Common DNA Markers Can Account for More Than Half of the Genetic Influence on Cognitive Abilities

Psychological Science

Volumn 24, Issue 4, 2013, Pages 562-568

  Plomin, Robert ^a   Haworth, Claire M A ^a   Meaburn, Emma L ^b   Price, Thomas S ^c   Davis, Oliver S P ^d  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

behavioral genetics; cognitive ability; cognitive development; genetics

Indexed keywords

EID: 84876196443     PISSN: 09567976     EISSN: 14679280     Source Type: Journal    
DOI: 10.1177/0956797612457952     Document Type: Article

References (38)

1. Chabris C. F.,Hebert B. M.,Benjamin D. J.,Beauchamp J.,Cesarini D.,van der Loos M., Laibson D.Most reported genetic associations with general intelligence are probably false positives.Psychological Science. 2012;23:1314-1323.
2. Cirulli E. T.,Goldstein D. B.Uncovering the roles of rare variants in common disease through whole-genome sequencing.Nature Reviews Genetics. 2010;11:415-425.
3. Davies G.,Tenesa A.,Payton A.,Yang J.,Harris S. E.,Liewald D., Deary I. J.Genome-wide association studies establish that human intelligence is highly heritable and polygenic.Molecular Psychiatry. 2011;16:996-1005.
4. Davis O. S. P.,Butcher L. M.,Docherty S. J.,Meaburn E. M.,Curtis C. J. C.,Simpson A., Plomin R.A three-stage genome-wide association study of general cognitive ability: Hunting the small effects.Behavior Genetics. 2010;40:759-767.
5. Davis O. S. P.,Haworth C. M. A.,Plomin R.Dramatic increase in heritability of cognitive development from early to middle childhood: An 8-year longitudinal study of 8,700 pairs of twins.Psychological Science. 2009a;20:1301-1308.
6. Davis O. S. P.,Haworth C. M. A.,Plomin R.Learning abilities and disabilities: Generalist genes in early adolescence.Cognitive Neuropsychiatry. 2009b;14:312-331.
7. Deary I. J.Intelligence.Annual Review of Psychology. 2012;63:453-482.
8. Deary I. J.,Johnson W.,Houlihan L. M.Genetic foundations of human intelligence.Human Genetics. 2009;126:215-232.
9. Deary I. J.,Penke L.,Johnson W.The neuroscience of human intelligence differences.Nature Reviews Neuroscience. 2010;11:201-211.
10. Deary I. J.,Yang J.,Davies G.,Harris S. E.,Tenesa A.,Liewald D., Visscher P. M.Genetic contributions to stability and change in intelligence from childhood to old age.Nature. 2012;482:212-215.
11. Gibson G.Rare and common variants: Twenty arguments.Nature Reviews Genetics. 2012;13:135-145.
12. Haworth C. M. A.,Harlaar N.,Kovas Y.,Davis O. S. P.,Oliver B. R.,Hayiou-Thomas M. E., Plomin R.Internet cognitive testing of large samples needed in genetic research.Twin Research and Human Genetics. 2007;10:554-563.
13. Haworth C. M. A.,Plomin R.Quantitative genetics in the era of molecular genetics: Learning abilities and disabilities as an example.Journal of the American Academy of Child & Adolescent Psychiatry. 2010;49:783-793.
14. Haworth C. M. A.,Wright M. J.,Luciano M.,Martin N. G.,de Geus E. J. C.,van Beijsterveldt C. E. M., Plomin R.The heritability of general cognitive ability increases linearly from childhood to young adulthood.Molecular Psychiatry. 2010;15:1112-1120.
15. HindorffL. A.MacArthurJ.MoralesJ.JunkinsH. A.HallP. N.KlemmA. K.ManolioT. A. (2013). A catalog of published genome-wide association studies. Retrieved from www.genome.gov/gwastudies.
16. HowieB. N.DonnellyP.MarchiniJ. (2009). A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genetics, 5, e1000529. Retrieved from http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000529.
17. Kovas Y.,Haworth C. M. A.,Dale P. S.,Plomin R.The genetic and environmental origins of learning abilities and disabilities in the early school years.Monographs of the Society for Research in Child Development. 2007;72 (3): 1-144.
18. Lango Allen H.,Estrada K.,Lettre G.,Berndt S. I.,Weedon M. N.,Rivadeneira F., Hirschhorn J. N.Hundreds of variants clustered in genomic loci and biological pathways affect human height.Nature. 2010;467:832-838.
19. Lee S. H.,DeCandia T. R.,Ripke S.,Yang J.Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs.Nature Genetics. 2012;44:247-250.
20. Lee S. H.,Wray N. R.,Goddard M. E.,Visscher P. M.Estimating missing heritability for disease from genome-wide association studies.American Journal of Human Genetics. 2011;88:294-305.
21. Lubke G. H.,Hottenga J. J.,Walters R.,Laurin C.,de Geus E. J.,Willemsen G., Boomsma D. I.Estimating the genetic variance of major depressive disorder due to all single nucleotide polymorphisms.Biological Psychiatry. 2012;:.
22. Maher B.Personal genomes: The case of the missing heritability.Nature. 2008;456:18-21.
23. McCarthy M. I.,Abecasis G. R.,Cardon L. R.,Goldstein D. B.,Little J.,Ioannidis J. P. A.,Hirschhorn J. N.Genome-wide association studies for complex traits: Consensus, uncertainty and challenges.Nature Reviews Genetics. 2008;9:356-369.
24. Nisbett R. E.,Aronson J.,Blair C.,Dickens W.,Flynn J.,Halpern D. F.,Turkheimer E.Intelligence: New findings and theoretical developments.American Psychologist. 2012;67:130-159.
25. Oliver B. R.,Plomin R.Twins Early Development Study (TEDS): A multivariate, longitudinal genetic investigation of language, cognition and behaviour problems from childhood through adolescence.Twin Research and Human Genetics. 2007;10:96-105.
26. Payton A.The impact of genetic research on our understanding of normal cognitive ageing: 1995 to 2009.Neuropsychology Review. 2009;19:451-477.
27. Plomin R.Child development and molecular genetics: 14 years later.Child Development. 2012;:.
28. Plomin R.,DeFries J. C.,Knopik V. S.,Neiderhiser J. M.Behavioral genetics. 2013). Behavioral genetics (6th ed.). New York, NY: Worth.New York, NY: Worth; 2013:.
29. Plomin R.,Kovas Y.Generalist genes and learning disabilities.Psychological Bulletin. 2005;131:592-617.
30. Speliotes E. K.,Willer C. J.,Berndt S. I.,Monda K. L.,Thorleifsson G.,Jackson A. U., Loos R. J. F.Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.Nature Genetics. 2010;42:937-948.
31. Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.Nature Genetics. 2009;41:1330-1334.
32. van Soelen I. L. C.,Brouwer R. M.,van Leeuwen M.,Kahn R. S.,Hulshoff Pol H. E.,Boomsma D. I.Heritability of verbal and performance intelligence in a pediatric longitudinal sample.Twin Research and Human Genetics. 2011;14:119-128.
33. VinkhuyzenA. A. E.PedersenN. L.YangJ.LeeS. H.MagnussonP. K. E.IaconoW. G. WrayN. R. (2012). Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion. Translational Psychiatry, 2, e102. Retrieved from http://www.nature.com/tp/journal/v2/n4/full/tp201227a.html.
34. Vinkhuyzen A. A. E.,van der Sluis S.,Maes H. H. M.,Posthuma D.Reconsidering the heritability of intelligence in adulthood: Taking assortative mating and cultural transmission into account.Behavior Genetics. 2012;42:187-198.
35. Visscher P. M.,Brown M. A.,McCarthy M. I.,Yang J.Five years of GWAS discovery.American Journal of Human Genetics. 2012;90:7-24.
36. Yang J.,Benyamin B.,McEvoy B. P.,Gordon S.,Henders A. K.,Nyholt D. R., Visscher P. M.Common SNPs explain a large proportion of the heritability for human height.Nature Genetics. 2010;42:565-569.
37. Yang J.,Lee S. H.,Goddard M. E.,Visscher P. M.GCTA: A tool for genome-wide complex trait analysis.American Journal of Human Genetics. 2011;88:76-82.
38. Yang J.,Manolio T. A.,Pasquale L. R.,Boerwinkle E.,Caporaso N.,Cunningham J. M., Visscher P. M.Genome partitioning of genetic variation for complex traits using common SNPs.Nature Genetics. 2011;43:519-525.