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Volumn 1263, Issue , 2015, Pages 127-138

Small-molecule screening using Drosophila models of human neurological disorders

Author keywords

Chemical screening; Drosophila melanogaster; Fruit fly; Human diseases; Small molecules

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATAXIA; DISEASE MODEL; DROSOPHILA MELANOGASTER; FRAGILE X ASSOCIATED TREMOR ATAXIA SYNDROME; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; SCREENING; TREMOR; ANIMAL; DROSOPHILA; DRUG EFFECTS; DRUG SCREENING; HUMAN; MOLECULAR LIBRARY; NEURODEGENERATIVE DISEASES; PROCEDURES;

EID: 84922051907     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4939-2269-7_10     Document Type: Article
Times cited : (4)

References (26)
  • 1
    • 58149503687 scopus 로고    scopus 로고
    • Drosophila D1 dopamine receptor mediates caffeine-induced arousal
    • Andretic R et al (2008) Drosophila D1 dopamine receptor mediates caffeine-induced arousal. Proc Natl Acad Sci U S A 105: 20392-20397
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 20392-20397
    • Andretic, R.1
  • 2
    • 0034708062 scopus 로고    scopus 로고
    • Dopamine modulates acute responses to cocaine, nicotine and ethanol in Drosophila
    • Bainton RJ et al (2000) Dopamine modulates acute responses to cocaine, nicotine and ethanol in Drosophila. Curr Biol 10: 187-194
    • (2000) Curr Biol , vol.10 , pp. 187-194
    • Bainton, R.J.1
  • 3
    • 0032518346 scopus 로고    scopus 로고
    • Stereotypic behavioral responses to free-base cocaine and the development of behavioral sensitization in Drosophila
    • McClung C, Hirsh J (1998) Stereotypic behavioral responses to free-base cocaine and the development of behavioral sensitization in Drosophila. Curr Biol 8: 109-112
    • (1998) Curr Biol , vol.8 , pp. 109-112
    • McClung, C.1    Hirsh, J.2
  • 4
    • 0032511188 scopus 로고    scopus 로고
    • Ethanol intoxication in Drosophila: genetic and pharmacological evidence for regulation by the cAMP signaling pathway
    • Moore MS et al (1998) Ethanol intoxication in Drosophila: genetic and pharmacological evidence for regulation by the cAMP signaling pathway. Cell 93: 997-1007
    • (1998) Cell , vol.93 , pp. 997-1007
    • Moore, M.S.1
  • 5
    • 0037049244 scopus 로고    scopus 로고
    • Hallucinogens and Drosophila: linking serotonin receptor activation to behavior
    • Nichols CD et al (2002) Hallucinogens and Drosophila: linking serotonin receptor activation to behavior. Neuroscience 115: 979-984
    • (2002) Neuroscience , vol.115 , pp. 979-984
    • Nichols, C.D.1
  • 6
    • 0036903001 scopus 로고    scopus 로고
    • Drugs, flies, and videotape: the effects of ethanol and cocaine on Drosophila locomotion
    • Rothenfluh A, Heberlein U (2002) Drugs, flies, and videotape: the effects of ethanol and cocaine on Drosophila locomotion. Curr Opin Neurobiol 12: 639-645
    • (2002) Curr Opin Neurobiol , vol.12 , pp. 639-645
    • Rothenfluh, A.1    Heberlein, U.2
  • 7
    • 0043208992 scopus 로고    scopus 로고
    • Drosophila metabolize 1, 4-butanediol into gamma-hydroxybutyric acid in vivo
    • Satta R, Dimitrijevic N, Manev H (2003) Drosophila metabolize 1, 4-butanediol into gamma-hydroxybutyric acid in vivo. Eur J Pharmacol 473: 149-152
    • (2003) Eur J Pharmacol , vol.473 , pp. 149-152
    • Satta, R.1    Dimitrijevic, N.2    Manev, H.3
  • 8
    • 0037222831 scopus 로고    scopus 로고
    • Invertebrate models of drug abuse
    • Wolf FW, Heberlein U (2003) Invertebrate models of drug abuse. J Neurobiol 54: 161-178
    • (2003) J Neurobiol , vol.54 , pp. 161-178
    • Wolf, F.W.1    Heberlein, U.2
  • 9
    • 0019945644 scopus 로고
    • Genetic transformation of Drosophila with transposable element vectors
    • Rubin GM, Spradling AC (1982) Genetic transformation of Drosophila with transposable element vectors. Science 218: 348-353
    • (1982) Science , vol.218 , pp. 348-353
    • Rubin, G.M.1    Spradling, A.C.2
  • 10
    • 0027160708 scopus 로고
    • Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    • Brand AH, Perrimon N (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118: 401-415
    • (1993) Development , vol.118 , pp. 401-415
    • Brand, A.H.1    Perrimon, N.2
  • 11
    • 3242677215 scopus 로고    scopus 로고
    • Gene expression systems in Drosophila: a synthesis of time and space
    • McGuire SE, Roman G, Davis RL (2004) Gene expression systems in Drosophila: a synthesis of time and space. Trends Genet 20: 384-391
    • (2004) Trends Genet , vol.20 , pp. 384-391
    • McGuire, S.E.1    Roman, G.2    Davis, R.L.3
  • 12
    • 0035940413 scopus 로고    scopus 로고
    • P[Switch], a system for spatial and temporal control of gene expression in Drosophila melanogaster
    • Roman G et al (2001) P[Switch], a system for spatial and temporal control of gene expression in Drosophila melanogaster. Proc Natl Acad Sci U S A 98: 12602-12607
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 12602-12607
    • Roman, G.1
  • 13
    • 34447530305 scopus 로고    scopus 로고
    • A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila
    • Dietzl G et al (2007) A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature 448: 151-156
    • (2007) Nature , vol.448 , pp. 151-156
    • Dietzl, G.1
  • 14
    • 0242657586 scopus 로고    scopus 로고
    • A rapid cellular FRET assay of polyglutamine aggregation identifies a novel inhibitor
    • Pollitt SK et al (2003) A rapid cellular FRET assay of polyglutamine aggregation identifies a novel inhibitor. Neuron 40: 685-694
    • (2003) Neuron , vol.40 , pp. 685-694
    • Pollitt, S.K.1
  • 15
    • 33745239787 scopus 로고    scopus 로고
    • Biologically active molecules that reduce polyglutamine aggregation and toxicity
    • Desai UA et al (2006) Biologically active molecules that reduce polyglutamine aggregation and toxicity. Hum Mol Genet 15: 2114-2124
    • (2006) Hum Mol Genet , vol.15 , pp. 2114-2124
    • Desai, U.A.1
  • 16
    • 41049102573 scopus 로고    scopus 로고
    • Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila
    • Chang S et al (2008) Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila. Nat Chem Biol 4: 256-263
    • (2008) Nat Chem Biol , vol.4 , pp. 256-263
    • Chang, S.1
  • 17
    • 0000502460 scopus 로고    scopus 로고
    • The fragile X syndrome
    • Scriver CR, Beaudet al, Valle D, Childs B, Kinzler KW, Vogelstein B (eds), McGraw-Hill Companies, New York
    • Warren ST, Sherman SL (2001) The fragile X syndrome. In: Scriver CR, Beaudet al, Valle D, Childs B, Kinzler KW, Vogelstein B (eds) The metabolic & molecular bases of inherited disease. McGraw-Hill Companies, New York, pp 1257-1290
    • (2001) The metabolic & molecular bases of inherited disease , pp. 1257-1290
    • Warren, S.T.1    Sherman, S.L.2
  • 18
    • 0005968048 scopus 로고    scopus 로고
    • Epidemiology
    • Hagerman RJ (ed), The Johns Hopkins University Press, Baltimore, MD
    • Sherman S (2002) Epidemiology. In: Hagerman RJ (ed) Fragile X syndrome: diagnosis, treatment and research. The Johns Hopkins University Press, Baltimore, MD, pp 136-168
    • (2002) Fragile X syndrome: diagnosis, treatment and research , pp. 136-168
    • Sherman, S.1
  • 19
    • 0036591683 scopus 로고    scopus 로고
    • The fragile X premutation: into the phenotypic fold
    • Hagerman RJ, Hagerman PJ (2002) The fragile X premutation: into the phenotypic fold. Curr Opin Genet Dev 12: 278-283
    • (2002) Curr Opin Genet Dev , vol.12 , pp. 278-283
    • Hagerman, R.J.1    Hagerman, P.J.2
  • 20
    • 2342635196 scopus 로고    scopus 로고
    • The fragile-X premutation: a maturing perspective
    • Hagerman PJ, Hagerman RJ (2004) The fragile-X premutation: a maturing perspective. Am J Hum Genet 74: 805-816
    • (2004) Am J Hum Genet , vol.74 , pp. 805-816
    • Hagerman, P.J.1    Hagerman, R.J.2
  • 21
    • 0041880131 scopus 로고    scopus 로고
    • RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila
    • Jin P et al (2003) RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila. Neuron 39: 739-747
    • (2003) Neuron , vol.39 , pp. 739-747
    • Jin, P.1
  • 22
    • 33750124210 scopus 로고    scopus 로고
    • Techniques for analysis, sorting, and dispensing of C. elegans on the COPAS flow-sorting system
    • Pulak R (2006) Techniques for analysis, sorting, and dispensing of C. elegans on the COPAS flow-sorting system. Methods Mol Biol 351: 275-286
    • (2006) Methods Mol Biol , vol.351 , pp. 275-286
    • Pulak, R.1
  • 23
    • 80355139374 scopus 로고    scopus 로고
    • Assaying locomotor, learning, and memory deficits in Drosophila models of neurodegeneration
    • Ali YO et al (2011) Assaying locomotor, learning, and memory deficits in Drosophila models of neurodegeneration. J Vis Exp 49: 2504
    • (2011) J Vis Exp , vol.49 , pp. 2504
    • Ali, Y.O.1
  • 24
    • 0036672758 scopus 로고    scopus 로고
    • CREB and the discovery of cognitive enhancers
    • Scott R et al (2002) CREB and the discovery of cognitive enhancers. J Mol Neurosci 19: 171-177
    • (2002) J Mol Neurosci , vol.19 , pp. 171-177
    • Scott, R.1
  • 25
    • 66249138246 scopus 로고    scopus 로고
    • High-throughput ethomics in large groups of Drosophila
    • Branson K et al (2009) High-throughput ethomics in large groups of Drosophila. Nat Methods 6: 451-457
    • (2009) Nat Methods , vol.6 , pp. 451-457
    • Branson, K.1
  • 26
    • 63949088398 scopus 로고    scopus 로고
    • Automated monitoring and analysis of social behavior in Drosophila
    • Dankert H et al (2009) Automated monitoring and analysis of social behavior in Drosophila. Nat Methods 6: 297-303
    • (2009) Nat Methods , vol.6 , pp. 297-303
    • Dankert, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.