Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression

Nature Neuroscience

Volumn 18, Issue 3, 2015, Pages 435-446

  Chung, Woosuk ^a   Choi, Su Yeon ^a   Lee, Eunee ^b   Park, Haram ^a   Kang, Jaeseung ^a   Park, Hanwool ^a   Choi, Yeonsoo ^a   Lee, Dongsoo ^b   Park, Sae Geun ^a   Kim, Ryunhee ^a   Cho, Yi Sul ^c   Choi, Jeonghoon ^a   Kim, Myoung Hwan ^d,e   Lee, Jong Won ^b   Lee, Seungjoon ^a   Rhim, Issac ^b   Jung, Min Whan ^a,b   Kim, Daesoo ^a   Bae, Yong Chul ^c   Kim, Eunjoon ^a,b  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Institute for Basic Science   (South Korea)

^c Kyungpook National University   (South Korea)

^d Seoul National University College of Medicine   (South Korea)

^e Seoul National University Bundang Hospital   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; F ACTIN; INSULIN RECEPTOR SUBSTRATE; MEMANTINE; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; AMINO ACID RECEPTOR BLOCKING AGENT; IRSP53 PROTEIN, MOUSE; NERVE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENTION DEFICIT DISORDER; AUTISM; BRAIN FUNCTION; CONTROLLED STUDY; HIPPOCAMPUS; HYPERACTIVITY; IMPAIRED SOCIAL INTERACTION; MENTAL DISEASE; MOUSE; MUTANT; NERVE CELL PLASTICITY; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; SCHIZOPHRENIA; SOCIAL INTERACTION; SYNAPTIC TRANSMISSION; ANIMAL; C57BL MOUSE; CASE CONTROL STUDY; CELL CULTURE; DRUG EFFECTS; EXPLORATORY BEHAVIOR; FEEDING BEHAVIOR; GENE EXPRESSION REGULATION; GENETICS; GROOMING; MALE; METABOLISM; MUTATION; NERVE CELL; NEWBORN; PHYSIOLOGY; RECOGNITION; SOCIAL BEHAVIOR DISORDERS; TRANSGENIC MOUSE; ULTRASTRUCTURE; VOCALIZATION;

ANIMALS; ANIMALS, NEWBORN; CASE-CONTROL STUDIES; CELLS, CULTURED; EXCITATORY AMINO ACID ANTAGONISTS; EXPLORATORY BEHAVIOR; FEEDING BEHAVIOR; GENE EXPRESSION REGULATION; GROOMING; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; NERVE TISSUE PROTEINS; NEURONS; RECEPTOR, METABOTROPIC GLUTAMATE 5; RECEPTORS, N-METHYL-D-ASPARTATE; RECOGNITION (PSYCHOLOGY); SOCIAL BEHAVIOR DISORDERS; VOCALIZATION, ANIMAL;

EID: 84923819589     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.3927     Document Type: Article

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