Principal component analysis as a tool for library design: A case study investigating natural products, brand-name drugs, natural product-like libraries, and drug-like libraries

Methods in Molecular Biology

Volumn 1263, Issue , 2015, Pages 225-242

  Wenderski, Todd A ^a   Stratton, Christopher F ^a   Bauer, Renato A ^a   Kopp, Felix ^a   Tan, Derek S ^a  

^a NONE

Author keywords

Diversity oriented synthesis; Drugs; Libraries; Macrocycles; Medium rings; Natural products; Principal component analysis (PCA); Ring expansion

Indexed keywords

MACROCYCLIC COMPOUND; NATURAL PRODUCT; BIOLOGICAL PRODUCT; DRUG; MOLECULAR LIBRARY;

ANALYTIC METHOD; ARTICLE; CHEMICAL MODIFICATION; DRUG STRUCTURE; PHYSICAL CHEMISTRY; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; CHEMISTRY; DRUG DESIGN; MOLECULAR LIBRARY; PROCEDURES;

BIOLOGICAL PRODUCTS; DRUG DESIGN; PHARMACEUTICAL PREPARATIONS; PRINCIPAL COMPONENT ANALYSIS; SMALL MOLECULE LIBRARIES;

EID: 84922051710     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4939-2269-7_18     Document Type: Article

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