Efficient temporally-controlled targeted mutagenesis in smooth muscle cells of the adult mouse

Genesis

Volumn 47, Issue 1, 2009, Pages 14-18

  Wendling, Olivia ^a,b,c   Bornert, Jean Marc ^a,b,c   Chambon, Pierre ^a,b,c,d   Metzger, Daniel ^a,b,c  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b INSERM   (France)

^c UNIVERSITÉ DE STRASBOURG   (France)

^d l'alimentation et l'Environnement   (France)

Author keywords

Conditional mutagenesis; Cre ERT2; Mouse; Smooth muscle cells; Tamoxifen

Indexed keywords

CRE RECOMBINASE; GENOMIC DNA; SMOOTH MUSCLE ACTIN; TAMOXIFEN;

ADULT ANIMAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CONTROLLED STUDY; ENZYME ACTIVITY; GENE FUNCTION; HEART MUSCLE CELL; HISTOCHEMISTRY; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; SOMATIC MUTATION; TRANSGENIC MOUSE; VASCULAR SMOOTH MUSCLE; VISCERA; AGING; ANIMAL; GENETIC ENGINEERING; GENETICS; METABOLISM; METHODOLOGY; PHYSIOLOGY; TIME;

ANIMALIA; BACTERIA (MICROORGANISMS); MUS; MUS MUSCULUS;

AGING; ANIMALS; GENETIC ENGINEERING; MICE; MICE, TRANSGENIC; MUTAGENESIS; MYOCYTES, SMOOTH MUSCLE; TIME FACTORS;

EID: 67449084189     PISSN: 1526954X     EISSN: 1526968X     Source Type: Journal    
DOI: 10.1002/dvg.20448     Document Type: Article

References (17)

1. Akagi K, Sandig V, Vooijs M, Van der Valk M, Giovannini M, Strauss M, Berns A. 1997. Cre-mediated somatic site-specific recombination in mice. Nucleic Acids Res 25:1766-1773.
2. Fatigati V, Murphy RA. 1984. Actin and tropomyosin variants in smooth muscles. Dependence on tissue type. J Biol Chem 259:14383-14388.
3. Holtwick R, Gotthardt M, Skryabin B, Steinmetz M, Potthast R, Zetsche B, Hammer RE, Herz J, Kuhn M. 2002. Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure. Proc Natl Acad Sci USA 99:7142-7147.
4. Kuhbandner S, Brummer S, Metzger D, Chambon P, Hofmann F, Feil R. 2000. Temporally controlled somatic mutagenesis in smooth muscle. Genesis 28:15-22.
5. Lee EC, Yu D, Martinez de Velasco J, Tessarollo L, Swing DA, Court DL, Jenkins NA, Copeland NG. 2001. A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA. Genomics 73:56-65.
6. Lepore JJ, Cheng L, Min Lu M, Mericko PA, Morrisey EE, Parmacek MS. 2005. High-efficiency somatic mutagenesis in smooth muscle cells and cardiac myocytes in SM22alpha-Cre transgenic mice. Genesis 41:179-184.
7. Metzger D, Li M, Chambon P. 2005. Targeted somatic mutagenesis in the mouse epidermis. Methods Mol Biol 289:329-340.
8. Miano JM, Ramanan N, Georger MA, de Mesy Bentley KL, Emerson RL, Balza RO Jr, Xiao Q, Weiler H, Ginty DD, Misra RP. 2004. Restricted inactivation of serum response factor to the cardiovascular system. Proc Natl Acad Sci USA 101:17132-17137.
9. Owens GK, Kumar MS, Wamhoff BR. 2004. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev 84:767-801.
10. Regan CP, Manabe I, Owens GK. 2000. Development of a smooth muscle-targeted cre recombinase mouse reveals novel insights regarding smooth muscle myosin heavy chain promoter regulation. Circ Res 87:363-369.
11. Schuler M, Ali F, Metzger E, Chambon P, Metzger D. 2005. Temporally controlled targeted somatic mutagenesis in skeletal muscles of the mouse. Genesis 41:165-170.
12. Slezak M, Goritz C, Niemiec A, Frisen J, Chambon P, Metzger D, Pfrieger FW. 2007. Transgenic mice for conditional gene manipulation in astroglial cells. Glia 55:1565-1576.
13. Soriano P. 1999. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21:70-71.
14. Wamhoff BR, Sinha S, Owens GK. 2007. Conditional mouse models to study developmental and pathophysiological gene function in muscle. Handbk Exp Pharmacol 178:441-468.
15. Woodcock-Mitchell J, Mitchell JJ, Low RB, Kieny M, Sengel P, Rubbia L, Skalli O, Jackson B, Gabbiani G. 1988. Alpha-smooth muscle actin is transiently expressed in embryonic rat cardiac and skeletal muscles. Differentiation 39:161-166.
16. Xin HB, Deng KY, Rishniw M, Ji G, Kotlikoff MI. 2002. Smooth muscle expression of Cre recombinase and eGFP in transgenic mice. Physiol Genomics 10:211-215.
17. Zhang J, Zhong W, Cui T, Yang M, Hu X, Xu K, Xie C, Xue C, Gibbons GH, Liu C, Li L, Chen YE. 2006. Generation of an adult smooth muscle cell-targeted Cre recombinase mouse model. Arterioscler Thromb Vasc Biol 26:e23-e24.