Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds

Biomaterials

Volumn 37, Issue , 2015, Pages 194-207

  Spiller, Kara L ^a,b   Nassiri, Sina ^b   Witherel, Claire E ^b   Anfang, Rachel R ^a   Ng, Johnathan ^a   Nakazawa, Kenneth R ^a   Yu, Tony ^b   Vunjak Novakovic, Gordana ^a  

^a Fu Foundation School of Engineering and Applied Science   (United States)

^b DREXEL UNIVERSITY   (United States)

Author keywords

Bone; Cytokines; Immunomodulation; Macrophages; Regenerative medicine; Vascularization

Indexed keywords

BONE; COENZYMES; GENE EXPRESSION; MACROPHAGES; PHYSIOLOGY; POLARIZATION; REGENERATIVE MEDICINE; TISSUE; TISSUE REGENERATION;

BIOTIN-STREPTAVIDIN; CYTOKINES; IMMUNO MODULATIONS; IMPLANTATION MODELS; MACROPHAGE PHENOTYPES; SCAFFOLDS FOR TISSUE ENGINEERING; SEQUENTIAL DELIVERY; VASCULARIZATION;

SCAFFOLDS (BIOLOGY);

BIOTIN; CCL18 PROTEIN; CD206 ANTIGEN; CD31 ANTIGEN; CELL ANTIGEN; CHEMOKINE RECEPTOR CCR7; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 4; MACROPHAGE DERIVED CHEMOKINE; MDC PROTEIN; MRC1 PROTEIN; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR BB; PROTEIN; STREPTAVIDIN; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN; BIOLOGICAL MARKER; CYTOKINE; IMMUNOLOGIC FACTOR;

ANIMAL EXPERIMENT; ARTICLE; BONE REGENERATION; BONE SCAFFOLD; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG DELIVERY SYSTEM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOMODULATION; IN VIVO STUDY; MACROPHAGE; MOUSE; NONHUMAN; PHENOTYPE; POLARIZATION; PRIORITY JOURNAL; STAINING; SUSTAINED DRUG RELEASE; TISSUE ENGINEERING; TISSUE SCAFFOLD; UPREGULATION; VASCULARIZATION; ANGIOGENESIS; ANIMAL; BONE; C57BL MOUSE; CELL POLARITY; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; IMPLANT; KINETICS; METABOLISM; SECRETION (PROCESS); SUBCUTANEOUS TISSUE; TIME FACTOR;

MURINAE;

ANIMALS; BIOMARKERS; BONE AND BONES; CELL POLARITY; CYTOKINES; DRUG DELIVERY SYSTEMS; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOLOGIC FACTORS; IMPLANTS, EXPERIMENTAL; KINETICS; MACROPHAGES; MICE, INBRED C57BL; NEOVASCULARIZATION, PHYSIOLOGIC; PHENOTYPE; SUBCUTANEOUS TISSUE; TIME FACTORS; TISSUE SCAFFOLDS;

EID: 84922249973     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.10.017     Document Type: Article

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