High expression of Beclin-1 predicts favorable prognosis for patients with colorectal cancer

Clinics and Research in Hepatology and Gastroenterology

Volumn 39, Issue 1, 2015, Pages 98-106

  Yang, Zuli ^a   Ghoorun, Roshan Ara ^a   Fan, Xinjuan ^b   Wu, Peihuang ^b   Bai, Yang ^a   Li, Jizheng ^a   Chen, Hao ^a   Wang, Lei ^a   Wang, Jianping ^a  

^a THE SIXTH AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BECLIN 1; APOPTOSIS REGULATORY PROTEIN; BECN1 PROTEIN, HUMAN; MEMBRANE PROTEIN;

ADULT; AGED; ARTICLE; AUTOPHAGY; CANCER PATIENT; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; COLORECTAL CANCER; DISEASE FREE SURVIVAL; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PREDICTION; TISSUE MICROARRAY; BIOSYNTHESIS; COLORECTAL NEOPLASMS; METABOLISM; MIDDLE AGED; MORTALITY; PROGNOSIS;

APOPTOSIS REGULATORY PROTEINS; COLORECTAL NEOPLASMS; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; PROGNOSIS;

EID: 84922253816     PISSN: 22107401     EISSN: 2210741X     Source Type: Journal    
DOI: 10.1016/j.clinre.2014.06.014     Document Type: Article

References (29)

1. Haggar F.A., Boushey R.P. Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors. Clin Colon Rectal Surg 2009, 22(4):191-197.
2. http://www.seer.cancer.gov/statfacts/html/colorect.html.
3. Helgi B., Ulrik W., Lars H., Bengt G. Survival endpoints in colorectal cancer and the effect of second primary other cancer on disease free survival. BMC Cancer 2011, 11:438.
4. Wan X.B., Zhao Y., Fan X.J., Cai H.M., Zhang Y., Chen M.Y., et al. Molecular prognostic prediction for locally advanced nasopharyngeal carcinoma by support vector machine integrated approach. PLoS ONE 2012, 7:e31989.
5. Kelley R.K., Wang G., Venook A.P. Biomarker use in colorectal cancer therapy. J Natl Compr Canc Netw 2011, 9(11):1293-1302.
6. Dunn W.A. Autophagy and related mechanisms of lysosome-mediated protein degradation. Trends Cell Biol 1994, 4(4):139-143.
7. Liang X.H., Kleeman L.K., Jiang H.H., Gordon G., Goldman J.E., Berry G., et al. Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol 1998, 72(11):8586-8596.
8. Koneri K., Goi T., Hirono Y., Katayama K., Yamaguchi A. Beclin 1 gene inhibits tumor growth in colon cancer cell lines. Anticancer Res 2007, 27:1453-1457.
9. Mathew R., Karantza-Wadsworth V., White E. Assessing metabolic stress and autophagy status in epithelial tumors. Methods Enzymol 2009, 453:53-81.
10. Chifenti B., Locci M.T., Lazzeri G., Guagnozzi M., Dinucci D., Chiellini F., et al. Autophagy-related protein LC3 and Beclin-1 in the first trimester of pregnancy. Clin Exp Reprod Med 2013, 40(1):33-37.
11. Xia P., Wang J.J., Zhao B.B., Song C.L. The role of beclin-1 expression in patients with gastric cancer: a meta-analysis. Tumour Biol 2013, 34(6):3303-3307.
12. Huang L., Wang S., Li S.S., Yang X.M. Prognostic significance of beclin-1 expression in laryngeal squamous cell carcinoma. Pathol Oncol Res 2013, 19(4):771-777.
13. Lin H.X., Qiu H.J., Zeng F., Rao H.L., Yang G.F., Kung H.F., et al. Decreased expression of Beclin 1 correlates closely with Bcl-xL expression and poor prognosis of ovarian carcinoma. PLoS ONE 2013, 8(4):e60516.
14. Fan X.J., Wan X.B., Huang Y., Cai H.M., Fu X.H., Yang Z.L., et al. Epithelial-mesenchymal transition biomarkers and support vector machine guided model in preoperatively predicting regional lymph node metastasis for rectal cancer. Br J Cancer 2012, 106(11):1735-1741.
15. Lao V.V., Welcsh P., Luo Y., Carter K.T., Dzieciatkowski S., Dintzis S., et al. Altered RECQ helicase expression in sporadic primary colorectal cancers. Transl Oncol 2013, 6(4):458-469.
16. Zlobec I., Vuong T., Hayashi S., Haegert D., Tornillo L., Terracciano L., et al. A simple and reproducible scoring system for EGFR in colorectal cancer: application to prognosis and prediction of response to preoperative brachytherapy. Br J Cancer 2007, 96:793-800.
17. Baynes R.D., Gansert J. Kras mutational status as a predictor of epidermal growth factor receptor inhibitor efficacy in colorectal cancer. Am J Ther 2009, 16:554-561.
18. Amado R.G., Wolf M., Peeters M., Van Cutsem E., Siena S., Freeman D.J., et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 2008, 26(10):1626-1634.
19. Di Nicolantonio F., Martini M., Molinari F., Sartore-Bianchi A., Arena S., Saletti P., et al. Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol 2008, 26(35):5705-5712.
20. Tsuchihara K.L., Fujii S., Esumi H. Autophagy and cancer: dynamism of the metabolism of tumor cells and tissues. Cancer Lett 2009, 278(2):130-138.
21. Aita V.M., Liang X.H., Murty V.V., Pincus D.L., Yu W., Cayanis E., et al. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics 1999, 59(1):59-65.
22. Li B.X., Li C.Y., Peng R.Q., Wu X.J., Wang H.Y., Wan D.S., et al. The expression of beclin 1 is associated with favorable prognosis in stage IIIB colon cancers. Autophagy 2009, 5:303-306.
23. Ahn C.H., Jeong E.G., Lee J.W., Kim M.S., Kim S.H., Kim S.S., et al. Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers. APMIS 2007, 115:1344-1349.
24. Yang X.Q., Chen C., Wang F.B., Peng C.W., Li Y. Preoperative serum carcinoembryonic antigen, carbohydrate antigen19-9 and carbohydrate antigen 125 as prognostic factors for recurrence-free survival in colorectal cancer. Asian Pac J Cancer Prev 2011, 12(5):1251-1256.
25. Kim H.S., Lee S.H., Do S.I., Lim S.J., Park Y.K., Kim Y.W. Clinicopathologic correlation of beclin-1 expression in pancreatic ductal adenocarcinoma. Pathol Res Pract 2011, 207(4):247-252.
26. Roesly H.B., Khan M.R., Chen H.D., Hill K.A., Narendran N., Watts G.S., et al. The decreased expression of Beclin-1 correlates with progression to esophageal adenocarcinoma: the role of deoxycholic acid. Am J Physiol Gastrointest Liver Physiol 2012, 302(8):G864-G872.
27. Chen Y., Lu Y., Lu C., Zhang L. Beclin-1 expression is a predictor of clinical outcome in patients with esophageal squamous cell carcinoma and correlated to hypoxia-inducible factor (HIF)-1 alpha expression. POR 2009, 9(3):487-493.
28. Ding Z.B., Shi Y.H., Zhou J., Qiu S.J., Xu Y., Dai Z., et al. Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma. Cancer Res 2008, 9(22):9167.
29. Geng Q.R., Xu D.Z., He L.J., Lu J.B., Zhou Z.W., Zhan Y.Q., et al. Beclin-1 expression is a significant predictor of survival in patients with lymph node-positive gastric cancer. PLoS ONE 2012, 7(9):e45968.