Immunohistochemistry as first-line screening for detecting colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome: A 2-antibody panel may be as predictive as a 4-antibody panel

American Journal of Surgical Pathology

Volumn 33, Issue 11, 2009, Pages 1639-1645

  Shia, Jinru ^a   Tang, Laura H ^a   Vakiani, Efsevia ^a   Guillem, Jose G ^a   Stadler, Zsofia K ^a   Soslow, Robert A ^a   Katabi, Nora ^a   Weiser, Martin R ^a   Paty, Philip B ^a   Temple, Larissa K ^a   Nash, Garrett M ^a   Wong, W Douglas ^a   Offit, Kenneth ^a   Klimstra, David S ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

DNA mismatch repair; HNPCC; Immunohistochemistry; Lynch syndrome; Microsatellite instability; MSI

Indexed keywords

MISMATCH REPAIR PROTEIN PMS2; PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH6;

ADULT; ARTICLE; CANCER PATIENT; CANCER RISK; CANCER SCREENING; COLORECTAL CANCER; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DNA REPAIR; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MISMATCH REPAIR; PROTEIN DEPLETION; RETROSPECTIVE STUDY; TUMOR CELL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOCARCINOMA; ADENOSINE TRIPHOSPHATASES; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA MISMATCH REPAIR; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; HUMANS; IMMUNOENZYME TECHNIQUES; MASS SCREENING; MIDDLE AGED; MUTATION; MUTS HOMOLOG 2 PROTEIN; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; TUMOR MARKERS, BIOLOGICAL;

EID: 70350437372     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e3181b15aa2     Document Type: Article

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