Structure-activity analysis of human ghrelin O-acyltransferase reveals chemical determinants of ghrelin selectivity and acyl group recognition

Biochemistry

Volumn 54, Issue 4, 2015, Pages 1100-1110

  Darling, Joseph E ^a   Zhao, Feifei ^b   Loftus, Rosemary J ^a   Patton, Leslie M ^a   Gibbs, Richard A ^b   Hougland, James L ^a  

^a SYRACUSE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING ENERGY; BIOACTIVITY; BIOINFORMATICS; BIOMIMETICS; ENZYMES; FUNCTIONAL GROUPS; PEPTIDES; PLANTS (BOTANY); SUBSTRATES;

BIOINFORMATICS ANALYSIS; BIOLOGICAL OBSERVATIONS; ENZYME INTERACTION; N-TERMINAL SEQUENCES; PEPTIDE SUBSTRATES; POST-TRANSLATIONAL MODIFICATIONS; STRUCTURE ACTIVITY; SUBSTRATE RECOGNITION;

CHEMICAL ANALYSIS;

ACYL COENZYME A; ACYLTRANSFERASE; CARBON; FUNCTIONAL GROUP; GHRELIN; GHRELIN O ACYLTRANSFERASE; GLYCINE; PALMITOYL COENZYME A; SERINE; THREONINE; UNCLASSIFIED DRUG; GHRELIN O-ACYLTRANSFERASE, HUMAN; PROTEIN BINDING;

ACYLATION; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; APPETITE; ARTICLE; BIOINFORMATICS; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DIABETES MELLITUS; ENERGY BALANCE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STRUCTURE; HUMAN; HYDROGEN BOND; OBESITY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMISTRY; GENETICS; INSECT; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; STRUCTURE ACTIVITY RELATION;

ACYLATION; ACYLTRANSFERASES; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; GHRELIN; HUMANS; INSECTS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84922260959     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi5010359     Document Type: Article

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