Epistatic interactions between genetic disorders of hemoglobin can explain why the sickle-cell gene is uncommon in the Mediterranean

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 50, 2009, Pages 21242-21246

  Penman, Bridget S ^a   Pybus, Oliver G ^a   Weatherall, David J ^b   Gupta, Sunetra ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Epistasis; Host genetics; Human evolution; Malaria; Thalassemia

Indexed keywords

HEMOGLOBIN;

ALPHA THALASSEMIA; ARTICLE; BETA THALASSEMIA; CELL PROTECTION; GENE FREQUENCY; GENE MUTATION; GENETIC ANALYSIS; GENETIC DISORDER; GENETIC EPISTASIS; GENOTYPE; HETEROZYGOTE; HUMAN; MALARIA; PRIORITY JOURNAL; SICKLE CELL; SOUTHERN EUROPE;

AFRICA; ANEMIA, SICKLE CELL; EPISTASIS, GENETIC; GENE FREQUENCY; HEMOGLOBINS, ABNORMAL; HUMANS; MALARIA; MEDITERRANEAN ISLANDS; THALASSEMIA;

EID: 75849133408     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0910840106     Document Type: Article

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