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Volumn 8, Issue 4, 2013, Pages

Decreased Expression of Beclin 1 Correlates Closely with Bcl-xL Expression and Poor Prognosis of Ovarian Carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

BECLIN 1; PROTEIN BCL XL;

EID: 84875738196     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060516     Document Type: Article
Times cited : (51)

References (42)
  • 3
    • 0028084765 scopus 로고
    • FIGO stage, histology, histologic grade, age and race as prognostic factors in determining survival for cancers of the female gynecological system: an analysis of 1973-87 SEER cases of cancers of the endometrium, cervix, ovary, vulva, and vagina
    • Kosary CL, (1994) FIGO stage, histology, histologic grade, age and race as prognostic factors in determining survival for cancers of the female gynecological system: an analysis of 1973-87 SEER cases of cancers of the endometrium, cervix, ovary, vulva, and vagina. Semin Surg Oncol 10: 31-46.
    • (1994) Semin Surg Oncol , vol.10 , pp. 31-46
    • Kosary, C.L.1
  • 4
    • 0036365026 scopus 로고    scopus 로고
    • Current diagnosis and treatment modalities for ovarian cancer
    • Schwartz PE, (2002) Current diagnosis and treatment modalities for ovarian cancer. Cancer Treat Res 107: 99-118.
    • (2002) Cancer Treat Res , vol.107 , pp. 99-118
    • Schwartz, P.E.1
  • 5
    • 39749171410 scopus 로고    scopus 로고
    • Early events in the pathogenesis of epithelial ovarian cancer
    • Landen CN Jr, Birrer MJ, Sood AK, (2008) Early events in the pathogenesis of epithelial ovarian cancer. J Clin Oncol 26: 995-1005.
    • (2008) J Clin Oncol , vol.26 , pp. 995-1005
    • Landen Jr, C.N.1    Birrer, M.J.2    Sood, A.K.3
  • 6
    • 0000906170 scopus 로고    scopus 로고
    • Induction of autophagy and inhibition of tumorigenesis by beclin 1
    • Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, et al. (1999) Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402: 672-676.
    • (1999) Nature , vol.402 , pp. 672-676
    • Liang, X.H.1    Jackson, S.2    Seaman, M.3    Brown, K.4    Kempkes, B.5
  • 7
    • 0001488499 scopus 로고    scopus 로고
    • Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein
    • Liang XH, Kleeman LK, Jiang HH, Gordon G, Goldman JE, et al. (1998) Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol 72: 8586-8596.
    • (1998) J Virol , vol.72 , pp. 8586-8596
    • Liang, X.H.1    Kleeman, L.K.2    Jiang, H.H.3    Gordon, G.4    Goldman, J.E.5
  • 8
    • 59149090850 scopus 로고    scopus 로고
    • Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy
    • Pattingre S, Bauvy C, Carpentier S, Levade T, Levine B, et al. (2009) Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy. J Biol Chem 284: 2719-2728.
    • (2009) J Biol Chem , vol.284 , pp. 2719-2728
    • Pattingre, S.1    Bauvy, C.2    Carpentier, S.3    Levade, T.4    Levine, B.5
  • 9
    • 25144457455 scopus 로고    scopus 로고
    • Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
    • Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, et al. (2005) Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122: 927-939.
    • (2005) Cell , vol.122 , pp. 927-939
    • Pattingre, S.1    Tassa, A.2    Qu, X.3    Garuti, R.4    Liang, X.H.5
  • 10
    • 10344262564 scopus 로고    scopus 로고
    • Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes
    • Shimizu S, Kanaseki T, Mizushima N, Mizuta T, Arakawa-Kobayashi S, et al. (2004) Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol 6: 1221-1228.
    • (2004) Nat Cell Biol , vol.6 , pp. 1221-1228
    • Shimizu, S.1    Kanaseki, T.2    Mizushima, N.3    Mizuta, T.4    Arakawa-Kobayashi, S.5
  • 11
    • 43649104579 scopus 로고    scopus 로고
    • Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
    • Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, et al. (2008) Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem 283: 10892-10903.
    • (2008) J Biol Chem , vol.283 , pp. 10892-10903
    • Zhang, H.1    Bosch-Marce, M.2    Shimoda, L.A.3    Tan, Y.S.4    Baek, J.H.5
  • 13
    • 60549089824 scopus 로고    scopus 로고
    • Overexpression of EIF-5A2 is an independent predictor of outcome in patients of urothelial carcinoma of the bladder treated with radical cystectomy
    • Chen W, Luo JH, Hua WF, Zhou FJ, Lin MC, et al. (2009) Overexpression of EIF-5A2 is an independent predictor of outcome in patients of urothelial carcinoma of the bladder treated with radical cystectomy. Cancer Epidemiol Biomarkers Prev 18: 400-408.
    • (2009) Cancer Epidemiol Biomarkers Prev , vol.18 , pp. 400-408
    • Chen, W.1    Luo, J.H.2    Hua, W.F.3    Zhou, F.J.4    Lin, M.C.5
  • 14
    • 34347344990 scopus 로고    scopus 로고
    • Ambra1 regulates autophagy and development of the nervous system
    • Fimia GM, Stoykova A, Romagnoli A, Giunta L, Di Bartolomeo S, et al. (2007) Ambra1 regulates autophagy and development of the nervous system. Nature 447: 1121-1125.
    • (2007) Nature , vol.447 , pp. 1121-1125
    • Fimia, G.M.1    Stoykova, A.2    Romagnoli, A.3    Giunta, L.4    Di Bartolomeo, S.5
  • 15
    • 34848899280 scopus 로고    scopus 로고
    • Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis
    • Takahashi Y, Coppola D, Matsushita N, Cualing HD, Sun M, et al. (2007) Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol 9: 1142-1151.
    • (2007) Nat Cell Biol , vol.9 , pp. 1142-1151
    • Takahashi, Y.1    Coppola, D.2    Matsushita, N.3    Cualing, H.D.4    Sun, M.5
  • 16
    • 39049194057 scopus 로고    scopus 로고
    • The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function
    • Furuya N, Yu J, Byfield M, Pattingre S, Levine B, (2005) The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy 1: 46-52.
    • (2005) Autophagy , vol.1 , pp. 46-52
    • Furuya, N.1    Yu, J.2    Byfield, M.3    Pattingre, S.4    Levine, B.5
  • 17
    • 59249089394 scopus 로고    scopus 로고
    • Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG
    • Itakura E, Kishi C, Inoue K, Mizushima N, (2008) Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell 19: 5360-5372.
    • (2008) Mol Biol Cell , vol.19 , pp. 5360-5372
    • Itakura, E.1    Kishi, C.2    Inoue, K.3    Mizushima, N.4
  • 18
    • 34248998801 scopus 로고    scopus 로고
    • Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1
    • Maiuri MC, Le Toumelin G, Criollo A, Rain JC, Gautier F, et al. (2007) Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J 26: 2527-2539.
    • (2007) EMBO J , vol.26 , pp. 2527-2539
    • Maiuri, M.C.1    Le Toumelin, G.2    Criollo, A.3    Rain, J.C.4    Gautier, F.5
  • 20
    • 9144240441 scopus 로고    scopus 로고
    • Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
    • Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, et al. (2003) Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 112: 1809-1820.
    • (2003) J Clin Invest , vol.112 , pp. 1809-1820
    • Qu, X.1    Yu, J.2    Bhagat, G.3    Furuya, N.4    Hibshoosh, H.5
  • 21
    • 0345166111 scopus 로고    scopus 로고
    • Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
    • Yue Z, Jin S, Yang C, Levine AJ, Heintz N, (2003) Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A 100: 15077-15082.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 15077-15082
    • Yue, Z.1    Jin, S.2    Yang, C.3    Levine, A.J.4    Heintz, N.5
  • 22
    • 34047271129 scopus 로고    scopus 로고
    • Protein and mRNA expression of autophagy gene Beclin 1 in human brain tumours
    • Miracco C, Cosci E, Oliveri G, Luzi P, Pacenti L, et al. (2007) Protein and mRNA expression of autophagy gene Beclin 1 in human brain tumours. Int J Oncol 30: 429-436.
    • (2007) Int J Oncol , vol.30 , pp. 429-436
    • Miracco, C.1    Cosci, E.2    Oliveri, G.3    Luzi, P.4    Pacenti, L.5
  • 23
    • 65249135974 scopus 로고    scopus 로고
    • Prognostic significance of Beclin 1-dependent apoptotic activity in hepatocellular carcinoma
    • Shi YH, Ding ZB, Zhou J, Qiu SJ, Fan J, (2009) Prognostic significance of Beclin 1-dependent apoptotic activity in hepatocellular carcinoma. Autophagy 5: 380-382.
    • (2009) Autophagy , vol.5 , pp. 380-382
    • Shi, Y.H.1    Ding, Z.B.2    Zhou, J.3    Qiu, S.J.4    Fan, J.5
  • 24
    • 37549063395 scopus 로고    scopus 로고
    • Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers
    • Ahn CH, Jeong EG, Lee JW, Kim MS, Kim SH, et al. (2007) Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers. APMIS 115: 1344-1349.
    • (2007) APMIS , vol.115 , pp. 1344-1349
    • Ahn, C.H.1    Jeong, E.G.2    Lee, J.W.3    Kim, M.S.4    Kim, S.H.5
  • 25
    • 77953708091 scopus 로고    scopus 로고
    • Elevated Beclin 1 expression is correlated with HIF-1alpha in predicting poor prognosis of nasopharyngeal carcinoma
    • Wan XB, Fan XJ, Chen MY, Xiang J, Huang PY, et al. (2010) Elevated Beclin 1 expression is correlated with HIF-1alpha in predicting poor prognosis of nasopharyngeal carcinoma. Autophagy 6: 395-404.
    • (2010) Autophagy , vol.6 , pp. 395-404
    • Wan, X.B.1    Fan, X.J.2    Chen, M.Y.3    Xiang, J.4    Huang, P.Y.5
  • 26
    • 77955899223 scopus 로고    scopus 로고
    • Beclin 1 expression: predictor of prognosis in patients with extranodal natural killer T-cell lymphoma, nasal type
    • Huang JJ, Li HR, Huang Y, Jiang WQ, Xu RH, et al. (2010) Beclin 1 expression: predictor of prognosis in patients with extranodal natural killer T-cell lymphoma, nasal type. Autophagy 6: 777-783.
    • (2010) Autophagy , vol.6 , pp. 777-783
    • Huang, J.J.1    Li, H.R.2    Huang, Y.3    Jiang, W.Q.4    Xu, R.H.5
  • 27
    • 58149084586 scopus 로고    scopus 로고
    • Decreased expression of autophagy-related proteins in malignant epithelial ovarian cancer
    • Shen Y, Li DD, Wang LL, Deng R, Zhu XF, (2008) Decreased expression of autophagy-related proteins in malignant epithelial ovarian cancer. Autophagy 4: 1067-1068.
    • (2008) Autophagy , vol.4 , pp. 1067-1068
    • Shen, Y.1    Li, D.D.2    Wang, L.L.3    Deng, R.4    Zhu, X.F.5
  • 28
    • 8444244786 scopus 로고    scopus 로고
    • X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization
    • Camp RL, Dolled-Filhart M, Rimm DL, (2004) X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res 10: 7252-7259.
    • (2004) Clin Cancer Res , vol.10 , pp. 7252-7259
    • Camp, R.L.1    Dolled-Filhart, M.2    Rimm, D.L.3
  • 29
    • 79954551933 scopus 로고    scopus 로고
    • Expressions of the gamma2 chain of laminin-5 and secreted protein acidic and rich in cysteine in esophageal squamous cell carcinoma and their relation to prognosis
    • Xue LY, Zou SM, Zheng S, Liu XY, Wen P, et al. (2011) Expressions of the gamma2 chain of laminin-5 and secreted protein acidic and rich in cysteine in esophageal squamous cell carcinoma and their relation to prognosis. Chin J Cancer 30: 69-78.
    • (2011) Chin J Cancer , vol.30 , pp. 69-78
    • Xue, L.Y.1    Zou, S.M.2    Zheng, S.3    Liu, X.Y.4    Wen, P.5
  • 30
    • 30644472260 scopus 로고    scopus 로고
    • Expression of cytoplasmic and nuclear Survivin in primary and secondary human glioblastoma
    • Xie D, Zeng YX, Wang HJ, Wen JM, Tao Y, et al. (2006) Expression of cytoplasmic and nuclear Survivin in primary and secondary human glioblastoma. Br J Cancer 94: 108-114.
    • (2006) Br J Cancer , vol.94 , pp. 108-114
    • Xie, D.1    Zeng, Y.X.2    Wang, H.J.3    Wen, J.M.4    Tao, Y.5
  • 31
    • 84867509337 scopus 로고    scopus 로고
    • Expression of RRM1 and its association with resistancy to gemcitabine-based chemotherapy in advanced nasopharyngeal carcinoma
    • Zhao LP, Xue C, Zhang JW, Hu ZH, Zhao YY, et al. (2012) Expression of RRM1 and its association with resistancy to gemcitabine-based chemotherapy in advanced nasopharyngeal carcinoma. Chin J Cancer 31: 476-483.
    • (2012) Chin J Cancer , vol.31 , pp. 476-483
    • Zhao, L.P.1    Xue, C.2    Zhang, J.W.3    Hu, Z.H.4    Zhao, Y.Y.5
  • 33
    • 78651506355 scopus 로고    scopus 로고
    • High expression of H3K27me3 in human hepatocellular carcinomas correlates closely with vascular invasion and predicts patients worse prognosis
    • Cai MY, Hou JH, Rao HL, Luo RZ, Li M, et al. (2011) High expression of H3K27me3 in human hepatocellular carcinomas correlates closely with vascular invasion and predicts patients worse prognosis. Mol Med 1-2: 12-20.
    • (2011) Mol Med , vol.1-2 , pp. 12-20
    • Cai, M.Y.1    Hou, J.H.2    Rao, H.L.3    Luo, R.Z.4    Li, M.5
  • 34
    • 0017277826 scopus 로고
    • Monte Carlo principles and applications
    • Raeside DE, (1976) Monte Carlo principles and applications. Phys Med Biol 21: 181-197.
    • (1976) Phys Med Biol , vol.21 , pp. 181-197
    • Raeside, D.E.1
  • 35
    • 34147193472 scopus 로고    scopus 로고
    • Cell biology: autophagy and cancer
    • Levine B, (2007) Cell biology: autophagy and cancer. Nature 446: 745-747.
    • (2007) Nature , vol.446 , pp. 745-747
    • Levine, B.1
  • 37
    • 56449107131 scopus 로고    scopus 로고
    • Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma
    • Ding ZB, Shi YH, Zhou J, Qiu SJ, Xu Y, et al. (2008) Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma. Cancer Res 68: 9167-9175.
    • (2008) Cancer Res , vol.68 , pp. 9167-9175
    • Ding, Z.B.1    Shi, Y.H.2    Zhou, J.3    Qiu, S.J.4    Xu, Y.5
  • 38
    • 70349641918 scopus 로고    scopus 로고
    • Beclin-1 expression is a predictor of clinical outcome in patients with esophageal squamous cell carcinoma and correlated to hypoxia-inducible factor (HIF)-1alpha expression
    • Chen Y, Lu Y, Lu C, Zhang L, (2009) Beclin-1 expression is a predictor of clinical outcome in patients with esophageal squamous cell carcinoma and correlated to hypoxia-inducible factor (HIF)-1alpha expression. Pathol Oncol Res 15: 487-493.
    • (2009) Pathol Oncol Res , vol.15 , pp. 487-493
    • Chen, Y.1    Lu, Y.2    Lu, C.3    Zhang, L.4
  • 39
    • 65249180744 scopus 로고    scopus 로고
    • The expression of beclin 1 is associated with favorable prognosis in stage IIIB colon cancers
    • Li BX, Li CY, Peng RQ, Wu XJ, Wang HY, et al. (2009) The expression of beclin 1 is associated with favorable prognosis in stage IIIB colon cancers. Autophagy 5: 303-306.
    • (2009) Autophagy , vol.5 , pp. 303-306
    • Li, B.X.1    Li, C.Y.2    Peng, R.Q.3    Wu, X.J.4    Wang, H.Y.5
  • 40
    • 70349649219 scopus 로고    scopus 로고
    • The prognostic role of Beclin 1 protein expression in high-grade gliomas
    • Pirtoli L, Cevenini G, Tini P, Vannini M, Oliveri G, et al. (2009) The prognostic role of Beclin 1 protein expression in high-grade gliomas. Autophagy 5: 930-936.
    • (2009) Autophagy , vol.5 , pp. 930-936
    • Pirtoli, L.1    Cevenini, G.2    Tini, P.3    Vannini, M.4    Oliveri, G.5
  • 41
    • 34249037565 scopus 로고    scopus 로고
    • Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein
    • Oberstein A, Jeffrey PD, Shi Y, (2007) Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. J Biol Chem 282: 13123-13132.
    • (2007) J Biol Chem , vol.282 , pp. 13123-13132
    • Oberstein, A.1    Jeffrey, P.D.2    Shi, Y.3


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