-
1
-
-
51949097274
-
Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog
-
Buglino, J. A., and Resh, M. D. (2008) Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog. J. Biol. Chem. 283, 22076-22088
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 22076-22088
-
-
Buglino, J.A.1
Resh, M.D.2
-
2
-
-
27644441955
-
Differential range and activity of various forms of the Hedgehog protein
-
Dawber, R. J., Hebbes, S., Herpers, B., Docquier, F., and van den Heuvel, M. (2005) Differential range and activity of various forms of the Hedgehog protein. BMC Dev. Biol. 5, 21
-
(2005)
BMC Dev. Biol.
, vol.5
, pp. 21
-
-
Dawber, R.J.1
Hebbes, S.2
Herpers, B.3
Docquier, F.4
Van Den Heuvel, M.5
-
3
-
-
0036339605
-
Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling
-
Micchelli, C. A., The, I., Selva, E., Mogila, V., and Perrimon, N. (2002) Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling. Development 129, 843-851
-
(2002)
Development
, vol.129
, pp. 843-851
-
-
Micchelli, C.A.1
The, I.2
Selva, E.3
Mogila, V.4
Perrimon, N.5
-
4
-
-
1842853184
-
Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates
-
Chen, M. H., Li, Y. J., Kawakami, T., Xu, S. M., and Chuang, P. T. (2004) Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev. 18, 641-659
-
(2004)
Genes Dev.
, vol.18
, pp. 641-659
-
-
Chen, M.H.1
Li, Y.J.2
Kawakami, T.3
Xu, S.M.4
Chuang, P.T.5
-
5
-
-
0035942989
-
Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein
-
Lee, J. D., and Treisman, J. E. (2001) Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein. Curr. Biol. 11, 1147-1152
-
(2001)
Curr. Biol.
, vol.11
, pp. 1147-1152
-
-
Lee, J.D.1
Treisman, J.E.2
-
6
-
-
0035860538
-
Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal
-
Chamoun, Z., Mann, R. K., Nellen, D., von Kessler, D. P., Bellotto, M., Beachy, P. A., and Basler, K. (2001) Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal. Science 293, 2080-2084
-
(2001)
Science
, vol.293
, pp. 2080-2084
-
-
Chamoun, Z.1
Mann, R.K.2
Nellen, D.3
Von Kessler, D.P.4
Bellotto, M.5
Beachy, P.A.6
Basler, K.7
-
7
-
-
0035577854
-
Hedgehog signaling in animal development: Paradigms and principles
-
Ingham, P. W., and McMahon, A. P. (2001) Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 15, 3059-3087
-
(2001)
Genes Dev.
, vol.15
, pp. 3059-3087
-
-
Ingham, P.W.1
McMahon, A.P.2
-
8
-
-
77955420936
-
Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer
-
Barakat, M. T., Humke, E. W., and Scott, M. P. (2010) Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer. Trends Mol. Med. 16, 337-348
-
(2010)
Trends Mol. Med.
, vol.16
, pp. 337-348
-
-
Barakat, M.T.1
Humke, E.W.2
Scott, M.P.3
-
9
-
-
84884921969
-
Targeting cancer stem cells to suppress acquired chemotherapy resistance
-
Vidal, S. J., Rodriguez-Bravo, V., Galsky, M., Cordon-Cardo, C., and Domingo-Domenech, J. (2014) Targeting cancer stem cells to suppress acquired chemotherapy resistance. Oncogene 33, 4451-4463
-
(2014)
Oncogene
, vol.33
, pp. 4451-4463
-
-
Vidal, S.J.1
Rodriguez-Bravo, V.2
Galsky, M.3
Cordon-Cardo, C.4
Domingo-Domenech, J.5
-
10
-
-
85027939713
-
Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma
-
Petrova, E., Matevossian, A., and Resh, M. D. (2015) Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene 34, 263-268
-
(2015)
Oncogene
, vol.34
, pp. 263-268
-
-
Petrova, E.1
Matevossian, A.2
Resh, M.D.3
-
11
-
-
84897564024
-
Attenuation of hedgehog acyltransferase-catalyzed sonic Hedgehog palmitoylation causes reduced signaling, proliferation and invasiveness of human carcinoma cells
-
Konitsiotis, A. D., Chang, S. C., Jovanović, B., Ciepla, P., Masumoto, N., Palmer, C. P., Tate, E. W., Couchman, J. R., and Magee, A. I. (2014) Attenuation of hedgehog acyltransferase-catalyzed sonic Hedgehog palmitoylation causes reduced signaling, proliferation and invasiveness of human carcinoma cells. PLoS ONE 9, e89899
-
(2014)
PLoS ONE
, vol.9
, pp. e89899
-
-
Konitsiotis, A.D.1
Chang, S.C.2
Jovanović, B.3
Ciepla, P.4
Masumoto, N.5
Palmer, C.P.6
Tate, E.W.7
Couchman, J.R.8
Magee, A.I.9
-
12
-
-
84877583655
-
The hedgehog processing pathway is required for NSCLC growth and survival
-
Rodriguez-Blanco, J., Schilling, N. S., Tokhunts, R., Giambelli, C., Long, J., Liang Fei, D., Singh, S., Black, K. E., Wang, Z., Galimberti, F., Bejarano, P. A., Elliot, S., Glassberg, M. K., Nguyen, D. M., Lockwood, W. W., Lam, W. L., Dmitrovsky, E., Capobianco, A. J., and Robbins, D. J. (2013) The hedgehog processing pathway is required for NSCLC growth and survival. Oncogene 32, 2335-2345
-
(2013)
Oncogene
, vol.32
, pp. 2335-2345
-
-
Rodriguez-Blanco, J.1
Schilling, N.S.2
Tokhunts, R.3
Giambelli, C.4
Long, J.5
Liang Fei, D.6
Singh, S.7
Black, K.E.8
Wang, Z.9
Galimberti, F.10
Bejarano, P.A.11
Elliot, S.12
Glassberg, M.K.13
Nguyen, D.M.14
Lockwood, W.W.15
Lam, W.L.16
Dmitrovsky, E.17
Capobianco, A.J.18
Robbins, D.J.19
-
13
-
-
84893539239
-
The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma
-
Justilien, V., Walsh, M. P., Ali, S. A., Thompson, E. A., Murray, N. R., and Fields, A. P. (2014) The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma. Cancer Cell 25, 139-151
-
(2014)
Cancer Cell
, vol.25
, pp. 139-151
-
-
Justilien, V.1
Walsh, M.P.2
Ali, S.A.3
Thompson, E.A.4
Murray, N.R.5
Fields, A.P.6
-
14
-
-
84875424307
-
Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling
-
Petrova, E., Rios-Esteves, J., Ouerfelli, O., Glickman, J. F., and Resh, M. D. (2013) Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling. Nat. Chem. Biol. 9, 247-249
-
(2013)
Nat. Chem. Biol.
, vol.9
, pp. 247-249
-
-
Petrova, E.1
Rios-Esteves, J.2
Ouerfelli, O.3
Glickman, J.F.4
Resh, M.D.5
-
15
-
-
0034161499
-
A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling
-
Hofmann, K. (2000) A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling. Trends Biochem. Sci. 25, 111-112
-
(2000)
Trends Biochem. Sci.
, vol.25
, pp. 111-112
-
-
Hofmann, K.1
-
16
-
-
84884558970
-
Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins
-
Rios-Esteves, J., and Resh, M. D. (2013) Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins. Cell Rep. 4, 1072-1081
-
(2013)
Cell Rep.
, vol.4
, pp. 1072-1081
-
-
Rios-Esteves, J.1
Resh, M.D.2
-
17
-
-
44049094269
-
Ghrelin octanoylation mediated by an orphan lipid transferase
-
Gutierrez, J. A., Solenberg, P. J., Perkins, D. R., Willency, J. A., Knierman, M. D., Jin, Z., Witcher, D. R., Luo, S., Onyia, J. E., and Hale, J. E. (2008) Ghrelin octanoylation mediated by an orphan lipid transferase. Proc. Natl. Acad. Sci. U.S.A. 105, 6320-6325
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 6320-6325
-
-
Gutierrez, J.A.1
Solenberg, P.J.2
Perkins, D.R.3
Willency, J.A.4
Knierman, M.D.5
Jin, Z.6
Witcher, D.R.7
Luo, S.8
Onyia, J.E.9
Hale, J.E.10
-
18
-
-
38849090670
-
Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone
-
Yang, J., Brown, M. S., Liang, G., Grishin, N. V., and Goldstein, J. L. (2008) Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 132, 387-396
-
(2008)
Cell
, vol.132
, pp. 387-396
-
-
Yang, J.1
Brown, M.S.2
Liang, G.3
Grishin, N.V.4
Goldstein, J.L.5
-
19
-
-
84887445660
-
Architectural organization of the metabolic regulatory enzyme ghrelin O-acyltransferase
-
Taylor, M. S., Ruch, T. R., Hsiao, P. Y., Hwang, Y., Zhang, P., Dai, L., Huang, C. R., Berndsen, C. E., Kim, M. S., Pandey, A., Wolberger, C., Marmorstein, R., Machamer, C., Boeke, J. D., and Cole, P. A. (2013) Architectural organization of the metabolic regulatory enzyme ghrelin O-acyltransferase. J. Biol. Chem. 288, 32211-32228
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 32211-32228
-
-
Taylor, M.S.1
Ruch, T.R.2
Hsiao, P.Y.3
Hwang, Y.4
Zhang, P.5
Dai, L.6
Huang, C.R.7
Berndsen, C.E.8
Kim, M.S.9
Pandey, A.10
Wolberger, C.11
Marmorstein, R.12
Machamer, C.13
Boeke, J.D.14
Cole, P.A.15
-
20
-
-
48749084114
-
MemBrain: Improving the accuracy of predicting transmembrane helices
-
Shen, H., and Chou, J. J. (2008) MemBrain: improving the accuracy of predicting transmembrane helices. PLoS ONE 3, e2399
-
(2008)
PLoS ONE
, vol.3
, pp. e2399
-
-
Shen, H.1
Chou, J.J.2
-
21
-
-
34047151404
-
Improving the accuracy of transmembrane protein topology prediction using evolutionary information
-
Jones, D. T. (2007) Improving the accuracy of transmembrane protein topology prediction using evolutionary information. Bioinformatics 23, 538-544
-
(2007)
Bioinformatics
, vol.23
, pp. 538-544
-
-
Jones, D.T.1
-
22
-
-
84866158866
-
Detecting pore-lining regions in transmembrane protein sequences
-
Nugent, T., and Jones, D. T. (2012) Detecting pore-lining regions in transmembrane protein sequences. BMC Bioinformatics 13, 169
-
(2012)
BMC Bioinformatics
, vol.13
, pp. 169
-
-
Nugent, T.1
Jones, D.T.2
-
23
-
-
44449083478
-
Prediction of membrane-protein topology from first principles
-
Bernsel, A., Viklund, H., Falk, J., Lindahl, E., von Heijne, G., and Elofsson, A. (2008) Prediction of membrane-protein topology from first principles. Proc. Natl. Acad. Sci. U.S.A. 105, 7177-7181
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 7177-7181
-
-
Bernsel, A.1
Viklund, H.2
Falk, J.3
Lindahl, E.4
Von Heijne, G.5
Elofsson, A.6
-
24
-
-
3042579686
-
Best α-helical transmembrane protein topology predictions are achieved using hidden Markov models and evolutionary information
-
Viklund, H., and Elofsson, A. (2004) Best α-helical transmembrane protein topology predictions are achieved using hidden Markov models and evolutionary information. Protein Sci. 13, 1908-1917
-
(2004)
Protein Sci.
, vol.13
, pp. 1908-1917
-
-
Viklund, H.1
Elofsson, A.2
-
25
-
-
48249151108
-
OCTOPUS: Improving topology prediction by two-track ANN-based preference scores and an extended topological grammar
-
Viklund, H., and Elofsson, A. (2008) OCTOPUS: improving topology prediction by two-track ANN-based preference scores and an extended topological grammar. Bioinformatics 24, 1662-1668
-
(2008)
Bioinformatics
, vol.24
, pp. 1662-1668
-
-
Viklund, H.1
Elofsson, A.2
-
26
-
-
67849130558
-
TOPCONS: Consensus prediction of membrane protein topology
-
Bernsel, A., Viklund, H., Hennerdal, A., and Elofsson, A. (2009) TOPCONS: consensus prediction of membrane protein topology. Nucleic Acids Res. 37, W465-W468
-
(2009)
Nucleic Acids Res.
, vol.37
, pp. W465-W468
-
-
Bernsel, A.1
Viklund, H.2
Hennerdal, A.3
Elofsson, A.4
-
27
-
-
0035104092
-
TM Finder: A prediction program for transmembrane protein segments using a combination of hydrophobicity and nonpolar phase helicity scales
-
Deber, C. M., Wang, C., Liu, L. P., Prior, A. S., Agrawal, S., Muskat, B. L., and Cuticchia, A. J. (2001) TM Finder: a prediction program for transmembrane protein segments using a combination of hydrophobicity and nonpolar phase helicity scales. Protein Sci. 10, 212-219
-
(2001)
Protein Sci.
, vol.10
, pp. 212-219
-
-
Deber, C.M.1
Wang, C.2
Liu, L.P.3
Prior, A.S.4
Agrawal, S.5
Muskat, B.L.6
Cuticchia, A.J.7
-
28
-
-
33747871503
-
ZPRED: Predicting the distance to the membrane center for residues in α-helical membrane proteins
-
Granseth, E., Viklund, H., and Elofsson, A. (2006) ZPRED: predicting the distance to the membrane center for residues in α-helical membrane proteins. Bioinformatics 22, e191-e196
-
(2006)
Bioinformatics
, vol.22
, pp. e191-e196
-
-
Granseth, E.1
Viklund, H.2
Elofsson, A.3
-
29
-
-
77955293319
-
Identification of conserved regions and residues within Hedgehog acyltransferase critical for palmitoylation of Sonic Hedgehog
-
Buglino, J. A., and Resh, M. D. (2010) Identification of conserved regions and residues within Hedgehog acyltransferase critical for palmitoylation of Sonic Hedgehog. PLoS ONE 5, e11195
-
(2010)
PLoS ONE
, vol.5
, pp. e11195
-
-
Buglino, J.A.1
Resh, M.D.2
-
30
-
-
33746361201
-
Structural classification and prediction of reentrant regions in α-helical transmembrane proteins: Application to complete genomes
-
Viklund, H., Granseth, E., and Elofsson, A. (2006) Structural classification and prediction of reentrant regions in α-helical transmembrane proteins: application to complete genomes. J. Mol. Biol. 361, 591-603
-
(2006)
J. Mol. Biol.
, vol.361
, pp. 591-603
-
-
Viklund, H.1
Granseth, E.2
Elofsson, A.3
-
31
-
-
84897873840
-
Protter: Interactive protein feature visualization and integration with experimental proteomic data
-
Omasits, U., Ahrens, C. H., Müller, S., and Wollscheid, B. (2014) Protter: interactive protein feature visualization and integration with experimental proteomic data. Bioinformatics 30, 884-886
-
(2014)
Bioinformatics
, vol.30
, pp. 884-886
-
-
Omasits, U.1
Ahrens, C.H.2
Müller, S.3
Wollscheid, B.4
|