Neferine isolated from Nelumbo nucifera enhances anti-cancer activities in Hep3B cells: Molecular mechanisms of cell cycle arrest, ER stress induced apoptosis and anti-angiogenic response

Phytomedicine

Volumn 20, Issue 11, 2013, Pages 1013-1022

  Yoon, Jin Soo ^a   Kim, Hwa Mi ^b   Yadunandam, Anandam Kasin ^a   Kim, Nan Hee ^a   Jung, Hyun Ah ^c   Choi, Jae Sue ^a   Kim, Chi Yeon ^b   Kim, Gun Do ^a  

^a Pukyong National University   (South Korea)

^b Gyeongsang National University School of Medicine   (South Korea)

^c Chonbuk National University   (South Korea)

Author keywords

Apoptosis; Cell cycle arrest; ER stress; Hep3B; Neferine; Nelumbo nucifera

Indexed keywords

BIM PROTEIN; CALNEXIN; CALPAIN 2; CASPASE 12; CASPASE 6; CASPASE 7; CASPASE 8; CYCLIN D1; CYCLIN D3; CYCLIN DEPENDENT KINASE 4; MYC PROTEIN; NEFERINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAK; PROTEIN BAX; PROTEIN BID; PUMA PROTEIN; TRANSCRIPTION FACTOR E2F1;

ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; CELL CYCLE ARREST; CELL MIGRATION; CELL POPULATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; FLUORESCENCE; HUMAN; HUMAN CELL; NELUMBO NUCIFERA; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; WESTERN BLOTTING;

2-(4-IODOPHENYL)-3-(4-NITROPHENYL)-5-(2,4-DISULFOPHENYL)-2H-TETRAZOLIUM, MONOSODIUM SALT; 4,6-DIAMIDINO-2-PHENYLINDOLE DIHYDROCHLORIDE HYDRATE; APOPTOSIS; BOVINE SERUM ALBUMIN; BSA; CDKS; CELL CYCLE ARREST; CYCLIN-DEPENDENT KINASES; DAPI; DFF; DIMETHYL SULFOXIDE; DMSO; DNA FRAGMENTATION FACTOR; ENDOPLASMIC RETICULUM; ER; ER STRESS; GAPDH; GFP; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; GREEN FLUORESCENT PROTEIN; HBV; HCC; HEP3B; HEPATITIS B VIRUS; HEPATOCELLULAR CARCINOMA; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUVECS; LC3B; LIGHT CHAIN 3 B; MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION; MOMP; NEFERINE; NELUMBO NUCIFERA; PARP; PBS; PCD; PDI; PHOSPHATE-BUFFERED SALINE; POLY(ADP-RIBOSE) POLYMERASE; PROGRAMMED CELL DEATH; PROTEIN DISULFIDE ISOMERASE; SIRT6; SIRTUIN-6; WST-1;

ANGIOGENESIS INHIBITORS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; AUTOPHAGY; BENZYLISOQUINOLINES; CARCINOMA, HEPATOCELLULAR; CELL CYCLE CHECKPOINTS; CELL LINE; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM STRESS; HEPATITIS B VIRUS; HUMANS; LIVER; LIVER NEOPLASMS; NELUMBO; PHYTOTHERAPY; PLANT EXTRACTS; SEEDS; SIGNAL TRANSDUCTION;

HEPATITIS B VIRUS; NELUMBO NUCIFERA;

EID: 84880773508     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2013.03.024     Document Type: Article

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