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Volumn 65, Issue 4, 2014, Pages 257-266

Molecular pathology of colorectal cancer

Author keywords

Chromosomal instability; Colorectal carcinoma; CpG island methylator phenotype (CIMP); KRAS; Microsatellite instability; Molecular pathology

Indexed keywords

CARCINOMA; CHROMOSOMAL INSTABILITY; COLORECTAL NEOPLASMS; HUMAN; LARGE INTESTINE; MICROSATELLITE INSTABILITY; MOLECULAR DIAGNOSIS; PATHOLOGY;

EID: 84922011142     PISSN: 12339687     EISSN: None     Source Type: Journal    
DOI: 10.5114/pjp.2014.48094     Document Type: Review
Times cited : (39)

References (50)
  • 1
    • 79952431304 scopus 로고    scopus 로고
    • Predictive, personalized, preventive, participatory (P4) cancer medicine
    • Hood L, Friend SH. Predictive, personalized, preventive, participatory (P4) cancer medicine Nat Rev Clin Oncol 2011; 8: 184-187.
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 184-187
    • Hood, L.1    Friend, S.H.2
  • 2
    • 84922049413 scopus 로고    scopus 로고
    • Colorectal cancer
    • (Ed. Stewart BW and Wild CP). IARC Press, Lyon
    • Bosman FT. Colorectal cancer. In: World Cancer Report 2014 (Ed. Stewart BW and Wild CP). IARC Press, Lyon 2014; 32-402.
    • (2014) World Cancer Report 2014 , pp. 32-402
    • Bosman, F.T.1
  • 3
    • 79751489596 scopus 로고    scopus 로고
    • Molecular genetics of colorectal cancer
    • Fearon ER Molecular genetics of colorectal cancer. Annu Rev Pathol Mech Dis 2011; 6: 479-507.
    • (2011) Annu Rev Pathol Mech Dis , vol.6 , pp. 479-507
    • Fearon, E.R.1
  • 4
    • 84877619075 scopus 로고    scopus 로고
    • A colorectal cancer classification system that associates cellular phenotype and responses to therapy
    • Sadanandam A, Lyssiotis CA, Homicsko K, et al. A colorectal cancer classification system that associates cellular phenotype and responses to therapy. Nat Med 2013; 19: 619-625.
    • (2013) Nat Med , vol.19 , pp. 619-625
    • Sadanandam, A.1    Lyssiotis, C.A.2    Homicsko, K.3
  • 5
    • 84877600884 scopus 로고    scopus 로고
    • Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions
    • De Sousa E Melo F, Wang X, Jansen M, et al. Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions. Nat Med 2013; 19: 614-618.
    • (2013) Nat Med , vol.19 , pp. 614-618
    • De Sousa, E.1    Melo, F.2    Wang, X.3    Jansen, M.4
  • 6
    • 84885184379 scopus 로고    scopus 로고
    • Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer
    • Budinska E, Popovici V, Tejpar S, et al. Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer. J Pathol 2013; 231: 63-76.
    • (2013) J Pathol , vol.231 , pp. 63-76
    • Budinska, E.1    Popovici, V.2    Tejpar, S.3
  • 7
    • 28244497009 scopus 로고    scopus 로고
    • A genetic model for colorectal carcinogenesis
    • Fearon ER, Vogelstein B. A genetic model for colorectal carcinogenesis. Cell 1996; 87: 159-170.
    • (1996) Cell , vol.87 , pp. 159-170
    • Fearon, E.R.1    Vogelstein, B.2
  • 8
    • 0028152314 scopus 로고
    • Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer
    • Hemminki A, Peltomäki P, Mecklin JP, et al. Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer. Nat Genet 1994; 8: 405-410.
    • (1994) Nat Genet , vol.8 , pp. 405-410
    • Hemminki, A.1    Peltomäki, P.2    Mecklin, J.P.3
  • 9
    • 26944443724 scopus 로고    scopus 로고
    • Serrated adenoma of the colorectum and the DNA-methylator phenotype
    • Jass JR. Serrated adenoma of the colorectum and the DNA-methylator phenotype. Nat Clin Pract Oncol 2005; 2: 398-405.
    • (2005) Nat Clin Pract Oncol , vol.2 , pp. 398-405
    • Jass, J.R.1
  • 10
    • 84877769352 scopus 로고    scopus 로고
    • Germline and somatic polymerase ε and δ mutations define a new class of hypermutated colorectal and endometrial cancers
    • Briggs S, Tomlinson I. Germline and somatic polymerase ε and δ mutations define a new class of hypermutated colorectal and endometrial cancers. J Pathol 2013; 230: 148-153.
    • (2013) J Pathol , vol.230 , pp. 148-153
    • Briggs, S.1    Tomlinson, I.2
  • 11
    • 0026630266 scopus 로고
    • APC mutations occur early during colorectal tumorigenesis
    • Powell SM, Zilz N, Beazer-Barclay Y, et al. APC mutations occur early during colorectal tumorigenesis. Nature 1992; 359: 235-237.
    • (1992) Nature , vol.359 , pp. 235-237
    • Powell, S.M.1    Zilz, N.2    Beazer-Barclay, Y.3
  • 12
    • 0026726952 scopus 로고
    • Molecular analysis of APC mutations in familial adenomatous polyposis and spoadic colon carcinomas
    • Cottrell S, Bicknell D, Kaklamanis L, Bodmer WF. Molecular analysis of APC mutations in familial adenomatous polyposis and spoadic colon carcinomas. Lancet 1992; 340: 626-630.
    • (1992) Lancet , vol.340 , pp. 626-630
    • Cottrell, S.1    Bicknell, D.2    Kaklamanis, L.3    Bodmer, W.F.4
  • 14
    • 33846074011 scopus 로고    scopus 로고
    • Correlations between mutation site in APC and phenotype of familial adenomatous polyposis (FAP): A review of the literature
    • Nieuwenhuis MH, Vasen HF. Correlations between mutation site in APC and phenotype of familial adenomatous polyposis (FAP): a review of the literature. Crit Rev Oncol Hematol 2007; 61: 153-161.
    • (2007) Crit Rev Oncol Hematol , vol.61 , pp. 153-161
    • Nieuwenhuis, M.H.1    Vasen, H.F.2
  • 15
    • 0026894053 scopus 로고
    • Somatic mutations of the APC gene in colorectal tumors: Mutation cluster region in the APC gene
    • Miyoshi Y, Nagase H, Ando H, et al. Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet 1992; 1: 229-233.
    • (1992) Hum Mol Genet , vol.1 , pp. 229-233
    • Miyoshi, Y.1    Nagase, H.2    Ando, H.3
  • 16
    • 84874645608 scopus 로고    scopus 로고
    • A combined oncogenic pathway signature of BRAF, KRAS and PI3KCA mutation improves colorectal cancer classification and cetuximab treatment prediction
    • Tian S, Simon I, Moreno V, et al. A combined oncogenic pathway signature of BRAF, KRAS and PI3KCA mutation improves colorectal cancer classification and cetuximab treatment prediction. Gut 2013; 62: 540-549.
    • (2013) Gut , vol.62 , pp. 540-549
    • Tian, S.1    Simon, I.2    Moreno, V.3
  • 17
    • 0032882705 scopus 로고    scopus 로고
    • Telomerase activation in colorectal carcinogenesis
    • Yan P, Saraga EP, Bouzourene H, et al. Telomerase activation in colorectal carcinogenesis. J Pathol 1999; 189: 207-212.
    • (1999) J Pathol , vol.189 , pp. 207-212
    • Yan, P.1    Saraga, E.P.2    Bouzourene, H.3
  • 21
    • 0024243893 scopus 로고
    • Hereditary nonpolyposis colorectal cancer – Lynch syndromes I and II
    • Lynch HT, Lanspa SJ, Boman BM, et al. Hereditary nonpolyposis colorectal cancer – Lynch syndromes I and II. Gastroenterol Clin North Am 1988; 17: 679-712.
    • (1988) Gastroenterol Clin North Am , vol.17 , pp. 679-712
    • Lynch, H.T.1    Lanspa, S.J.2    Boman, B.M.3
  • 22
    • 0028108802 scopus 로고
    • Mismatch repair genes on chromosomes 2p and 3p account for a major share of hereditary nonpolyposis colorectal cancer families evaluable by linkage
    • Nyström-Lahti M, Parsons R, Sistonen P, et al. Mismatch repair genes on chromosomes 2p and 3p account for a major share of hereditary nonpolyposis colorectal cancer families evaluable by linkage. Am J Hum Genet 1994; 55: 659-665.
    • (1994) Am J Hum Genet , vol.55 , pp. 659-665
    • Nyström-Lahti, M.1    Parsons, R.2    Sistonen, P.3
  • 23
    • 34249792086 scopus 로고    scopus 로고
    • Microsatellite instability markers for identifying early-onset colorectal cancers caused by germ-line mutations in DNA mismatch repair genes
    • Mead LJ, Jenkins MA, Young J, et al. Microsatellite instability markers for identifying early-onset colorectal cancers caused by germ-line mutations in DNA mismatch repair genes. Clin Cancer Res. 2007; 13: 2865-2869.
    • (2007) Clin Cancer Res , vol.13 , pp. 2865-2869
    • Mead, L.J.1    Jenkins, M.A.2    Young, J.3
  • 24
    • 70350437372 scopus 로고    scopus 로고
    • Immunohistochemistry as first-line screening for detecting colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome: A 2-antibody panel may be as predictive as a 4-antibody panel
    • Shia J, Tang LH, Vakiani E, et al. Immunohistochemistry as first-line screening for detecting colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome: a 2-antibody panel may be as predictive as a 4-antibody panel. Am J Surg Pathol 2009; 33: 1639-1645.
    • (2009) Am J Surg Pathol , vol.33 , pp. 1639-1645
    • Shia, J.1    Tang, L.H.2    Vakiani, E.3
  • 25
    • 0032146118 scopus 로고    scopus 로고
    • Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability
    • Cunningham JM, Christensen ER, Tester DJ, et al. Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability. Cancer Res 1998; 58: 3455-3460.
    • (1998) Cancer Res , vol.58 , pp. 3455-3460
    • Cunningham, J.M.1    Christensen, E.R.2    Tester, D.J.3
  • 26
    • 79958261864 scopus 로고    scopus 로고
    • Microsatellite instability in the management of colorectal cancer
    • Pino MS, Chung DC. Microsatellite instability in the management of colorectal cancer. Expert Rev Gastroenterol Hepatol 2011; 5: 385-399.
    • (2011) Expert Rev Gastroenterol Hepatol , vol.5 , pp. 385-399
    • Pino, M.S.1    Chung, D.C.2
  • 27
    • 84876191473 scopus 로고    scopus 로고
    • Regulatory T lymphocytes are associated with less aggressive histologic features in microsatellite-unstable colorectal cancers
    • Tougeron D, Maby P, Elie N, et al. Regulatory T lymphocytes are associated with less aggressive histologic features in microsatellite-unstable colorectal cancers. PLoS One 2013; 8: e61001.
    • (2013) PLoS One , vol.8
    • Tougeron, D.1    Maby, P.2    Elie, N.3
  • 28
    • 84896739540 scopus 로고    scopus 로고
    • Replicative DNA polymerase mutations in cancer
    • Heitzer E, Tomlinson I. Replicative DNA polymerase mutations in cancer. Curr Opin Genet Dev 2014; 24: 107-113.
    • (2014) Curr Opin Genet Dev , vol.24 , pp. 107-113
    • Heitzer, E.1    Tomlinson, I.2
  • 29
    • 48549101423 scopus 로고    scopus 로고
    • CpG island methylator phenotype (CIMP) in cancer: Causes and implications
    • Teodoridis JM, Hardie C, Brown R. CpG island methylator phenotype (CIMP) in cancer: causes and implications. Cancer Lett 2008; 268: 177-186.
    • (2008) Cancer Lett , vol.268 , pp. 177-186
    • Teodoridis, J.M.1    Hardie, C.2    Brown, R.3
  • 30
    • 78649985198 scopus 로고    scopus 로고
    • Update on the serrated pathway to colorectal carcinoma
    • Snover DC. Update on the serrated pathway to colorectal carcinoma. Hum Pathol 2011; 42: 1-10.
    • (2011) Hum Pathol , vol.42 , pp. 1-10
    • Snover, D.C.1
  • 31
    • 84872670401 scopus 로고    scopus 로고
    • The serrated pathway to colorectal carcinoma: Current concepts and challenges
    • Bettington M, Walker N, Clouston A, et al. The serrated pathway to colorectal carcinoma: current concepts and challenges. Histopathology 2013; 62: 367-386.
    • (2013) Histopathology , vol.62 , pp. 367-386
    • Bettington, M.1    Walker, N.2    Clouston, A.3
  • 32
    • 33746092527 scopus 로고    scopus 로고
    • Advanced colorectal polyps with the molecular and morphological features of serrated polyps and adenomas: Concept of a ‚fusion' pathway to colorectal cancer
    • Jass JR, Baker K, Zlobec I, et al. Advanced colorectal polyps with the molecular and morphological features of serrated polyps and adenomas: concept of a ‚fusion' pathway to colorectal cancer. Histopathology 2006; 49: 121-131.
    • (2006) Histopathology , vol.49 , pp. 121-131
    • Jass, J.R.1    Baker, K.2    Zlobec, I.3
  • 33
    • 84896856425 scopus 로고    scopus 로고
    • Reconciliation of classification systems defining molecular subtypes of colorectal cancer: Interrelationships and clinical implications
    • Sadanandam A, Wang X, de Sousa E Melo F, et al. Reconciliation of classification systems defining molecular subtypes of colorectal cancer: interrelationships and clinical implications. Cell Cycle 2014; 13: 353-357.
    • (2014) Cell Cycle , vol.13 , pp. 353-357
    • Sadanandam, A.1    Wang, X.2    de Sousa, E.3    Melo, F.4
  • 34
    • 84904273594 scopus 로고    scopus 로고
    • Controversies in colorectal cancer screening
    • Pox CP. Controversies in colorectal cancer screening. Digestion 2014; 89: 274-281.
    • (2014) Digestion , vol.89 , pp. 274-281
    • Pox, C.P.1
  • 35
    • 84897509377 scopus 로고    scopus 로고
    • Multitarget stool DNA testing for colorectal-cancer screening
    • Imperiale TF, Ransohoff DF, Itzkowitz SH, et al. Multitarget stool DNA testing for colorectal-cancer screening. N Engl J Med 2014; 370: 1287-1297.
    • (2014) N Engl J Med , vol.370 , pp. 1287-1297
    • Imperiale, T.F.1    Ransohoff, D.F.2    Itzkowitz, S.H.3
  • 36
    • 79960987047 scopus 로고    scopus 로고
    • Challenges in the management of stage II colon cancer
    • Dotan E, Cohen SJ. Challenges in the management of stage II colon cancer. Semin Oncol 2011; 38: 511-520.
    • (2011) Semin Oncol , vol.38 , pp. 511-520
    • Dotan, E.1    Cohen, S.J.2
  • 37
    • 84885012223 scopus 로고    scopus 로고
    • Enabling transparent and collaborative computational analysis of 12 tumor types within The Cancer Genome Atlas
    • Omberg L, Ellrott K, Yuan Y, et al. Enabling transparent and collaborative computational analysis of 12 tumor types within The Cancer Genome Atlas. Nat Genet 2013; 45: 1121-1126.
    • (2013) Nat Genet , vol.45 , pp. 1121-1126
    • Omberg, L.1    Ellrott, K.2    Yuan, Y.3
  • 38
    • 84879114673 scopus 로고    scopus 로고
    • Independent validation of a prognostic genomic signature (ColoPrint) for patients with stage II colon cancer
    • Maak M, Simon I, Nitsche U, et al. Independent validation of a prognostic genomic signature (ColoPrint) for patients with stage II colon cancer. Ann Surg 2013; 257: 1053-1058.
    • (2013) Ann Surg , vol.257 , pp. 1053-1058
    • Maak, M.1    Simon, I.2    Nitsche, U.3
  • 39
    • 84922049412 scopus 로고    scopus 로고
    • Validation of the 12-gene colon cancer recurrence score as a predictor of recurrence risk in stage II and III rectal cancer patients
    • pii: Dju269
    • Reimers MS, Kuppen PJ, Lee M, et al. Validation of the 12-gene colon cancer recurrence score as a predictor of recurrence risk in stage II and III rectal cancer patients. J Natl Cancer Inst 2014; 106 pii: dju269. doi: 10.1093/jnci/dju269.
    • (2014) J Natl Cancer Inst , vol.106
    • Reimers, M.S.1    Kuppen, P.J.2    Lee, M.3
  • 40
    • 84984993533 scopus 로고    scopus 로고
    • Test of four colon cancer risk-scores in formalin fixed paraffin embedded microarray gene expression data
    • pii: Dju247
    • Di Narzo AF, Tejpar S, Rossi S, et al. Test of four colon cancer risk-scores in formalin fixed paraffin embedded microarray gene expression data. J Natl Cancer Inst 2014; 106 pii: dju247. doi: 10.1093/jnci/dju247.
    • (2014) J Natl Cancer Inst , vol.106
    • Di Narzo, A.F.1    Tejpar, S.2    Rossi, S.3
  • 41
    • 79958784152 scopus 로고    scopus 로고
    • Adjuvant treatment of colon cancer: What is next?
    • Van Loon K, Venook AP. Adjuvant treatment of colon cancer: what is next? Curr Opin Oncol 2011; 23: 403-409.
    • (2011) Curr Opin Oncol , vol.23 , pp. 403-409
    • Van Loon, K.1    Venook, A.P.2
  • 42
    • 84872069927 scopus 로고    scopus 로고
    • Identification of the biomarkers for the prediction of efficacy in first-line chemotherapy of metastatic colorectal cancer patients using SELDI-TOF-MS and artificial neural networks
    • Yuan Y, Tan CW, Shen H, et al. Identification of the biomarkers for the prediction of efficacy in first-line chemotherapy of metastatic colorectal cancer patients using SELDI-TOF-MS and artificial neural networks. Hepatogastroenterology 2012; 59: 2461-2465.
    • (2012) Hepatogastroenterology , vol.59 , pp. 2461-2465
    • Yuan, Y.1    Tan, C.W.2    Shen, H.3
  • 43
    • 84863115876 scopus 로고    scopus 로고
    • Predictive biomarkers with potential of converting conventional chemotherapy to targeted therapy in patients with metastatic colorectal cancer
    • Jensen NF, Smith DH, Nygård SB, et al. Predictive biomarkers with potential of converting conventional chemotherapy to targeted therapy in patients with metastatic colorectal cancer. Scand J Gastroenterol 2012; 47: 340-355.
    • (2012) Scand J Gastroenterol , vol.47 , pp. 340-355
    • Jensen, N.F.1    Smith, D.H.2    Nygård, S.B.3
  • 44
    • 33646228635 scopus 로고    scopus 로고
    • KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
    • Lièvre A, Bachet JB, Le Corre D, et al. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res 2006; 66: 3992-3995.
    • (2006) Cancer Res , vol.66 , pp. 3992-3995
    • Lièvre, A.1    Bachet, J.B.2    Le Corre, D.3
  • 45
    • 84875742535 scopus 로고    scopus 로고
    • Mutant KRAS codon 12 and 13 alleles in patients with metastatic colorectal cancer: Assessment as prognostic and predictive biomarkers of response to panitumumab
    • Peeters M, Douillard JY, Van Cutsem E, et al. Mutant KRAS codon 12 and 13 alleles in patients with metastatic colorectal cancer: assessment as prognostic and predictive biomarkers of response to panitumumab. J Clin Oncol 2013; 31: 759-765.
    • (2013) J Clin Oncol , vol.31 , pp. 759-765
    • Peeters, M.1    Douillard, J.Y.2    Van Cutsem, E.3
  • 46
    • 77955277111 scopus 로고    scopus 로고
    • Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis
    • De Roock W, Claes B, Bernasconi D, et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol 2010; 11: 753-762.
    • (2010) Lancet Oncol , vol.11 , pp. 753-762
    • De Roock, W.1    Claes, B.2    Bernasconi, D.3
  • 47
    • 77952892341 scopus 로고    scopus 로고
    • Integrated molecular dissection of the epidermal growth factor receptor (EGFR) [corrected] oncogenic pathway to predict response to EGFR-targeted monoclonal antibodies in metastatic colorectal cancer
    • Sartore-Bianchi A, Bencardino K, Di Nicolantonio F, et al. Integrated molecular dissection of the epidermal growth factor receptor (EGFR) [corrected] oncogenic pathway to predict response to EGFR-targeted monoclonal antibodies in metastatic colorectal cancer. Target Oncol 2010; 5: 19-28.
    • (2010) Target Oncol , vol.5 , pp. 19-28
    • Sartore-Bianchi, A.1    Bencardino, K.2    Di Nicolantonio, F.3
  • 48
    • 84914182003 scopus 로고    scopus 로고
    • Acquired resistance to EGFR-targeted therapies in colorectal cancer
    • Van Emburgh BO, Sartore-Bianchi A, Di Nicolantonio F, et al. Acquired resistance to EGFR-targeted therapies in colorectal cancer. Mol Oncol 2014; 8: 1084-1094.
    • (2014) Mol Oncol , vol.8 , pp. 1084-1094
    • Van Emburgh, B.O.1    Sartore-Bianchi, A.2    Di Nicolantonio, F.3
  • 49
    • 77949435827 scopus 로고    scopus 로고
    • Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer
    • Bardelli A, Siena S. Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer. J Clin Oncol 2010; 28: 1254-1261.
    • (2010) J Clin Oncol , vol.28 , pp. 1254-1261
    • Bardelli, A.1    Siena, S.2
  • 50
    • 84887497121 scopus 로고    scopus 로고
    • The quest to overcome resistance to EGFR-targeted therapies in cancer
    • Chong CR, Jänne PA. The quest to overcome resistance to EGFR-targeted therapies in cancer. Nat Med 2013; 19: 1389-1400.
    • (2013) Nat Med , vol.19 , pp. 1389-1400
    • Chong, C.R.1    Jänne, P.A.2


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