Kinetic analysis of the multistep aggregation mechanism of monoclonal antibodies

Journal of Physical Chemistry B

Volumn 118, Issue 36, 2014, Pages 10595-10606

  Nicoud, Lucrèce ^a   Arosio, Paolo ^b   Sozo, Margaux ^a   Yates, Andrew ^c   Norrant, Edith ^c   Morbidelli, Massimo ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UCB PHARMA   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; DIMERS; KINETICS; LIGHT SCATTERING; MONOCLONAL ANTIBODIES; MONOMERS; ORGANIC POLYMERS; PROTEINS; RATE CONSTANTS; SIZE EXCLUSION CHROMATOGRAPHY; SURFACE PLASMON RESONANCE;

AGGREGATE DISTRIBUTION; AVERAGE MOLECULAR WEIGHT; ELECTROSTATIC REPULSION; EXPERIMENTAL CHARACTERIZATION; LIGHT SCATTERING TECHNIQUES; MICROSCOPIC RATE CONSTANTS; POPULATION BALANCE EQUATION; PROTEIN-PROTEIN INTERACTIONS;

AGGLOMERATION;

GLYCOSYLATED IGG; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY;

BIOLOGICAL MODEL; CHEMICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; GEL CHROMATOGRAPHY; KINETICS; PROTEIN MULTIMERIZATION; PROTEIN UNFOLDING; RADIATION SCATTERING; STATIC ELECTRICITY; VALIDATION STUDY;

ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, GEL; COMPUTER SIMULATION; IMMUNOGLOBULIN G; KINETICS; MODELS, CHEMICAL; MODELS, IMMUNOLOGICAL; PROTEIN MULTIMERIZATION; PROTEIN UNFOLDING; SCATTERING, RADIATION; STATIC ELECTRICITY;

EID: 84922112474     PISSN: 15206106     EISSN: 15205207     Source Type: Journal    
DOI: 10.1021/jp505295j     Document Type: Article

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