Glycyrrhetinic acid induces G1-phase cell cycle arrest in human non-small cell lung cancer cells through endoplasmic reticulum stress pathway

International Journal of Oncology

Volumn 46, Issue 3, 2015, Pages 981-988

  Zhu, Jie ^a   Chen, Meijuan ^a   Chen, Ning ^a   Ma, Aizhen ^a   Zhu, Chunyan ^a   Zhao, Ruolin ^a   Jiang, Miao ^a   Zhou, Jing ^a   Ye, Lihong ^a   Fu, Haian ^b   Zhang, Xu ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell cycle arrest; ER stress; Glycyrrhetinic acid; NSCLC

Indexed keywords

CASPASE 3; CASPASE 7; CASPASE 9; CYCLIN D1; CYCLIN D3; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2C; CYCLIN E; GLUCOSE REGULATED PROTEIN 78; GLYCYRRHETINIC ACID; TRANSCRIPTION FACTOR E2F1; ANTINEOPLASTIC AGENT; CYCLINE; ENDOPLASMIC RETICULUM GLYCOPROTEIN P72; HEAT SHOCK PROTEIN; HERBACEOUS AGENT; MEMBRANE PROTEIN; MOLECULAR CHAPERONE GRP78; RETINOBLASTOMA PROTEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; NON SMALL CELL LUNG CANCER; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; PROTEIN UNFOLDING; UNFOLDED PROTEIN RESPONSE; UPREGULATION; WESTERN BLOTTING; CARCINOMA, NON-SMALL-CELL LUNG; DRUG EFFECTS; LUNG NEOPLASMS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLINS; DRUGS, CHINESE HERBAL; ENDOPLASMIC RETICULUM STRESS; G1 PHASE CELL CYCLE CHECKPOINTS; GLYCYRRHETINIC ACID; HEAT-SHOCK PROTEINS; HUMANS; LUNG NEOPLASMS; MEMBRANE GLYCOPROTEINS; PHOSPHORYLATION; RETINOBLASTOMA PROTEIN;

EID: 84921914999     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2015.2819     Document Type: Article

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