Necrostatin-1 mitigates mitochondrial dysfunction post-spinal cord injury

Neuroscience

Volumn 289, Issue , 2015, Pages 224-232

  Wang, Y ^a,b   Wang, J ^b   Yang, H ^a   Zhou, J ^a   Feng, X ^b   Wang, H ^b   Tao, Y ^b  

^a THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b CLINICAL MEDICAL COLLEGE OF YANGZHOU UNIVERSITY   (China)

Author keywords

Functional protection; Mitochondria; Necroptosis; Necrostatin 1; Spinal cord injury

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; CYTOCHROME C; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; NECROSTATIN 1; NEUROPROTECTIVE AGENT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UNCLASSIFIED DRUG; CALCIUM; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; MITOCHONDRIAL PROTEIN; NECROSTATIN-1; TFAM PROTEIN, RAT; TRANSCRIPTION FACTOR; TTC11 PROTEIN, RAT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOGENESIS; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DRUG MECHANISM; FIS1 GENE; GENE EXPRESSION REGULATION; MALE; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL GENE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MITOCHONDRION SWELLING; MNF1 GENE; MNF2 GENE; NEUROPROTECTION; NONHUMAN; PROTEIN SECRETION; RAT; SPINAL CORD INJURY; ANIMAL; DISEASE MODEL; DRUG EFFECTS; METABOLISM; MITOCHONDRIAL DYNAMICS; ORGANELLE BIOGENESIS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; SPINAL CORD; SPINAL CORD INJURIES; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CYTOCHROMES C; DISEASE MODELS, ANIMAL; IMIDAZOLES; INDOLES; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL PROTEINS; NEUROPROTECTIVE AGENTS; ORGANELLE BIOGENESIS; RANDOM ALLOCATION; RATS, SPRAGUE-DAWLEY; SPINAL CORD; SPINAL CORD INJURIES; TRANSCRIPTION FACTORS;

EID: 84921951975     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.12.061     Document Type: Article

References (45)

1. Azbill R.D., Mu X., Bruce-Keller A.J., Mattson M.P., Springer J.E. Impaired mitochondrial function, oxidative stress and altered antioxidant enzyme activities following traumatic spinal cord injury. Brain Res 1997, 765:283-290.
2. Beattie M.S., Hermann G.E., Rogers R.C., Bresnahan J.C. Cell death in models of spinal cord injury. Prog Brain Res 2002, 137:37-47.
3. Bethea J.R., Dietrich W.D. Targeting the host inflammatory response in traumatic spinal cord injury. Curr Opin Neurol 2002, 15:355-360.
4. Cao Y., Lv G., Wang Y.S., Fan Z.K., Bi Y.L., Zhao L., Guo Z.P. Mitochondrial fusion and fission after spinal sacord injury in rats. Brain Res 2013, 1522:59-66.
5. Chang P., Dong W., Zhang M., Wang Z., Wang Y., Wang T., Gao Y., Meng H., Luo B., Luo C., Chen X., Tao L. Anti-necroptosis chemical necrostatin-1 can also suppress apoptotic and autophagic pathway to exert neuroprotective effect in mice intracerebral hemorrhage model. J Mol Neurosci 2014, 52:242-249.
6. Choo Y.S., Johnson G.V., MacDonald M., Detloff P.J., Lesort M. Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release. Hum Mol Genet 2004, 13:1407-1420.
7. Degterev A., Huang Z., Boyce M., Li Y., Jagtap P., Mizushima N., Cuny G.D., Mitchison T.J., Moskowitz M.A., Yuan J. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol 2005, 1:112-119.
8. Deniaud A., Sharaf el dein O., Maillier E., Poncet D., Kroemer G., Lemaire C., Brenner C. Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis. Oncogene 2008, 27:285-299.
9. Du Y., Ko K.M. Effects of emodin treatment on mitochondrial ATP generation capacity and antioxidant components as well as susceptibility to ischemia-reperfusion injury in rat hearts: single versus multiple doses and gender difference. Life Sci 2005, 77:2770-2782.
10. Dutta R., McDonough J., Yin X., Peterson J., Chang A., Torres T., Gudz T., Macklin W.B., Lewis D.A., Fox R.J., Rudick R., Mirnics K., Trapp B.D. Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients. Ann Neurol 2006, 59:478-489.
11. Fricker M., Vilalta A., Tolkovsky A.M., Brown G.C. Caspase inhibitors protect neurons by enabling selective necroptosis of inflamed microglia. J Biol Chem 2013, 288:9145-9152.
12. 2+ and ROS in alpha-tocopheryl succinate-induced mitochondrial permeabilization. Int J Cancer 2010, 127:1823-1832.
13. Hou H., Zhang L., Zhang L., Liu D., Mao Z., Du H., Tang P. Acute spinal cord injury in rats induces autophagy activation. Turk Neurosurg 2014, 24:369-373.
14. Kadenbach B., Ramzan R., Moosdorf R., Vogt S. The role of mitochondrial membrane potential in ischemic heart failure. Mitochondrion 2011, 11:700-706.
15. Keeney P.M., Bennett J.P. ALS spinal neurons show varied and reduced mtDNA gene copy numbers and increased mtDNA gene deletions. Mol Neurodegener 2010, 5:21.
16. Kim H.Y., Chung J.M., Chung K. Increased production of mitochondrial superoxide in the spinal cord induces pain behaviors in mice: the effect of mitochondrial electron transport complex inhibitors. Neurosci Lett 2008, 447:87-91.
17. Lee K.K., Shimoji M., Hossain Q.S., Sunakawa H., Aniya Y. Novel function of glutathione transferase in rat liver mitochondrial membrane: role for cytochrome c release from mitochondria. Toxicol Appl Pharmacol 2008, 232:109-118.
18. Lee S.J., Zhang J., Choi A.M., Kim H.P. Mitochondrial dysfunction induces formation of lipid droplets as a generalized response to stress. Oxid Med Cell Longev 2013, 2013:327167.
19. Li M., Xia T., Jiang C.S., Li L.J., Fu J.L., Zhou Z.C. Cadmium directly induced the opening of membrane permeability pore of mitochondria which possibly involved in cadmium-triggered apoptosis. Toxicology 2003, 194:19-33.
20. Lu J., Ashwell K.W., Waite P. Advances in secondary spinal cord injury: role of apoptosis. Spine (Phila Pa 1976) 2000, 25:1859-1866.
21. Mahad D.J., Ziabreva I., Campbell G., Lax N., White K., Hanson P.S., Lassmann H., Turnbull D.M. Mitochondrial changes within axons in multiple sclerosis. Brain 2009, 132:1161-1174.
22. 2+ signals in smooth muscle. Pflugers Arch 2012, 464:51-62.
23. McEwen M.L., Sullivan P.G., Rabchevsky A.G., Springer J.E. Targeting mitochondrial function for the treatment of acute spinal cord injury. Neurotherapeutics 2011, 8:168-179.
24. Morimoto N., Miyazaki K., Kurata T., Ikeda Y., Matsuura T., Kang D., Ide T., Abe K. Effect of mitochondrial transcription factor a overexpression on motor neurons in amyotrophic lateral sclerosis model mice. J Neurosci Res 2012, 90:1200-1208.
25. Osellame L.D., Blacker T.S., Duchen M.R. Cellular and molecular mechanisms of mitochondrial function. Best Pract Res Clin Endocrinol Metab 2012, 26:711-723.
26. Oyinbo C.A. Secondary injury mechanisms in traumatic spinal cord injury: a nugget of this multiply cascade. Acta Neurobiol Exp (Wars) 2011, 71:281-299.
27. 2+ in mitochondrial dysfunction and disease. Cell Calcium 2009, 45:643-650.
28. Patel S.P., Sullivan P.G., Lyttle T.S., Rabchevsky A.G. Acetyl-l-carnitine ameliorates mitochondrial dysfunction following contusion spinal cord injury. J Neurochem 2010, 114:291-301.
29. 2+-induced reactive oxygen species production promotes cytochrome c release from rat liver mitochondria via mitochondrial permeability transition (MPT)-dependent and MPT-independent mechanisms: role of cardiolipin. J Biol Chem 2004, 279:53103-53108.
30. Picca A., Pesce V., Fracasso F., Joseph A.M., Leeuwenburgh C., Lezza A.M. A comparison among the tissue-specific effects of aging and calorie restriction on TFAM amount and TFAM-binding activity to mtDNA in rat. Biochim Biophys Acta 2014, 1840:2184-2191.
31. Ravikumar R., McEwen M.L., Springer J.E. Post-treatment with the cyclosporin derivative, NIM811, reduced indices of cell death and increased the volume of spared tissue in the acute period following spinal cord contusion. J Neurotrauma 2007, 24:1618-1630.
32. Ricci J.E., Muñoz-Pinedo C., Fitzgerald P., Bailly-Maitre B., Perkins G.A., Yadava N., Scheffler I.E., Ellisman M.H., Green D.R. Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain. Cell 2004, 117:773-786.
33. Roy S.S., Hajnóczky G. Calcium, mitochondria and apoptosis studied by fluorescence measurements. Methods 2008, 46:213-223.
34. Scatena R. Mitochondria and cancer: a growing role in apoptosis, cancer cell metabolism and dedifferentiation. Adv Exp Med Biol 2012, 942:287-308.
35. Thau N., Knippenberg S., Körner S., Rath K.J., Dengler R., Petri S. Decreased mRNA expression of PGC-1α and PGC-1α-regulated factors in the SOD1G93A ALS mouse model and in human sporadic ALS. J Neuropathol Exp Neurol 2012, 71:1064-1074.
36. Titsworth W.L., Liu N.K., Xu X.M. Role of secretory phospholipase a(2) in CNS inflammation: implications in traumatic spinal cord injury. CNS Neurol Disord Drug Targets 2008, 7:254-269.
37. Tochigi M., Inoue T., Suzuki-Karasaki M., Ochiai T., Ra C., Suzuki-Karasaki Y. Hydrogen peroxide induces cell death in human TRAIL-resistant melanoma through intracellular superoxide generation. Int J Oncol 2013, 42:863-872.
38. Wang Y., Gu J., Wang J., Feng X., Tao Y., Jiang B., He J., Wang Q., Yang J., Zhang S., Cai J., Sun Y. BDNF and NT-3 expression by using glucocorticoid-induced bicistronic expression vector pGC-BDNF-IRES-NT3 protects apoptotic cells in a cellular injury model. Brain Res 2012, 1448:137-143.
39. Wang Y.Q., Wang L., Zhang M.Y., Wang T., Bao H.J., Liu W.L., Dai D.K., Zhang L., Chang P., Dong W.W., Chen X.P., Tao L.Y. Necrostatin-1 suppresses autophagy and apoptosis in mice traumatic brain injury model. Neurochem Res 2012, 37:1849-1858.
40. Wang Y., Wang H., Tao Y., Zhang S., Wang J., Feng X. Necroptosis inhibitor necrostatin-1 promotes cell protection and physiological function in traumatic spinal cord injury. Neuroscience 2014, 266:91-101.
41. Xu X., Chua K.W., Chua C.C., Liu C.F., Hamdy R.C., Chua B.H. Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury. Brain Res 2010, 1355:189-194.
42. Yeo J.E., Kim J.H., Kang S.K. Selenium attenuates ROS-mediated apoptotic cell death of injured spinal cord through prevention of mitochondria dysfunction; in vitro and in vivo study. Cell Physiol Biochem 2008, 21:225-238.
43. Yoboue E.D., Mougeolle A., Kaiser L., Averet N., Rigoulet M., Devin A. The role of mitochondrial biogenesis and ROS in the control of energy supply in proliferating cells. Biochim Biophys Acta 2014, 1837:1093-1098.
44. Yu D., Li M., Ni B., Kong J., Zhang Z. Induction of neuronal mitophagy in acute spinal cord injury in rats. Neurotox Res 2013, 24:512-522.
45. Zhu S., Zhang Y., Bai G., Li H. Necrostatin-1 ameliorates symptoms in R6/2 transgenic mouse model of Huntington's disease. Cell Death Dis 2011, 2:e115.