2010) Investigational New Drugs , vol.28 , pp. 844-853
    • Okamoto, I.1    Miyazaki, M.2    Morinaga, R.3
  • 33
    • 51049095131 scopus 로고    scopus 로고
    • A phase I trial of the oral, multikinase inhibitor sorafenib in combination with carboplatin and paclitaxel
    • Flaherty K.T., Schiller J., Schuchter L.M., et al. A phase I trial of the oral, multikinase inhibitor sorafenib in combination with carboplatin and paclitaxel. Clinical Cancer Research 2008, 14:4836-4842.
    • (2008) Clinical Cancer Research , vol.14 , pp. 4836-4842
    • Flaherty, K.T.1    Schiller, J.2    Schuchter, L.M.3
  • 34
    • 77951639655 scopus 로고    scopus 로고
    • Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer
    • Scagliotti G., Novello S., von Pawel J., et al. Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer. Journal of Clinical Oncology 2010, 28:1835-1842.
    • (2010) Journal of Clinical Oncology , vol.28 , pp. 1835-1842
    • Scagliotti, G.1    Novello, S.2    von Pawel, J.3
  • 35
    • 84865721505 scopus 로고    scopus 로고
    • Phase III, randomized, double-blind, placebo-controlled trial of gemcitabine/cisplatin alone or with sorafenib for the first-line treatment of advanced, nonsquamous non-small-cell lung cancer
    • Paz-Ares L.G., Biesma B., Heigener D., et al. Phase III, randomized, double-blind, placebo-controlled trial of gemcitabine/cisplatin alone or with sorafenib for the first-line treatment of advanced, nonsquamous non-small-cell lung cancer. Journal of Clinical Oncology 2012, 30:3084-3092.
    • (2012) Journal of Clinical Oncology , vol.30 , pp. 3084-3092
    • Paz-Ares, L.G.1    Biesma, B.2    Heigener, D.3
  • 36
    • 79957857433 scopus 로고    scopus 로고
    • The BATTLE trial: personalizing therapy for lung cancer
    • Kim E.S., Herbst R.S., Wistuba I.I., et al. The BATTLE trial: personalizing therapy for lung cancer. Cancer Discovery 2011, 1:44-53.
    • (2011) Cancer Discovery , vol.1 , pp. 44-53
    • Kim, E.S.1    Herbst, R.S.2    Wistuba, I.I.3
  • 38
    • 39149120621 scopus 로고    scopus 로고
    • Multicenter, phase II trial of sunitinib in previously treated, advanced non-small-cell lung cancer
    • Socinski M.A., Novello S., Brahmer J.R., et al. Multicenter, phase II trial of sunitinib in previously treated, advanced non-small-cell lung cancer. Journal of Clinical Oncology 2008, 26:650-656.
    • (2008) Journal of Clinical Oncology , vol.26 , pp. 650-656
    • Socinski, M.A.1    Novello, S.2    Brahmer, J.R.3
  • 39
    • 70350655546 scopus 로고    scopus 로고
    • Phase II study of continuous daily sunitinib dosing in patients with previously treated advanced non-small cell lung cancer
    • Novello S., Scagliotti G.V., Rosell R., et al. Phase II study of continuous daily sunitinib dosing in patients with previously treated advanced non-small cell lung cancer. British Journal of Cancer 2009, 101:1543-1548.
    • (2009) British Journal of Cancer , vol.101 , pp. 1543-1548
    • Novello, S.1    Scagliotti, G.V.2    Rosell, R.3
  • 40
    • 77649322923 scopus 로고    scopus 로고
    • Safety and efficacy of combining sunitinib with bevacizumab+paclitaxel/carboplatin in non-small cell lung cancer
    • Socinski M., Scappaticci F.A., Samant M., Kolb M.M., Kozloff M. Safety and efficacy of combining sunitinib with bevacizumab+paclitaxel/carboplatin in non-small cell lung cancer. Journal of Thoracic Oncology 2010, 5:354-360.
    • (2010) Journal of Thoracic Oncology , vol.5 , pp. 354-360
    • Socinski, M.1    Scappaticci, F.A.2    Samant, M.3    Kolb, M.M.4    Kozloff, M.5
  • 41
    • 33847405376 scopus 로고    scopus 로고
    • Pazopanib: a novel multitargeted tyrosine kinase inhibitor
    • Sonpavde G., Hutson T.E. Pazopanib: a novel multitargeted tyrosine kinase inhibitor. Current Oncology Reports 2007, 9:115-119.
    • (2007) Current Oncology Reports , vol.9 , pp. 115-119
    • Sonpavde, G.1    Hutson, T.E.2
  • 43
    • 77955503066 scopus 로고    scopus 로고
    • Phase II proof-of-concept study of pazopanib monotherapy in treatment-naive patients with stage I/II resectable non-small-cell lung cancer
    • Altorki N., Lane M.E., Bauer T., et al. Phase II proof-of-concept study of pazopanib monotherapy in treatment-naive patients with stage I/II resectable non-small-cell lung cancer. Journal of Clinical Oncology 2010, 28:3131-3137.
    • (2010) Journal of Clinical Oncology , vol.28 , pp. 3131-3137
    • Altorki, N.1    Lane, M.E.2    Bauer, T.3
  • 44
    • 20144370978 scopus 로고    scopus 로고
    • AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
    • Wedge S.R., Kendrew J., Hennequin L.F., et al. AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Research 2005, 65:4389-4400.
    • (2005) Cancer Research , vol.65 , pp. 4389-4400
    • Wedge, S.R.1    Kendrew, J.2    Hennequin, L.F.3
  • 45
    • 42949105645 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of daily oral AZD2171, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer: the National Cancer Institute of Canada clinical trials group
    • Laurie S.A., Gauthier I., Arnold A., et al. Phase I and pharmacokinetic study of daily oral AZD2171, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer: the National Cancer Institute of Canada clinical trials group. Journal of Clinical Oncology 2008, 26:1871-1878.
    • (2008) Journal of Clinical Oncology , vol.26 , pp. 1871-1878
    • Laurie, S.A.1    Gauthier, I.2    Arnold, A.3
  • 46
    • 73949092851 scopus 로고    scopus 로고
    • Randomized, double-blind trial of carboplatin and paclitaxel with either daily oral cediranib or placebo in advanced non-small-cell lung cancer: NCIC clinical trials group BR24 study
    • Goss G.D., Arnold A., Shepherd F.A., et al. Randomized, double-blind trial of carboplatin and paclitaxel with either daily oral cediranib or placebo in advanced non-small-cell lung cancer: NCIC clinical trials group BR24 study. Journal of Clinical Oncology 2010, 28:49-55.
    • (2010) Journal of Clinical Oncology , vol.28 , pp. 49-55
    • Goss, G.D.1    Arnold, A.2    Shepherd, F.A.3
  • 47
    • 77957092171 scopus 로고    scopus 로고
    • Cediranib, a VEGF receptor 1, 2, and 3 inhibitor, and pemetrexed in patients (pts) with recurrent non-small cell lung cancer (NSCLC)
    • abstr e19007
    • Gadgeel S.M., Wozniak A., Edelman M., et al. Cediranib, a VEGF receptor 1, 2, and 3 inhibitor, and pemetrexed in patients (pts) with recurrent non-small cell lung cancer (NSCLC). Journal of Clinical Oncology 2009, 27. abstr e19007.
    • (2009) Journal of Clinical Oncology , vol.27
    • Gadgeel, S.M.1    Wozniak, A.2    Edelman, M.3
  • 48
    • 49649123154 scopus 로고    scopus 로고
    • BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy
    • Hilberg F., Roth G.J., Krssak M., et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Research 2008, 68:4774-4782.
    • (2008) Cancer Research , vol.68 , pp. 4774-4782
    • Hilberg, F.1    Roth, G.J.2    Krssak, M.3
  • 49
    • 79957452054 scopus 로고    scopus 로고
    • A phase II double-blind study to investigate efficacy and safety of two doses of the triple angiokinase inhibitor BIBF 1120 in patients with relapsed advanced non-small-cell lung cancer
    • Reck M., Kaiser R., Eschbach C., et al. A phase II double-blind study to investigate efficacy and safety of two doses of the triple angiokinase inhibitor BIBF 1120 in patients with relapsed advanced non-small-cell lung cancer. Annals of Oncology 2011, 22:1374-1381.
    • (2011) Annals of Oncology , vol.22 , pp. 1374-1381
    • Reck, M.1    Kaiser, R.2    Eschbach, C.3
  • 50
    • 77952325749 scopus 로고    scopus 로고
    • Phase I open-label study of continuous treatment with BIBF 1120, a triple angiokinase inhibitor, and pemetrexed in pretreated non-small cell lung cancer patients
    • Ellis P.M., Kaiser R., Zhao Y., Stopfer P., Gyorffy S., Hanna N. Phase I open-label study of continuous treatment with BIBF 1120, a triple angiokinase inhibitor, and pemetrexed in pretreated non-small cell lung cancer patients. Clinical Cancer Research 2010, 16:2881-2889.
    • (2010) Clinical Cancer Research , vol.16 , pp. 2881-2889
    • Ellis, P.M.1    Kaiser, R.2    Zhao, Y.3    Stopfer, P.4    Gyorffy, S.5    Hanna, N.6
  • 51
    • 58149337448 scopus 로고    scopus 로고
    • Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3
    • Hu-Lowe D.D., Zou H.Y., Grazzini M.L., et al. Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3. Clinical Cancer Research 2008, 14:7272-7283.
    • (2008) Clinical Cancer Research , vol.14 , pp. 7272-7283
    • Hu-Lowe, D.D.1    Zou, H.Y.2    Grazzini, M.L.3
  • 52
    • 68949127256 scopus 로고    scopus 로고
    • Efficacy and safety of axitinib in patients with advanced non-small-cell lung cancer: results from a phase II study
    • Schiller J.H., Larson T., Ou S.H., et al. Efficacy and safety of axitinib in patients with advanced non-small-cell lung cancer: results from a phase II study. Journal of Clinical Oncology 2009, 27:3836-3841.
    • (2009) Journal of Clinical Oncology , vol.27 , pp. 3836-3841
    • Schiller, J.H.1    Larson, T.2    Ou, S.H.3
  • 53
    • 78651105332 scopus 로고    scopus 로고
    • Axitinib (AG-013736; AG) combined with chemotherapy in patients (pts) with advanced non-small cell lung cancer (NSCLC) and other solid tumors
    • abstr 3559
    • Martin L., Kozloff M., Krzakowski M., et al. Axitinib (AG-013736; AG) combined with chemotherapy in patients (pts) with advanced non-small cell lung cancer (NSCLC) and other solid tumors. Journal of Clinical Oncology 2009, 27. abstr 3559.
    • (2009) Journal of Clinical Oncology , vol.27
    • Martin, L.1    Kozloff, M.2    Krzakowski, M.3
  • 54
    • 33749000911 scopus 로고    scopus 로고
    • AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts
    • Polverino A., Coxon A., Starnes C., et al. AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. Cancer Research 2006, 66:8715-8721.
    • (2006) Cancer Research , vol.66 , pp. 8715-8721
    • Polverino, A.1    Coxon, A.2    Starnes, C.3
  • 55
    • 84865095318 scopus 로고    scopus 로고
    • An international, randomized, placebo-controlled, double-blind phase III study (MONET1) of motesanib plus carboplatin/paclitaxel (C/P) in patients with advanced nonsquamous non-small cell lung cancer (NSCLC)
    • Scagliotti G., Vynnychenko I., Ichinose Y., et al. An international, randomized, placebo-controlled, double-blind phase III study (MONET1) of motesanib plus carboplatin/paclitaxel (C/P) in patients with advanced nonsquamous non-small cell lung cancer (NSCLC). Journal of Clinical Oncology 2012, 30:2829-2836.
    • (2012) Journal of Clinical Oncology , vol.30 , pp. 2829-2836
    • Scagliotti, G.1    Vynnychenko, I.2    Ichinose, Y.3
  • 56
    • 0842311621 scopus 로고    scopus 로고
    • Vascular targeting agents as cancer F therapeutics
    • Thorpe P.E. Vascular targeting agents as cancer F therapeutics. Clinical Cancer Research 2004, 10:415-427.
    • (2004) Clinical Cancer Research , vol.10 , pp. 415-427
    • Thorpe, P.E.1
  • 57
    • 74549118938 scopus 로고    scopus 로고
    • The development of the tumor vascular-disrupting agent ASA404 (vadimezan, DMXAA): current status and future opportunities
    • Head M., Jameson M.B. The development of the tumor vascular-disrupting agent ASA404 (vadimezan, DMXAA): current status and future opportunities. Expert Opinion on Investigational Drugs 2010, 19:295-304.
    • (2010) Expert Opinion on Investigational Drugs , vol.19 , pp. 295-304
    • Head, M.1    Jameson, M.B.2
  • 58
    • 57449103348 scopus 로고    scopus 로고
    • Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer
    • McKeage M.J., Von Pawel J., Reck M., et al. Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer. British Journal of Cancer 2008, 99:2006-2012.
    • (2008) British Journal of Cancer , vol.99 , pp. 2006-2012
    • McKeage, M.J.1    Von Pawel, J.2    Reck, M.3
  • 59
    • 80051638135 scopus 로고    scopus 로고
    • Randomized phase III placebo-controlled trial of carboplatin and paclitaxel with or without the vascular disrupting agent vadimezan (ASA404) in advanced non-small-cell lung cancer
    • Lara P.N., Douillard J.Y., Nakagawa K., et al. Randomized phase III placebo-controlled trial of carboplatin and paclitaxel with or without the vascular disrupting agent vadimezan (ASA404) in advanced non-small-cell lung cancer. Journal of Clinical Oncology 2011, 29:2965-2971.
    • (2011) Journal of Clinical Oncology , vol.29 , pp. 2965-2971
    • Lara, P.N.1    Douillard, J.Y.2    Nakagawa, K.3
  • 61
    • 79952764349 scopus 로고    scopus 로고
    • Phase I/II study of pemetrexed with or without ABT-751 in advanced or metastatic non-small-cell lung cancer
    • Rudin C.M., Mauer A., Smakal M., et al. Phase I/II study of pemetrexed with or without ABT-751 in advanced or metastatic non-small-cell lung cancer. Journal of Clinical Oncology 2011, 29:1075-1082.
    • (2011) Journal of Clinical Oncology , vol.29 , pp. 1075-1082
    • Rudin, C.M.1    Mauer, A.2    Smakal, M.3
  • 62
    • 36048982143 scopus 로고    scopus 로고
    • Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer
    • Herbst R.S., O'Neill V.J., Fehrenbacher L., et al. Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer. Journal of Clinical Oncology 2007, 25:4743-4750.
    • (2007) Journal of Clinical Oncology , vol.25 , pp. 4743-4750
    • Herbst, R.S.1    O'Neill, V.J.2    Fehrenbacher, L.3
  • 63
    • 20244381389 scopus 로고    scopus 로고
    • Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer
    • Herbst R.S., Johnson D.H., Mininberg E., et al. Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer. Journal of Clinical Oncology 2005, 23:2544-2555.
    • (2005) Journal of Clinical Oncology , vol.23 , pp. 2544-2555
    • Herbst, R.S.1    Johnson, D.H.2    Mininberg, E.3
  • 64
    • 84876092935 scopus 로고    scopus 로고
    • Bevacizumab (B) and erlotinib (E) as first-line therapy in metastatic nonsquamous non-small cell lung cancer (NSCLC) followed by platinum-based chemotherapy (CT) at disease progression (PD): a multicenter phase II trial, SAKK 19/05
    • abstr 7651
    • Zappa F., Droege C., Betticher D., et al. Bevacizumab (B) and erlotinib (E) as first-line therapy in metastatic nonsquamous non-small cell lung cancer (NSCLC) followed by platinum-based chemotherapy (CT) at disease progression (PD): a multicenter phase II trial, SAKK 19/05. Journal of Clinical Oncology 2011, 79. abstr 7651.
    • (2011) Journal of Clinical Oncology , vol.79
    • Zappa, F.1    Droege, C.2    Betticher, D.3
  • 65
    • 79957823572 scopus 로고    scopus 로고
    • Efficacy of bevacizumab plus erlotinib versus erlotinib alone in advanced non-small-cell lung cancer after failure of standard first-line chemotherapy (BeTa): a double-blind, placebo-controlled, phase 3 trial
    • Herbst R.S., Ansari R., Bustin F., et al. Efficacy of bevacizumab plus erlotinib versus erlotinib alone in advanced non-small-cell lung cancer after failure of standard first-line chemotherapy (BeTa): a double-blind, placebo-controlled, phase 3 trial. Lancet 2011, 377:1846-1854.
    • (2011) Lancet , vol.377 , pp. 1846-1854
    • Herbst, R.S.1    Ansari, R.2    Bustin, F.3
  • 66
    • 78449274913 scopus 로고    scopus 로고
    • Overall survival (OS) in ATLAS, a phase IIIb trial comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy (chemo) with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC)
    • for the Ai, abstr 7526
    • Kabbinavar F., Miller V.A., Johnson B.E., O'Connor P., Soh C. Overall survival (OS) in ATLAS, a phase IIIb trial comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy (chemo) with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC). Journal of Clinical Oncology 2010, 28. for the Ai, abstr 7526.
    • (2010) Journal of Clinical Oncology , vol.28
    • Kabbinavar, F.1    Miller, V.A.2    Johnson, B.E.3    O'Connor, P.4    Soh, C.5
  • 67
    • 34948838898 scopus 로고    scopus 로고
    • Randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non small-cell lung cancer
    • Heymach J.V., Johnson B.E., Prager D., et al. Randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non small-cell lung cancer. Journal of Clinical Oncology 2007, 25:4270-4277.
    • (2007) Journal of Clinical Oncology , vol.25 , pp. 4270-4277
    • Heymach, J.V.1    Johnson, B.E.2    Prager, D.3
  • 68
    • 66349087009 scopus 로고    scopus 로고
    • Vandetanib versus gefitinib in patients with advanced non-small-cell lung cancer: results from a two-part, double-blind, randomized phase ii study
    • Natale R.B., Bodkin D., Govindan R., et al. Vandetanib versus gefitinib in patients with advanced non-small-cell lung cancer: results from a two-part, double-blind, randomized phase ii study. Journal of Clinical Oncology 2009, 27:2523-2529.
    • (2009) Journal of Clinical Oncology , vol.27 , pp. 2523-2529
    • Natale, R.B.1    Bodkin, D.2    Govindan, R.3
  • 69
    • 79960541722 scopus 로고    scopus 로고
    • Vandetanib: first global approval
    • Commander H., Whiteside G., Perry C. Vandetanib: first global approval. Drugs 2011, 71:1355-1365.
    • (2011) Drugs , vol.71 , pp. 1355-1365
    • Commander, H.1    Whiteside, G.2    Perry, C.3
  • 70
    • 77949894217 scopus 로고    scopus 로고
    • Clinical course of advanced non-small-cell lung cancer patients experiencing hypertension during treatment with bevacizumab in combination with carboplatin and paclitaxel on ECOG 4599
    • Dahlberg S.E., Sandler A.B., Brahmer J.R., Schiller J.H., Johnson D.H. Clinical course of advanced non-small-cell lung cancer patients experiencing hypertension during treatment with bevacizumab in combination with carboplatin and paclitaxel on ECOG 4599. Journal of Clinical Oncology 2010, 28:949-954.
    • (2010) Journal of Clinical Oncology , vol.28 , pp. 949-954
    • Dahlberg, S.E.1    Sandler, A.B.2    Brahmer, J.R.3    Schiller, J.H.4    Johnson, D.H.5
  • 71
    • 65549088617 scopus 로고    scopus 로고
    • Association of diastolic blood pressure (dBP)>90mmHg with overall survival (OS) in patients treated with axitinib (AG-013736)
    • abstr 3543
    • Rini B.I., Schiller H.J., Fruehauf J.P., et al. Association of diastolic blood pressure (dBP)>90mmHg with overall survival (OS) in patients treated with axitinib (AG-013736). Journal of Clinical Oncology 2008, 26. abstr 3543.
    • (2008) Journal of Clinical Oncology , vol.26
    • Rini, B.I.1    Schiller, H.J.2    Fruehauf, J.P.3
  • 72
    • 66149188254 scopus 로고    scopus 로고
    • Baseline vascular endothelial growth factor concentration as a potential predictive marker of benefit from vandetanib in non-small cell lung cancer
    • Hanrahan E.O., Ryan A.J., Mann H., et al. Baseline vascular endothelial growth factor concentration as a potential predictive marker of benefit from vandetanib in non-small cell lung cancer. Clinical Cancer Research 2009, 15:3600-3609.
    • (2009) Clinical Cancer Research , vol.15 , pp. 3600-3609
    • Hanrahan, E.O.1    Ryan, A.J.2    Mann, H.3
  • 73
    • 70449130019 scopus 로고    scopus 로고
    • Vascular endothelial growth factor A and vascular endothelial growth factor receptor 2 expression in non-small cell lung cancer patients: relation to prognosis
    • Bonnesen B., Pappot H., Holmstav J., Skov B.G. Vascular endothelial growth factor A and vascular endothelial growth factor receptor 2 expression in non-small cell lung cancer patients: relation to prognosis. Lung Cancer 2009, 66:314-318.
    • (2009) Lung Cancer , vol.66 , pp. 314-318
    • Bonnesen, B.1    Pappot, H.2    Holmstav, J.3    Skov, B.G.4
  • 74
    • 40949111793 scopus 로고    scopus 로고
    • Cell adhesion molecules, vascular endothelial growth factor, and basic fibroblast growth factor in patients with non-small cell lung cancer treated with chemotherapy with or without bevacizumab - an Eastern Cooperative Oncology Group Study
    • Dowlati A., Gray R., Sandler A.B., Schiller J.H., Johnson D.H. Cell adhesion molecules, vascular endothelial growth factor, and basic fibroblast growth factor in patients with non-small cell lung cancer treated with chemotherapy with or without bevacizumab - an Eastern Cooperative Oncology Group Study. Clinical Cancer Research 2008, 14:1407-1412.
    • (2008) Clinical Cancer Research , vol.14 , pp. 1407-1412
    • Dowlati, A.1    Gray, R.2    Sandler, A.B.3    Schiller, J.H.4    Johnson, D.H.5
  • 75
    • 39749096242 scopus 로고    scopus 로고
    • VEGF polymorphisms and survival in early-stage non-small-cell lung cancer
    • Heist R.S., Zhai R., Liu G., et al. VEGF polymorphisms and survival in early-stage non-small-cell lung cancer. Journal of Clinical Oncology 2008, 26:856-862.
    • (2008) Journal of Clinical Oncology , vol.26 , pp. 856-862
    • Heist, R.S.1    Zhai, R.2    Liu, G.3
  • 76
    • 67650380136 scopus 로고    scopus 로고
    • Biomarkers of response and resistance to antiangiogenic therapy
    • Jain R.K., Duda D.G., Willett C.G., et al. Biomarkers of response and resistance to antiangiogenic therapy. Nature Reviews Clinical Oncology 2009, 6:327-338.
    • (2009) Nature Reviews Clinical Oncology , vol.6 , pp. 327-338
    • Jain, R.K.1    Duda, D.G.2    Willett, C.G.3
  • 77
    • 34547820876 scopus 로고    scopus 로고
    • Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells
    • Shojaei F., Wu X., Malik A.K., et al. Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells. Nature Biotechnology 2007, 25:911-920.
    • (2007) Nature Biotechnology , vol.25 , pp. 911-920
    • Shojaei, F.1    Wu, X.2    Malik, A.K.3
  • 78
    • 0031038068 scopus 로고    scopus 로고
    • Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis
    • Relf M., LeJeune S., Scott P.A., et al. Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Research 1997, 57:963-969.
    • (1997) Cancer Research , vol.57 , pp. 963-969
    • Relf, M.1    LeJeune, S.2    Scott, P.A.3
  • 79
    • 4644304024 scopus 로고    scopus 로고
    • Antiangiogenic therapy of cerebral melanoma metastases results in sustained tumor progression via vessel co-option
    • Leenders W.P., Kusters B., Verrijp K., et al. Antiangiogenic therapy of cerebral melanoma metastases results in sustained tumor progression via vessel co-option. Clinical Cancer Research 2004, 10:6222-6230.
    • (2004) Clinical Cancer Research , vol.10 , pp. 6222-6230
    • Leenders, W.P.1    Kusters, B.2    Verrijp, K.3
  • 80
    • 34247887624 scopus 로고    scopus 로고
    • Blockade of the vascular endothelial growth factor-receptor 2 pathway inhibits the growth of human renal cell carcinoma, RBM1-IT4, in the kidney but not in the bone of nude mice
    • Karashima T., Inoue K., Fukata S., et al. Blockade of the vascular endothelial growth factor-receptor 2 pathway inhibits the growth of human renal cell carcinoma, RBM1-IT4, in the kidney but not in the bone of nude mice. International Journal of Clinical Oncology 2007, 30:937-945.
    • (2007) International Journal of Clinical Oncology , vol.30 , pp. 937-945
    • Karashima, T.1    Inoue, K.2    Fukata, S.3
  • 81
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • Casanovas O., Hicklin D.J., Bergers G., Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 2005, 8:299-309.
    • (2005) Cancer Cell , vol.8 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 82
    • 35548982639 scopus 로고    scopus 로고
    • Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels
    • Fischer C., Jonckx B., Mazzone M., et al. Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. Cell 2007, 131:463-475.
    • (2007) Cell , vol.131 , pp. 463-475
    • Fischer, C.1    Jonckx, B.2    Mazzone, M.3
  • 83
    • 33846149645 scopus 로고    scopus 로고
    • AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
    • Batchelor T.T., Sorensen A.G., di Tomaso E., et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 2007, 11:83-95.
    • (2007) Cancer Cell , vol.11 , pp. 83-95
    • Batchelor, T.T.1    Sorensen, A.G.2    di Tomaso, E.3
  • 84
    • 33644833910 scopus 로고    scopus 로고
    • Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
    • Motzer R.J., Michaelson M.D., Redman B.G., et al. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. Journal of Clinical Oncology 2006, 24:16-24.
    • (2006) Journal of Clinical Oncology , vol.24 , pp. 16-24
    • Motzer, R.J.1    Michaelson, M.D.2    Redman, B.G.3
  • 85
    • 30944452436 scopus 로고    scopus 로고
    • Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients
    • Willett C.G., Boucher Y., Duda D.G., et al. Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients. Journal of Clinical Oncology 2005, 23:8136-8139.
    • (2005) Journal of Clinical Oncology , vol.23 , pp. 8136-8139
    • Willett, C.G.1    Boucher, Y.2    Duda, D.G.3
  • 86
    • 0037154738 scopus 로고    scopus 로고
    • Effect of p53 status on tumor response to antiangiogenic therapy
    • Yu J.L., Rak J.W., Coomber B.L., Hicklin D.J., Kerbel R.S. Effect of p53 status on tumor response to antiangiogenic therapy. Science 2002, 295:1526-1528.
    • (2002) Science , vol.295 , pp. 1526-1528
    • Yu, J.L.1    Rak, J.W.2    Coomber, B.L.3    Hicklin, D.J.4    Kerbel, R.S.5
  • 88
    • 79960719135 scopus 로고    scopus 로고
    • Molecular selection trumps clinical selection
    • Shepherd F.A. Molecular selection trumps clinical selection. Journal of Clinical Oncology 2011, 29:2843-2844.
    • (2011) Journal of Clinical Oncology , vol.29 , pp. 2843-2844
    • Shepherd, F.A.1
  • 89
    • 84876078592 scopus 로고    scopus 로고
    • Bayer Healthcare Pharmaceuticals Inc., Onyx Pharmaceuticals Inc.
    • June 14, Available from:, [accessed 29.09.11]
    • Bayer Healthcare Pharmaceuticals Inc., Onyx Pharmaceuticals Inc. Phase 3 trial of Nexavar in first-line advanced non-small cell lung cancer does not meet primary endpoint of overall survival June 14, 2010, Available from:, [accessed 29.09.11]. http://wwwonyx-pharmcom/viewcfm/685/Phase-3-Trial-of-Nexavar-in-First-Line-Advanced-Non-Small-Cell-Lung-Cancer-Does-Not-Meet-Primary-Endpoint-of-Overall-Survival.
    • (2010) Phase 3 trial of Nexavar in first-line advanced non-small cell lung cancer does not meet primary endpoint of overall survival
  • 90
    • 77952345253 scopus 로고    scopus 로고
    • BIBF 1120 for the treatment of non-small cell lung cancer
    • Reck M. BIBF 1120 for the treatment of non-small cell lung cancer. Expert Opinion on Investigational Drugs 2010, 19:789-794.
    • (2010) Expert Opinion on Investigational Drugs , vol.19 , pp. 789-794
    • Reck, M.1
  • 91
    • 84857597028 scopus 로고    scopus 로고
    • Phase II trial of PTK787/ZK 222584 (vatalanib) administered orally once-daily or in two divided daily doses as second-line monotherapy in relapsed or progressing patients with stage IIIB/IV non-small-cell lung cancer (NSCLC)
    • Gauler T.C., Besse B., Mauguen A., et al. Phase II trial of PTK787/ZK 222584 (vatalanib) administered orally once-daily or in two divided daily doses as second-line monotherapy in relapsed or progressing patients with stage IIIB/IV non-small-cell lung cancer (NSCLC). Annals of Oncology 2011, 23:678-687.
    • (2011) Annals of Oncology , vol.23 , pp. 678-687
    • Gauler, T.C.1    Besse, B.2    Mauguen, A.3
  • 92
    • 70349477817 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, phase IIIb trial (ATLAS) comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC)
    • LBA8002, for the Ai
    • Miller V.A., O'Connor P., Soh C., Kabbinavar F. A randomized, double-blind, placebo-controlled, phase IIIb trial (ATLAS) comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC). Journal of Clinical Oncology 2009, 27:LBA8002. for the Ai.
    • (2009) Journal of Clinical Oncology , vol.27
    • Miller, V.A.1    O'Connor, P.2    Soh, C.3    Kabbinavar, F.4
  • 93
    • 77954035012 scopus 로고    scopus 로고
    • Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial
    • Herbst R.S., Sun Y., Eberhardt W.E., et al. Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial. Lancet Oncology 2010, 11:619-626.
    • (2010) Lancet Oncology , vol.11 , pp. 619-626
    • Herbst, R.S.1    Sun, Y.2    Eberhardt, W.E.3
  • 94
    • 79952742483 scopus 로고    scopus 로고
    • Vandetanib plus pemetrexed for the second-line treatment of advanced non-small-cell lung cancer: a randomized, double-blind phase III trial
    • de Boer R.H., Arrieta O., Yang C.H., et al. Vandetanib plus pemetrexed for the second-line treatment of advanced non-small-cell lung cancer: a randomized, double-blind phase III trial. Journal of Clinical Oncology 2011, 29:1067-1074.
    • (2011) Journal of Clinical Oncology , vol.29 , pp. 1067-1074
    • de Boer, R.H.1    Arrieta, O.2    Yang, C.H.3
  • 95
    • 79952748468 scopus 로고    scopus 로고
    • Phase III trial of vandetanib compared with erlotinib in patients with previously treated advanced non-small-cell lung cancer
    • Natale R.B., Thongprasert S., Greco F.A., et al. Phase III trial of vandetanib compared with erlotinib in patients with previously treated advanced non-small-cell lung cancer. Journal of Clinical Oncology 2011, 29:1059-1066.
    • (2011) Journal of Clinical Oncology , vol.29 , pp. 1059-1066
    • Natale, R.B.1    Thongprasert, S.2    Greco, F.A.3
  • 96
    • 78049395323 scopus 로고    scopus 로고
    • Vandetanib versus placebo in patients with advanced non-small cell lung cancer (NSCLC) after prior therapy with an EGFR tyrosine kinase inhibitor (TKI): a randomized, double-blind phase III trial (ZEPHYR)
    • abstr 7525
    • Lee J., Hirsh V., Park K., et al. Vandetanib versus placebo in patients with advanced non-small cell lung cancer (NSCLC) after prior therapy with an EGFR tyrosine kinase inhibitor (TKI): a randomized, double-blind phase III trial (ZEPHYR). Journal of Clinical Oncology 2010, 28. abstr 7525.
    • (2010) Journal of Clinical Oncology , vol.28
    • Lee, J.1    Hirsh, V.2    Park, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.