Intractable wounds and infections: The role of impaired vascularity and advanced surgical methods for treatment

American Journal of Surgery

Volumn 187, Issue 5 SUPPL. 1, 2004, Pages S44-S55

  Hausman, Michael R ^a   Rinker, Brian D ^b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; BONE MORPHOGENETIC PROTEIN; DOXORUBICIN; FIBROBLAST GROWTH FACTOR; FUMAGILLOL CHLOROACETYLCARBAMATE; METHOTREXATE; STEROID; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; BONE GRAFT; BONE GROWTH; COST BENEFIT ANALYSIS; EXTRACELLULAR MATRIX; FRACTURE HEALING; FRACTURE NONUNION; GENE TARGETING; HUMAN; INJURY; MICROCIRCULATION; MODEL; MORBIDITY; MORTALITY; MUSCLE FLAP; NONHUMAN; OSTEOMYELITIS; PRIORITY JOURNAL; RADIATION; REGULATORY MECHANISM; SKIN GRAFT; STEM CELL; SUBCUTANEOUS TISSUE; SURGICAL TECHNIQUE; TARGET CELL; TREATMENT OUTCOME; UPREGULATION; VASCULAR DISEASE; VASCULARIZATION; WOUND DRESSING; WOUND HEALING; WOUND INFECTION; XENOGRAFT;

EID: 2442496395     PISSN: 00029610     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9610(03)00304-0     Document Type: Article

References (45)

1. Bax B.E., Wozney J.M., Ashhurst D.E. Bone morphogenetic protein-2 increases the rate of callus formation after fracture of the rabbit tibia. Calcif Tissue Int. 65:1999;83-89
2. Croteau S., Rauch F., Silvestri A., Hamdy R.C. Bone morphogenetic proteins in orthopedics from basic science to clinical practice. Orthopedics. 22:1999;686-687
3. Einhorn T.A., Lane J.M., Burstein A.H., Kopman C.R., Vigorita V.J. The healing of segmental bone defects induced by demineralized bone matrix a radiographic and biomechanical study. J Bone Joint Surg Am. 66:1984;274-279
4. Einhorn T.A. Enhancement of fracture healing. Instr Course Lect. 45:1996;401-416
5. Kawaguchi H., Kurokawa T., Hanada K., et al. Stimulation of fracture repair by recombinant human basic fibroblast growth factor in normal and streptozotocin-diabetic rats. Endocrinology. 135:1994;774-781
6. Steinbrech D.S., Mehrara B.J., Rowe N.M., et al. Gene expression of TGF-beta, TGF-beta receptor, and extracellular matrix proteins during membranous bone healing in rats. Plast Reconstr Surg. 105:2000;2028-2038
7. Trueta J. Blood supply and the rate of healing of tibial fractures. Clin Orthop. 105:1974;11-26
8. Brighton C.T., Friedlaender G.E., Lane J.M. Bone formation and repair. 1994;American Academy of Orthopaedic Surgeons, Rosemont, IL
9. Kagel E.M., Einhorn T.A. Alterations of fracture healing in the diabetic condition. Iowa Orthop J. 16:1996;147-152
10. Laing E.J. Problems in wound healing associated with chemotherapy and radiation therapy. Probl Vet Med. 2:1990;433-441
11. Friedlaender G.E., Tross R.B., Doganis A.C., Kirkwood J.M., Baron R. Effects of chemotherapeutic agents on bone I. Short-term methotrexate and doxorubicin (Adriamycin) treatment in a rat model. J Bone Joint Surg Am. 66:1984;602-607
12. Rhinelander F.W. The normal microcirculation of diaphyseal cortex and its response to fracture. J Bone Joint Surg Am. 50:1968;784-800
13. Trueta J. Nonunion of fractures. Clin Orthop. 43:1965;23-35
14. Rhinelander F.W. The normal circulation of bone and its response to surgical intervention. J Biomed Mater Res. 8:1974;87-90
15. Rhinelander F.W., Phillips R.S., Steel W.M., Beer J.C. Microangiography in bone healing II. Displaced closed fractures. J Bone Joint Surg Am. 50:1968;643-662
16. Han C.K., Ahn S.K., Choi N.S., et al. Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2. Bioorg Med Chem Lett. 10:2000;39-43
17. Mitchell C.G., Slight J., Donaldson K. Diffusible component from the spore surface of the fungus Aspergillus fumigatus which inhibits the macrophage oxidative burst is distinct from gliotoxin and other hyphal toxins. Thorax. 52:1997;796-801
18. Ingber D., Fujita T., Kishimoto S., et al. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature. 348:1990;555-557
19. Zhang Y., Griffith E.C., Sage J., Jacks T., Liu J.O. Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21WAF1/CIP1. Proc Natl Acad Sci U S A. 97:2000;6427-6432
20. Wang J., Lou P., Henkin J. Selective inhibition of endothelial cell proliferation by fumagillin is not due to differential expression of methionine aminopeptidases. J Cell Biochem. 77:2000;465-473
21. Griffith E.C., Su Z., Turk B.E., et al. Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin. Chem Biol. 4:1997;461-471
22. Griffith E.C., Su Z., Niwayama S., Ramsay C.A., Chang Y.H., Liu J.O. Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2. Proc Natl Acad Sci U S A. 95:1998;15183-15188
23. Turk B.E., Su Z., Liu J.O. Synthetic analogues of TNP-470 and ovalicin reveal a common molecular basis for inhibition of angiogenesis and immunosuppression. Bioorg Med Chem. 6:1998;1163-1169
24. Wallace AL, Draper ER, Strachan RK, McCarthy ID, Hughes SP. The vascular response to fracture micromovement. Clin Orthop 1994;301:281-290
25. Glowacki J. Angiogenesis in fracture repair. Clin Orthop 1998;355(suppl):S82-S89
26. Rhinelander FW. Minimal internal fixation of tibial fractures. Clin Orthop 1975;107:188-220
27. Richards R.R., Mahoney J.L., Minas T. Influence of soft tissue coverage on the healing of cortical defects in canine diaphyseal bone. Ann Plast Surg. 16:1986;296-304
28. Richards R.R., Orsini E.C., Mahoney J.L., Verschuren R. The influence of muscle flap coverage on the repair of devascularized tibial cortex an experimental investigation in the dog. Plast Reconstr Surg. 79:1987;946-958
29. Richards R.R., McKee M.D., Paitich C.B., Anderson G.I., Bertoia J.T. A comparison of the effects of skin coverage and muscle flap coverage on the early strength of union at the site of osteotomy after devascularization of a segment of canine tibia. J Bone Joint Surg Am. 73:1991;1323-1330
30. Richards R.R., Schemitsch E.H. Effect of muscle flap coverage on bone blood flow following devascularization of a segment of tibia an experimental investigation in the dog. J Orthop Res. 7:1989;550-558
31. Pelker R.R., Friedlaender G.E., Panjabi M.M., et al. Chemotherapy-induced alterations in the biomechanics of rat bone. J Orthop Res. 3:1985;91-95
32. Pelker R.R., Friedlaender G.E., Panjabi M.M., Kapp D., Doganis A. Radiation-induced alterations of fracture healing biomechanics. J Orthop Res. 2:1984;90-96
33. Ferrara N. Molecular and biological properties of vascular endothelial growth factor. J Mol Med. 77:1999;527-543
34. Padubidri A., Browne E. Jr. Effect of vascular endothelial growth factor (VEGF) on survival of random extension of axial pattern skin flaps in the rat. Ann Plast Surg. 37:1996;604-611
35. Taub P.J., Marmur J.D., Zhang W.X., et al. Locally administered vascular endothelial growth factor cDNA increases survival of ischemic experimental skin flaps. Plast Reconstr Surg. 102:1998;2033-2039
36. Schemitsch E.H., Weinberg J.A., McKee M.D., Richards R.R. The relative importance of intramedullary, intracortical, and extraosseous soft-tissue blood flow to the repair of devascularized canine tibial cortex. Ann Plast Surg. 38:1997;623-631
37. Wilson J.W., Rhinelander F.W., Stewart C.L. Vascularization of cancellous chip bone grafts. Am J Vet Res. 46:1985;1691-1699
38. Attinger C., Cooper P. Soft tissue reconstruction for calcaneal fractures or osteomyelitis. Orthop Clin North Am. 32:2001;135-170
39. Attinger C. Soft-tissue coverage for lower-extremity trauma. Orthop Clin North Am. 26:1995;295-334
40. Keller K., Vasconez H.C. Customized composite reconstruction of extensive midfacial defects. Ann Plast Surg. 40:1998;291-296
41. Khouri R.K., Upton J., Shaw W.W. Prefabrication of composite free flaps through staged microvascular transfer an experimental and clinical study. Plast Reconstr Surg. 87:1991;108-115
42. Khouri R.K., Ozbek M.R., Hruza G.J., Young V.L. Facial reconstruction with prefabricated induced expanded (PIE) supraclavicular skin flaps. Plast Reconstr Surg. 95:1995;1007-1017
43. Safak T., Akyurek M., Ozcan G., Kecik A., Aydin M. Osteocutaneous flap prefabrication based on the principle of vascular induction an experimental and clinical study. Plast Reconstr Surg. 105:2000;1304-1313
44. Alam M.I., Asahina I., Seto I., Oda M., Enomoto S. Prefabricated vascularized bone flap a tissue transformation technique for bone reconstruction. Plast Reconstr Surg. 108:2001;952-958
45. Karp N.S., Bass L.S., Kasabian A.K., Eidelman Y., Hausman M.R. Balloon assisted endoscopic harvest of the latissimus dorsi muscle. Plast Reconstr Surg. 100:1997;1161-1167