Decreased astrocytic thrombospondin-1 secretion after chronic ammonia treatment reduces the level of synaptic proteins: In vitro and in vivo studies

Journal of Neurochemistry

Volumn 131, Issue 3, 2014, Pages 333-347

  Jayakumar, Arumugam R ^a   Tong, Xiao Y ^b   Curtis, Kevin M ^c   Ruiz Cordero, Roberto ^b   Shamaladevi, Nagarajarao ^b   Abuzamel, Missa ^b   Johnstone, Joshua ^a   Gaidosh, Gabriel ^d   Rama Rao, Kakulavarapu V ^a   Norenberg, Michael D ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c GERIATRIC RESEARCH EDUCATION AND CLINICAL CENTER   (United States)

^d UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

ammonia; astrocytes; chronic hepatic encephalopathy; synaptic proteins; thrombospondin 1

Indexed keywords

AMMONIA; CELL EXTRACT; METFORMIN; POSTSYNAPTIC DENSITY PROTEIN 95; SYNAPTOPHYSIN; SYNAPTOTAGMIN; THROMBOSPONDIN 1; ANTIOXIDANT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYC PROTEIN; NERVE PROTEIN; TUBULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL LEVEL; CONTROLLED STUDY; CULTURE MEDIUM; DRUG EFFECT; FETUS; HEPATIC ENCEPHALOPATHY; IN VITRO STUDY; IN VIVO STUDY; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; RAT MODEL; SYNAPSE; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; FEMALE; METABOLISM; PREGNANCY; TOXICITY;

RATTUS;

AMMONIA; ANIMALS; ANTIOXIDANTS; ASTROCYTES; FEMALE; HEPATIC ENCEPHALOPATHY; NERVE TISSUE PROTEINS; NF-KAPPA B; PREGNANCY; PROTO-ONCOGENE PROTEINS C-MYC; RATS; SYNAPSES; SYNAPTOPHYSIN; THROMBOSPONDIN 1; TUBULIN;

EID: 84922256449     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12810     Document Type: Article

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