Mechanistic studies of the negative epistatic malaria-protective interaction between sickle cell trait and α+thalassemia

EBioMedicine

Volumn 1, Issue 1, 2014, Pages 29-36

  Opi, D Herbert ^a,b   Ochola, Lucy B ^a   Tendwa, Metrine ^a   Siddondo, Bethsheba R ^a   Ocholla, Harold ^a   Fanjo, Harry ^a   Ghumra, Ashfaq ^b   Ferguson, David J P ^c   Rowe, J Alexandra ^b   Williams, Thomas N ^a,d  

^a KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d ST MARY S HOSPITAL   (United Kingdom)

Author keywords

Cytoadhesion; Epistasis; Malaria; PfEMP1; Red blood cells; Sickle cell trait; +thalassemia

Indexed keywords

COMPLEMENT COMPONENT C3B RECEPTOR; ERYTHROCYTE MEMBRANE PROTEIN 1; INTERCELLULAR ADHESION MOLECULE 1;

ALPHA THALASSEMIA; ARTICLE; BINDING ASSAY; CELL ADHESION ASSAY; CELL SELECTION; CHILD; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; EPISTASIS; ERYTHROCYTE PARAMETERS; ERYTHROCYTE ROSETTING; FLOW CYTOMETRY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN CELL; INFANT; MAJOR CLINICAL STUDY; MALARIA CONTROL; NONHUMAN; PHENOTYPE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; SICKLE CELL TRAIT;

EID: 84921941111     PISSN: None     EISSN: 23523964     Source Type: Journal    
DOI: 10.1016/j.ebiom.2014.10.006     Document Type: Article

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