메뉴 건너뛰기




Volumn 132, Issue 5, 2013, Pages 495-508

Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus

Author keywords

[No Author keywords available]

Indexed keywords

BETA CAROTENE;

EID: 84876500725     PISSN: 03406717     EISSN: 14321203     Source Type: Journal    
DOI: 10.1007/s00439-012-1258-z     Document Type: Article
Times cited : (97)

References (69)
  • 1
    • 84862134307 scopus 로고    scopus 로고
    • Inclusion of gene-gene and gene-environment interactions unlikely to dramatically improve risk prediction for complex diseases
    • 10.1016/j.ajhg.2012.04.017 22633398 10.1016/j.ajhg.2012.04.017 1:CAS:528:DC%2BC38Xns1Wltb8%3D
    • Aschard H, Chen J, Cornelis MC, Chibnik LB, Karlson EW, Kraft P (2012) Inclusion of gene-gene and gene-environment interactions unlikely to dramatically improve risk prediction for complex diseases. Am J Hum Genet 90:962-972. doi: 10.1016/j.ajhg.2012.04.017
    • (2012) Am J Hum Genet , vol.90 , pp. 962-972
    • Aschard, H.1    Chen, J.2    Cornelis, M.C.3    Chibnik, L.B.4    Karlson, E.W.5    Kraft, P.6
  • 2
    • 84858383401 scopus 로고    scopus 로고
    • Diabetes mellitus and the beta-cell: The last ten years
    • 10.1016/j.cell.2012.02.010 22424227 10.1016/j.cell.2012.02.010 1:CAS:528:DC%2BC38Xkt1Cqt7Y%3D
    • Ashcroft FM, Rorsman P (2012) Diabetes mellitus and the beta-cell: the last ten years. Cell 148:1160-1171. doi: 10.1016/j.cell.2012.02.010
    • (2012) Cell , vol.148 , pp. 1160-1171
    • Ashcroft, F.M.1    Rorsman, P.2
  • 3
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Statist Soc B 57:289-300
    • (1995) J R Statist Soc B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 4
    • 0035892865 scopus 로고    scopus 로고
    • Which plasma antioxidants are most related to fruit and vegetable consumption?
    • 11744516 10.1093/aje/154.12.1113 1:STN:280:DC%2BD3MnpslGruw%3D%3D
    • Block G, Norkus E, Hudes M, Mandel S, Helzlsouer K (2001) Which plasma antioxidants are most related to fruit and vegetable consumption? Am J Epidemiol 154:1113-1118
    • (2001) Am J Epidemiol , vol.154 , pp. 1113-1118
    • Block, G.1    Norkus, E.2    Hudes, M.3    Mandel, S.4    Helzlsouer, K.5
  • 5
    • 78650123270 scopus 로고    scopus 로고
    • Permutation and parametric bootstrap tests for gene-gene and gene-environment interactions
    • 20384625 10.1111/j.1469-1809.2010.00572.x
    • Bůžková P, Lumley T, Rice K (2011) Permutation and parametric bootstrap tests for gene-gene and gene-environment interactions. Ann Hum Genet 75:36-45
    • (2011) Ann Hum Genet , vol.75 , pp. 36-45
    • Bůžková, P.1    Lumley, T.2    Rice, K.3
  • 6
    • 77956518751 scopus 로고    scopus 로고
    • Fruit and vegetable intake and incidence of type 2 diabetes mellitus: Systematic review and meta-analysis
    • 10.1136/bmj.c4229 20724400 10.1136/bmj.c4229
    • Carter P, Gray LJ, Troughton J, Khunti K, Davies MJ (2010) Fruit and vegetable intake and incidence of type 2 diabetes mellitus: systematic review and meta-analysis. BMJ 341:c4229. doi: 10.1136/bmj.c4229
    • (2010) BMJ , vol.341 , pp. 4229
    • Carter, P.1    Gray, L.J.2    Troughton, J.3    Khunti, K.4    Davies, M.J.5
  • 7
    • 0003447646 scopus 로고    scopus 로고
    • CDC and National Center for Health Statistics (NCHS)
    • CDC and National Center for Health Statistics (NCHS) (2003) National health and nutrition examination survey analytic guidelines. http://www.cdc.gov/nchs/data/nhanes/nhanes-03-04/nhanes-analytic-guidelines-dec- 2005.pdf. Accessed 19 Feb 2010
    • (2003) National Health and Nutrition Examination Survey Analytic Guidelines
  • 8
    • 0003447646 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention (CDC)
    • Centers for Disease Control and Prevention (CDC) (2009) National Health and Nutrition Examination Survey. CDC. http://www.cdc.gov/nchs/nhanes/. Accessed 1 Sep 2009
    • (2009) National Health and Nutrition Examination Survey. CDC
  • 9
    • 80052724921 scopus 로고    scopus 로고
    • Personalized medicine: Progress and promise
    • 10.1146/annurev-genom-082410-101446 21721939 10.1146/annurev-genom- 082410-101446 1:CAS:528:DC%2BC3MXht1yksbrJ
    • Chan IS, Ginsburg GS (2011) Personalized medicine: progress and promise. Annu Rev Genomics Hum Genet 12:217-244. doi: 10.1146/annurev-genom-082410-101446
    • (2011) Annu Rev Genomics Hum Genet , vol.12 , pp. 217-244
    • Chan, I.S.1    Ginsburg, G.S.2
  • 10
    • 78149437703 scopus 로고    scopus 로고
    • Non-synonymous and synonymous coding SNPs show similar likelihood and effect size of human disease association
    • 10.1371/journal.pone.0013574 21042586 10.1371/journal.pone.0013574
    • Chen R, Davydov EV, Sirota M, Butte AJ (2010) Non-synonymous and synonymous coding SNPs show similar likelihood and effect size of human disease association. PLoS One 5:e13574. doi: 10.1371/journal.pone.0013574
    • (2010) PLoS One , vol.5 , pp. 13574
    • Chen, R.1    Davydov, E.V.2    Sirota, M.3    Butte, A.J.4
  • 11
    • 4344665860 scopus 로고    scopus 로고
    • Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules
    • 15331542 10.2337/diabetes.53.9.2330 1:CAS:528:DC%2BD2cXns1Shs7w%3D
    • Chimienti F, Devergnas S, Favier A, Seve M (2004) Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes 53:2330-2337
    • (2004) Diabetes , vol.53 , pp. 2330-2337
    • Chimienti, F.1    Devergnas, S.2    Favier, A.3    Seve, M.4
  • 12
    • 24744451161 scopus 로고    scopus 로고
    • ZnT-8, a pancreatic beta-cell-specific zinc transporter
    • 10.1007/s10534-005-3687-9 16158222 10.1007/s10534-005-3687-9 1:CAS:528:DC%2BD2MXpvFOksbg%3D
    • Chimienti F, Favier A, Seve M (2005) ZnT-8, a pancreatic beta-cell-specific zinc transporter. Biometals 18:313-317. doi: 10.1007/s10534-005-3687-9
    • (2005) Biometals , vol.18 , pp. 313-317
    • Chimienti, F.1    Favier, A.2    Seve, M.3
  • 13
    • 63649145042 scopus 로고    scopus 로고
    • TCF7L2, dietary carbohydrate, and risk of type 2 diabetes in US women
    • 10.3945/ajcn.2008.27058 19211816 10.3945/ajcn.2008.27058 1:CAS:528:DC%2BD1MXjslSksbg%3D
    • Cornelis MC, Qi L, Kraft P, Hu FB (2009) TCF7L2, dietary carbohydrate, and risk of type 2 diabetes in US women. Am J Clin Nutr 89:1256-1262. doi: 10.3945/ajcn.2008.27058
    • (2009) Am J Clin Nutr , vol.89 , pp. 1256-1262
    • Cornelis, M.C.1    Qi, L.2    Kraft, P.3    Hu, F.B.4
  • 14
    • 79952624880 scopus 로고    scopus 로고
    • Use of genetic markers and gene-diet interactions for interrogating population-level causal influences of diet on health
    • doi: 10.1007/s12263-010-0181-y
    • Davey Smith G (2010) Use of genetic markers and gene-diet interactions for interrogating population-level causal influences of diet on health. Genes Nutr 6:27-43. doi: 10.1007/s12263-010-0181-y
    • (2010) Genes Nutr , vol.6 , pp. 27-43
    • Davey Smith, G.1
  • 15
    • 0037497326 scopus 로고    scopus 로고
    • The double puzzle of diabetes
    • 10.1038/423599a 12789325 10.1038/423599a 1:CAS:528:DC%2BD3sXkt1ykurc%3D
    • Diamond J (2003) The double puzzle of diabetes. Nature 423:599-602. doi: 10.1038/423599a
    • (2003) Nature , vol.423 , pp. 599-602
    • Diamond, J.1
  • 16
    • 84867572461 scopus 로고    scopus 로고
    • Serum vitamins A and e as modifiers of lipid trait genetics in the National Health and Nutrition Examination Surveys as part of the Population Architecture using Genomics and Epidemiology (PAGE) study
    • 10.1007/s00439-012-1186-y 22688886
    • Dumitrescu L, Goodloe R, Brown-Gentry K, Mayo P, Allen M, Jin H, Gillani NB, Schnetz-Boutaud N, Dilks HH, Crawford DC (2012) Serum vitamins A and E as modifiers of lipid trait genetics in the National Health and Nutrition Examination Surveys as part of the Population Architecture using Genomics and Epidemiology (PAGE) study. Hum Genet. doi: 10.1007/s00439-012-1186-y
    • (2012) Hum Genet
    • Dumitrescu, L.1    Goodloe, R.2    Brown-Gentry, K.3    Mayo, P.4    Allen, M.5    Jin, H.6    Gillani, N.B.7    Schnetz-Boutaud, N.8    Dilks, H.H.9    Crawford, D.C.10
  • 19
    • 84855925920 scopus 로고    scopus 로고
    • Rare and common variants: Twenty arguments
    • 10.1038/nrg3118 10.1038/nrg3118
    • Gibson G (2011) Rare and common variants: twenty arguments. Nat Rev Genet 13:135-145. doi: 10.1038/nrg3118
    • (2011) Nat Rev Genet , vol.13 , pp. 135-145
    • Gibson, G.1
  • 20
    • 0035704552 scopus 로고    scopus 로고
    • The thrifty phenotype hypothesis
    • 11809615 10.1093/bmb/60.1.5 1:STN:280:DC%2BD38%2Fot12mug%3D%3D
    • Hales CN, Barker DJ (2001) The thrifty phenotype hypothesis. Br Med Bull 60:5-20
    • (2001) Br Med Bull , vol.60 , pp. 5-20
    • Hales, C.N.1    Barker, D.J.2
  • 24
    • 67249117049 scopus 로고    scopus 로고
    • Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
    • 10.1073/pnas.0903103106 19474294 10.1073/pnas.0903103106 1:CAS:528:DC%2BD1MXot1Cgur4%3D
    • Hindorff LA, Sethupathy P, Junkins HA, Ramos EM, Mehta JP, Collins FS, Manolio TA (2009b) Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci USA 106:9362-9367. doi: 10.1073/pnas.0903103106
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 9362-9367
    • Hindorff, L.A.1    Sethupathy, P.2    Junkins, H.A.3    Ramos, E.M.4    Mehta, J.P.5    Collins, F.S.6    Manolio, T.A.7
  • 25
    • 15944383403 scopus 로고    scopus 로고
    • Gene-environment interactions in human diseases
    • doi: 10.1038/nrg1578
    • Hunter DJ (2005) Gene-environment interactions in human diseases. Nat Rev Genet 6: 287-298. doi: 10.1038/nrg1578
    • (2005) Nat Rev Genet , vol.6 , pp. 287-298
    • Hunter, D.J.1
  • 26
    • 33846563409 scopus 로고    scopus 로고
    • Why most published research findings are false
    • 16060722 10.1371/journal.pmed.0020124
    • Ioannidis JPA (2005) Why most published research findings are false. PLoS Med 2:e124
    • (2005) PLoS Med , vol.2 , pp. 124
    • Ioannidis, J.P.A.1
  • 27
    • 33745600563 scopus 로고    scopus 로고
    • Commentary: Grading the credibility of molecular evidence for complex diseases
    • Ioannidis JP (2006) Commentary: grading the credibility of molecular evidence for complex diseases. Int J Epidemiol 35:572-578 (discussion 593-596). doi: 10.1093/ije/dyl003
    • (2006) Int J Epidemiol , vol.35 , pp. 572-578
    • Ioannidis, J.P.1
  • 28
    • 70349969413 scopus 로고    scopus 로고
    • Population-wide generalizability of genome-wide discovered associations
    • doi: 10.1093/jnci/djp298
    • Ioannidis JP (2009) Population-wide generalizability of genome-wide discovered associations. J Natl Cancer Inst 101:1297-1299. doi: 10.1093/jnci/djp298
    • (2009) J Natl Cancer Inst , vol.101 , pp. 1297-1299
    • Ioannidis, J.P.1
  • 29
    • 77049105601 scopus 로고    scopus 로고
    • Researching genetic versus nongenetic determinants of disease: A comparison and proposed unification
    • 10.1126/scitranslmed.3000247
    • Ioannidis J, Loy EY, Poulton R, Chia KS (2009) Researching genetic versus nongenetic determinants of disease: a comparison and proposed unification. Sci Transl Med 1:8
    • (2009) Sci Transl Med , vol.1 , pp. 8
    • Ioannidis, J.1    Loy, E.Y.2    Poulton, R.3    Chia, K.S.4
  • 30
    • 80051552041 scopus 로고    scopus 로고
    • The false-positive to false-negative ratio in epidemiologic studies
    • 10.1097/EDE.0b013e31821b506e 21490505 10.1097/EDE.0b013e31821b506e
    • Ioannidis JP, Tarone R, McLaughlin JK (2011) The false-positive to false-negative ratio in epidemiologic studies. Epidemiology 22:450-456. doi: 10.1097/EDE.0b013e31821b506e
    • (2011) Epidemiology , vol.22 , pp. 450-456
    • Ioannidis, J.P.1    Tarone, R.2    McLaughlin, J.K.3
  • 31
    • 58449085469 scopus 로고    scopus 로고
    • Invited commentary: From genome-wide association studies to gene-environment-wide interaction studies-challenges and opportunities
    • (discussion 234-235). doi: 10.1093/aje/kwn351
    • Khoury MJ, Wacholder S (2009) Invited commentary: from genome-wide association studies to gene-environment-wide interaction studies-challenges and opportunities. Am J Epidemiol 169:227-230 (discussion 234-235). doi: 10.1093/aje/kwn351
    • (2009) Am J Epidemiol , vol.169 , pp. 227-230
    • Khoury, M.J.1    Wacholder, S.2
  • 32
    • 0023949570 scopus 로고
    • An epidemiologic approach to ecogenetics
    • 3337114 1:STN:280:DyaL1c7gtlGksA%3D%3D
    • Khoury MJ, Adams MJ Jr, Flanders WD (1988) An epidemiologic approach to ecogenetics. Am J Hum Genet 42:89-95
    • (1988) Am J Hum Genet , vol.42 , pp. 89-95
    • Khoury, M.J.1    Adams, Jr.M.J.2    Flanders, W.D.3
  • 37
    • 77951702343 scopus 로고    scopus 로고
    • Genetic heterogeneity in human disease
    • 10.1016/j.cell.2010.03.032 20403315 10.1016/j.cell.2010.03.032 1:CAS:528:DC%2BC3cXmtVWns7g%3D
    • McClellan J, King MC (2010) Genetic heterogeneity in human disease. Cell 141:210-217. doi: 10.1016/j.cell.2010.03.032
    • (2010) Cell , vol.141 , pp. 210-217
    • McClellan, J.1    King, M.C.2
  • 39
    • 70349566593 scopus 로고
    • Diabetes mellitus: A "thrifty" genotype rendered detrimental by "progress"?
    • 13937884 1:STN:280:DyaF387ivFGmtw%3D%3D
    • Neel JV (1962) Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? Am J Hum Genet 14:353-362
    • (1962) Am J Hum Genet , vol.14 , pp. 353-362
    • Neel, J.V.1
  • 41
    • 1842539516 scopus 로고    scopus 로고
    • A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other
    • doi: 10.1086/383251
    • Nyholt DR (2004) A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet 74:765-769. doi: 10.1086/383251
    • (2004) Am J Hum Genet , vol.74 , pp. 765-769
    • Nyholt, D.R.1
  • 42
    • 77953886372 scopus 로고    scopus 로고
    • An environment-wide association study (EWAS) on type 2 diabetes mellitus
    • 10.1371/journal.pone.0010746 20505766 10.1371/journal.pone.0010746
    • Patel CJ, Bhattacharya J, Butte AJ (2010) An environment-wide association study (EWAS) on type 2 diabetes mellitus. PLoS One 5:e10746. doi: 10.1371/journal.pone.0010746
    • (2010) PLoS One , vol.5 , pp. 10746
    • Patel, C.J.1    Bhattacharya, J.2    Butte, A.J.3
  • 43
    • 84863534875 scopus 로고    scopus 로고
    • Data-driven integration of epidemiological and toxicological data to select candidate interacting genes and environmental factors in association with disease
    • Patel CJ, Chen R, Butte AJ (2012a) Data-driven integration of epidemiological and toxicological data to select candidate interacting genes and environmental factors in association with disease. Bioinformatics 28(12):i121-i126
    • (2012) Bioinformatics , vol.28 , Issue.12
    • Patel, C.J.1    Chen, R.2    Butte, A.J.3
  • 44
    • 84863511620 scopus 로고    scopus 로고
    • Systematic evaluation of environmental factors: Persistent pollutants and nutrients correlated with serum lipid levels
    • doi: 10.1093/ije/dys003
    • Patel CJ, Cullen MR, Ioannidis JP, Butte AJ (2012b) Systematic evaluation of environmental factors: persistent pollutants and nutrients correlated with serum lipid levels. Int J Epidemiol. doi: 10.1093/ije/dys003
    • (2012) Int J Epidemiol.
    • Patel, C.J.1    Cullen, M.R.2    Ioannidis, J.P.3    Butte, A.J.4
  • 45
    • 40949127393 scopus 로고    scopus 로고
    • How to interpret a genome-wide association study
    • doi: 10.1001/jama.299.11.1335
    • Pearson TA, Manolio TA (2008) How to interpret a genome-wide association study. J Am Med Assoc 299:1335-1344. doi: 10.1001/jama.299.11.1335
    • (2008) J Am Med Assoc , vol.299 , pp. 1335-1344
    • Pearson, T.A.1    Manolio, T.A.2
  • 49
    • 0025031812 scopus 로고
    • No adjustments are needed for multiple comparisons
    • 2081237 10.1097/00001648-199001000-00010 1:STN:280:DyaK3M7otlShtA%3D%3D
    • Rothman KJ (1990) No adjustments are needed for multiple comparisons. Epidemiology 1:43-46
    • (1990) Epidemiology , vol.1 , pp. 43-46
    • Rothman, K.J.1
  • 51
    • 34248171143 scopus 로고    scopus 로고
    • Medicine. Environmental biology and human disease
    • doi: 10.1126/science.1141331
    • Schwartz D, Collins F (2007) Medicine. Environmental biology and human disease. Science 316:695-696. doi: 10.1126/science.1141331
    • (2007) Science , vol.316 , pp. 695-696
    • Schwartz, D.1    Collins, F.2
  • 54
    • 38049023073 scopus 로고    scopus 로고
    • Clustered environments and randomized genes: A fundamental distinction between conventional and genetic epidemiology
    • doi: 10.1371/journal.pmed.0040352
    • Smith GD, Lawlor DA, Harbord R, Timpson N, Day I, Ebrahim S (2007) Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology. PLoS Med 4:e352. doi: 10.1371/journal.pmed.0040352
    • (2007) PLoS Med , vol.4
    • Smith, G.D.1    Lawlor, D.A.2    Harbord, R.3    Timpson, N.4    Day, I.5    Ebrahim, S.6
  • 55
    • 67949092845 scopus 로고    scopus 로고
    • Effects of vitamins C and e and beta-carotene on the risk of type 2 diabetes in women at high risk of cardiovascular disease: A randomized controlled trial
    • doi: 10.3945/ajcn.2009.27491
    • Song Y, Cook NR, Albert CM, Van Denburgh M, Manson JE (2009) Effects of vitamins C and E and beta-carotene on the risk of type 2 diabetes in women at high risk of cardiovascular disease: a randomized controlled trial. Am J Clin Nutr 90:429-437. doi: 10.3945/ajcn.2009.27491
    • (2009) Am J Clin Nutr , vol.90 , pp. 429-437
    • Song, Y.1    Cook, N.R.2    Albert, C.M.3    Van Denburgh, M.4    Manson, J.E.5
  • 56
    • 56549098554 scopus 로고    scopus 로고
    • Thrifty genes for obesity, an attractive but flawed idea, and an alternative perspective: The 'drifty gene' hypothesis
    • 10.1038/ijo.2008.161 10.1038/ijo.2008.161 1:CAS:528:DC%2BD1cXhtlyjtrzM
    • Speakman JR (2008) Thrifty genes for obesity, an attractive but flawed idea, and an alternative perspective: the 'drifty gene' hypothesis. Int J Obesity 32:1611-1617. doi: 10.1038/ijo.2008.161
    • (2008) Int J Obesity , vol.32 , pp. 1611-1617
    • Speakman, J.R.1
  • 58
    • 0036020892 scopus 로고    scopus 로고
    • A direct approach to false discovery rates
    • 10.1111/1467-9868.00346
    • Storey JD (2002) A direct approach to false discovery rates. J R Statist Soc B 64:479-498
    • (2002) J R Statist Soc B , vol.64 , pp. 479-498
    • Storey, J.D.1
  • 59
    • 77949772292 scopus 로고    scopus 로고
    • Gene-environment-wide association studies: Emerging approaches
    • doi: 10.1038/nrg2764
    • Thomas D (2010) Gene-environment-wide association studies: emerging approaches. Nat Rev Genet 11:259-272. doi: 10.1038/nrg2764
    • (2010) Nat Rev Genet , vol.11 , pp. 259-272
    • Thomas, D.1
  • 63
    • 84862909349 scopus 로고    scopus 로고
    • Five years of GWAS discovery
    • 10.1016/j.ajhg.2011.11.029 22243964 10.1016/j.ajhg.2011.11.029 1:CAS:528:DC%2BC38XovFGgtQ%3D%3D
    • Visscher PM, Brown MA, McCarthy MI, Yang J (2012) Five years of GWAS discovery. Am J Hum Genet 90:7-24. doi: 10.1016/j.ajhg.2011.11.029
    • (2012) Am J Hum Genet , vol.90 , pp. 7-24
    • Visscher, P.M.1    Brown, M.A.2    McCarthy, M.I.3    Yang, J.4
  • 65
    • 4444358685 scopus 로고    scopus 로고
    • Gamma-tocopherol - An underestimated vitamin?
    • 10.1159/000079555 15256801 10.1159/000079555 1:CAS:528: DC%2BD2cXmslCht7k%3D
    • Wagner KH, Kamal-Eldin A, Elmadfa I (2004) Gamma-tocopherol - an underestimated vitamin? Ann Nutr Metab 48:169-188. doi: 10.1159/000079555
    • (2004) Ann Nutr Metab , vol.48 , pp. 169-188
    • Wagner, K.H.1    Kamal-Eldin, A.2    Elmadfa, I.3
  • 66
    • 78649794378 scopus 로고    scopus 로고
    • The meaning of interaction
    • 10.1159/000321967 21150212 10.1159/000321967
    • Wang X, Elston RC, Zhu X (2010) The meaning of interaction. Hum Hered 70:269-277. doi: 10.1159/000321967
    • (2010) Hum Hered , vol.70 , pp. 269-277
    • Wang, X.1    Elston, R.C.2    Zhu, X.3
  • 69
    • 0035856920 scopus 로고    scopus 로고
    • Global and societal implications of the diabetes epidemic
    • 10.1038/414782a 11742409 10.1038/414782a 1:CAS:528:DC%2BD38Xhtlymtg%3D%3D
    • Zimmet P, Alberti KG, Shaw J (2001) Global and societal implications of the diabetes epidemic. Nature 414:782-787. doi: 10.1038/414782a
    • (2001) Nature , vol.414 , pp. 782-787
    • Zimmet, P.1    Alberti, K.G.2    Shaw, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.