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Volumn 58, Issue 2, 2015, Pages 295-303

Effect of zinc supplementation on insulin secretion: interaction between zinc and SLC30A8 genotype in Old Order Amish

Author keywords

Insulin secretion; Pharmacogenetic; SLC30A8; Type 2 diabetes; Zinc

Indexed keywords

GLUCOSE; INSULIN; PROINSULIN; SLC30A8 PROTEIN; UNCLASSIFIED DRUG; ZINC ACETATE; ZINC TRANSPORTER; CATION TRANSPORT PROTEIN; SLC30A8 PROTEIN, HUMAN;

EID: 84922093330     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3419-1     Document Type: Article
Times cited : (35)

References (50)
  • 1
    • 0037034257 scopus 로고    scopus 로고
    • Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    • Diabetes Prevention Program Research Group (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393–403
    • (2002) N Engl J Med , vol.346 , pp. 393-403
    • Diabetes Prevention Program Research Group1
  • 2
    • 77957601724 scopus 로고    scopus 로고
    • Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program
    • COI: 1:CAS:528:DC%2BC3cXhsVGhs7fF, PID: 20682687
    • Jablonski KA, McAteer JB, de Bakker PIW et al (2010) Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. Diabetes 59:2672–2681
    • (2010) Diabetes , vol.59 , pp. 2672-2681
    • Jablonski, K.A.1    McAteer, J.B.2    de Bakker, P.I.W.3
  • 3
    • 12944308811 scopus 로고    scopus 로고
    • Common polymorphisms of the PPAR-gamma2 (Pro12Ala) and PGC-1alpha (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial
    • COI: 1:CAS:528:DC%2BD2MXmsVCjtw%3D%3D, PID: 15592662
    • Andrulionyte L, Zacharova J, Chiasson JL, Laakso M (2004) Common polymorphisms of the PPAR-gamma2 (Pro12Ala) and PGC-1alpha (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial. Diabetologia 47:2176–2184
    • (2004) Diabetologia , vol.47 , pp. 2176-2184
    • Andrulionyte, L.1    Zacharova, J.2    Chiasson, J.L.3    Laakso, M.4
  • 4
    • 13244279651 scopus 로고    scopus 로고
    • The G-250A substitution in the promoter region of the hepatic lipase gene is associated with the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial
    • COI: 1:CAS:528:DC%2BD2MXit1eju74%3D, PID: 15656877
    • Zacharova J, Todorova BR, Chiasson JL, Laakso M (2005) The G-250A substitution in the promoter region of the hepatic lipase gene is associated with the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial. J Intern Med 257:185–193
    • (2005) J Intern Med , vol.257 , pp. 185-193
    • Zacharova, J.1    Todorova, B.R.2    Chiasson, J.L.3    Laakso, M.4
  • 5
    • 34547585382 scopus 로고    scopus 로고
    • Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTS study
    • COI: 1:CAS:528:DC%2BD2sXos12qsbk%3D, PID: 17519421
    • Pearson ER, Donnelly LA, Kimber C et al (2007) Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTS study. Diabetes 56:2178–2182
    • (2007) Diabetes , vol.56 , pp. 2178-2182
    • Pearson, E.R.1    Donnelly, L.A.2    Kimber, C.3
  • 6
    • 79251612707 scopus 로고    scopus 로고
    • Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3cXhs1Wis7zL, PID: 21186350
    • Zhou K, Bellenguez C, Spencer CC et al (2011) Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet 43:117–120
    • (2011) Nat Genet , vol.43 , pp. 117-120
    • Zhou, K.1    Bellenguez, C.2    Spencer, C.C.3
  • 7
    • 66649121405 scopus 로고    scopus 로고
    • Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study
    • COI: 1:CAS:528:DC%2BD1MXntFanu7s%3D, PID: 19336679
    • Zhou K, Donnelly LA, Kimber CH et al (2009) Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study. Diabetes 58:1434–1439
    • (2009) Diabetes , vol.58 , pp. 1434-1439
    • Zhou, K.1    Donnelly, L.A.2    Kimber, C.H.3
  • 8
    • 56749101779 scopus 로고    scopus 로고
    • Genotype score in addition to common risk factors for prediction of type 2 diabetes
    • COI: 1:CAS:528:DC%2BD1cXhtl2gurnE, PID: 19020323
    • Meigs JB, Shrader P, Sullivan LM et al (2008) Genotype score in addition to common risk factors for prediction of type 2 diabetes. N Engl J Med 359:2208–2219
    • (2008) N Engl J Med , vol.359 , pp. 2208-2219
    • Meigs, J.B.1    Shrader, P.2    Sullivan, L.M.3
  • 9
    • 55649105963 scopus 로고    scopus 로고
    • Clinical risk factors, DNA variants, and the development of type 2 diabetes
    • COI: 1:CAS:528:DC%2BD1cXhtl2gurnF, PID: 19020324
    • Lyssenko V, Jonsson A, Almgren P et al (2008) Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med 359:2220–2232
    • (2008) N Engl J Med , vol.359 , pp. 2220-2232
    • Lyssenko, V.1    Jonsson, A.2    Almgren, P.3
  • 10
    • 84863593506 scopus 로고    scopus 로고
    • Current genetic data do not improve the prediction of type 2 diabetes mellitus: the Colaus Study
    • COI: 1:CAS:528:DC%2BC38XhtFGqsr7E, PID: 22535968
    • Schmid R, Vollenweider P, Bastardot F, Vaucher J, Waeber G, Marques-Vidal P (2012) Current genetic data do not improve the prediction of type 2 diabetes mellitus: the Colaus Study. J Clin Endocrinol Metab 97:E1338–E1341
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. E1338-E1341
    • Schmid, R.1    Vollenweider, P.2    Bastardot, F.3    Vaucher, J.4    Waeber, G.5    Marques-Vidal, P.6
  • 11
    • 79955957666 scopus 로고    scopus 로고
    • SLC30A8 polymorphism and type 2 diabetes risk: evidence from 27 study groups
    • COI: 1:CAS:528:DC%2BC3MXmtVyltLk%3D, PID: 20167458
    • Jing YL, Sun QM, Bi Y, Shen SM, Zhu DL (2011) SLC30A8 polymorphism and type 2 diabetes risk: evidence from 27 study groups. Nutr Metab Cardiovasc Dis 21:398–405
    • (2011) Nutr Metab Cardiovasc Dis , vol.21 , pp. 398-405
    • Jing, Y.L.1    Sun, Q.M.2    Bi, Y.3    Shen, S.M.4    Zhu, D.L.5
  • 12
    • 77950520084 scopus 로고    scopus 로고
    • Meta-analysis and functional effects of the SlC30A8 rs13266634 polymorphism on isolated human pancreatic islets
    • COI: 1:CAS:528:DC%2BC3cXks1Wisrg%3D, PID: 20138556
    • Cauchi S, del Guerra S, Choquet H et al (2010) Meta-analysis and functional effects of the SlC30A8 rs13266634 polymorphism on isolated human pancreatic islets. Mol Genet Metab 100:77–82
    • (2010) Mol Genet Metab , vol.100 , pp. 77-82
    • Cauchi, S.1    del Guerra, S.2    Choquet, H.3
  • 13
    • 33847176604 scopus 로고    scopus 로고
    • A genome-wide association study identifies novel risk loci for type 2 diabetes
    • COI: 1:CAS:528:DC%2BD2sXhvFGiurw%3D, PID: 17293876
    • Sladek R, Rocheleau G, Rung J et al (2007) A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445:881–885
    • (2007) Nature , vol.445 , pp. 881-885
    • Sladek, R.1    Rocheleau, G.2    Rung, J.3
  • 14
    • 34249885875 scopus 로고    scopus 로고
    • A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
    • COI: 1:CAS:528:DC%2BD2sXmtVyitrY%3D
    • Scott LJ, Mohlke KL, Bonnycastle LL et al (2007) A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (New York, NY) 316:1341–1345
    • (2007) Science (New York, NY) , vol.316 , pp. 1341-1345
    • Scott, L.J.1    Mohlke, K.L.2    Bonnycastle, L.L.3
  • 15
    • 34249888775 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    • COI: 1:CAS:528:DC%2BD2sXmtVyitrk%3D, PID: 17463246
    • Saxena R, Voight BF, Lyssenko V et al (2007) Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316:1331–1336
    • (2007) Science , vol.316 , pp. 1331-1336
    • Saxena, R.1    Voight, B.F.2    Lyssenko, V.3
  • 16
    • 67650248695 scopus 로고    scopus 로고
    • Confirmation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population
    • COI: 1:CAS:528:DC%2BD1MXos1Gjsr4%3D, PID: 19401414
    • Takeuchi F, Serizawa M, Yamamoto K et al (2009) Confirmation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Diabetes 58:1690–1699
    • (2009) Diabetes , vol.58 , pp. 1690-1699
    • Takeuchi, F.1    Serizawa, M.2    Yamamoto, K.3
  • 17
    • 4344665860 scopus 로고    scopus 로고
    • Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules
    • COI: 1:CAS:528:DC%2BD2cXns1Shs7w%3D, PID: 15331542
    • Chimienti F, Devergnas S, Favier A, Seve M (2004) Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes 53:2330–2337
    • (2004) Diabetes , vol.53 , pp. 2330-2337
    • Chimienti, F.1    Devergnas, S.2    Favier, A.3    Seve, M.4
  • 18
    • 24744439439 scopus 로고    scopus 로고
    • Zinc-ligand interactions modulate assembly and stability of the insulin hexamer—a review
    • COI: 1:CAS:528:DC%2BD2MXpvFOksbw%3D, PID: 16158220
    • Dunn MF (2005) Zinc-ligand interactions modulate assembly and stability of the insulin hexamer—a review. Biometals 18:295–303
    • (2005) Biometals , vol.18 , pp. 295-303
    • Dunn, M.F.1
  • 19
    • 61349111509 scopus 로고    scopus 로고
    • Insulin granule biogenesis, trafficking and exocytosis
    • COI: 1:CAS:528:DC%2BD1MXptlSitLs%3D, PID: 19251047
    • Hou JC, Min L, Pessin JE (2009) Insulin granule biogenesis, trafficking and exocytosis. Vitam Horm 80:473–506
    • (2009) Vitam Horm , vol.80 , pp. 473-506
    • Hou, J.C.1    Min, L.2    Pessin, J.E.3
  • 20
    • 41849117959 scopus 로고    scopus 로고
    • The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients—the EUGENE2 study
    • COI: 1:CAS:528:DC%2BD1cXkt1yjs78%3D, PID: 18324385
    • Boesgaard TW, Zilinskaite J, Vanttinen M et al (2008) The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients—the EUGENE2 study. Diabetologia 51:816–820
    • (2008) Diabetologia , vol.51 , pp. 816-820
    • Boesgaard, T.W.1    Zilinskaite, J.2    Vanttinen, M.3
  • 21
    • 80054097446 scopus 로고    scopus 로고
    • Association of the SLC30A8 missense polymorphism R325W with proinsulin levels at baseline and after lifestyle, metformin or troglitazone intervention in the Diabetes Prevention Program
    • COI: 1:STN:280:DC%2BC3Mbht1yisA%3D%3D, PID: 21779873
    • Majithia A, Jablonski K, McAteer J et al (2011) Association of the SLC30A8 missense polymorphism R325W with proinsulin levels at baseline and after lifestyle, metformin or troglitazone intervention in the Diabetes Prevention Program. Diabetologia 54:2570–2574
    • (2011) Diabetologia , vol.54 , pp. 2570-2574
    • Majithia, A.1    Jablonski, K.2    McAteer, J.3
  • 22
    • 70349147046 scopus 로고    scopus 로고
    • Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men
    • COI: 1:CAS:528:DC%2BD1MXhtFChsbbE, PID: 19502414
    • Stancakova A, Kuulasmaa T, Paananen J et al (2009) Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men. Diabetes 58:2129–2136
    • (2009) Diabetes , vol.58 , pp. 2129-2136
    • Stancakova, A.1    Kuulasmaa, T.2    Paananen, J.3
  • 23
    • 41149178492 scopus 로고    scopus 로고
    • Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion
    • COI: 1:CAS:528:DC%2BD1cXjsFGiu7o%3D, PID: 18264689
    • Kirchhoff K, Machicao F, Haupt A et al (2008) Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion. Diabetologia 51:597–601
    • (2008) Diabetologia , vol.51 , pp. 597-601
    • Kirchhoff, K.1    Machicao, F.2    Haupt, A.3
  • 24
    • 34249828965 scopus 로고    scopus 로고
    • A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
    • COI: 1:CAS:528:DC%2BD2sXlvVSgtL4%3D, PID: 17460697
    • Steinthorsdottir V, Thorleifsson G, Reynisdottir I et al (2007) A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 39:770–775
    • (2007) Nat Genet , vol.39 , pp. 770-775
    • Steinthorsdottir, V.1    Thorleifsson, G.2    Reynisdottir, I.3
  • 25
    • 84885050266 scopus 로고    scopus 로고
    • The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance
    • COI: 1:CAS:528:DC%2BC3sXhsF2rtb3M, PID: 24051378
    • Tamaki M, Fujitani Y, Hara A et al (2013) The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance. J Clin Invest 123:4513–4524
    • (2013) J Clin Invest , vol.123 , pp. 4513-4524
    • Tamaki, M.1    Fujitani, Y.2    Hara, A.3
  • 26
    • 0033574249 scopus 로고    scopus 로고
    • A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group
    • COI: 1:CAS:528:DyaK1MXitFChs7k%3D, PID: 10075613
    • Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D (1999) A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 130:461–470
    • (1999) Ann Intern Med , vol.130 , pp. 461-470
    • Levey, A.S.1    Bosch, J.P.2    Lewis, J.B.3    Greene, T.4    Rogers, N.5    Roth, D.6
  • 27
    • 0034032564 scopus 로고    scopus 로고
    • Diabetes in the Old Order Amish: characterization and heritability analysis of the Amish Family Diabetes Study
    • COI: 1:STN:280:DC%2BD3cvitVSmuw%3D%3D, PID: 10834415
    • Hsueh WC, Mitchell BD, Aburomia R et al (2000) Diabetes in the Old Order Amish: characterization and heritability analysis of the Amish Family Diabetes Study. Diabetes Care 23:595–601
    • (2000) Diabetes Care , vol.23 , pp. 595-601
    • Hsueh, W.C.1    Mitchell, B.D.2    Aburomia, R.3
  • 28
    • 84922088216 scopus 로고    scopus 로고
    • Dietary supplement fact sheet: zinc
    • Office of Dietary Supplements of the National Institutes of Health (2013) Dietary supplement fact sheet: zinc. Available from http://ods.od.nih.gov/FactSheets/Zinc_pf.asp, Accessed 7 July 2014
    • (2013) Available from
  • 29
    • 0021813187 scopus 로고
    • Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • COI: 1:CAS:528:DyaL2MXlslKnu7k%3D, PID: 3899825
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412–419
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 30
    • 44949264223 scopus 로고    scopus 로고
    • Copper, chromium, manganese, iron, nickel, and zinc levels in biological samples of diabetes mellitus patients
    • COI: 1:CAS:528:DC%2BD1cXjvVaitrs%3D, PID: 18193174
    • Kazi TG, Afridi HI, Kazi N et al (2008) Copper, chromium, manganese, iron, nickel, and zinc levels in biological samples of diabetes mellitus patients. Biol Trace Elem Res 122:1–18
    • (2008) Biol Trace Elem Res , vol.122 , pp. 1-18
    • Kazi, T.G.1    Afridi, H.I.2    Kazi, N.3
  • 31
    • 84875547765 scopus 로고    scopus 로고
    • Serum trace elements in obese women with or without diabetes
    • COI: 1:CAS:528:DC%2BC3sXpvVarsL4%3D, PID: 23563378
    • Yerlikaya FH, Toker A, Aribas A (2013) Serum trace elements in obese women with or without diabetes. Indian J Med Res 137:339–345
    • (2013) Indian J Med Res , vol.137 , pp. 339-345
    • Yerlikaya, F.H.1    Toker, A.2    Aribas, A.3
  • 32
    • 65349196681 scopus 로고    scopus 로고
    • Prospective study of zinc intake and risk of type 2 diabetes in women
    • COI: 1:CAS:528:DC%2BD1MXltFSksrs%3D, PID: 19171718
    • Sun Q, van Dam RM, Willett WC, Hu FB (2009) Prospective study of zinc intake and risk of type 2 diabetes in women. Diabetes Care 32:629–634
    • (2009) Diabetes Care , vol.32 , pp. 629-634
    • Sun, Q.1    van Dam, R.M.2    Willett, W.C.3    Hu, F.B.4
  • 33
    • 84875107188 scopus 로고    scopus 로고
    • Zinc and glycemic control: a meta-analysis of randomised placebo controlled supplementation trials in humans
    • COI: 1:CAS:528:DC%2BC3sXktlKhu7Y%3D
    • Capdor J, Foster M, Petocz P, Samman S (2013) Zinc and glycemic control: a meta-analysis of randomised placebo controlled supplementation trials in humans. J Trace Elem Med Biol: Organ Soc Miner Trace Elem 27:137–142
    • (2013) J Trace Elem Med Biol: Organ Soc Miner Trace Elem , vol.27 , pp. 137-142
    • Capdor, J.1    Foster, M.2    Petocz, P.3    Samman, S.4
  • 35
    • 84899081311 scopus 로고    scopus 로고
    • Interactions between zinc transporter-8 gene (SLC30A8) and plasma zinc concentrations for impaired glucose regulation and type 2 diabetes
    • COI: 1:CAS:528:DC%2BC2cXnt1Khtb0%3D, PID: 24306209
    • Shan Z, Bao W, Zhang Y et al (2014) Interactions between zinc transporter-8 gene (SLC30A8) and plasma zinc concentrations for impaired glucose regulation and type 2 diabetes. Diabetes 63:1796–1803
    • (2014) Diabetes , vol.63 , pp. 1796-1803
    • Shan, Z.1    Bao, W.2    Zhang, Y.3
  • 37
    • 84885624282 scopus 로고    scopus 로고
    • Analysis of serum and urinal copper and zinc in Chinese northeast population with the prediabetes or diabetes with and without complications
    • Xu J, Zhou Q, Liu G, Tan Y, Cai L (2013) Analysis of serum and urinal copper and zinc in Chinese northeast population with the prediabetes or diabetes with and without complications. Oxidative Med Cell Longev 2013:635214
    • (2013) Oxidative Med Cell Longev , vol.2013 , pp. 635214
    • Xu, J.1    Zhou, Q.2    Liu, G.3    Tan, Y.4    Cai, L.5
  • 38
    • 0142024832 scopus 로고    scopus 로고
    • Suggested lower cutoffs of serum zinc concentrations for assessing zinc status: reanalysis of the Second National Health and Nutrition Examination Survey data (1976-1980)
    • COI: 1:CAS:528:DC%2BD3sXnslGjsb8%3D, PID: 14522734
    • Hotz C, Peerson JM, Brown KH (2003) Suggested lower cutoffs of serum zinc concentrations for assessing zinc status: reanalysis of the Second National Health and Nutrition Examination Survey data (1976-1980). Am J Clin Nutr 78:756–764
    • (2003) Am J Clin Nutr , vol.78 , pp. 756-764
    • Hotz, C.1    Peerson, J.M.2    Brown, K.H.3
  • 39
    • 84876500725 scopus 로고    scopus 로고
    • Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus
    • COI: 1:CAS:528:DC%2BC3sXmt1Kqs74%3D, PID: 23334806
    • Patel C, Chen R, Kodama K, Ioannidis JA, Butte A (2013) Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus. Hum Genet 132:495–508
    • (2013) Hum Genet , vol.132 , pp. 495-508
    • Patel, C.1    Chen, R.2    Kodama, K.3    Ioannidis, J.A.4    Butte, A.5
  • 40
    • 80052880822 scopus 로고    scopus 로고
    • Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant
    • COI: 1:CAS:528:DC%2BC3MXhtFymsbbL, PID: 21810599
    • Kanoni S, Nettleton JA, Hivert M-F et al (2011) Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant. Diabetes 60:2407–2416
    • (2011) Diabetes , vol.60 , pp. 2407-2416
    • Kanoni, S.1    Nettleton, J.A.2    Hivert, M.-F.3
  • 41
    • 70349113136 scopus 로고    scopus 로고
    • Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants
    • COI: 1:CAS:528:DC%2BD1MXhtFChsbbO, PID: 19542200
    • Nicolson TJ, Bellomo EA, Wijesekara N et al (2009) Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes 58:2070–2083
    • (2009) Diabetes , vol.58 , pp. 2070-2083
    • Nicolson, T.J.1    Bellomo, E.A.2    Wijesekara, N.3
  • 42
    • 70349280000 scopus 로고    scopus 로고
    • Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice
    • COI: 1:CAS:528:DC%2BD1MXhtFGrt7%2FI, PID: 19706465
    • Lemaire K, Ravier MA, Schraenen A et al (2009) Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice. Proc Natl Acad Sci U S A 106:14872–14877
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 14872-14877
    • Lemaire, K.1    Ravier, M.A.2    Schraenen, A.3
  • 43
    • 77955514154 scopus 로고    scopus 로고
    • Beta cell-specific ZnT8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion
    • COI: 1:CAS:528:DC%2BC3cXotVKgs7k%3D, PID: 20424817
    • Wijesekara N, Dai FF, Hardy AB et al (2010) Beta cell-specific ZnT8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion. Diabetologia 53:1656–1668
    • (2010) Diabetologia , vol.53 , pp. 1656-1668
    • Wijesekara, N.1    Dai, F.F.2    Hardy, A.B.3
  • 44
    • 66249128300 scopus 로고    scopus 로고
    • Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion
    • PID: 19479076
    • Fu Y, Tian W, Pratt EB et al (2009) Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion. PLoS One 4:e5679
    • (2009) PLoS One , vol.4 , pp. e5679
    • Fu, Y.1    Tian, W.2    Pratt, E.B.3
  • 45
    • 33751183948 scopus 로고    scopus 로고
    • In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion
    • COI: 1:CAS:528:DC%2BD28Xht1GksrbP, PID: 16984975
    • Chimienti F, Devergnas S, Pattou F et al (2006) In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion. J Cell Sci 119:4199–4206
    • (2006) J Cell Sci , vol.119 , pp. 4199-4206
    • Chimienti, F.1    Devergnas, S.2    Pattou, F.3
  • 46
    • 69249226366 scopus 로고    scopus 로고
    • Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion
    • COI: 1:CAS:528:DC%2BD1MXosV2hurs%3D, PID: 19450229
    • Pound LD, Sarkar SA, Benninger RK et al (2009) Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion. Biochem J 421:371–376
    • (2009) Biochem J , vol.421 , pp. 371-376
    • Pound, L.D.1    Sarkar, S.A.2    Benninger, R.K.3
  • 47
    • 84863027577 scopus 로고    scopus 로고
    • Characterization of the human SLC30A8 promoter and intronic enhancer
    • COI: 1:CAS:528:DC%2BC38Xjt1ekug%3D%3D, PID: 21798992
    • Pound LD, Sarkar SA, Cauchi S et al (2011) Characterization of the human SLC30A8 promoter and intronic enhancer. J Mol Endocrinol 47:251–259
    • (2011) J Mol Endocrinol , vol.47 , pp. 251-259
    • Pound, L.D.1    Sarkar, S.A.2    Cauchi, S.3
  • 48
    • 84897407583 scopus 로고    scopus 로고
    • Loss-of-function mutations in SLC30A8 protect against type 2 diabetes
    • COI: 1:CAS:528:DC%2BC2cXjtl2jtrY%3D, PID: 24584071
    • Flannick J, Thorleifsson G, Beer NL et al (2014) Loss-of-function mutations in SLC30A8 protect against type 2 diabetes. Nat Genet 46:357–363
    • (2014) Nat Genet , vol.46 , pp. 357-363
    • Flannick, J.1    Thorleifsson, G.2    Beer, N.L.3
  • 49
    • 79957515571 scopus 로고    scopus 로고
    • A low-risk ZnT-8 allele (W325) for post-transplantation diabetes mellitus is protective against cyclosporin A-induced impairment of insulin secretion
    • COI: 1:CAS:528:DC%2BC3cXjvFKqurw%3D, PID: 20351753
    • Kim I, Kang ES, Yim YS et al (2011) A low-risk ZnT-8 allele (W325) for post-transplantation diabetes mellitus is protective against cyclosporin A-induced impairment of insulin secretion. Pharmacogenomics J 11:191–198
    • (2011) Pharmacogenomics J , vol.11 , pp. 191-198
    • Kim, I.1    Kang, E.S.2    Yim, Y.S.3
  • 50
    • 77954067996 scopus 로고    scopus 로고
    • Three-dimensional structure of beta-cell-specific zinc transporter, ZnT-8, predicted from the type 2 diabetes-associated gene variant SLC30A8 R325W
    • PID: 20525392
    • Weijers RN (2010) Three-dimensional structure of beta-cell-specific zinc transporter, ZnT-8, predicted from the type 2 diabetes-associated gene variant SLC30A8 R325W. Diabetol Metab Syndr 2:33
    • (2010) Diabetol Metab Syndr , vol.2 , pp. 33
    • Weijers, R.N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.