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Volumn 41, Issue 2, 2011, Pages 498-507

NF-κB in the mechanism of brain edema in acute liver failure: Studies in transgenic mice

Author keywords

Acute liver failure; Ammonia; Astrocyte swelling; INOS; NADPH oxidase; NF B

Indexed keywords

AMMONIA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOACETAMIDE;

EID: 78650604333     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2010.10.021     Document Type: Article
Times cited : (41)

References (66)
  • 1
    • 0033619660 scopus 로고    scopus 로고
    • Hepatic encephalopathy: molecular mechanisms underlying the clinical syndrome
    • Albrecht J., Jones E.A. Hepatic encephalopathy: molecular mechanisms underlying the clinical syndrome. J. Neurol. Sci. 1999, 170:38-146.
    • (1999) J. Neurol. Sci. , vol.170 , pp. 38-146
    • Albrecht, J.1    Jones, E.A.2
  • 2
    • 0029874138 scopus 로고    scopus 로고
    • The NF-kappa B and I kappa B proteins: new discoveries and insights
    • Baldwin A.S. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu. Rev. Immunol. 1996, 14:649-683.
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 649-683
    • Baldwin, A.S.1
  • 3
    • 0025854274 scopus 로고
    • The double-edged role of nitric oxide in brain function and superoxide-mediated injury
    • Beckman J.S. The double-edged role of nitric oxide in brain function and superoxide-mediated injury. J. Dev. Physiol. 1991, 15:53-59.
    • (1991) J. Dev. Physiol. , vol.15 , pp. 53-59
    • Beckman, J.S.1
  • 4
    • 77149125563 scopus 로고    scopus 로고
    • IL-1 or TNF receptor gene deletion delays onset of encephalopathy and attenuates brain edema in experimental acute liver failure
    • Bémeur C., et al. IL-1 or TNF receptor gene deletion delays onset of encephalopathy and attenuates brain edema in experimental acute liver failure. Neurochem. Int. 2010, 56:213-215.
    • (2010) Neurochem. Int. , vol.56 , pp. 213-215
    • Bémeur, C.1
  • 5
    • 0033990345 scopus 로고    scopus 로고
    • Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries
    • Bowie A., O'Neill L.A. Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries. Biochem. Pharmacol. 2000, 59:13-23.
    • (2000) Biochem. Pharmacol. , vol.59 , pp. 13-23
    • Bowie, A.1    O'Neill, L.A.2
  • 6
    • 38049117573 scopus 로고    scopus 로고
    • Astroglial nuclear factor-kappaB regulates learning and memory and synaptic plasticity in female mice
    • Bracchi-Ricard V., et al. Astroglial nuclear factor-kappaB regulates learning and memory and synaptic plasticity in female mice. J. Neurochem. 2008, 104:611-623.
    • (2008) J. Neurochem. , vol.104 , pp. 611-623
    • Bracchi-Ricard, V.1
  • 7
    • 22344431751 scopus 로고    scopus 로고
    • Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury
    • Brambilla R., et al. Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury. J. Exp. Med. 2005, 202:145-156.
    • (2005) J. Exp. Med. , vol.202 , pp. 145-156
    • Brambilla, R.1
  • 8
    • 67649506550 scopus 로고    scopus 로고
    • Transgenic inhibition of astroglial NF-kappa B leads to increased axonal sparing and sprouting following spinal cord injury
    • Brambilla R., et al. Transgenic inhibition of astroglial NF-kappa B leads to increased axonal sparing and sprouting following spinal cord injury. J. Neurochem. 2009, 110:765-778.
    • (2009) J. Neurochem. , vol.110 , pp. 765-778
    • Brambilla, R.1
  • 9
    • 64849094450 scopus 로고    scopus 로고
    • Transgenic inhibition of astroglial NF-kappa B improves functional outcome in experimental autoimmune encephalomyelitis by suppressing chronic central nervous system inflammation
    • Brambilla R., et al. Transgenic inhibition of astroglial NF-kappa B improves functional outcome in experimental autoimmune encephalomyelitis by suppressing chronic central nervous system inflammation. J. Immunol. 2009, 182:2628-2640.
    • (2009) J. Immunol. , vol.182 , pp. 2628-2640
    • Brambilla, R.1
  • 10
    • 33845895245 scopus 로고    scopus 로고
    • Brain edema and intracranial hypertension in fulminant hepatic failure: pathophysiology and management
    • Detry O., et al. Brain edema and intracranial hypertension in fulminant hepatic failure: pathophysiology and management. World. J. Gastroenterol. 2006, 12:7405-7412.
    • (2006) World. J. Gastroenterol. , vol.12 , pp. 7405-7412
    • Detry, O.1
  • 11
    • 0025110472 scopus 로고
    • The benzodiazepine receptor in cultured astrocytes from genetically epilepsy prone rats
    • Ducis I., et al. The benzodiazepine receptor in cultured astrocytes from genetically epilepsy prone rats. Brain. Res. 1990, 531:318-321.
    • (1990) Brain. Res. , vol.531 , pp. 318-321
    • Ducis, I.1
  • 12
    • 67651148406 scopus 로고    scopus 로고
    • Inactivation of astroglial NF-kappa B promotes survival of retinal neurons following ischemic injury
    • Dvoriantchikova G., et al. Inactivation of astroglial NF-kappa B promotes survival of retinal neurons following ischemic injury. Eur. J. Neurosci. 2009, 30:175-185.
    • (2009) Eur. J. Neurosci. , vol.30 , pp. 175-185
    • Dvoriantchikova, G.1
  • 13
    • 34247242055 scopus 로고    scopus 로고
    • Transgenic glial nuclear factor-kappa B inhibition decreases formalin pain in mice
    • Fu E.S., et al. Transgenic glial nuclear factor-kappa B inhibition decreases formalin pain in mice. Neuroreport 2007, 18:713-717.
    • (2007) Neuroreport , vol.18 , pp. 713-717
    • Fu, E.S.1
  • 14
    • 76349109675 scopus 로고    scopus 로고
    • Transgenic inhibition of glial NF-kappa B reduces pain behavior and inflammation after peripheral nerve injury
    • Fu E.S., et al. Transgenic inhibition of glial NF-kappa B reduces pain behavior and inflammation after peripheral nerve injury. Pain 2010, 148:509-518.
    • (2010) Pain , vol.148 , pp. 509-518
    • Fu, E.S.1
  • 15
    • 0025318104 scopus 로고
    • Reversal of the behavioral and electrophysiological abnormalities of an animal model of hepatic encephalopathy by benzodiazepine receptor ligands
    • Gammal S., et al. Reversal of the behavioral and electrophysiological abnormalities of an animal model of hepatic encephalopathy by benzodiazepine receptor ligands. Hepatology 1990, 11:371-378.
    • (1990) Hepatology , vol.11 , pp. 371-378
    • Gammal, S.1
  • 16
    • 0021795068 scopus 로고
    • Morphologic effects of ammonia on primary astrocyte cultures: I. Light microscopic studies
    • Gregorios J.B., et al. Morphologic effects of ammonia on primary astrocyte cultures: I. Light microscopic studies. J. Neuropathol. Exp. Neurol. 1985, 44:397-403.
    • (1985) J. Neuropathol. Exp. Neurol. , vol.44 , pp. 397-403
    • Gregorios, J.B.1
  • 17
    • 0032694105 scopus 로고    scopus 로고
    • Hepatic encephalopathy: an update of pathophysiologic mechanisms
    • Hazell A.S., Butterworth R.F. Hepatic encephalopathy: an update of pathophysiologic mechanisms. Proc. Soc. Exp. Biol. Med. 1999, 222:99-112.
    • (1999) Proc. Soc. Exp. Biol. Med. , vol.222 , pp. 99-112
    • Hazell, A.S.1    Butterworth, R.F.2
  • 18
    • 0028045735 scopus 로고
    • Brain ion and amino acid contents during edema development in hepatic encephalopathy
    • Hilgier W., Olson J.E. Brain ion and amino acid contents during edema development in hepatic encephalopathy. J. Neurochem. 1994, 62:197-204.
    • (1994) J. Neurochem. , vol.62 , pp. 197-204
    • Hilgier, W.1    Olson, J.E.2
  • 19
    • 0029562295 scopus 로고
    • Acute liver failure and hyperammonemia increase peripheral-type benzodiazepine receptor binding and pregnenolone synthesis in mouse brain
    • Itzhak Y., et al. Acute liver failure and hyperammonemia increase peripheral-type benzodiazepine receptor binding and pregnenolone synthesis in mouse brain. Brain. Res. 1995, 705:345-348.
    • (1995) Brain. Res. , vol.705 , pp. 345-348
    • Itzhak, Y.1
  • 20
    • 2942541144 scopus 로고    scopus 로고
    • Stable compounds of cigarette smoke induce endothelial superoxide anion production via NADPH oxidase activation
    • Jaimes E.A., et al. Stable compounds of cigarette smoke induce endothelial superoxide anion production via NADPH oxidase activation. Arterioscler. Thromb. Vasc. Biol. 2004, 24:1031-1036.
    • (2004) Arterioscler. Thromb. Vasc. Biol. , vol.24 , pp. 1031-1036
    • Jaimes, E.A.1
  • 21
    • 0034959801 scopus 로고    scopus 로고
    • The inflammatory basis of intracranial hypertension in acute liver failure
    • Jalan R., Williams R. The inflammatory basis of intracranial hypertension in acute liver failure. J. Hepatol. 2001, 34:940-942.
    • (2001) J. Hepatol. , vol.34 , pp. 940-942
    • Jalan, R.1    Williams, R.2
  • 22
    • 33646949200 scopus 로고    scopus 로고
    • Oxidative stress and mitogen-activated protein kinase phos-phorylation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes
    • Jayakumar A.R., et al. Oxidative stress and mitogen-activated protein kinase phos-phorylation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes. J. Neurosci. 2006, 26:4774-4784.
    • (2006) J. Neurosci. , vol.26 , pp. 4774-4784
    • Jayakumar, A.R.1
  • 23
    • 57749099241 scopus 로고    scopus 로고
    • Na-K-Cl cotransporter-1 in the mechanism of ammonia-induced astrocyte swelling
    • Jayakumar A.R., et al. Na-K-Cl cotransporter-1 in the mechanism of ammonia-induced astrocyte swelling. J. Biol. Chem. 2008, 283:33874-33882.
    • (2008) J. Biol. Chem. , vol.283 , pp. 33874-33882
    • Jayakumar, A.R.1
  • 24
    • 64349096033 scopus 로고    scopus 로고
    • Calcium in the mechanism of ammonia-induced astrocyte swelling
    • Jayakumar A.R., et al. Calcium in the mechanism of ammonia-induced astrocyte swelling. J. Neurochem. 2009, 109(Suppl 1):252-257.
    • (2009) J. Neurochem. , vol.109 , Issue.SUPPL 1 , pp. 252-257
    • Jayakumar, A.R.1
  • 25
    • 65549138899 scopus 로고    scopus 로고
    • Direct evidence for central proinflammatory mechanisms in rats with experimental acute liver failure: protective effect of hypothermia
    • Jiang W., et al. Direct evidence for central proinflammatory mechanisms in rats with experimental acute liver failure: protective effect of hypothermia. J. Cereb. Blood. Flow. Metab. 2009, 29:944-952.
    • (2009) J. Cereb. Blood. Flow. Metab. , vol.29 , pp. 944-952
    • Jiang, W.1
  • 26
    • 0022330330 scopus 로고
    • Plasticity of astrocytes in primary cultures: an experimental tool and a reason for methodological caution
    • Juurlink B.H., Hertz L. Plasticity of astrocytes in primary cultures: an experimental tool and a reason for methodological caution. Dev. Neurosci. 1985, 7:263-277.
    • (1985) Dev. Neurosci. , vol.7 , pp. 263-277
    • Juurlink, B.H.1    Hertz, L.2
  • 27
    • 0023499934 scopus 로고
    • Anisotonic media and glutamate-induced ion transport and volume responses in primary astrocyte cultures
    • Kimelberg H.K. Anisotonic media and glutamate-induced ion transport and volume responses in primary astrocyte cultures. J. Physiol (Paris) 1987, 82:294-303.
    • (1987) J. Physiol (Paris) , vol.82 , pp. 294-303
    • Kimelberg, H.K.1
  • 28
    • 0022595320 scopus 로고
    • Glial fibrillary acidic protein and S-100 protein in human hepatic encephalopathy: immunocytochemical demonstration of dissociation of two glia-associated proteins
    • Kimura T., Budka H. Glial fibrillary acidic protein and S-100 protein in human hepatic encephalopathy: immunocytochemical demonstration of dissociation of two glia-associated proteins. Acta. Neuropathol. 1986, 70:17-21.
    • (1986) Acta. Neuropathol. , vol.70 , pp. 17-21
    • Kimura, T.1    Budka, H.2
  • 29
    • 4644359359 scopus 로고    scopus 로고
    • Regulation of the expression of inducible nitric oxide synthase
    • Kleinert H., et al. Regulation of the expression of inducible nitric oxide synthase. Eur. J. Pharmacol. 2004, 500:255-266.
    • (2004) Eur. J. Pharmacol. , vol.500 , pp. 255-266
    • Kleinert, H.1
  • 30
    • 0016562984 scopus 로고
    • A method using 3-O-methyl-D-glucose and phloretin for the determination of intracellular water space of cells in monolayer culture
    • Kletzien R.F., et al. A method using 3-O-methyl-D-glucose and phloretin for the determination of intracellular water space of cells in monolayer culture. Ann. Biochem. 1975, 68:537-544.
    • (1975) Ann. Biochem. , vol.68 , pp. 537-544
    • Kletzien, R.F.1
  • 31
    • 0021967542 scopus 로고
    • Measurement of GFAP in hepatic encephalopathy by ELISA and transblots
    • Kretzschmar H.A., et al. Measurement of GFAP in hepatic encephalopathy by ELISA and transblots. J. Neuropathol. Exp. Neurol. 1985, 44:459-471.
    • (1985) J. Neuropathol. Exp. Neurol. , vol.44 , pp. 459-471
    • Kretzschmar, H.A.1
  • 32
    • 67650294069 scopus 로고    scopus 로고
    • Hypothermia for the treatment of ischemic and hemorrhagic stroke
    • Linares G., Mayer S.A. Hypothermia for the treatment of ischemic and hemorrhagic stroke. Crit. Care. Med. 2009, 37:S243-S249.
    • (2009) Crit. Care. Med. , vol.37
    • Linares, G.1    Mayer, S.A.2
  • 33
    • 51649097967 scopus 로고    scopus 로고
    • Essential role of nuclear factor-kappaB for NADPH oxidase activity in normal and anhidrotic ectodermal dysplasia leukocytes
    • Luengo-Blanco M., et al. Essential role of nuclear factor-kappaB for NADPH oxidase activity in normal and anhidrotic ectodermal dysplasia leukocytes. Blood 2008, 112:1453-1460.
    • (2008) Blood , vol.112 , pp. 1453-1460
    • Luengo-Blanco, M.1
  • 34
    • 37549051753 scopus 로고    scopus 로고
    • Regulation of NADPH oxidase subunit p22(phox) by NF-kB in human aortic smooth muscle cells
    • Manea A., et al. Regulation of NADPH oxidase subunit p22(phox) by NF-kB in human aortic smooth muscle cells. Arch. Physiol. Biochem. 2007, 113:163-172.
    • (2007) Arch. Physiol. Biochem. , vol.113 , pp. 163-172
    • Manea, A.1
  • 35
    • 0018379684 scopus 로고
    • Correlation of plasma and brain amino acid and putative neurotransmitter alterations during acute hepatic coma in the rat
    • Mans A.M., et al. Correlation of plasma and brain amino acid and putative neurotransmitter alterations during acute hepatic coma in the rat. J. Neurochem. 1979, 32:285-292.
    • (1979) J. Neurochem. , vol.32 , pp. 285-292
    • Mans, A.M.1
  • 36
    • 0018146391 scopus 로고
    • A simple gravimetric technique for measurement of cerebral edema
    • Marmarou A., et al. A simple gravimetric technique for measurement of cerebral edema. J. Neurosurg. 1978, 49:530-537.
    • (1978) J. Neurosurg. , vol.49 , pp. 530-537
    • Marmarou, A.1
  • 37
    • 0017735996 scopus 로고
    • A light and electron microscopic study of experimental portal-systemic (ammonia) encephalopathy. Progression and reversal of the disorder
    • Norenberg M.D. A light and electron microscopic study of experimental portal-systemic (ammonia) encephalopathy. Progression and reversal of the disorder. Lab. Invest. 1977, 36:618-627.
    • (1977) Lab. Invest. , vol.36 , pp. 618-627
    • Norenberg, M.D.1
  • 38
    • 0030448092 scopus 로고    scopus 로고
    • Astrocytic-ammonia interactions in hepatic encephalopathy
    • Norenberg M.D. Astrocytic-ammonia interactions in hepatic encephalopathy. Semin. Liver. Dis. 1996, 16:245-253.
    • (1996) Semin. Liver. Dis. , vol.16 , pp. 245-253
    • Norenberg, M.D.1
  • 39
    • 0025330683 scopus 로고
    • Ammonia induced decrease in glial fibrillary acidic protein in cultured astrocytes
    • Norenberg M.D., et al. Ammonia induced decrease in glial fibrillary acidic protein in cultured astrocytes. J. Neuropathol. Exp. Neurol. 1990, 49:399-405.
    • (1990) J. Neuropathol. Exp. Neurol. , vol.49 , pp. 399-405
    • Norenberg, M.D.1
  • 40
    • 0025882742 scopus 로고
    • Ammonia-induced astrocyte swelling in primary culture
    • Norenberg M.D., et al. Ammonia-induced astrocyte swelling in primary culture. Neurochem. Res. 1991, 16:833-836.
    • (1991) Neurochem. Res. , vol.16 , pp. 833-836
    • Norenberg, M.D.1
  • 41
    • 5444262536 scopus 로고    scopus 로고
    • Oxidative stress in the pathogenesis of hepatic encephalopathy
    • Norenberg M.D., et al. Oxidative stress in the pathogenesis of hepatic encephalopathy. Metab Brain Dis. 2004, 19:313-329.
    • (2004) Metab Brain Dis. , vol.19 , pp. 313-329
    • Norenberg, M.D.1
  • 42
    • 35449004571 scopus 로고    scopus 로고
    • New concepts in the mechanism of ammonia-induced astrocyte swelling
    • Norenberg M.D., et al. New concepts in the mechanism of ammonia-induced astrocyte swelling. Metab. Brain. Dis. 2007, 22:219-234.
    • (2007) Metab. Brain. Dis. , vol.22 , pp. 219-234
    • Norenberg, M.D.1
  • 43
    • 60449101891 scopus 로고    scopus 로고
    • Signaling factors in the mechanism of ammonia neurotoxicity
    • Norenberg M.D., et al. Signaling factors in the mechanism of ammonia neurotoxicity. Metab. Brain. Dis. 2009, 24:103-117.
    • (2009) Metab. Brain. Dis. , vol.24 , pp. 103-117
    • Norenberg, M.D.1
  • 44
    • 33645293490 scopus 로고    scopus 로고
    • The role of infection and inflammation in the pathogenesis of hepatic encephalopathy and cerebral edema in acute liver failure
    • O'Beirne J.P., et al. The role of infection and inflammation in the pathogenesis of hepatic encephalopathy and cerebral edema in acute liver failure. Nat. Clin. Pract. Gastroenterol. Hepatol. 2006, 3:118-119.
    • (2006) Nat. Clin. Pract. Gastroenterol. Hepatol. , vol.3 , pp. 118-119
    • O'Beirne, J.P.1
  • 46
    • 77749237129 scopus 로고    scopus 로고
    • Brain edema in acute liver failure: inhibition by L-histidine
    • Rama Rao K.V., et al. Brain edema in acute liver failure: inhibition by L-histidine. Am. J. Pathol. 2010, 176:1400-1408.
    • (2010) Am. J. Pathol. , vol.176 , pp. 1400-1408
    • Rama Rao, K.V.1
  • 47
    • 34247547012 scopus 로고    scopus 로고
    • Hypoosmotic swelling and ammonia increase oxidative stress by NADPH oxidase in cultured astrocytes and vital brain slices
    • Reinehr R., et al. Hypoosmotic swelling and ammonia increase oxidative stress by NADPH oxidase in cultured astrocytes and vital brain slices. Glia 2007, 55:758-771.
    • (2007) Glia , vol.55 , pp. 758-771
    • Reinehr, R.1
  • 48
    • 0030056280 scopus 로고    scopus 로고
    • Resuscitation from severe brain trauma
    • Rosomoff H.L., et al. Resuscitation from severe brain trauma. Crit. Care. Med. 1996, 24:S48-S56.
    • (1996) Crit. Care. Med. , vol.24
    • Rosomoff, H.L.1
  • 49
    • 0027416830 scopus 로고
    • Effect of inhibition of ornithine aminotransferase on thioacetamide-induced hepatogenic encephalopathy
    • Sarhan S., et al. Effect of inhibition of ornithine aminotransferase on thioacetamide-induced hepatogenic encephalopathy. Neurochem. Res. 1993, 18:539-549.
    • (1993) Neurochem. Res. , vol.18 , pp. 539-549
    • Sarhan, S.1
  • 50
    • 0036581130 scopus 로고    scopus 로고
    • Ammonia induces MK-801-sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes
    • Schliess F., et al. Ammonia induces MK-801-sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes. FASEB J. 2002, 16:739-741.
    • (2002) FASEB J. , vol.16 , pp. 739-741
    • Schliess, F.1
  • 51
    • 27144492341 scopus 로고    scopus 로고
    • The pathophysiologic basis of hepatic encephalopathy: central role for ammonia and inflammation
    • Shawcross D., et al. The pathophysiologic basis of hepatic encephalopathy: central role for ammonia and inflammation. Cell. Mol. Life. Sci. 2005, 62:2295-2304.
    • (2005) Cell. Mol. Life. Sci. , vol.62 , pp. 2295-2304
    • Shawcross, D.1
  • 52
    • 50849122660 scopus 로고    scopus 로고
    • NF-kappaB in the mechanism of ammonia-induced astrocyte swelling in culture
    • Sinke A.P., et al. NF-kappaB in the mechanism of ammonia-induced astrocyte swelling in culture. J. Neurochem. 2008, 106:2302-2311.
    • (2008) J. Neurochem. , vol.106 , pp. 2302-2311
    • Sinke, A.P.1
  • 53
    • 0019812127 scopus 로고
    • Glial fibrillary acidic protein in hepatic encephalopathy. An immunohistochemical study
    • Sobel R.A., et al. Glial fibrillary acidic protein in hepatic encephalopathy. An immunohistochemical study. J. Neuropathol. Exp. Neurol. 1981, 40:625-632.
    • (1981) J. Neuropathol. Exp. Neurol. , vol.40 , pp. 625-632
    • Sobel, R.A.1
  • 54
    • 0030613758 scopus 로고    scopus 로고
    • NF-kappaB activation: the I kappaB kinase revealed?
    • Stancovski I., Baltimore D. NF-kappaB activation: the I kappaB kinase revealed?. Cell 1997, 91:299-302.
    • (1997) Cell , vol.91 , pp. 299-302
    • Stancovski, I.1    Baltimore, D.2
  • 55
    • 0033538533 scopus 로고    scopus 로고
    • Amelioration of experimental allergic encephalomyelitis in Lewis rats by lovastatin
    • Stanislaus R., et al. Amelioration of experimental allergic encephalomyelitis in Lewis rats by lovastatin. Neurosci. Lett. 1999, 269:71-74.
    • (1999) Neurosci. Lett. , vol.269 , pp. 71-74
    • Stanislaus, R.1
  • 56
    • 0026321620 scopus 로고
    • Intracellular pH rises and astrocytes swell after portacaval anastomosis in rats
    • Swain M.S., et al. Intracellular pH rises and astrocytes swell after portacaval anastomosis in rats. Am. J. Physiol. 1991, 261:R1491-R1496.
    • (1991) Am. J. Physiol. , vol.261
    • Swain, M.S.1
  • 57
    • 0026516232 scopus 로고
    • Ammonia and related amino acids in the pathogenesis of brain edema in acute ischemic liver failure in rats
    • Swain M., et al. Ammonia and related amino acids in the pathogenesis of brain edema in acute ischemic liver failure in rats. Hepatology 1992, 15:449-453.
    • (1992) Hepatology , vol.15 , pp. 449-453
    • Swain, M.1
  • 58
    • 0023607036 scopus 로고
    • Electron microscopic evaluation of brain edema in rabbits with galactosamine-induced fulminant hepatic failure: ultrastructure and integrity of the blood-brain barrier
    • Traber P.G., et al. Electron microscopic evaluation of brain edema in rabbits with galactosamine-induced fulminant hepatic failure: ultrastructure and integrity of the blood-brain barrier. Hepatology 1987, 7:1272-1277.
    • (1987) Hepatology , vol.7 , pp. 1272-1277
    • Traber, P.G.1
  • 60
    • 0021045693 scopus 로고
    • Acute hyperammonemia in the young primate: physiologic and neuropathologic correlates
    • Voorhies T.M., et al. Acute hyperammonemia in the young primate: physiologic and neuropathologic correlates. Pediatr. Res. 1983, 17:970-975.
    • (1983) Pediatr. Res. , vol.17 , pp. 970-975
    • Voorhies, T.M.1
  • 61
    • 0030062478 scopus 로고    scopus 로고
    • Inhibition of glutamine synthetase reduces ammonia-induced astrocyte swelling in rat
    • Willard-Mack C.L., et al. Inhibition of glutamine synthetase reduces ammonia-induced astrocyte swelling in rat. Neuroscience 1996, 71:589-599.
    • (1996) Neuroscience , vol.71 , pp. 589-599
    • Willard-Mack, C.L.1
  • 62
    • 35448939296 scopus 로고    scopus 로고
    • Brain cytokine flux in acute liver failure and its relationship with intracranial hypertension
    • Wright G., et al. Brain cytokine flux in acute liver failure and its relationship with intracranial hypertension. Metab. Brain. Dis. 2007, 22:375-388.
    • (2007) Metab. Brain. Dis. , vol.22 , pp. 375-388
    • Wright, G.1
  • 63
    • 0027939931 scopus 로고
    • Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase
    • Xie Q.W., et al. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J. Biol. Chem. 1994, 269:4705-4708.
    • (1994) J. Biol. Chem. , vol.269 , pp. 4705-4708
    • Xie, Q.W.1
  • 64
    • 0038403914 scopus 로고    scopus 로고
    • Excitotoxic mechanism of cell swelling in rat cerebral cortical slices treated acutely with ammonia
    • Zielinska M., et al. Excitotoxic mechanism of cell swelling in rat cerebral cortical slices treated acutely with ammonia. Neurochem. Int. 2003, 43:299-303.
    • (2003) Neurochem. Int. , vol.43 , pp. 299-303
    • Zielinska, M.1
  • 65
    • 0024502916 scopus 로고
    • Hepatic encephalopathy in thioacetamide induced acute liver failure in rats: characterization of an improved model and study of amino acid-ergic neurotransmission
    • Zimmermann Z., et al. Hepatic encephalopathy in thioacetamide induced acute liver failure in rats: characterization of an improved model and study of amino acid-ergic neurotransmission. Hepatology 1989, 9:54-60.
    • (1989) Hepatology , vol.9 , pp. 54-60
    • Zimmermann, Z.1
  • 66
    • 0033672168 scopus 로고    scopus 로고
    • Effects of ammonia exposition on glioma cells: changes in cell volume and organic osmolytes studied by diffusion-weighted and high-resolution NMR spectroscopy
    • Zwingmann C., et al. Effects of ammonia exposition on glioma cells: changes in cell volume and organic osmolytes studied by diffusion-weighted and high-resolution NMR spectroscopy. Dev. Neurosci. 2000, 22:463-471.
    • (2000) Dev. Neurosci. , vol.22 , pp. 463-471
    • Zwingmann, C.1


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